TOGA Hirohisa

Researcher Profile & Settings

Research

Overview of research:
Pathogenesis and therapy of acute lung injury

Special Field

• Internal Medicine Respiratory System

Education

• Kanazawa University Faculty of Medicine

Degree

• Ph.D in Medicine

Research Activities

Published Papers

• Trafficking of newly synthesized surfactant protein B to the lamellar body in alveolar type II cells, Osanai Kazuhiro, Mizuno Shiro, Toga Hirohisa, Takahashi Keiji, Cell and Tissue Research, 381:427-438, Sep. 2020
  DOI:10.1007/s00441-020-03232-7
• Effectiveness of Long Pepper Extract in Reducing Leg Swelling in Healthy Women during Prolonged SittingーA Randomized,Double-blind,Placebo-controlled Crossover Trialー, Yuki Fujimoto, Keiji Fujimoto, Rieko Oikawa, Mio Sawada, Mutsumi Tsuchishima, Junji Moriya, Hiroaki Uenishi, Hisakazu Furuta, Junji Kobayashi, Shiro Mizuno, Hirohisa Toga, Noboru Takekoshi, Susumu Yoshino, Yasuo Miyake, Nobuaki Ohto, Sumiyo Akazawa, Japanese Pharmacology & Therapeutics, 48:401-407, Mar. 2020
• Prediction of Oxygen Saturation by Pulse Oximetory from Image and Sound Data with Long Short-term Memory Recurrent Neural Network, (Takehiro.Kasahara), Yuji.Yonezawa, Yoshihiro.Ueda, Masatoshi.Saito, Koji.Kojima, Yuki.Fujimoto, Hirohisa.Toga, Hidetaka.Nambo, Sensors and Materials, 30:1447-1455, Jul. 2018
• ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema, Nojiri Masafumi;Mizuno Shiro;Nishiki Kazuaki;Kato Ryo;Nakagawa Ken;Oikawa Taku;Iguchi Masaharu;Osanai Kazuhiro;Ishizaki Takeshi;Toga Hirohisa, Pulmonary pharmacology & Therapeutics, 48:80-87, Feb. 2018
  DOI:10.1016/j.pupt.2017.09.004
• p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD, Shiro.Mizuno, Takeshi.Ishizaki, Maiko.Kadowaki, Masaya.Akai, Kohei.Shiozaki, Masaharu.Iguchi, Taku.Oikawa, Ken.Nakagawa, Kazuhiro.Osanai, Hirohisa.Toga, Jose.Gomez-Arroyo, Donatas.Kraskauskas, Carlyne.D.Cool, Herman.J.Bogaard, Norbert.F.Voelkel, CHEST, 152:58-69, Jul. 2017
• A case of pulmonary arteriovenous malformation having difficulty in differential diagnosis of the hemoptysis during each menstrual period, Yutaka.Takahara, Ryo.Kato, Ken.Nakagawa, Shiro.Mizuno, Kazuhiro.Osanai, Hirohisa.Toga, Annals of the Japanese Respiratory Society, 6:215-219, May 2017
• Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats, Kazuhiro.Osanai, Keisuke.Nakase, Takashi.Sakuma, Kazuaki.Nishiki, Masafumi.Nojiri, Ryo.Kato, Masatoshi.Saito, Yuki.Fujimoto, Shiro.Mizuno, Hirohisa.Toga, Respiratory Research, 18:70, Apr. 2017
• Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease., R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki, N.F.Voelkel, H.Toga, Respiratory research, 17:139-151, 2016
• The therapeutic strategy for clinical stage IA non-small cell lung cancer patients who are ineligible for lobectomy, N.Motono, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, H.Toga, M.Matoba, M.Sagawa, Haigan, 56:183-188, 2016
• A critical role of Dectin-1 in hypersensitivity pneumonitis., M.Higashino, T.Yabe-Wada, S.Matsuda, K.Takeda, K.Anzawa, T.Mochizuki, K.Makimura, S.Saijyo, Y.Iwakura, H.Toga, A.Nakamura, Inflammation Research, 65:235-244, 2016
  DOI:10.1007/s00011-015-0910-1
• Role of p53 in lung tissue remodeling, S.Mizuno, HJ.Bogaard, T.Ishizaki, H.Toga, World Journal of Respirology, 5:40-46, May 2015
