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ジョージ ジョセフ ジョセフ ジョージ

所属部署名肝胆膵内科学
職名准教授
 
 

研究者基本情報

基本情報

連絡先等

研究

    研究の概要:
    Molecular pathogenesis of hepatic fibrosis and hepatocellular carcinoma. Role of oxidative stress and current therapeutic approaches.

専門分野

  • 消化器内科学

学位

  • 医学博士
  • 生化学博士

所属学協会

  • 2005年- Curr年American Association for Cancer Research, Membership # 125380
  • 2007年- Curr年American Association for the Study of Liver Diseases, Membership # 111392
  • 2019年- Curr年Asian Pacific Association for the Study of the Liver, Membership # MN-2082

経歴

  • 2009年07月- 2010年08月Mount Sinai School of Medicine, New York; Division of Liver Diseases, Department of Medicine; 助教

研究活動情報

論文

  • Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in ratsYuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi MikihiroEuropean Journal of Pharmacology863:1726812019年12月
  • Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic FibrosisJoseph George, Mikihiro Tsutsumi, Mutsumi TsuchishimaScientific Reports9:7082019年01月
  • Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosisJoseph George, Mutsumi Tsuchishima, Mikihiro TsutsumiCell Death & Disease10:182019年01月
  • Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry.George JosephBiological Chemistry399:499-5092018年
  • Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice.George Joseph;Yan Irene K;Patel TusharLaboratory Investigation98:895-9102018年
  • MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in miceGeorge, Joseph; Tsutsumi, Mikihiro; Tsuchishima, MutsumiJOURNAL OF CELLULAR AND MOLECULAR MEDICINE21:3821-38352017年
  • GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats.K. Tamura, N. Hayashi, J. George, M. Toshikuni, T. Arisawa, J. Hiratake, M. Tsuchishima, M. TsutsumiAmerican Journal of Physiology: Gastrointestinal and Liver Physiology311:G305-G3122016年
  • Noncoding RNA as therapeutic targets for hepatocellular carcinoma.Joseph George, Tushar PatelSeminars in Liver Disease35:63-742015年
  • Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus InfectionY. Matsue, M. Tsutsumi, N. Hayashi, T. Saito, M. Tsuchishima, N. Toshikuni, T. Arisawa, J. GeorgePLoS One10:e0118744-e01187442015年
  • Serum endocan as a survival predictor for patients with liver cirrhosisN. Toshikuni, K.Ozaki, J. George, M. TsutsumiCanadian Journal of Gastroenterology and Hepatology29:427-4302015年
  • Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinomaK. Ozaki, N. Toshikuni, J. George, T. Minato, Y. Matsue, T. Arisawa, M. TsutsumiJournal of Cancer5:221-2302014年
  • Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosisT. Minato, M. Tsutsumi, M. Tsuchishima, N. Hayashi, T. Saito, Y. Matsue, N. Toshikuni, T. Arisawa, J. GeorgeMolecular Medicine (Cambridge, Mass.)20:490-5022014年
  • Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease.N. Hayashi, J. George, M. Takeuchi, A. Fukumura, N. Toshikuni, T. Arisawa, M. TsutsumiPloS One8:e70034-e70034 (1-14)2013年
  • Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study.N. Hayashi, J. George, H. Shiroeda, T. Saito, N. Toshikuni, M. Tsuchishima, T. Arisawa, M. TsutsumiJournal of Gastroenterology and Hepatology28:1015-10182013年
  • Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult.M. Tsuchishima, J. George, H. Shiroeda, T. Arisawa, T. Takegami, M. TsutsumiDigestive Diseases and Sciences58:1923-19332013年
  • Osteopontin, an oxidant stress-sensitive cytokine,up-regulates collagen-I via integrin α(V) β(3) engagement and PI3K-pAkt-NFκB signaling.Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N.Hepatology55:594-6082012年
  • Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches.Mormone E, George J, Nieto N.Chemico-Biological Interactions193:225-2312011年
  • Transgenic expression of human MMP-9 augments monocrotaline induced pulmonary arterial hypertension in mice.George J, D'Armiento J.Journal of Hypertension29:299-3082011年
  • Survivin knockdown and concurrent 4-HPR treatment attenuated human glioblastoma in vitro and in vivo.George J, Banik NL, Ray SK.Neuro-Oncology12:1088-11012010年
  • Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines.George J, Banik NL, Ray SK.International Journal of Biochemistry and Cell Biology42:1164-11732010年
  • Genistein induces receptor and mitochondrial pathways and increases apoptosis during Bcl-2 knockdown in human malignant neuroblastoma SK-N-DZ cells.George J, Banik NL, Ray SK.Journal of Neuroscience Research88:877-8862010年
  • Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma.George J, Banik NL, Ray SK.Clinical Cancer Research15:7186-71952009年
  • Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth.George J, Banik NL, Ray SK.Journal of Cellular and Molecular Medicine13:4205-42182009年
  • Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cellsGeorge J, Banik NL, Ray SK.Neurochemical Research34:66-782009年
  • Biodegradable honeycomb collagen scaffold for dermal tissue engineering.George J, Onodera J, Miyata T.Journal of Biomedical Materials Research 2008; 87A (4): 1103-1111.87A:1103-11112008年
  • Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats.Joseph GeorgeBiochemistry and Cell Biology86:235-2432008年
  • Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis.George J, Gondi CS, Dinh DH, Gujrati M, Rao JS.Clinical Cancer Research13:3507-35172007年
  • siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats.Joseph George, Mikihiro TsutsumiGene Therapy14:790-8032007年
  • Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis.Joseph GeorgeClinical Biochemistry39:984-9912006年
  • Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds.Joseph George, Yoshinori Kuboki, Teruo Miyata.Biotechnology and Bioengineering95:404-4112006年
  • Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine induced esophageal carcinogenesis in rats.Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S.Journal of Gastroenterology and Hepatology21:805-8132006年
  • Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury.Joseph George, Robert SternClinica Chimica Acta348:189-1972004年
  • Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats.Joseph George, Mikihiro Tsutsumi, Shujiro TakaseInternational Journal of Biochemistry and Cell Biology36:307-3192004年
  • Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats.Joseph GeorgeClinica Chimica Acta335:39-472003年
  • Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.George J, Rao KR, Stern R, Chandrakasan G.Toxicology156:129-1382001年
  • Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine.George J, Chandrakasan G.Clinical Biochemistry33:563-5702000年
  • Lactate dehydrogenase isoenzymes in dimethylnitrosamine induced hepatic fibrosis.George J, Chandrakasan G.Journal of Clinical Biochemistry and Nutrition22:51-621997年
  • Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen.George J, Chandrakasan G.Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology1292:215-2221996年
  • Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats.George J, Chandrakasan G.International Journal of Biochemistry and Cell Biology28:353-3611996年

書籍等出版物

  • Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas.
    Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies.
    Joseph George, Naren L. Banik, Swapan K. Ray
    Ray S.K. (Editor), Springer Science/Humana Press, New York, pp. 282-298, 2010年
  • The Application of Atelocollagen Solution for Lacrimal Duct Occlusion.
    Lacrimal Gland, Tear Film and Dry Eye Syndromes 3: Basic Science and Clinical Relevance.
    Jun Onodera, Akihiko Saito, Joseph George, Toru Iwasaki, Hiroshi Ito, Yu Aso, Takashi Hamano, Atushi Kanai, Teruo Miyata, Yutaka Nagai
    Kluwer Academic/Plenum Publishers, New York, pp. 1277-1281, 2002年


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