KOHNO Hiroyuki

FacultyMedical Science, Department of Immunology
PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Experimental Pathology, Tumor immunology

Education

  • Hokkaido University Faculty of Pharmaceutical Science

Degree

  • Ph.D in Medicine

Research Activities

Published Papers

  • Effects of β-adrenoceptor antagonists on anaphylactic hypotension in conscious, W.Zhang, T.Shibamoto, Y.Kurata, H.Kohno, European journal of pharmacology.650:303-3082011
  • Aqueous and ethanolic extract fractions from the Barazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Y.Yasui, S.Miyamoto, M.Kim, H.Kohno, S.Sugie, T.Tanaka, Oncology reports.20:493-4992008
  • Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice, H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, K.Wakabayashi, T.Tanaka, Clinical cancer research : an official journal of the American Association for Cancer Research.13:2519-25252007
  • Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model, H.Kohno, Y.Totsuka, Y.Yasui, R.Suzuki, S.Sugie, K.Wakabayashi, T.Tanaka, International journal of cancer. Journal international du cancer.121:1659-16642007
  • Lack of enhancing effect of lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran sodium sulfate, (S.Miyamoto), R.Suzuki, Y.Yasui, H. Kohno, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka, J. Toxicol. Pathol.20:93-1002007
  • Dietary β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice, K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki, Oncology reports.17:297-3042007
  • Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice, K.Hayashi, R.Suzuki, S.Miyamoto, S.Yoshitani, H.Kohno, S.Sugie, S.Takashima, T.Tanaka, Nutrition and cancer.58:75-842007
  • Chemopreventive effects of conjugated linolenic acids (CLN) occurring in plant seed oils, (B.Narayan), M.Hosokawa, Y.Yasui, R.Suzuki, H.Kohno, T.Tanaka, K.Miyashita, Current nutrition & food science.3:309-3182007
  • A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male ApcMin/+ mice, H.Kohno, M.Takahashi, Y.Yasui, R. Suzuki, S.Miyamoto, Y.Kamanaka, M.Naka, T.Maruyama, K.Wakabayashi, T.Tanaka, International journal of cancer. Journal international du cancer.121:506-5132007
  • A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis, Y.Yasui, R.Suzuki, S.Miyamoto, T.Tsukamoto, S.Sugie, H.Kohno, T.Tanaka, International journal of cancer. Journal international du cancer.121:2331-23392007
  • 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats, Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, F.Beppu, M.Hosokawa, K.Miyashita, T.Tanaka, Nutrition and cancer.59:82-912007
  • β-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice, (K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, Y.Yamada, T.Oyama, T.Kuno, Y.Hirose, A.Hara, H.Mori, Cancer letters.239:123-1282006
  • Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: Comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines, Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita, Chemotherapy52:220-2252006
  • Strain differences in susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice, R.Suzuki, H.Kohno, S.Sugie, H.Nakagama, T.Tanaka, Carcinogenesis.27:162-1692006
  • Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats, (S.Miyamoto), H.Kohno, R.Suzuki, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka, Oncology reports.15:1169-11732006
  • Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells, (F.Beppu), M.Hosokawa, L.Tanaka, H.Kohno, T.Tanaka, K.Miyashita, The Journal of nutritional biochemistry17:830-8362006
  • Lack of enhancing effects of degraded λ-carrageenan on the development of β-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane, (K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, T.Kuno, Y.Hirose, A.Hara, H.Mori, Cancer letters.238:69-752006
  • Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells, Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita, Anticancer research.26:1855-18602006
  • Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice, H.Kohno, R.Suzuki, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka, International journal of cancer. Journal international du cancer.118:2936-29422006
  • Dextran sodium sulfate strongly promotes colorectal carcinogenesis in ApcMin/+ mice: Inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms, T.Tanaka, H.Kohno, R.Suzuki, K.Hata, S.Sugie, N.Niho, K.Sakano, M.Takahashi, K.Wakabayashi, International journal of cancer. Journal international du cancer.118:25-342006
  • Chemopreventive Effects of Nobiletin against Genotoxicity Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Lung of gpt delta Transgenic Mice, (M.Ikeda), K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Nohmi, Genes and Environment28:84-912006
  • Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats, R.Suzuki, Y.Yasui, H.Kohno, S.Miyamoto, M.Hosokawa, K.Miyashita, T.Tanaka, Oncology reports.16:989-9962006
  • An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies, R.Suzuki, H.Kohno, M.Suzui, N.Yoshimi, H.Tsuda, K.Wakabayashi, T.Tanaka, Carcinogenesis.27:619-6302006
  • Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats, TANAKA Takuji, KOHNO Hiroyuki, SHIMADA Reona, KAGAMI Seiko, YAMAGUCHI Fumio, KATAOKA Shigehiro, ARIGA Toshiaki, MURAKAMI Akira, KOSHIMIZU Koichi, OHIGASHI Hajime, Carcinogenesis21:1183-11892000
  • Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats., TANAKA Takuji, KOHNO Hiroyuki, TSUKIO Yoshiaki, HONJO Shiro, TANINO Mikio, MIYAKE Masaki, WADA Keiji, Bio Factors13:213-2182000
  • Prevention of colonic preneoplastic lesions by the β-cryptoxanthin and hesperidin rich powder prepared from Citrus Unshiu Marc. juice in male F344 rats., KOHNO Hiroyuki, MAEDA Masayo, HONJO Shiro, MURAKAMI Manabu, SHIMADA Reona, MASUDA Shinji, AZUMA Yoshihiro, OGAWA Hiroshi, TANAKA Takuji, J. Toxicol. Pathol.12:209-2151999
  • Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin, TANAKA Takuji, KAWABATA Kunihiro, HONJO Shiro, KOHNO Hiroyuki, MURAKAMI Manabu, SHIMADA Reona, MATSUNAGA Kengo, YAMADA Yasuhiro, SHIMIZU Masahito, Oncol. Rep.6:1333-13401999
  • Differentiation-and apoptosis-inducing activities of phospholipids containing docosahexaenoic acid for mouse myeloid leukemia M1 cells, (HOSOKAWA Masashi), MINAMI Keiichi, KOHNO Hiroyuki, TANAKA Yukihisa, HIBINO Hidehiko, Fisheries Sci.65:798-7991999
  • Apoptosis-inducing effect of fucoxanthin on human leukemia cell line HL-60., (HOSOKAWA Masashi), WANEZAKI Satoshi, MIYAUCHI Kozue, KURIHARA Hideyuki, KOHNO Hiroyuki, KAWABATA Jun, ODASHIMA Shizuo, TAKAHASHI Koretaro, Food Sci. Technol. Res.5:243-2461999
  • Effects of phospholipids containing docosahexaenoic acid on differentiation and growth of HL-60 human promyelocytic liukemia cells, (TOCHIZAWA Kaoru), HOSOKAWA Masashi, KURIHARA Hideyuki, KOHNO Hiroyuki, ODASHIMA Shizuo, TAKAHASHI Koretaro, J. Jpn. Oil Chem. Soc.46:383-3901996
  • Induction of differentiation of B16 melanoma cells by saikosaponin derivatives., KOHNO Hiroyuki, J. Kanazawa Med. Univ.20:224-2311995
  • Major histocompatibility complex restriction of maternally induced suppression in young adult mice., (FUJII Yuji), LI Ai-li, KOHNO Hiroyuki, YAMAGUCHI Nobuo, Immunology80:337-3421993
  • Passive airpouch anaphylaxis in Rats. 2. Pharmacological characterization., (KONNO-AMANO Satoshi), HIRAO Tetsuji, KOHNO Hiroyuki, MORI Hiroshi, SATO Yoshihisa, International Archives of Allergy and Applied Immunology90:331-3371989
  • An investigation of the immune suppression induced by some saikosaponin derivatives., KOHNO Hiroyuki, YAMAZAKI Masakazu, JYUMONJI Noriyuki, YAMAGUCHI Nobuo, ODASHIMA Shizuo, International Journal of Immunopharmacology10:845-8501988
  • Effect of saikosaponin derivatives upon the immune response against T-independent antigens in mice., YAMAGUCHI Nobuo, KOHNO Hiroyuki, TAWARA Mitsuko, ODASHIMA Shizuo, ABE Hiroko, International Journal of Immunopharmacology7:827-8321985