• ABPA-like Clinical Condition Associated with Bronchial Stenosis After Lung Lobectomy, T.Oikawa, R.Kato, S.Kitadate, S.Shinomiya, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga, The Journal of the Japan Society for Rsepiratory Endoscopy, 37:203-208, Mar. 2015
• A Case of Pulmonary Langerhans Cell Histiocytosis Diagnosed by a Cell Block from Bronchoalveolar Lavage Fluid, Y.Takahara, K.Nakase, M.Nojiri, R.Kato, S.Shinomiya, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, The Journal of the Japan Society for Respiratory Endoscopy, 37:240-244, Mar. 2015
• Pulmonary vascular and airway responses to systemic vasoconstrictors in anesthetized BALB/c mice. , M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.Toga, Journal of cardiovascular pharmacology, 65:325-334, 2015
• Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks, S.Mizuno, T.Ishizaki, H.Toga, A.Sakai, J.Isakova, E.Taalaibekova, Z.Baiserkeev, B.Kojonazarov, A.Aldashev, Biomed Research International, 2015:1-6, 2015
  DOI:10.1155/2015/196904
• A case of IgG4-related kidney disease complicated by eosinophilic lung disease, H.Adachi, H.Okuyama, H.Yamaya, N.Kurose, K.Kojima, H.Toga, H.Yokoyama, CEN Case Reports, :1-7, Dec. 2014
• Adenovector-mediated gene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats, M.Zhou, K.Osanai, M.Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno, Y.Muraki, H.Toga, Critical care medicine., 42:e716-e724, Nov. 2014
• A three-microphone acoustic reflection technique using transmitted acoustic waves in the airway, Y.Fujimoto, J.Huang, T.Fukunaga, R.Kato, M.Higashino, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, M.Saito, M.Kobayashi, K.Kojima, T.Oikawa, K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, S.Mizuno, K.Osanai, H.Toga, Journal of applied physiology (Bethesda, Md. : 1985), 115:1119-1125, Sep. 2013
• A case of empyema thoracis by Nocardia farcinica successfully treated with sitafloxacin, T.Oikawa, R.Kato, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga, 2:424-428, Jul. 2013
• A case of lung abscess caused by community-acquired methicillin-resistant Staphylococcus aureus, M.Saito, T.Oikawa, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga, 2:295-299, May 2013
• Nitric oxide and β2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice., S.Shinomiya, T.Shibamoto, Y.Kurata, Y.Kuda, W..Zhang, M.Tanida, H.Toga, Experimental lung research., 39:119-129, Jan. 2013
• Assessment of treatment effect for acromegaly with sleep disordered breathing., A.Sakai, H.Toga, O.Tachibana, T.Miwa, 116:612-618, 2013
• A Case of rapidly progressing pulmonary mycosis caused by Aspergillus niger developing fungus ball-like shadows, M.Saito, S.Shinomiya, S.Kitadate, Y.Takahara, A. Yamaya, K.Kouji, Y.Fujimoto, T.Oikawa, K.Nakagawa, K.Tsishihara, M.Iguchi, K.Osanai, H.Toga, 33:33-37, Jan. 2011
• Two cases of Birt-Hogg-Dube' syndrome in a family, K.Nakagawa, S.Kitadate, M.Saito, Y.Fujimoto, K.Kojima, T.Oikawa, K.Oikawa, M.Iguchi, J.Huang, K.Osanai, H.Toga, K.Araida, 56:133-137, Jan. 2011
• Aquaporin as a novel player in cancer cell the invasion of cancer cells, Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami, S.Katsuda, 35:55-60, Aug. 2010
• Current situations and issues in respiratory medicine in Japan, (H.Kimura), H.Toga, M.Yamaya, M.Mishima, T.Nukiwa, S.Kudo, JMAJ: Japan Medical Association Journal, 53:178-184, Jun. 2010
• Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-pudlak syndrome, K.Osanai, J.Higuchi, R.Oikawa, M.Kobayashi, K.Tsuchihara, M.Iguchi, J.Huang, D.R.Voelker, H.Toga, American journal of physiology. Lung cellular and molecular physiology., 298:L243-L251, Feb. 2010
• Hepatic microvascular pressure during anaphylactic shock in anesthetized rats, H.Takano, T.Shibamoto, W.Zhang, Y.Kurata, H.Toga, Microvascular research, 78:169-173, 2009
• Endobronchial treatment using spiral-z stent and electrosurgery, H.Aikawa, M.Sagawa, M.Tanaka, Y.Machida, M.Ueno, K.Usuda, T.Tobe, H.Toga, T.Sakuma, 33:141-144, Dec. 2008
• A mulation in rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice, K.Osanai, R.Oikawa, J.Higuchi, M.Kobayashi, K.Tsuchihara, M.Iguchi, J.Huang, H.Toga, D.R.Voelker, The American journal of pathology., 173:1265-1274, Nov. 2008
• A case of broncholithiasis lithoptysis occurring spontaneously after repeated pneumonia, R. Oikawa, Y. Takahara, A. Yamaya, M. Saito, K. Kojima, Y. Tachi, T. Oikawa, K. Nakagawa, K. Tsuchihara, M. Iguchi, T. Tobe, M. Takahashi, J. Huang, K. Osanai, H. Toga, 46:126-130, Feb. 2008
• Standard classification of autofluorescence bronchoscopy findings, (T.Nakajima), Y.Shibuya, H.Honda, F.Imamura, M.Satou, H.Isobe, Y.Ohno, T.Tsuchida, H.Toga, S.Hayashi, K.Mastui, T.Miyazawa, A.Yokoyama, N.Kurimoto, H.Saka, M.Tsuboi, H.Horinouchi, K.Yasufuku, T.Fujisawa, 47:215-221, Jun. 2007
• Lung Carcinoma : diffusion-weighted MR imaging-preliminary evaluation with apparent diffusion coefficient, M.Matoba, H.Tonami, T.Kondou, H.Yokota, K.Higashi, H.Toga, T.Sakuma, 243:570-577, May 2007
• Microvessel density : correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas, J. F. Guo, K.Higashi, Y.Ueda, M.Oguchi, T.Takegami, H.Toga, T.Sakuma, H.Yokota, S.Katsuda, H.Tonami, I.Yamamoto, Journal of nuclear medicine : official publication, Society of Nuclear Medicine., 47:419-425, Mar. 2006
• Pulmonary surfactant transport in alveolar type Ⅱ cells, K.Osanai, C.Tsuchihara, R.Hatta, T.Oikawa, K.Tsuichihara, M.Iguchi, T.Seki, M.Takahashi, J.Huang, H.Toga, Respirology (Carlton, Vic.), 11:S70-S73, Jan. 2006
• Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine, T.Sakuma, X.Gu, Z.Wang, S.Maeda, M.Sugita, M.Sagawa, K.Osanai, H.Toga, L.B.Ware, G.Folkesson, M.A.Matthay, Critical care medicine., 34:676-681, 2006
• Fluorodeoxyglucose uptake correlates with the growth pattern of small peripheral pulmonary adenocarcinoma, M.Sagawa, K.Higashi, M.Sugita, Y.Ueda, S.Maeda, H.Toga, T.Sakuma, Surgery today., 36:230-234, 2006
• Denopamine stimulates alveolar fluid clearance via cystic flbrosis transmembrane conductance regulator in rat lungs, X.Gu, Z.Wang, J.Xu, S.Maeda, M.Sugita, M.Sagawa, H.Toga, T.Sakuma, Respirology (Carlton, Vic.), 11:566-571, 2006
• Bronchial embolization prior to the thoracoplasty for pulmonary aspergillosis, M.Sagawa, M.Sugita, M.Iguchi, Y.Sagara, H.Toga, S.Maeda, T.Sakuma, 30:20-22, Jun. 2005
• Expression and characterization of Rab38, a new member of the Rab samll G protein family, K.Osanai, K.Takahashi, K.Nakamura, M.Takahashi, M.Ishigaki, T.Sakuma, H.Toga, T.Suzuki, D.R.Voelker, Biological chemistry., 386:143-153, Feb. 2005
