甲野　裕之　コウノ ヒロユキ

研究者基本情報

研究

研究の概要:
実験病理学, 腫瘍免疫学

専門分野

• 実験病理学

学歴

• 北海道大学 薬学部 薬学

学位

• 博士(医学)

所属学協会

• 米国癌学会 Active Member

経歴

• 1982年- 1989年資生堂基礎科学研究所 研究員
• 1989年- 1995年金沢医科大学 助手
• 1995年- 2004年金沢医科大学 講師
• 2004年金沢医科大学 助教授

研究活動情報

論文

• Effects of β-adrenoceptor antagonists on anaphylactic hypotension in conscious, W.Zhang, T.Shibamoto, Y.Kurata, H.Kohno, European journal of pharmacology., 650:303-308, 2011年
• Aqueous and ethanolic extract fractions from the Barazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Y.Yasui, S.Miyamoto, M.Kim, H.Kohno, S.Sugie, T.Tanaka, Oncology reports., 20:493-499, 2008年
• Dietary beta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice., Miyazawa K, Miyamoto S, Suzuki R, Yasui Y, Ikeda R, Kohno H, Yano M, Tanaka T, Hata K, Suzuki K, Oncol Rep., 17:297-304, 2007年02月
• Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice, H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, K.Wakabayashi, T.Tanaka, Clinical cancer research : an official journal of the American Association for Cancer Research., 13:2519-2525, 2007年
• Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model, H.Kohno, Y.Totsuka, Y.Yasui, R.Suzuki, S.Sugie, K.Wakabayashi, T.Tanaka, International journal of cancer. Journal international du cancer., 121:1659-1664, 2007年
• Lack of enhancing effect of lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran sodium sulfate, (S.Miyamoto), R.Suzuki, Y.Yasui, H. Kohno, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka, J. Toxicol. Pathol., 20:93-100, 2007年
• Dietary β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice, K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki, Oncology reports., 17:297-304, 2007年
• Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice, K.Hayashi, R.Suzuki, S.Miyamoto, S.Yoshitani, H.Kohno, S.Sugie, S.Takashima, T.Tanaka, Nutrition and cancer., 58:75-84, 2007年
• Chemopreventive effects of conjugated linolenic acids (CLN) occurring in plant seed oils, (B.Narayan), M.Hosokawa, Y.Yasui, R.Suzuki, H.Kohno, T.Tanaka, K.Miyashita, Current nutrition & food science., 3:309-318, 2007年
• A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male ApcMin/+ mice, H.Kohno, M.Takahashi, Y.Yasui, R. Suzuki, S.Miyamoto, Y.Kamanaka, M.Naka, T.Maruyama, K.Wakabayashi, T.Tanaka, International journal of cancer. Journal international du cancer., 121:506-513, 2007年
• A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis, Y.Yasui, R.Suzuki, S.Miyamoto, T.Tsukamoto, S.Sugie, H.Kohno, T.Tanaka, International journal of cancer. Journal international du cancer., 121:2331-2339, 2007年
• 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats, Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, F.Beppu, M.Hosokawa, K.Miyashita, T.Tanaka, Nutrition and cancer., 59:82-91, 2007年
• β-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice, (K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, Y.Yamada, T.Oyama, T.Kuno, Y.Hirose, A.Hara, H.Mori, Cancer letters., 239:123-128, 2006年
• Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: Comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines, Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita, Chemotherapy, 52:220-225, 2006年
• Strain differences in susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice, R.Suzuki, H.Kohno, S.Sugie, H.Nakagama, T.Tanaka, Carcinogenesis., 27:162-169, 2006年
• Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats, (S.Miyamoto), H.Kohno, R.Suzuki, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka, Oncology reports., 15:1169-1173, 2006年
• Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells, (F.Beppu), M.Hosokawa, L.Tanaka, H.Kohno, T.Tanaka, K.Miyashita, The Journal of nutritional biochemistry, 17:830-836, 2006年
