Japanese

IKEDA Takayuki

■Faculty	Department of Biochemistry Ⅱ
■Position	Professor

Researcher Profile & Settings

Research

Overview of research:

1. RNA processing mechanism 2. A role of solube Flt-1

Education

Tohoku University Graduate School Division of Medicine

Degree

Ph.D in Medicine

Research Activities

Published Papers

Metformin mitigates DPP-4 inhibitor-induced breast cancer metastasis via suppression of mTOR signaling, Emi Kawakita, Fan Yang, Asako Kumagai, Yuta Takagaki, Munehiro Kitada, Yasuo Yoshitomi, Takayuki Ikeda, Yuka Nakamura, Yasuhito Ishigaki, Keizo Kanasaki, Daisuke Koya, Molecular Cancer Research, 19:61-73, Jan. 2021
DOI:doi:10.1158/1541-7786.MCR-20-0115
EAPC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells, Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura, Scientific reports, 11:19453, Sep. 2021
Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity, (Yao Yao), Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki, Molecular Cell, 80:437-451, Nov. 2020
Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA, Takayuki Ikeda, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Hideto Yonekura, International Journal of Molecular Sciences, 21:6460, Sep. 2020
Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open, 8:bio035691, Feb. 2019
Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis, Yang Fan, Takagaki Yuta, Yoshitomi Yasuo, Ikeda Takayuki, Li Jinpeng, Kitada Munehiro, Kumagai Asako, Kawakita Emi, Shi Sen, Kanasaki Keizo, Koya Daisuke, Cancer research, 79:735-746, Feb. 2019
DOI:10.1158/0008-5472.CAN-18-0620
JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science, 130:916-926, Jan. 2017
Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry, 413:155-164, 2016
Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One, 10:e0123232-e0123232, 2015
DOI:10.1371/journal.pone.0123232
Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate, T.Ikeda, S.Takasawa, N.Noguchi, K.Nata, A.Yamauchi, I.Takahashi, T.Yoshikawa, A.Sugawara, H.Yonekura, H.Okamoto, Molecular and cellular biochemistry., 366:69-80, Jul. 2012
Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura, The Biochemical journal., 436:399-407, Jun. 2011
Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers., 15:231-237, Apr. 2011
Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, Jan. 2011
A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene, (S.Takasawa), M.Kuroki, K.Nata, N.Noguchi, T.Ikeda, A.Yamauchi, H.Ota, A.Itaya-Hironaka, S.Sakuramoto-Tsuchida, I.Takahashi, T.Yoshikawa, T.Shimosegawa, H.Okamoto, Biochemical and biophysical research communications, 397:140-145, Jun. 2010
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010
FKBP12.6 disruption impairs glucose-induced insulin secretion, (N.Noguchi), T.Yoshikawa, T.Ikeda, I.Takahashi, N.J.Shervani, A.Uruno, A.Yamauchi, K.Nata, S.Takasawa, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 371:735-740, Jul. 2008
Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients, 13:2226, Jun. 2021
Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development, Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura, International Journal of Molecular Sciences, 22:2804, Mar. 2021
Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models., Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Ikeda, International Journal of Molecular Sciences, 24:3736, Feb. 2023

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.