GEORGE Joseph

Researcher Profile & Settings

Profile & Settings

https://www.josorge.com

Contact

georgej@kanazawa-med.ac.jp

Research

Overview of research:
Molecular pathogenesis of hepatic fibrosis and hepatocellular carcinoma. Role of oxidative stress and current therapeutic approaches.

Special Field

• Study of Liver Diseases

Degree

• Ph.D in Medicine

Association Memberships

• 2005- CurrAmerican Association for Cancer Research, Membership # 125380
• 2007- CurrAmerican Association for the Study of Liver Diseases, Membership # 111392
• 2019- CurrAsian Pacific Association for the Study of the Liver, Membership # MN-2082
• 2020- CurrFellow of the American Association for the Study of Liver Diseases (FAASLD), Membership # 111392

Academic & Professional Experience

• Jul. 2009- Aug. 2010Mount Sinai School of Medicine, New York; Division of Liver Diseases, Department of Medicine; Assistant Professor
• Jun. 2014- Mar. 2016Mayo Clinic, Jacksonville, Florida, USA; Cancer Biology; Associate Professor

Research Activities

Published Papers

• Pemafibrate modulates peroxisome proliferator-activated receptor alpha and prevents alcohol-associated liver disease in rats., Takashi Saito, Joseph George, Kazuaki Ozaki, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Molecular Medicine, 31:145, Apr. 2025
  DOI:10.1186/s10020-025-01210-9
• Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches., George Joseph; Lu Yongke; Tsuchishima Mutsumi; Tsutsumi Mikihiro, Redox biology, 75:103258, Jun. 2024
  DOI:10.1016/j.redox.2024.103258
• Molecular pathogenesis of metabolic dysfunction-associated steatotic liver disease, steatohepatitis, hepatic fibrosis and liver cirrhosis., Saito Takashi;Tsuchishima Mutsumi;Tsutsumi Mikihiro; George Joseph, Journal of Cellular and Molecular Medicine, 28:e18491, Jun. 2024
  DOI:10.1111/jcmm.18491
• Interaction between fatty acid oxidation and ethanol metabolism in liver., Lu Yongke; George Joseph, American Journal of Physiology. Gastrointestinal and Liver Physiology, 326:G483-G494., May 2024
  DOI:10.1152/ajpgi.00281.2023
• Therapeutic implication of human placental extract to prevent liver cirrhosis in rats with metabolic dysfunction-associated steatohepatitis., Yamagata Mitsuyoshi;Tsuchishima Mutsumi;Saito Takashi;Tsutsumi Mikihiro; George Joseph, Clinical Science (Lond), 138:327-34905, Mar. 2024
  DOI:10.1042/CS20230533
• Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis., George Joseph; Tsuchishima Mutsumi;Tsutsumi Mikihiro, Biomedicine & Pharmacotherapy, 151:113111, Jul. 2022
  DOI:10.1016/j.biopha.2022.113111
• Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats, Molecular Medicine, 28:143, Nov. 2022
  DOI:10.1186/s10020-022-00566-6
• Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis, Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George, British Journal of Pharmacology, 177:5195-5207, Nov. 2020
  DOI:10.1111/bph.15258
• Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Journal of Molecular Medicine, 98:1203-1213, Sep. 2020
  DOI:10.1007/s00109-020-01950-7
• Metabolism and interactions of antileprosy drugs, Joseph George, Biochemical Pharmacology, 177:113993, Jul. 2020
  DOI:10.1016/j.bcp.2020.113993
• Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats, Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro, European Journal of Pharmacology, 863:172681, Dec. 2019
  DOI:10.1016/j.ejphar.2019.172681
• Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis, Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Scientific Reports, 9:708, Jan. 2019
  DOI:10.1038/s41598-018-37516-4
• Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Cell Death & Disease, 10:18, Jan. 2019
  DOI:10.1038/s41419-018-1272-8
• Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry., Joseph George, Biological Chemistry, 399:499-509, 2018
  DOI:10.1515/hsz-2017-0260
• Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice., George Joseph; Yan Irene K; Patel Tushar, Laboratory Investigation, 98:895-910, 2018
  DOI:10.1038/s41374-018-0053-4
• MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, George, Joseph; Tsutsumi, Mikihiro; Tsuchishima, Mutsumi, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21:3821-3835, 2017
  DOI:10.1111/jcmm.13304
• GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats., K. Tamura, N. Hayashi, J. George, M. Toshikuni, T. Arisawa, J. Hiratake, M. Tsuchishima, M. Tsutsumi, American Journal of Physiology: Gastrointestinal and Liver Physiology, 311:Ｇ305-Ｇ312, 2016
  DOI:10.1152/ajpgi.00439.2015
• Noncoding RNA as therapeutic targets for hepatocellular carcinoma., Joseph George, Tushar Patel, Seminars in Liver Disease, 35:63-74, 2015
  DOI:10.1055/s-0034-1397350
• Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, Y. Matsue, M. Tsutsumi, N. Hayashi, T. Saito, M. Tsuchishima, N. Toshikuni, T. Arisawa, J. George, PLoS One, 10:e0118744-e0118744, 2015
  DOI:10.1371/journal.pone.0118744
• Serum endocan as a survival predictor for patients with liver cirrhosis, N. Toshikuni, K. Ozaki, J. George, M. Tsutsumi, Canadian Journal of Gastroenterology and Hepatology, 29:427-430, 2015
  DOI:10.1155/2015/153805
• Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma, K. Ozaki, N. Toshikuni, J. George, T. Minato, Y. Matsue, T. Arisawa, M. Tsutsumi, Journal of Cancer, 5:221-230, 2014
  DOI:10.7150/jca.7691
• Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis, T. Minato, M. Tsutsumi, M. Tsuchishima, N. Hayashi, T. Saito, Y. Matsue, N. Toshikuni, T. Arisawa, J. George, Molecular Medicine (Cambridge, Mass.), 20:490-502, 2014
  DOI:10.2119/molmed.2014.00048
• Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease., N. Hayashi, J. George, M. Takeuchi, A. Fukumura, N. Toshikuni, T. Arisawa, M. Tsutsumi, PloS One, 8:e70034-e70034 (1-14), 2013
  DOI:10.1371/journal.pone.0070034
• Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study., N. Hayashi, J. George, H. Shiroeda, T. Saito, N. Toshikuni, M. Tsuchishima, T. Arisawa, M. Tsutsumi, Journal of Gastroenterology and Hepatology, 28:1015-1018, 2013
  DOI:10.1111/jgh.12137
• Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult., M. Tsuchishima, J. George, H. Shiroeda, T. Arisawa, T. Takegami, M. Tsutsumi, Digestive Diseases and Sciences, 58:1923-1933, 2013
  DOI:10.1007/s10620-013-2574-4
• Osteopontin, an oxidant stress-sensitive cytokine,up-regulates collagen-I via integrin α(V) β(3) engagement and PI3K-pAkt-NFκB signaling., Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N., Hepatology, 55:594-608, 2012
  DOI:10.1002/hep.24701
• Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches., Mormone E, George J, Nieto N., Chemico-Biological Interactions, 193:225-231, 2011
  DOI:10.1016/j.cbi.2011.07.001
• Transgenic expression of human MMP-9 augments monocrotaline induced pulmonary arterial hypertension in mice., George J, D'Armiento J., Journal of Hypertension, 29:299-308, 2011
  DOI:10.1097/HJH.0b013e328340a0e4
• Survivin knockdown and concurrent 4-HPR treatment attenuated human glioblastoma in vitro and in vivo., George J, Banik NL, Ray SK., Neuro-Oncology, 12:1088-1101, 2010
  DOI:10.1093/neuonc/noq079
• Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines., George J, Banik NL, Ray SK., International Journal of Biochemistry and Cell Biology, 42:1164-1173, 2010
  DOI:10.1016/j.biocel.2010.04.002
• Genistein induces receptor and mitochondrial pathways and increases apoptosis during Bcl-2 knockdown in human malignant neuroblastoma SK-N-DZ cells., George J, Banik NL, Ray SK., Journal of Neuroscience Research, 88:877-886, 2010
  DOI:10.1002/jnr.22244
• Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma., George J, Banik NL, Ray SK., Clinical Cancer Research, 15:7186-7195, 2009
  DOI:10.1158/1078-0432.CCR-09-1425
• Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth., George J, Banik NL, Ray SK., Journal of Cellular and Molecular Medicine, 13:4205-4218, 2009
