FacultyRegenerative Medicine Center
PositionAdjunct Professor (Regenerative Medicine Center)

Researcher Profile & Settings

Profile & Settings



    Overview of research:
    Molecular pathogenesis of hepatic fibrosis and hepatocellular carcinoma. Role of oxidative stress and current therapeutic approaches.

Special Field

  • Study of Liver Diseases


  • Ph.D in Medicine

Association Memberships

  • 2005CurrAmerican Association for Cancer Research, Membership # 125380
  • 2007CurrAmerican Association for the Study of Liver Diseases, Membership # 111392
  • 2019CurrAsian Pacific Association for the Study of the Liver, Membership # MN-2082
  • 2020CurrFellow of the American Association for the Study of Liver Diseases (FAASLD), Membership # 111392

Academic & Professional Experience

  • Jul. 2009Aug. 2010Mount Sinai School of Medicine, New York; Division of Liver Diseases, Department of Medicine; Assistant Professor
  • Jun. 2014Mar. 2016Mayo Clinic, Jacksonville, Florida, USA; Cancer Biology; Associate Professor

Research Activities

Published Papers

  • Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis, Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George, British Journal of Pharmacology177:5195-5207Nov. 2020
  • Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Journal of Molecular Medicine98:1203-1213Sep. 2020
  • Metabolism and interactions of antileprosy drugs, Joseph George, Biochemical Pharmacology177:113993Jul. 2020
  • Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats, Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro, European Journal of Pharmacology863:172681Dec. 2019
  • Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis, Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Scientific Reports9:708Jan. 2019
  • Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Cell Death & Disease10:18Jan. 2019
  • Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry., Joseph George, Biological Chemistry399:499-5092018
  • Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice., George Joseph; Yan Irene K; Patel Tushar, Laboratory Investigation98:895-9102018
  • MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, George, Joseph; Tsutsumi, Mikihiro; Tsuchishima, Mutsumi, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE21:3821-38352017
  • GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats., K. Tamura, N. Hayashi, J. George, M. Toshikuni, T. Arisawa, J. Hiratake, M. Tsuchishima, M. Tsutsumi, American Journal of Physiology: Gastrointestinal and Liver Physiology311:G305-G3122016
  • Noncoding RNA as therapeutic targets for hepatocellular carcinoma., Joseph George, Tushar Patel, Seminars in Liver Disease35:63-742015
  • Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, Y. Matsue, M. Tsutsumi, N. Hayashi, T. Saito, M. Tsuchishima, N. Toshikuni, T. Arisawa, J. George, PLoS One10:e0118744-e01187442015
  • Serum endocan as a survival predictor for patients with liver cirrhosis, N. Toshikuni, K. Ozaki, J. George, M. Tsutsumi, Canadian Journal of Gastroenterology and Hepatology29:427-4302015
  • Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma, K. Ozaki, N. Toshikuni, J. George, T. Minato, Y. Matsue, T. Arisawa, M. Tsutsumi, Journal of Cancer5:221-2302014
  • Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis, T. Minato, M. Tsutsumi, M. Tsuchishima, N. Hayashi, T. Saito, Y. Matsue, N. Toshikuni, T. Arisawa, J. George, Molecular Medicine (Cambridge, Mass.)20:490-5022014
  • Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease., N. Hayashi, J. George, M. Takeuchi, A. Fukumura, N. Toshikuni, T. Arisawa, M. Tsutsumi, PloS One8:e70034-e70034 (1-14)2013
  • Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study., N. Hayashi, J. George, H. Shiroeda, T. Saito, N. Toshikuni, M. Tsuchishima, T. Arisawa, M. Tsutsumi, Journal of Gastroenterology and Hepatology28:1015-10182013
  • Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult., M. Tsuchishima, J. George, H. Shiroeda, T. Arisawa, T. Takegami, M. Tsutsumi, Digestive Diseases and Sciences58:1923-19332013
  • Osteopontin, an oxidant stress-sensitive cytokine,up-regulates collagen-I via integrin α(V) β(3) engagement and PI3K-pAkt-NFκB signaling., Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N., Hepatology55:594-6082012
  • Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches., Mormone E, George J, Nieto N., Chemico-Biological Interactions193:225-2312011
