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田崎 隆史 タサキ タカフミ

所属部署名生命科学研究領域, 医動物学
職名准教授
 
 

研究者基本情報

研究

    研究の概要:
    1) N-end rule pathwayの生理機能とその分子機構の解析 2) UBR4とHPVE7の相互作用によるがん化機構の解析 3) 日本脳炎ウイルス複製に及ぼすLysosomeを介したタンパク分解系の役割

専門分野

  • 分子生物学
    Molecular Biology
  • ウイルス学
    腫瘍生物学
  • 実験動物学

学歴

  • 北海道大学 大学院 獣医学研究科
  • 北海道大学 獣医学部

学位

  • 博士(獣医学)

所属学協会

  • 2011年日本実験動物医学会 会員
  • 2014年日本実験動物学会 会員
  • 2012年日本獣医学会 会員
  • 2012年日本分子生物学会 会員
  • 2012年北陸実験動物研究会 役員
  • 2012年日本ウイルス学会 会員
  • 2017年07月American Association for Laboratory Animal Science 会員

経歴

  • 2012年02月金沢医科大学 准教授
  • 2005年09月- 2012年01月ピッツバーグ大学薬学部 Research Assistant Professor
  • 2002年09月- 2005年08月ピッツバーグ大学薬学部 Research Associate
  • 1999年06月- 2002年08月カフィフォルニア工科大学生物学部 Postdoctoral Scholar in Biology
  • 1998年04月- 1999年03月北海道大学免疫科学研究所 非常勤講師

