Metformin mitigates DPP-4 inhibitor-induced breast cancer metastasis via suppression of mTOR signaling, Emi Kawakita, Fan Yang, Asako Kumagai, Yuta Takagaki, Munehiro Kitada, Yasuo Yoshitomi, Takayuki Ikeda, Yuka Nakamura, Yasuhito Ishigaki, Keizo Kanasaki, Daisuke Koya, Molecular Cancer Research, 19:61-73, 2021年01月
EAPC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells, Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura, Scientific reports, 11:19453, 2021年09月
Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity, (Yao Yao), Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki, Molecular Cell, 80:437-451, 2020年11月
Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA, Takayuki Ikeda, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Hideto Yonekura, International Journal of Molecular Sciences, 21:6460, 2020年09月
Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open, 8:bio035691, 2019年02月
Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis, Yang Fan, Takagaki Yuta, Yoshitomi Yasuo, Ikeda Takayuki, Li Jinpeng, Kitada Munehiro, Kumagai Asako, Kawakita Emi, Shi Sen, Kanasaki Keizo, Koya Daisuke, Cancer research, 79:735-746, 2019年02月
JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science, 130:916-926, 2017年01月
Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry, 413:155-164, 2016年
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One, 10:e0123232-e0123232, 2015年
Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate, T.Ikeda, S.Takasawa, N.Noguchi, K.Nata, A.Yamauchi, I.Takahashi, T.Yoshikawa, A.Sugawara, H.Yonekura, H.Okamoto, Molecular and cellular biochemistry., 366:69-80, 2012年07月
Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura, The Biochemical journal., 436:399-407, 2011年06月
Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers., 15:231-237, 2011年04月
Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, 2011年01月
A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene, (S.Takasawa), M.Kuroki, K.Nata, N.Noguchi, T.Ikeda, A.Yamauchi, H.Ota, A.Itaya-Hironaka, S.Sakuramoto-Tsuchida, I.Takahashi, T.Yoshikawa, T.Shimosegawa, H.Okamoto, Biochemical and biophysical research communications, 397:140-145, 2010年06月
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010年
Important role of heparan sulfate in postnatal islet growth and insulin secretion., (I.Takahashi), N.Noguchi, K.Nata, S.Yamada, T.Kaneiwa, S.Mizumoto, T.Ikeda, K.Sugihara, M.Asano, T.Yoshikawa, A.Yamauchi, N.J.Shervani, A.Uruno, I.Kato, M.Unno, K.Sugahara, S.Takasawa, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 383:113-118, 2009年05月
Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells., (A.Yamauchi), I.Takahashi, S.Takasawa, K.Nata, N.Noguchi, T.Ikeda, T.Yoshikawa, N.J.Shervani, I.Suzuki, A.Uruno, M.Unno, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 379:743-748, 2009年02月
FKBP12.6 disruption impairs glucose-induced insulin secretion, (N.Noguchi), T.Yoshikawa, T.Ikeda, I.Takahashi, N.J.Shervani, A.Uruno, A.Yamauchi, K.Nata, S.Takasawa, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 371:735-740, 2008年07月
Cyclin D1 activation through ATF-2 in Reg-induced pancreatic s-cell regeneration, (S.Takasawa), T.Ikeda, T.Akiyama, K.Nata, K.Nakagawa, N.J.Shervani, N.Noguchi, S.Murakami-Kawaguchi, A.Yamauchi, I.Takahashi, T.Tomioka-Kumagai, H.Okamoto, FEBS letters, 580:585-591, 2006年01月
Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6, (T.Nakazawa), S.Takasawa, N.Noguchi, K.Nata, ATohgo, M.Mori, K.Nakagawara, T.Akiyama, T.Ikeda, A.Yamauchi, I.Takahashi, T.Yashikawa, H.Okamoto, Gene, 360: 55-64, 2005年10月
Comparative genomic hybridization and mutation analyses of sporadic schwannomas, T.Ikeda, S.Hashimoto, S.Fukushige, H.Ohmori, A.Horii, Journal of Neuro-Oncology, 72:225-230, 2005年05月
Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients, (N.J.Shervani), S.Takasawa, Y.Uchigata, T.Akiyama, K.Nakagawa, N.Noguchi, H.Takeda, I.Takahashi, A.Yamauchi, T.Ikeda, Y.Iwamoto, K.Nata, H.Okamoto, Eur J Clin Invest, 34: 752-758, 2004年11月
Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III, (K.Nata), L.Yi, X.Liqing, T.Ikeda, T.Akiyama, N.Noguchi, S.Kawaguchi, A.Yamauchi, I.Takahashi, N.J.Shervani, T.Onogawa, S.Takasawa, H.Okamoto, Gene, 340: 161-170, 2004年09月
Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma, (M.Kadota), Y.Tamaki, M.Sekimoto, Y.Fujiwara, N.Aritake, S.Hasegawa, T.kobayashi, T.Ikeda, A.Horii, M.Monden, Oncol Rep, 10: 35-38, 2003年01月
Production and characterization of Reg knockout mice: Reduced proliferation of pancreatic s-cell in Reg knockout mice, (M.Unno), K.Nata, N.Noguchi, Y.Narushima, T.Akiyama, T.Ikeda, K.Nakagawa, S.Takasawa, H.Okamoto, Diabetes., 51: S478-S483, 2002年12月
Germline mutation of the PTEN gene in a Japanese patient with Cowden’s disease, (N.kato), K.Kimura, H.Sugawara, S.Aoyagi, T.Ikeda, A.Horii, Int J Oncol, 18: 1017-1022, 2001年05月
Activation of Reg gene, a gene for insulin-producing s-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation, (T.Akiyama), S.Takasawa, K.Nata, S.Kobayashi, M.Abe, N.J.Shervani, T.Ikeda, K.Nakagawa, M.Unno, S.Matsuno, H.Okamoto, Proceedings of the National Academy of Sciences of the United States of America, 98: 48-53, 2001年01月
Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer, T.Ikeda, K.Yoshinaga, A.Suzuki, A.Sakurada, H.Ohmori, A.Horii, Oncol Rep, 7: 567-570, 2000年05月
Mutational analysis of the CTNNB1 (s-catenin) gene in human endometrial cancer: Frequent mutations at codon 34 that cause nuclear accumulation, T.Ikeda, K.Yoshinaga, S.Semba, E.Kondo, H.Ohmori, A.Horii, Oncol Rep, 7: 323-326, 2000年03月
Comparative genomic hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma, (Y.Komoike), Y.Tamaki, I.Sakita, N.Tomita, M.Ohue, M.Sekimoto, M.Miyazaki, M.Kadota, N.Masuda, M.Ooka, T.Ohnishi, Y.Nakano, T.Kozaki, T.Kobayashi, N.Matsuura, T.Ikeda, A.Horii, M.Monden, Int J Oncol, 14: 1157-1162, 1999年06月
Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients, 13:2226, 2021年06月
Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development, Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura, International Journal of Molecular Sciences, 22:2804, 2021年03月
Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models., Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Ikeda, International Journal of Molecular Sciences, 24:3736, 2023年02月