• Expression and characterization of Rab38, a new member of the Rab small G protein family., TOGA Hirohisa, Biol Chem, 2005
• Clinical efficacy and saftey of transdermal tulobuterol in the treatment of stable COPD: an open-label comparison with inhaled salmeterol, (Y.Fukuchi), A.Nagai, K.Seyama, M.Nisimura, K.Hirata, K.Kubo, M.Ichinose, H.Aizawa, H.Toga, BAREC Research Group, Treatments in respiratory medicine., 4:447-455, 2005
• Catecholamine clearance from alveolar spaces of rat and human lungs., TOGA Hirohisa, Respiration, 2005
• Catecholamine clearance from alveolar spaces of rat and human lungs, T.Sakuma, X.Gu, M.Sugita, M.Sagawa, M.Sakuda, H.Toga, Respiration, 72:189-196, 2005
• Video-assisted thoracoscopic wedge resection for pulmonary sequestration, *T.Sakuma, *M.Sugita, *M.Sagawa, M.Ishigaki, H.Toga, The Annals of thoracic surgery., 78:1844-1845, 2004
• Video-assisted bronchial stump reinforcement with an intercostal muscle flap, *M.Sagawa, *M.Sugita, Y.Takeda, H.Toga, T.Sakuma, The Annals of thoracic surgery., 78:2165-2166, 2004
• Uridine 5'-triphosphate stimulates alveolar fluid clearance in the isolated rat lungs., TOGA Hirohisa, J Pharmacol Sci, 2004
• Uridine 5'-triphosphate stimulates alveolar fluid clearance in the isolated rat lungs, *T.Sakuma, *X.Gu, *M.Sugita, *M.Sagawa, M.Sakuda, H.Toga, Journal of pharmacological sciences., 95:420-425, 2004
• Role of CXC chemokines in ventilator-induced lung injury in rats., TOGA Hirohisa, J Jpn Med Soc Biol Interface, 2004
• Role of CXC chemokines in ventilator-induced lung injury in rats, H.Toga, K.Tsuchihara, C.Tsuchihara, T.Tobe, M.Iguchi, M.Takahashi, M.Ishigaki, J.Huang, K.Osanai, *T.Fukunaga, *T.Sakuma, K.Takahashi, et al., Journal of Japanese Medical Society for Biological Interface, 35:9-16, 2004
• Maximal inspiratory flow with nasal continuous positive airway pressure in patients with sleep-disordered breathing:relevance to the upper airway reflex, J.Huang, Y.Tachi, *T.Fukunaga, K.Tsuchihara, M.Iguchi, T.Tobe, M.Takahashi, M.Ishigaki, K.Osanai, H.Toga, et al., Japanese Journal of Applied Physiology, 34:169-176, 2004
• Maximal inspiratory flow with nasal continuous positive airway pressure in patients with sleep-disordered breathing: relevance to the upper airway reflex., TOGA Hirohisa, Jpn J Clin Physiol, 2004
• Malnutrition impairs alveolar fluid clearance in rat lungs, *T.Sakuma, *Y. Zhao, *M.Sugita, *M.Sagawa, H.Toga, *T.Ishibashi, *M.Nishio, et al., American journal of physiology. Lung cellular and molecular physiology., 286:L1268-L1274, 2004
• Malnutrition impaires alveolar fluid clearance in rat lungs., TOGA Hirohisa, Am J Physiol (Lung), 2004
• Detection of inspiratory flow limitation with cardiogenic flow oscillation in patients with obstructive sleep apnea., TOGA Hirohisa, Jpn J Clin Physiol, 2004
• Detection of inspiratory flow limitation with cardiogenic flow oscillation in patients with obstructive sleep apnea, J.Huang, Y.Tachi, *T.Fukunaga, K.Tsuchihara, M.Iguchi, T.Tobe, M.Takahashi, M.Ishigaki, K.Osanai, H.Toga, et al., Japanese Journal of Applied Physiology, 34:161-167, 2004
• A prostacyclin analogue, OP-41483α-CD, restores the ability of a β2-adrenergic agonist to stimulate alveolar fluid clearance in rats　, *T.Sakuma, *Y.Zhao, *M.Sugita, *M.Sagawa, H.Toga, et al., Surgery today., 34:429-436, 2004