研究活動情報

論文

  • Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter WavesMasami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Masao Taki, Kanako Wake, Soichi Watanabe, Maya Mizuno, Takafumi Tasaki, Hiroshi SasakiJournal of Infrared, Millimeter, and Terahertz Waves10762:912-9252018年09月
  • The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome(Sung Tae.Kim), (Yoon Jee.Lee), Takafumi.Tasaki, Su Ran.Mun, Joonsung.Hwang, Min Jueng.Kang, Srinivasrao.Ganipisetti, Eugene C.Yi, Bo Yeon.Kim, Yong Tae.KwonJOURNAL OF CELL SCIENCE131:jcs2176462018年09月
  • Establishment of COS-JC cells persistently producing archetype JC polyomavirus(Souichi.Nukuzuma), Chiyoko.Nukuzuma, Masanori.Kameoka, Shigeki.Sugiura, Kazuo.Nakamichi, Takafumi.Tasaki, Koushi.Hidaka, Tsutomu.TakegamiMICROBIOLOGY AND IMMUNOLOGY62:524-5302018年08月
  • The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins(Sung Tae.Kim), (Yoon Jee.Lee), Takafumi.Tasaki, Joonsung.Hwang, Min Jueng.Kang, Eugene C.Yi, Bo Yeon.Kim, Yong Tae.KwonPLOS ONE13:e02022602018年08月
  • CPT11 prevents virus replication in JCI cells persistently infected with JC polyomavirus.(Souichi.Nukuzuma), Chiyoko.Nukuzuma, Masanori.Kameoka, Shigeki.Sugiura, Kazuo.Nakamichi, Takafumi.Tasaki, Tsutomu.TakegamiMicrobiology and immunology61:2322017年
  • Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virusM.Taniguchi, T.Tasaki, H.Ninomiya, Y.Ueda, K.Kuremoto, S.Mitsutake, Y.Igarashi, T.Okazaki, T.TakegamiScientific Reports6:37829-378292016年11月
  • Impaired Japanese encephalitis virus replication in p62/SQSTM1 deficient mouse embryonic fibroblastsT.Tasaki, S. Nukuzuma, T. TakegamiMicrobiology and Immunology60:708-7112016年10月
  • Suppressive effect of topoisomerase inhibitors on JC polyomavirus propagation in human neuroblastoma cells(S.Nukuzuma), K.Nakamichi, M.Kameoka, S.Sugiura, C.Nukuzuma, T.Tasaki, T.TakegamiMicrobiology and Immunology60:253-2602016年04月
  • Japanese encephalitis virus replication and inhibitory effect of shRNA in miceM.Murakami, T.Tasaki, S.Nukuzuma, H.Minato, T.Nojima, Y.Ishigaki, T.TakegamiAdvances in Microbiology6:462-4702016年
  • Replication of IMR-32-adapted JC virus clones in human embryonic kidney cells(S.Nukuzuma), S.Sugiura, K.Nakamichi, M.Kameoka, C.Nukuzuma, T.Tasaki, T.TakegamiMicrobiology and Immunology59:238-2422015年
  • TNF-α stimulates efficient JC virus replication in neuroblastoma cells(S.Nukuzuma), K.Nakamichi, M.Kameoka, S.Sugiura, C.Nukuzuma, T.Tasaki, T.TakegamiJournal of medical virology.86:2026-20322014年12月
  • The N-end rule proteolytic system in autophagy.(ST.Kim), T.Tasaki, A.Zakrzewska, YD.Yoo, KS.Sung, S-H.Kim, H.Cha-Molstad, J.Hwang, KA.Kim, BY.Kim, YT.KwonAutophagy9:1100-11032013年07月
  • The N-end rule and retroviral infection: no effect on integrase.(G.Boso), T.Tasaki, YT.Kwon, NV.SomiaVirology journal [electronic resource]10:233;1-142013年07月
  • UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagyT.Tasaki, ST. Kim, A. Zakrzewska, BE. Lee, MJ. Kang, YD. Yoo, HJ. Cha-Molstad, J. Hwang, NK. Soung, KS. Sung, SH. Kim, MD. Nguyen, M. Sun, EC. Yi, BY. Kim, YT. KwonProceedings of the National Academy of Sciences of the United States of America110:3800-38052013年03月
  • The N-End rule pathwayT.Tasaki, SM. Sriram, KS. Park, YT. KwonAnnual review of biochemistry81:261-2892012年04月
  • Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability(C. Meisenberg), PS. Tait, II. Dianova, K. Wright, MJ. Edelmann, N. Ternette, T.Tasaki, BM. Kessler, JL. Parsons, YT. Kwon, GL. DianovNucleic acids research40:701-7112012年01月
  • The substrate recognition domains of the N-end rule pathwayT.Tasaki, Zakrzewska A, DD. Dudgeon, Y. Jiang, JS. Lazo, YT. KwonThe Journal of biological chemistry.284:1884-18952009年01月
  • Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway(MJ. Lee), K. Pal, T.Tasaki, S. Roy, Y. Jiang, JY. An, R. Banerjee, YT. KwonProceedings of the National Academy of Sciences of the United States of America105: 100-1052008年01月
  • The mammalian N-end rule pathway: new insights into its components and physiological rolesT.Tasaki, YT. KwonTrends Biochem Sci32:520-5282007年10月
  • Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systemsT.Tasaki, R. Sohr, Z. Xia, R. Hellweg, H. Hortnagl, A. Varshavsky, YT. KwonThe Journal of biological chemistry.282:18510-185202007年06月
  • Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway(JY. An), JW. Seo, T.Tasaki, MJ. Lee, A. Varshavsky, YT. KwonProceedings of the National Academy of Sciences of the United States of America103: 6212-62172006年04月