  • Transgenic expression of human MMP-9 augments monocrotaline induced pulmonary arterial hypertension in mice., George J, D'Armiento J., Journal of Hypertension29:299-3082011
  • Survivin knockdown and concurrent 4-HPR treatment attenuated human glioblastoma in vitro and in vivo., George J, Banik NL, Ray SK., Neuro-Oncology12:1088-11012010
  • Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines., George J, Banik NL, Ray SK., International Journal of Biochemistry and Cell Biology42:1164-11732010
  • Genistein induces receptor and mitochondrial pathways and increases apoptosis during Bcl-2 knockdown in human malignant neuroblastoma SK-N-DZ cells., George J, Banik NL, Ray SK., Journal of Neuroscience Research88:877-8862010
  • Combination of hTERT knockdown and IFN-gamma treatment inhibited angiogenesis and tumor progression in glioblastoma., George J, Banik NL, Ray SK., Clinical Cancer Research15:7186-71952009
  • Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis, and tumor growth., George J, Banik NL, Ray SK., Journal of Cellular and Molecular Medicine13:4205-42182009
  • Bcl-2 siRNA augments taxol mediated apoptotic death in human glioblastoma U138MG and U251MG cells, George J, Banik NL, Ray SK., Neurochemical Research34:66-782009
  • Biodegradable honeycomb collagen scaffold for dermal tissue engineering., George J, Onodera J, Miyata T., Journal of Biomedical Materials Research87A:1103-11112008
  • Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats., Joseph George, Biochemistry and Cell Biology86:235-2432008
  • Restoration of tissue factor pathway inhibitor-2 in a human glioblastoma cell line triggers caspase-mediated pathway and apoptosis., George J, Gondi CS, Dinh DH, Gujrati M, Rao JS., Clinical Cancer Research13:3507-35172007
  • siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats., Joseph George, Mikihiro Tsutsumi, Gene Therapy14:790-8032007
  • Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis., Joseph George, Clinical Biochemistry39:984-9912006
  • Differentiation of mesenchymal stem cells into osteoblasts on honeycomb collagen scaffolds., Joseph George, Yoshinori Kuboki, Teruo Miyata., Biotechnology and Bioengineering95:404-4112006
  • Effect of chronic dietary ethanol in the promotion of N-nitrosomethylbenzylamine induced esophageal carcinogenesis in rats., Tsutsumi M, George J, Ishizawa K, Fukumura A, Takase S., Journal of Gastroenterology and Hepatology21:805-8132006
  • Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury., Joseph George, Robert Stern, Clinica Chimica Acta348:189-1972004
  • Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats., Joseph George, Mikihiro Tsutsumi, Shujiro Takase, International Journal of Biochemistry and Cell Biology36:307-3192004
  • Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats., Joseph George, Clinica Chimica Acta335:39-472003
  • Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen., George J, Rao KR, Stern R, Chandrakasan G., Toxicology156:129-1382001
  • Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine., George J, Chandrakasan G., Clinical Biochemistry33:563-5702000
  • Lactate dehydrogenase isoenzymes in dimethylnitrosamine induced hepatic fibrosis., George J, Chandrakasan G., Journal of Clinical Biochemistry and Nutrition22:51-621997
  • Molecular characteristics of dimethylnitrosamine induced fibrotic liver collagen., George J, Chandrakasan G., Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology1292:215-2221996
  • Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats., George J, Chandrakasan G., International Journal of Biochemistry and Cell Biology28:353-3611996
  • Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats28: 143:s10020-022-00566-6Nov. 2022

Books etc

  • Molecular Mechanisms of Taxol for Induction of Cell Death in Glioblastomas.
    Glioblastoma: Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies.
    Joseph George, Naren L. Banik, Swapan K. Ray
    Ray S.K. (Editor), Springer Science/Humana Press, New York, pp. 282-298,  2010
  • The Application of Atelocollagen Solution for Lacrimal Duct Occlusion.
    Lacrimal Gland, Tear Film and Dry Eye Syndromes 3: Basic Science and Clinical Relevance.
    Jun Onodera, Akihiko Saito, Joseph George, Toru Iwasaki, Hiroshi Ito, Yu Aso, Takashi Hamano, Atushi Kanai, Teruo Miyata, Yutaka Nagai
    Kluwer Academic/Plenum Publishers, New York, pp. 1277-1281,  2002