• A prostacyclin analogue, OP-41483 alfa-CD, restores the ability of a beta 2-adrenergic agonist to stimulate alveolar fluid clearance in rats., TOGA Hirohisa, Surg Today, 2004
• The in vitro epithelial repair capacity in acid-injured alveolar cell model, M. Ishigaki, *T. Sakuma, Y. Tachi, R. Hatta, T. Oikawa, K. Nakagawa, Y. Takeda, M. Iguchi, T. Tobe, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, et al., Journal of Japanese Medical Society for Biological Interface, 34: 69-70, 2003
• Mechanical stress on type II alveolar epithelial cells and production of CXC chemokines., TOGA Hirohisa, J Jpn Med Soc Biol Interface, 2003
• Mechanical stress on type II alveolar epithelial cells and production of CXC chemokines, H. Toga, K. Tsuchihara, M. Hida, K. Nakamura, C. Tsuchihara, T. Tobe, M. Iguchi, M. Ishigaki, Y. Nambu, K. Osanai, T. Sakuma, K. Takahashi, Journal of Japanese Medical Society for Biological Interface, 34: 77-80, 2003
• Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs, *T. Sakuma, *M. Sagawa, M. Hida, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, et al., The Journal of thoracic and cardiovascular surgery., 124: 668-674, 2002
• Time dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs., TOGA Hirohisa, J Thorac Cardiov Surg, 2002
• Inducible nitric oxide synthase expression and nuclear factor-κ B activation in alveolar typeⅡ cells in lung injury, H. Toga, *Y. Ueda, K. Osanai, M. Ishigaki, *S. Katsuda, K. Takahashi, N. Ohya, et al., Experimental lung research., 27: 485-504, 2001
• Inducible nitric oxide synthase expression and nuclear factor κB activation in alveolar type II cells in lung injury.(共著), TOGA Hirohisa, Exp Lung Res, 2001
• Inducible nitric oxide synthase expression and nuclear factor kappa B activation in alveolar type II cells in lung injury., TOGA Hirohisa, Exp Lung Res, 2001
• Expression and localization of a novel rab small G protein(rab38)in the rat lung.(共著), TOGA Hirohisa, Am J Pathol, 2001
• Expression and localization of a novel rab small G protein (rab38) in the rat lung., TOGA Hirohisa, Am J Pathol, 2001
• Expression and Localization of a novel Rab small G protein (Rab 38) in the rat lung, K. Osanai, M. Ishigaki, K. Takahashi, Y. Nambu, *T. Sakuma, H. Toga, N. Ohya, et al., The American journal of pathology., 158: 1665-1675, 2001
• Effects of hypoxia on alveolar fluid transport capacity in rat lungs., TOGA Hirohisa, J Appl Physiol, 2001
• Effect of hypoxia on alveolar fluid transport capacity in rat lungs, *T. Sakuma, M. Hida, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, et al., Journal of applied physiology (Bethesda, Md. : 1985), 91: 1766-1774, 2001
• Denopamine, a β1-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs.(共著), TOGA Hirohisa, J Appl Physiol, 2001
• Denopamine, a β1-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs, *T. Sakuma, C. Tsuchihara, M. Ishigaki, K. Osanai, Y. Nambu, H. Toga, K. Takahashi, N. Ohya, et al., Journal of applied physiology (Bethesda, Md. : 1985), 90: 10-16, 2001
• Denopamine, a beta 1-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs., TOGA Hirohisa, J Appl Physiol, 2001
• Betal-adrenergic agonist is a potential stimulator of alveolar fluid clearance in hyperoxic rat lungs.(共著), TOGA Hirohisa, Jpn J Pharmacol, 2001