• Lack of enhancing effects of degraded λ-carrageenan on the development of β-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane, (K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, T.Kuno, Y.Hirose, A.Hara, H.Mori, Cancer letters., 238:69-75, 2006年
• Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells, Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita, Anticancer research., 26:1855-1860, 2006年
• Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice, H.Kohno, R.Suzuki, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka, International journal of cancer. Journal international du cancer., 118:2936-2942, 2006年
• Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice, R.Suzuki, H.Kohno, Y.Yasui, K.Hata, S.Sugie, S.Miyamoto, K.Sugawara, T.Sumida, Y.Hirose, T.Tanaka, International journal of cancer. Journal international du cancer., 120:252-258, 2006年
• Dextran sodium sulfate strongly promotes colorectal carcinogenesis in ApcMin/+ mice: Inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms, T.Tanaka, H.Kohno, R.Suzuki, K.Hata, S.Sugie, N.Niho, K.Sakano, M.Takahashi, K.Wakabayashi, International journal of cancer. Journal international du cancer., 118:25-34, 2006年
• Chemopreventive Effects of Nobiletin against Genotoxicity Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Lung of gpt delta Transgenic Mice, (M.Ikeda), K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Nohmi, Genes and Environment, 28:84-91, 2006年
• Chemoprevention of colon carcinogenesis by dietary non-nutritive compounds, *T. Tanaka, H. Kohno, et al., Asian Pacific journal of cancer prevention : APJCP., 2: 165-177, 2006年
• Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats, R.Suzuki, Y.Yasui, H.Kohno, S.Miyamoto, M.Hosokawa, K.Miyashita, T.Tanaka, Oncology reports., 16:989-996, 2006年
• An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies, R.Suzuki, H.Kohno, M.Suzui, N.Yoshimi, H.Tsuda, K.Wakabayashi, T.Tanaka, Carcinogenesis., 27:619-630, 2006年
• Mechanistic insights of carcinogenesis and anti-carcinogenesis by dietary compounds, T.Tanaka, R.Suzuki, S.Miyamoto, H.Kohno, S.Sugie, 金沢医科大学雑誌, 30:275-287, 2005年12月
• β-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate, H.Kohno, R.Suzuki, S.Sugie, T.Tanaka, Cancer science., 96:69-76, 2005年
• Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice, S.Sugie, P.Q.Vinh, K.M. Wahidur Rahman, J.Ushida, H.Kohno, R.Suzuki, A.Hara, L.B.Quang, T.Tanaka, H.Mori, International journal of cancer. Journal international du cancer., 117:524-530, 2005年
• Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands, H.Kohno, R.Suzuki, S.Sugie, T.Tanaka, BMC cancer [electronic resource]., 5:46・1-12, 2005年
• Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-α-expressing oval-like cells and activated hepatic stellate cells, (T.Sano), M.Kagawa, M.Okuno, N.Ishibashi, M.Hashimoto, M.Yamamoto, R.Suzuki, H.Kohno, R.Matsushima-Nishiwaki, Y.Takano, H.Tsurumi, S.Kojima, S.L. Friedman, H.Moriwaki, T.Tanaka, Nutrition and cancer., 51:197-206, 2005年
• Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis, (M.Suzui), M.Inamine, T.Kaneshiro, T.Morioka, N.Yoshimi, R.Suzuki, H.Kohno, T.Tanaka, International journal of oncology, 27:1391-1399, 2005年
• Effect of α-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats, S.Sugie, M.Ohnishi, J.Ushida, T.Yamamoto, A.Hara, A.Koide, Y.Mori, H.Kohno, R.Suzuki, T.Tanaka, K.Wakabayashi, H.Mori, International journal of cancer. Journal international du cancer., 115:346-350, 2005年
• Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane, R.Suzuki, H.Kohno, S.Sugie, T.Tanaka, Histology and histopathology., 20:483-492, 2005年
• Docosahexanoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression, (H.Ishigamori), M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita, K.Takahashi, Molecular and cellular biochemistry., 275:127-133, 2005年
• Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats, H.Kohno, R.Suzuki, S.Sugie, H.Tsuda, T.Tanaka, Clinical cancer research : an official journal of the American Association for Cancer Research., 11:4962-4967, 2005年
• Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats, (K.Yoshida), T.Tanaka, Y.Hirose, F.Yamaguchi, H.Kohno, M.Toida, A.Hara, S.Sugie, T.Shibata, H.Mori, Cancer letters., 221:29-39, 2005年
• Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess β-catenin gene mutations and increases immunoreactivity for β-catenin, cyclooxygenase-2, and inducible nitric oxide synthase, T.Tanaka, R.Suzuki, H.Kohno, S.Sugie, M.Takahashi, K.Wakabayashi, Carcinogenesis., 26:229-238, 2005年
• Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer Caco-2 cells, (Y.Yasui), M.Hosokawa, T.Sahara, R.Suzuki, S.Ohgiya, H.Kohno, T.Tanaka, K.Miyashita, Prostaglandins, leukotrienes, and essential fatty acids., 73:113-119, 2005年
• Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate, R.Suzuki, H.Kohno, S.Sugie, T.Tanaka, Cancer science., 95:721-727, 2004年
• Preventive effects of powdered broccoli sprout on azoxymethane-induced rat colonic aberrant crypt foci, R.Suzuki, H.Kohno, S.Sugie, T.Tanaka, et al., J. Toxicol. Pathol., 17:119-126, 2004年
• Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats, R.Suzuki, H.Kohno, S.Sugie, T.Tanaka, et al., Cancer letters., 210:159-169, 2004年
• Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced clon carcinogenesis in rats, H.Kohno, R.Suzuki, T.Tanaka, et al., Cancer science., 95:481-486, 2004年
• Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats, T.Tanaka, H.Kohno, R.Suzuki, S.Sugie, Cancer letters., 210:129-137, 2004年
• Lack of modifying effects of 4-tert-octylphenol and benzyl butyl phthalate on 3,2’-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats, H.Kohno, R.Suzuki, S.Sugie, T.Tanaka, et al., Cancer science., 95:300-305, 2004年
• Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells, (M.Hosokawa), H.Kohno, T.Tanaka, et al., Biochimica et biophysica acta-molecular and cell biology of lipids, 1675:113-119, 2004年
• Extract of vinegar “Kurosu from unpolished rice inhibits the proliferation of human cancer cells", (K.Nanda ), H.Kohno, T.Tanaka, et al., Journal of experimental & clinical cancer research : CR, 23:69-75, 2004年
• Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats, (Y.Shimoji), H.Kohno, T.Tanaka, et al., Nutrition and cancer., 49:170-173, 2004年
• Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARγ expression and alteration of lipid composition, H.Kohno, R.Suzuki, T.Tanaka, et al., International journal of cancer. Journal international du cancer., 110:896-901, 2004年
• Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats, R.Suzuki, H.Kohno, T.Tanaka, et al., Biofactors, 21:111-114, 2004年
• An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-α expression and cell proliferation, (M.Kagawa), R.Suzuki, H.Kohno, T.Tanaka, et al., Carcinogenesis., 25:979-985, 2004年
• 八朔精油および脱テルペン八朔精油によるazoxymethane誘発大腸ACFの抑制, 甲野裕介, 田中卓二, R. Aroma, 4: 239-242, 2003年
• Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide, (K. Yoshida), T. Tanaka, H. Kohno, S. Sugie, et al., Cancer science., 94: 365-371, 2003年
• Extract of vinegar Kurosu" from unpolished rice inhibits the development of colonic aberrant crypt foci induced by azoxymethane", (Y. Shimoji), S. Sugie, H. Kohno, T. Tanaka, et al., J. Exp. Cancer Res., 4: 591-597, 2003年
• Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis, R. Suzuki, H. Kohno, S. Sugie, T. Tanaka, Asian Pacific journal of cancer prevention : APJCP., 4: 319-326, 2003年
• A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate, T. Tanaka, H. Kohno, R. Suzuki, S. Sugie, Cancer science., 94: 965-973, 2003年