  DOI:10.1111/j.1582-4934.2008.00539.x
• Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells, George J, Banik NL, Ray SK., Neurochemical Research, 34:66-78, 2009
  DOI:10.1007/s11064-008-9659-z
• Biodegradable honeycomb collagen scaffold for dermal tissue engineering., George J, Onodera J, Miyata T., Journal of Biomedical Materials Research, 87A:1103-1111, 2008
  DOI:10.1002/jbm.a.32277
• Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats., Joseph George, Biochemistry and Cell Biology, 86:235-243, 2008
  DOI:10.1139/o08-038
• Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis., George J, Gondi CS, Dinh DH, Gujrati M, Rao JS., Clinical Cancer Research, 13:3507-3517, 2007
  DOI:10.1158/1078-0432.CCR-06-3023
• siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats., Joseph George, Mikihiro Tsutsumi, Gene Therapy, 14:790-803, 2007
  DOI:10.1038/sj.gt.3302929
• Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis., Joseph George, Clinical Biochemistry, 39:984-991, 2006
  DOI:10.1016/j.clinbiochem.2006.07.002
• Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds., Joseph George, Yoshinori Kuboki, Teruo Miyata., Biotechnology and Bioengineering, 95:404-411, 2006
  DOI:10.1002/bit.20939
• Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine induced esophageal carcinogenesis in rats., Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S., Journal of Gastroenterology and Hepatology, 21:805-813, 2006
  DOI:10.1111/j.1440-1746.2005.04040.x
• Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury., Joseph George, Robert Stern, Clinica Chimica Acta, 348:189-197, 2004
  DOI:10.1016/j.cccn.2004.05.018
• Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats., Joseph George, Mikihiro Tsutsumi, Shujiro Takase, International Journal of Biochemistry and Cell Biology, 36:307-319, 2004
  DOI:10.1016/S1357-2725(03)00253-X
• Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats., Joseph George, Clinica Chimica Acta, 335:39-47, 2003
  DOI:10.1016/S0009-8981(03)00285-7
• Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen., George J, Rao KR, Stern R, Chandrakasan G., Toxicology, 156:129-138, 2001
  DOI:10.1016/S0300-483X(00)00352-8
• Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine., George J, Chandrakasan G., Clinical Biochemistry, 33:563-570, 2000
  DOI:10.1016/S0009-9120(00)00170-3
• Lactate dehydrogenase isoenzymes in dimethylnitrosamine induced hepatic fibrosis., George J, Chandrakasan G., Journal of Clinical Biochemistry and Nutrition, 22:51-62, 1997
  DOI:10.3164/jcbn.22.51
• Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen., George J, Chandrakasan G., Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1292:215-222, 1996
  DOI:10.1016/0167-4838(95)00202-2
• Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats., George J, Chandrakasan G., International Journal of Biochemistry and Cell Biology, 28:353-361, 1996
  DOI:10.1016/1357-2725(95)00140-9

Books etc

• Zymography: A Simple and Powerful Tool for the Assessment of MMP-2 and MMP-9 in Pathological Conditions.
  Zymography: Biological and Clinical Applications. Methods in Molecular Biology, vol 2918
  Joseph George
  Khalil, R.A. (Eds), Springer Science/Humana Press, New York, pp. 187-199,  2025
• Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas.
  Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies.
  Joseph George, Naren L. Banik, Swapan K. Ray
  Ray S.K. (Editor), Springer Science/Humana Press, New York, pp. 282-298,  2010
• The Application of Atelocollagen Solution for Lacrimal Duct Occlusion.
  Lacrimal Gland, Tear Film and Dry Eye Syndromes 3: Basic Science and Clinical Relevance.
  Jun Onodera, Akihiko Saito, Joseph George, Toru Iwasaki, Hiroshi Ito, Yu Aso, Takashi Hamano, Atushi Kanai, Teruo Miyata, Yutaka Nagai
  Kluwer Academic/Plenum Publishers, New York, pp. 1277-1281,  2002