• Beta1-Adrenoceptor simulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung, *T. Sakuma, C. Tsuchihara, M. Ishigaki, K. Osanai, Y. Nambu, H. Toga, K. Takahashi, N. Ohya, et al., Experimental lung research., 27: 453-468, 2001
• Beta1-Adrenergic Agonist a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs, T. Sakuma, M. Hida, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, Japanese journal of pharmacology., 85: 161-166, 2001
• Beta 1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung., TOGA Hirohisa, Exp Lung Res, 2001
• Beta 1-adrenergic agonist is a potential stimulator of alveolar fluid clearance in hyperoxic rat lungs., TOGA Hirohisa, Jpn J Pharmacol, 2001
• Apotosis of alveolar typeⅡ cells in acute respiratory distress syndrome, H. Toga, H. Kasakura, T. Tobe, *Y. Ueda, G. H. Yang, Y. Nambu, K. Osanai, *T. Sakuma, K. Takahashi, N. Ohya, et al., 32: 24-25, 2001
• A new nasal acoustic reflection technique to estimate pharyngeal cross-sectional area during sleep, J.Huang, N.Itai, T.Hoshiba, *T.Fukunaga, K.Yamanouchi, H.Toga, K.Takahashi, N.Ohya, 88:1457-1466, Apr. 2000
• Lung deflation impares alveolar epithelial fluid transport in ischemic rabbit and rat lungs.(共著), TOGA Hirohisa, Transplantation, 2000
• Lung deflation impares alveolar epithelial fluid transport in ischemic rabbit and rat lungs., TOGA Hirohisa, Transplantation, 2000
• Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs, T.Sakuma, C.Tsukano, M.Ishigaki, Y.Nambu, K.Osanai, H.Toga, K.Takahashi, N.Ohya, et al., Transplantation., 69:1785-1793, 2000
• A new nasal acoustic reflection technique to estimate pharyngeal cross-sectional area during sleep.(共著), TOGA Hirohisa, J Appl Physiol, 2000
• A new nasal acoustic reflection technique to estimate pharyngeal cross-sectional area during sleep., TOGA Hirohisa, J Appl Physiol, 2000
• Upregulation of alveolar epithelial fluid clearance following ischemia-reperfusion rat lung.(共著), TOGA Hirohisa, J Kanazawa Med Univ, 1998
• Pharyngeal cross-sectional area and pharyngeal compliance in normal males and females.(共著), TOGA Hirohisa, Respiration, 1998
• Effect of hypoxia on pulmonary blood flow-segmental vascular resistance relationship in perfused cat lungs.(共著), TOGA Hirohisa, J Appl Physiol, 1998
• Differential role of endothelium-dereived nitric oxide in the modulation of the systemic and pulmonary circulation in lambs.(共著), TOGA Hirohisa, Biol Neonate, 1996
• Differential responses of ovine intrapulmonary arteries and veins to acetylcholine.(共著), TOGA Hirohisa, Respir Physiol, 1996
• The effect of surfactant, blood flow and left atrial pressure on pulmonary vascular pressure profile in immature lamb lungs.(共著), TOGA Hirohisa, Pulmonary Circulation Research, 1995
• Role of nitric oxide and thromboxane A2 in hypoxic pulmonary vasoconstriction.(共著), TOGA Hirohisa, Pathophysiology, 1994
• Role of nitric oxide and cyclooxygenase metabolites in response of pulmonary segmental vessels to hypoxia.(共著), TOGA Hirohisa, Pulmonary Circulation Research, 1994
• Gender and underlying diseases affect the frequency of the concurrence of adult polymyositis/dermatomyositis and interstitial pneumonia.(共著), TOGA Hirohisa, Chest, 1994
• Effect of pulmonary blood flow on microvascular pressure profile determined by micropuncture in perfused cat lungs.(共著), TOGA Hirohisa, J Appl Physiol, 1994