• A novel geranylated derivative, ethyl 3- (4'-geranyloxy-3'-methoxyphenyl) -2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue, T. Tanaka, H. Kohno, et al., Oncology., 64: 166-175, 2003年
• A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression, (K. Yoshida), T. Tanaka, H. Kohno, et al., Histology and histopathology., 18: 39-48, 2003年
• Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats, H. Kohno, T. Tanaka, et al., International journal of cancer. Journal international du cancer., 101: 461-468, 2002年
• Prevention of colonic aberrant crypt foci by dietary feeding of chalcone and 2-hydroxychalcone in male F344 rats, H. Kohno, K. Yamaguchi, T. Tanaka, et al., J. Toxicol. Pathol., 15: 137-143, 2002年
• Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis, T. Tanaka, H. Kohno, et al., Carcinogenesis., 23: 1361-1367, 2002年
• Lack of modifying effects of 4-n-octylphenol on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats, H. Kohno, *Y. Tsukio, M. Tanino, T. Tanaka, et al., Ecotoxicology and environmental safety, 51: 210-215, 2002年
• Inhibitory effects of estrogenic compounds, 4-nonylphenol and genistein,on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats, T. Tanaka, H. Kohno, M. Tanino, et al., Ecotoxicology and environmental safety, 52: 38-45, 2002年
• Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats, (Y. Yanaida), H. Kohno, T. Tanaka, et al., Carcinogenesis., 23: 787-794, 2002年
• Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats, H. Kohno, T. Tanaka, et al., Japanese journal of cancer research : Gann., 93: 133-142, 2002年
• A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis, H. Kohno, M. Maeda, M. Tanino, *Y. Tsukio, T. Tanaka, et al., Cancer letters., 183: 131-139, 2002年
• Troglitazone, a ligand for peroxisome proliferator-activated receptor γ inhibits chemically-induced aberrant crypt foci in rats, H. Kohno, *S. Yoshitani, *S. Takashima, N. Yamaguchi, *T. Tanaka, et al., Japanese journal of cancer research : Gann., 92: 396-403, 2001年
• Synergistic effects of highly unsaturated fatty acid-containing phosphatidylethanolamine on differentiation of human leukemia HL-60 cells by dibutyryl cyclic adenosine monophosphate, (M. Hosokawa), H. Kohno, *T. Tanaka, et al., Japanese journal of cancer research : Gann., 92: 666-672, 2001年
• Ligands for peroxisome proliferator-activated receptor α and γ inhibit chemically-induced colitis and formation of aberrant crypt foci in rats, *T. Tanaka, H. Kohno, *S. Yoshitani, *S. Takashima, et al., Cancer research., 61: 2424-2428, 2001年
• Inhibitory effect of mandarin juice rich in β-cryptoxanthin and hesperidin on 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone-induced pulmonary tumorigenesis in mice, H. Kohno, *T. Tanaka, et al., Cancer letters., 174: 141-150, 2001年
• Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by citrus limonoids, obacunone and limonin, *T. Tanaka, *M. Maeda, H. Kohno, *M. Murakami, et al., Carcinogenesis., 22: 193-198, 2001年
• Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats, H. Kohno, *S. Yoshitani, *Y. Tsukio, *T. Tanaka, et al., Life sciences., 69: 901-913, 2001年
• Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone, *S. Yoshitani, *T. Tanaka, H. Kohno, *S. Takashima, International journal of oncology, 19: 929-939, 2001年
• Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet, *T. Tanaka, H. Kohno, *S. Yoshitani, *Y. Tsukio, et al., Life sciences., 69: 1935-1945, 2001年
• Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by Mandarian juices rich in β-cryptoxanthin and hesperidin, *T.Tanaka, H.Kohno, *M.Murakami, *R.Shimada, *S.Kagami, et al., International journal of cancer. Journal international du cancer., 88:146-150, 2000年
• Suppressing effects of dietary supplementation of the organoselenium 1,4-phenylenebis(methylene)selenocyanate and the citrus antioxidant auraptene on lung metastasis of melanoma cells in mice, *T.Tanaka, H.Kohno, *M.Murakami, et al., Cancer research., 60:3713-3716, 2000年
• Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats, TANAKA Takuji, KOHNO Hiroyuki, SHIMADA Reona, KAGAMI Seiko, YAMAGUCHI Fumio, KATAOKA Shigehiro, ARIGA Toshiaki, MURAKAMI Akira, KOSHIMIZU Koichi, OHIGASHI Hajime, Carcinogenesis, 21:1183-1189, 2000年
• Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats, *T.Tanaka, H.Kohno, *R.Shimada, *S.Kagami, et al., Carcinogenesis., 21:1183-1189, 2000年
• Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats, H.Kohno, N.Yamaguchi, *C.Ohdoi, *S.Odashima, *T.Tanaka, et al., Oncology reports., 7:1069-1074, 2000年
• Colitis-associated rat colon carcinogenesis induced by 1-hydroxyanthraquinone and methylazoxymethanol acetate, *T.Tanaka, H.Kohno, *M.Murakami, *R.Shimada, *S.Kagami, Oncology reports., 7:501-508, 2000年
• Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats., TANAKA Takuji, KOHNO Hiroyuki, TSUKIO Yoshiaki, HONJO Shiro, TANINO Mikio, MIYAKE Masaki, WADA Keiji, Bio Factors, 13:213-218, 2000年
• Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats, *T.Tanaka, H.Kohno, *S.Honjo, *M.Murakami, *T.Ota, et al., Jpn.J.Cancer Res., 91:25-33, 2000年
• Cancer chemoprevention by minor non-nutritient constituents of the diet:(2)Flavanols and caffeine in tea, *T.Tanaka, H.Kohno, *M.Murakami, *M.Tanino, *S.Yoshitani, Kanazawa Ika Daigaku zasshi = Journal of Kanazawa Medical University. Links , 25:1-8, 2000年
• Prevention of colonic preneoplastic lesions by the β-cryptoxanthin and hesperidin rich powder prepared from Citrus Unshiu Marc. juice in male F344 rats., KOHNO Hiroyuki, MAEDA Masayo, HONJO Shiro, MURAKAMI Manabu, SHIMADA Reona, MASUDA Shinji, AZUMA Yoshihiro, OGAWA Hiroshi, TANAKA Takuji, J. Toxicol. Pathol., 12:209-215, 1999年
• Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin, TANAKA Takuji, KAWABATA Kunihiro, HONJO Shiro, KOHNO Hiroyuki, MURAKAMI Manabu, SHIMADA Reona, MATSUNAGA Kengo, YAMADA Yasuhiro, SHIMIZU Masahito, Oncol. Rep., 6:1333-1340, 1999年
• Differentiation-and apoptosis-inducing activities of phospholipids containing docosahexaenoic acid for mouse myeloid leukemia M1 cells, (HOSOKAWA Masashi), MINAMI Keiichi, KOHNO Hiroyuki, TANAKA Yukihisa, HIBINO Hidehiko, Fisheries Sci., 65:798-799, 1999年
• Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HL-60., (HOSOKAWA Masashi), WANEZAKI Satoshi, MIYAUCHI Kozue, KURIHARA Hideyuki, KOHNO Hiroyuki, KAWABATA Jun, ODASHIMA Shizuo, TAKAHASHI Koretaro, Food Sci. Technol. Res., 5:243-246, 1999年
• Effects of phospholipids containing docosahexaenoic acid on differentiation and growth of HL-60 human promyelocytic liukemia cells, (TOCHIZAWA Kaoru), HOSOKAWA Masashi, KURIHARA Hideyuki, KOHNO Hiroyuki, ODASHIMA Shizuo, TAKAHASHI Koretaro, J. Jpn. Oil Chem. Soc., 46:383-390, 1996年
• 植物性配糖体サイコサポニンによる再分化誘導作用に関する研究, KOHNO Hiroyuki, J. Kanazawa Med. Univ., 20:224-231, 1995年
• Major histocompatibility complex restriction of maternally induced suppression in young adult mice., (FUJII Yuji), LI Ai-li, KOHNO Hiroyuki, YAMAGUCHI Nobuo, Immunology, 80:337-342, 1993年
• Passive airpouch anaphylaxis in Rats. 2. Pharmacological characterization., (KONNO-AMANO Satoshi), HIRAO Tetsuji, KOHNO Hiroyuki, MORI Hiroshi, SATO Yoshihisa, International Archives of Allergy and Applied Immunology, 90:331-337, 1989年
• An investigation of the immune suppression induced by some saikosaponin derivatives., KOHNO Hiroyuki, YAMAZAKI Masakazu, JYUMONJI Noriyuki, YAMAGUCHI Nobuo, ODASHIMA Shizuo, International Journal of Immunopharmacology, 10:845-850, 1988年
• Effect of saikosaponin derivatives upon the immune response against T-independent antigens in mice., YAMAGUCHI Nobuo, KOHNO Hiroyuki, TAWARA Mitsuko, ODASHIMA Shizuo, ABE Hiroko, International Journal of Immunopharmacology, 7:827-832, 1985年