  • RGS4 and RGS5 are in vivo substrates of the N-end rule pathway(MJ. Lee), T.Tasaki, K. Moroi, JY. An, S. Kimura, IV. Davydov, YT. KwonProceedings of the National Academy of Sciences of the United States of America102: 15030-150352005年10月
  • A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degronsT.Tasaki, LC. Mulder, A. Iwamatsu, MJ. Lee, IV. Davydov, A. Varshavsky, M. Muesing, YT. KwonMolecular and cellular biology25:7120-71362005年08月
  • Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway(YT. Kwon), Z. Xia, JY. An, T.Tasaki, IV. Davydov, JW. Seo, J. Sheng, Y. Xie, A. VarshavskyMolecular and cellular biology23: 8255-82712003年11月
  • Pairs of dipepetides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain(F. Du), F. Navarro-Garcia, Z. Xia, T.Tasaki, A. VarshavskyProceedings of the National Academy of Sciences of the United States of America99: 14110-141152002年10月
  • Inhibition of pseudorabies virus replication by a dominant-negative mutant of early protein 0 expressed in a tetracycline-regulated systemT.Tasaki, S. Taharaguchi, T. Kobayashi, S. Yoshino, E. OnoVeterinary Microbiology78:195-2032001年02月
  • Translational regulation of platelet-derived growth factor B chain (c-sis) mRNA by short open reading frames in the 5'-untranslated region(H. Nikami), T. Kobayashi, T.Tasaki, S. Yoshino, S. Taharaguchi, E. OnoPlatelets11:166-702000年05月
  • Resistance to pseudorabies virus infection in transgenic mice expressing the chimeric transgene that represses the immediate-early gene transcription(E. Ono), T.Tasaki, T. Kobayashi, S. Taharaguchi, H. Nikami, I. Miyoshi, N. Kasai, J. Arikawa, H. Kida, Y. ShimizuVirology.262:72-781999年09月
  • Decrease in hepatic CYP2C11 mRNA and increase in heme oxygenase activity after intracerebroventricular injection of bacterial endotoxin(Shimamoto Y), Tasaki T, Kitamura H, Hirose K, Kazusaka A, Fujita SJ. Vet. Med. Sci.61:609-131999年06月
  • Cytochrome P450 isoforms responsible for the N-deethylation and cyclohexane-hydroxylation of NS-21(Nakamura A), Hirota T, Morino A, Imaoka S, Funae Y, Yamamoto Y, Tasaki T, Masuda M, Kazusaka A, Fujita SXenobiotica29:243-2521999年03月
  • Pseudorabies virus (PRV) early protein 0 activates PRV gene transcription in combination with the immediate-early protein IE180 and enhances the infectivity of PRV genomic DNA(E. Ono), H. Nikami, T.Tasaki, H. KidaVeterinary Microbiology63:99-1071998年10月
  • Regio- and stereoselectivity in propranolol metabolism by dog liver microsomes and the expressed dog CYP2D15Tasaki T, Iwata H, Kazusaka A, Fujita SJournal of biochemistry.123:747-7511998年04月
  • Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2(Yamamoto Y), Tasaki T, Nakamura A, Iwata H, Kazusaka A, Gonzalez FJ, Fujita SPharmacogenetics8:73-821998年02月
  • Expression and characterization of dog CYP2D15 using baculovirus expression systemTasaki T, Nakamura A, Itoh S, Ohashi K, Yamamoto Y, Masuda M, Iwata H, Kazusaka A, Kamataki T, Fujita SJournal of biochemistry.123:162-1681998年01月
  • Strain differences in age-associated change in testosterone 6β-hydroxylation in Wistar and Dark Agouti rats(Maeda Y), Morita K, Tasaki T, Kazusaka A, Imaoka S, Funae Y, Fujita SEnviron Toxicol Pharmacol3:1-61997年02月
  • Impaired expression in DA rats of catalytically active P450BTL, immunochemically distinguishable from P4502D1: Immunological evidence with specific anti-peptide antibodies(Yamamoto Yukio), Nakamura Akio, Tasaki Takafumi, Umeda Shin, Sugimoto Chihiro, Imaoka Susumu, Fujita ShoichiBiomedical research (Tokyo, Japan)17: 331-3371996年
  • Purification and characterization of a dog cytochrome P450 isozyme belonging to the CYP2D subfamily and development of its antipeptide antibodyNakamura A, Yamamoto Y, Tasaki T, Sugimoto C, Masuda M, Kazusaka A, Fujita SDrug Metab Dispos23:1268-731995年11月
  • Anti-peptide antibodies to the P4502D subfamily in rat, dog and man(Nakamura A), Yamamoto Y, Tasaki T, Sugimoto C, Masuda M, Kazusaka A, Fujita SXenobiotica25:1103-1109:1103-11091995年11月

書籍等出版物

  • Japanese Encephalitis Virus Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in Persistent Infection
    Japanese Encephalitis
    T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma
    SMGroup (USA) 2015年08月

受賞

  • 2012年09月 北國がん研究振興財団 北國がん基金助成金
    田崎 隆史,

競争的資金

  • UBR4/p600-HPV16 E7相互作用による発がんメカニズム
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2013年 - 2015年  
    代表者:田崎隆史
  • ユビキチンリガーゼUBR4の組織特異的生理機能と分子機構
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2018年 - 2020年  
    代表者:田崎 隆史


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