• Alveolar hypoxia : Change in action of vasoactive substances and response of pulmonary capillary bed to increased blood flow.(共著), TOGA Hirohisa, Pathophysiology, 1994
• Tone-dependent nitric oxide production in ovine vessels in vitro.(共著), TOGA Hirohisa, Respir Physiol, 1993
• Effect of pulmonary blood flow rate on the longitudinal distribution of vascular resistance in cat lungs.(共著), TOGA Hirohisa, Jpn J Appl Physiol, 1993
• Vascular effects of platelet-activating factor in lambs : role of cyclo- and lipoxygenase.(共著), TOGA Hirohisa, J Appl Physiol, 1992
• Vascular effects of endothelin, platelet-activating factor and thromboxane A2 analogue in isolated ferret lungs.(共著), TOGA Hirohisa, Respir Physiol, 1992
• In vitro responses of intrapulmonary arteries and veins to endothelin-1.(共著), TOGA Hirohisa, Am J Physiol, 1992
• Comparison between occlusion and micropuncture pressures in the pulmonary circulation, with reference to pressure-flow relationship.(共著), TOGA Hirohisa, Pulmonary Circulation Research, 1992
• Positive pressure ventilation reverses phasic respiratory glottis narrowing in anesthetized dogs.(共著), TOGA Hirohisa, Control of breathing and dyspnea, Pergamon Press, 1991
• Microvascular pressure but not alveolar pressure determines driving pressure of pulmonary circulation in zone 2(West).(共著), TOGA Hirohisa, Microcirculation annual, 1991
• Measurement of the pharyngeal area in patients with obstructive sleep apnea during sleep using acoustic reflection technique.(共著), TOGA Hirohisa, Control of breathing and dyspnea, Pergamon Press, 1991
• Endothelin effects in isolated, perfused lamb lungs : role of cyclooxygenase inhibition and vasomotor tone.(共著), TOGA Hirohisa, Am J Physiol, 1991
• Effect of pulmonary blood flow on the longitudinal distribution of pulmonary vascular resistance : role of capillary recruitment.(共著), TOGA Hirohisa, The 31st international congress of pulmonary circulation., 1990
• Mouth pressure curve on abrupt interruption of airflow during forced expiration.(共著), TOGA Hirohisa, J Appl Physiol, 1989
• High-prequency ventilation by bilateral phrenic nerve stimulation in dogs.(共著), TOGA Hirohisa, Respiration, 1989
• Airway pressure-volume curve estimated by flow interruption during forced expiration.(共著), TOGA Hirohisa, J Appl Physiol, 1989
• Serum Creatinine/Cystatin C Ratio Associated with Cross-Sectional Area of Erector Spinae Muscles and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Takeshi Ishizaki, Hirohisa Toga, Shiro Mizuno, International Journal of Chronic Obstructive Pulmonary Disease, 2021:3513-3524, Dec. 2021
  DOI:10.2147/COPD.S339243
• Serum Derivatives of Reactive Oxygen Metabolites are Associated with Severity of Chronic Obstructive Pulmonary Disease and Affected by a P53 Gene Polymorphism, Koichi Yamamura, Masafumi Nojiri, Kazuaki Nishiki, Ryo Kato, Shohei Shinomiya, Yutaka Takahara, Taku Oikawa, Takeshi Iahizaki, Hirohisa Toga, Shiro Mizuno, International Journal of Chronic Obstructive Pulmonary Disease, 17:1589-1600, Jul. 2022
  DOI:10.2147/COPD.S366792
• Prognostic value of the serum creatinine/cystain C ratio in patients with chronic obstructive pulmonary disease, (Yasutaka Kawasak), Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Takeshi Ishizaki, Hirohisa Toga, Shiro Mizuno, Respiratory Investigation, 62:143-149, Jan. 2024