書籍等出版物

• Obesity: a risk for hepatocelullar carcinoma
  Cancer: Disease Progression and Chemoprevention(Takuji Tanaka)
  T.Tanaka, S.Miyamoto, Y.Yausi, H.Kohno, S.Sugie
  Research Signpost 2007年
• Chemopreventive effects of conjugated linolenic acids on colon cancer
  Cancer: Disease Progression and Chemoprevention(Takuji Tanaka)
  (M.Hosokawa), Y.Yausi, S.Suzuki, H.Kohno, T.Tanaka
  Research Signpost 2007年
• The prevention effects of β-cryptoxanthin and hesperidin rich powder prepared from Citrus unshiu Marc. juice on chemically induced tongue and colon carcinogenesis in rats
  Carcinogenesis and Modification of Carcinogenesis（Takuji Tanaka, Hiroyuki Tsuda）
  H.Kohno, R.Suzuki, S.Sugie, T.Sumida, Y.Azuma, H.Ogawa, T.Tanaka
  Research Signport 2005年
• The modifying effects of hesperidin glycoside on chemically-induced tongue and colon carcinogenesis in F344 rats
  Carcinogenesis and Modification of Carcinogenesis（Takuji Tanaka, Hiroyuki Tsuda）
  T.Tanaka, H.Kohno, R.Suzuki, S.Sugie, T.Kometani
  Research Signport 2005年
• A polyisoprenylated benzophenone garcinol inhibits azoxymethane-induced rat colon carcinogenesis
  Carcinogenesis and Modification of Carcinogenesis（Takuji Tanaka, Hiroyuki Tsuda）
  R.Suzuki, H.Kohno, S.Sugie, F.Yamaguchi, S.Kataoka, T.Ariga, T.Tanaka
  Research Signport 2005年
• Cancer chemoprevention by silymarin
  Res. Adv. in Cancer
  H. Kohno, S. Sugie, T. Tanaka, et al.
  Global Research Network 2003年
• Cancer chemoprevention by citrus components and juice
  Recent Res. Devel. Cancer
  T. Tanaka, H. Kohno
  Transworld Res. Network 2002年
• Citrus limonoids obacunone and limonin inhibit the development of a precursor lesion,aberrant crypt foci,for colon cancer in rats
  Citrus Limonoids:Functional chemicals in agriculture and foods.ACS Symposium Series No.758(M.K.Berhow,et al.)
  *T.Tanaka, H.Kohno, *S.Honjo, et al.
  American Chemical Society 2000年
• Bovine lactoferrin inhibits rat tongue carcinogenesis
  Lactoferrin:Structure,Function and Applications(K.Shimazaki,et al.)
  *T.Tanaka, H.Kohno, *S.Honjo, *M.Murakami, *R.Shimada, *S.Kagami, et al.
  Elvesier Sci. 2000年

