HAMAGUCHI Tsuyoshi

■FacultyDepartment of Neurology
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    The research is aimed at clarifying the current issues of each disease through medical practice, elucidating pathophysiology, and developing new diagnostic and therapeutic methods for all diseases involving neurology, including cerebrovascular, neurodegenerative, neuroinfectious, immune-related neurological, neuromuscular junction, and muscular diseases. I have been engaged in the research on prion diseases, which is transmissible among individuals mediated by protein, and, recently, I have also reported the neuropathological changes of Alzheimer's disease could be transmitted among individuals like prion diseases. I am also involved in a nationwide epidemiological study of progressive multifocal leukoencephalopathy, an infection of the brain with the JC virus.

Research Activities

Published Papers

  • Cerebrospinal Fluid Biomarkers and Amyloid-β Elimination from the brain in Cerebral Amyloid Angiopathy-Related Inflammation, (Kenji Sakai), Moeko Noguchi-Shinohara, Hidetomo Tanaka, Tokuhei Ikeda, Tsuyoshi Hamaguchi, Akiyoshi Kakita, Masahito Yamada and Kenjiro Ono, Journal of Alzheimer's Disease, 91:1173-1183, 2023
  • Vacuoles related to tissue neuron-astrocyte ratio and infiltration of macrophages/monocytes contribute to hyperintense brain signals on Creutzfeldt-Jakob disease, (Ayano Shima), Kenji Sakai, Fumio Yamashita, Tsuyoshi Hamaguchi, Tetsuyuki Kitamoto, Makoto Sakai, Masahito Yamada, Kenjiro Ono, Journal of the Neurological Sciences, 447:120612, 2023
  • Effects of melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia: a randomized controlled trial., (Moeko Noguchi-Shinohara), Tsuyoshi Hamaguchi, Kenji Sakai, Junji Komatsu, Kazuo Iwasa, Mai Horimoto, Hiroyuki Nakamura, Masahito Yamada, Kenjiro Ono, Journal of Alzheimer's Disease, 91:805-814, 2023
  • Nationwide laboratory surveillance of progressive multifocal leukoencephalopathy in Japan: Fiscal years 2011-2020., (Kazuo Nakamichi), Yoshiharu Miura, Toshio Shimokawa, Kenta Takahashi, Tadaki Suzuki, Nobuaki Funata, Masafumi Harada, Koichiro Mori, Nobuo Sanjo, Motohiro Yukitake, Kazuya Takahashi, Tsuyoshi Hamaguchi, Shoko Izaki, Satoru Oji, Jin Nakahara, Ryusuke Ae, Koki Kosami, Souichi Nukuzuma, Yosikazu Nakamura, Kyoichi Nomura, Shuji Kishida, Hidehiro Mizusawa, Masahito Yamada, Masaki Takao, Hideki Ebihara, Masayuki Saijo, Viruses, 15:968, 2023
  • Autochthonous Cryptococcus gattii genotype VGIIb infection in a Japanese patient with anti-granulocyte-macrophage colony-stimulating factor antibodies, Tsuyoshi Hamaguchi, Nobuaki Uchida, Michiyo Fujita-Nakata, Megumi Nakanishi, Yasuhiro Tsuchido, Miki Nagao, Yoshitsugu Iinuma, Masato Asahina, Journal of the Infection and Chemotherapy, 30:1069-1075, Oct. 2024
  • Sporadic Late-onset Nemaline Myopathy Associated with Sjögren’s Syndrome:A Case Report, Tsuyoshi Hamaguchi, Ichizo Nishino, Yasuki Hirano, Nobuaki Uchida, Michiyo Fujita-Nakata, Megumi Nakanishi, Tomoyuki Sakai, Masato Asahina, 63:2683-2687, Mar. 2024
  • Anti-GQ1b-antibody-associated Ophthalmoparesis Mimicking Unilateral Oculomotor Nerve Palsy with Spontaneous Recovery, (Yasuki Hirano), Michiyo Fujita-Nakata, Tsuyoshi Hamaguchi, Nobuaki Uchida, Megumi Nakanishi, Masato Asahina., J Kanazawa Med Univ, 49:77-79, Feb. 2024
  • A noninvasive test for human prion disease using hair roots and scalp, Sci Rep, 15:41492, Nov. 2025
  • Natalizumab-associated progressive multifocal leukoencephalopathy after natalizumab extended interval dosing therapy in Japan., (Takahashi K), Nakahara J, Miura Y, Ae R, Nakamichi K, Harada M, Mori K, Sanjo N, Yukitake M, Yokote H, Hamaguchi T, Yamada M, Takao M, 12:e200476, Nov. 2025
  • Acute transverse myelitis following SARS-CoV-2 infection during treatment for ulcerative colitis with anti-TNFα therapy, Tsuyoshi Hamaguchi, Michiyo Fujita-Nakata, Yuri Shojima, Nobuaki Uchida, Megumi Nakanishi, Tohru Itoh, Masato Asahina, Clinical Neurology and Neurosurgery, 252:108854, May 2025
  • Iatrogenic Cerebral Amyloid Angiopathy after Cadaveric Dura Mater Transplantation to an Intact Brain Surface: A Case Report, (Yuto Katsuyama), Yasuhiro Aida, Daisuke Kita, Fumihide Enkaku, Tsuyoshi Hamaguchi, NMC Case Report Journal, 12:317-321, 2025