競争的資金

• Wntシグナル伝達経路に着目した未分類肉腫分類の試み
  文部科学省：科学研究費　基盤研究(C)
  研究期間：2017年 - 2019年  
  代表者:甲野裕之
• 炎症関連大腸発がんにおけるレプチンシグナル系の関与
  文部科学省：科学研究費　基盤研究（Ｃ）
  研究期間：2011年 - 2013年  
  代表者:甲野裕之
• 炎症性大腸発がんにおける一酸化窒素のジェネティック作用とエピジェネティック作用
  文部科学省：科学研究費　基盤研究（Ｃ）
  研究期間：2007年 - 2008年  
  代表者:甲野裕之
• ヒトがん発生に係わる環境要因及び感受性要因に関する研究
  厚生労働省：がん研究助成金
  研究期間：2004年 - 2008年  
  代表者:2004-2006若林敬二（国立がん研究センター研究所）,2007-2008中釜　斉分担・連携研究者:甲野裕之
• 内分泌かく乱化学物質の発がんへの関与に関する研究（動物ﾓﾃﾞﾙによる内分泌かく乱物質の発がん修飾作用の解析(前立腺)）
  厚生労働省：がん研究助成金
  研究期間：2002年 - 2002年  
  代表者:津田洋幸（国立がんセンター研究所）分担・連携研究者:甲野裕之
• 動物モデルによる内分泌かく乱物質の発がん修飾作用の解析(前立腺)
  厚生労働省：がん研究助成金
  研究期間：2001年 - 2001年  
  代表者:朝元誠人（名古屋市立大学医学部）分担・連携研究者:甲野裕之
• 消化器がん発生に影響する食品中の要因に関する研究(口腔がん発生に対する影響因子)
  厚生労働省：がん研究助成金
  研究期間：2000年 - 2000年  
  代表者:朝元誠人（名古屋市立大学医学部）分担・連携研究者:甲野裕之
• がん転移形成におけるムコ多糖糖鎖の役割
  文部科学省：科学研究費　奨励研究（Ａ）
  研究期間：1994年 - 1994年  
  代表者:甲野裕之
• 水産物由来脂質及びビタミンの抗腫瘍活性に及ぼす総合効果
  その他省庁：水産庁委託研究費
  研究期間：1994年 - 1998年  
  代表者:甲野裕之
• がん細胞の形質変換による増殖・転移能の喪失に関する基礎的研究
  私学事業団：学術研究振興資金
  研究期間：1993年 - 1995年  
  代表者:小田島粛夫分担・連携研究者:甲野裕之
• 水産物由来硫酸多糖体の癌転移抑制作用に関する研究
  その他省庁：水産庁委託研究費
  研究期間：1992年 - 1993年  
  代表者:甲野裕之
• がんと摂取脂肪酸種の関連性とその解析
  その他：(財)北國がん研究振興財団北國がん基金研究助成金
  研究期間：1992年 - 1992年  
  代表者:甲野裕之
• 水産物由来の生理活性物質の抗腫瘍作用に関する研究
  その他省庁：水産庁委託研究費
  研究期間：1991年 - 1991年  
  代表者:甲野裕之
• 水産物由来の生理活性物質によるがん細胞の再分化誘導及び転移の抑制機構の解明
  その他省庁：水産庁委託研究費
  研究期間：1989年 - 1990年  
  代表者:甲野裕之