KURATA Yasutaka

Researcher Profile & Settings

Research

Overview of research:
I am studying the ionic and dynamical mechanisms of normal pacemaking and abnormal pacemaker activities (e.g., depolarization-induced automaticity, early afterdepolarization) in cardiac myocytes by patch-clamp experiments and mathematical analyses based on bifurcation theory. My another research interest is the mathematical modeling and computer simulation of ion channel dynamics using Markovian state schema and rate theory.

Special Field

• Physiology in General

Education

• Tottori University Graduate School Division of Medicine
• Tottori University Faculty of Medicine

Degree

• Ph.D in Medicine

Academic & Professional Experience

• May 2005Kanazawa Medical University Associate Professor

Research Activities

Published Papers

• Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1β production in murine macrophage-like J774.1 cells, Tomomi Notsu, Yasutaka Kurata, Haruaki Ninomiya, Fikri Taufiq, Koji Komatsu, Junichiro Miake, Tatsuya Sawano, Motokazu Tsuneto, Yasuaki Shirayoshi, Ichiro Hisatome, 46:2368-2377, Aug. 2023
• Theoretical prediction of early afterdepolarization-evoked triggered activity formation initiating ventricular reentrant arrhythmias, Kunichika Tsumoto, Takao Shimamoto, Yuma Aoji, Yukiko Himeno, Yuhichi Kuda, Mamoru Tanida, Akira Amano, Yasutaka Kurata, Computer Methods and Programs in Biomedicine, 240:107722, Oct. 2023
  DOI:https://doi.org/10.1016/j.cmpb.2023.107722
• Mechanisms of fever-induced QT prolongation and torsades de pointes in patients with KCNH2 mutation, Keisuke Usuda, Kenshi Hayashi, Tadashi Nakajima, Yasutaka Kurata, Shihe Cui, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Kenji Sakata, Soichiro Usui, Noboru Fujino, Yoshihiro Tanaka, Yoshiaki Kaneko, Masahiko Kurabayashi, Shoichi Tange, Takekatsu Saito, Kunio Ohta, Masakazu Yamagishi, Masayuki Takamura, 25:161, Jun. 2023
• Deep learning-based identification of sinoatrial node-like pacemaker cells from SHOX2/HCN4 double-positive cells differentiated from human iPS cells, Takayuki Wakimizu, Junpei Naito, Manabu Ishida, Yasutaka Kurata, Motokazu Tsuneto, Yasuaki Shirayoshi, Ichiro Hisatome, Journal of arrhythmia, 39:664-668, Jun. 2023
• Mechanisms for hypothermia during anaphylactic hypotension in awake rats, Toshishige Shibamoto, Munenori Ono, Mamoru Tanida, Yuhichi Kuda, Yasutaka Kurata , American journal of physiology. Regulatory, integrative and comparative physiology, 325:R446-R455, Nov. 2023
• Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes, (Peili Li), Yasutaka Kurata, Fikri Taufiq, Masanari Kuwabara, Haruaki Ninomiya, Katsumi Higaki, Motokazu Tsuneto, Yasuaki Shirayoshi, Miguel A. Lanaspa, Ichiro Hisatome, Molecular Biology Reports, 49:5939-5952, Feb. 2022
  DOI:10.1007/s11033-022-07378-1
• SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation, (Takayuki Wakimizu), Kumi Morikawa, Kenta Fukumura, Tetsuo Yuki, Takashi Adachi, Yasutaka Kurata, Junichiro Miake, Ichiro Hisatome, Motokazu Tsuneto, Yasuaki Shirayoshi, Regenerative Therapy, 21:239-249, Jul. 2022
  DOI:10.1016/j.reth.2022.07.012
• Bifurcations and Proarrhythmic Behaviors in Cardiac Electrical Excitations, Kunichika Tsumoto, Yasutaka Kurata, 12:459, Mar. 2022
• α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats., Hiromu Horie, Ichiro Hisatome, Yasutaka Kurata, Yasutaka Yamamoto, Tomomi Notsu, Maaya Adachi, Peili Li, Masanari Kuwabara, Takuki Sakaguchi, Yoshiharu Kinugasa, Junichiro Miake, Satoshi Koba, Motokazu Tsuneto, Yasuaki Shirayoshi, Haruaki Ninomiya, Shin Ito, Masafumi Kitakaze, Kazuhiro Yamamoto, Yasushi Yoshikawa, Motonobu Nishimura, Hypertension research : official journal of the Japanese Society of Hypertension, 45:283-291, 2021
  DOI:10.1038/s41440-021-00802-2
• Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction, Mai Watanabe, Hiromu Horie, Yasutaka Kurata, Yumiko Inoue, Tomomi Notsu, Takayuki Wakimizu, Maya Adachi, Kenshiro Yamamoto, Kumi Morikawa, Masanari Kuwabara, Takuki Sakaguchi, Takayuki Morisaki, Junichiro Miake, Motonobu Nishimura, Motokazu Tsuneto, Yasuaki Shirayoshi, Shin Ito, Masafumi Kitakaze, Haruaki Ninomiya, Kazuhiro Yamamoto, Ichiro Hisatome, Circulation Journal, 85:657-666, 2021
  DOI:10.1253/circj.CJ-20-0877
• Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of Spontaneous SR Ca2+ Release, Yasutaka Kurata, Kunichika Tsumoto, Kenshi Hayashi, Ichiro Hisatome, Yuhichi Kuda, Mamoru Tanida, Frontiers in Physiology, 10:1545, Jan. 2020
  DOI:10.3389/fphys.2019.01545
• Specific decreasing of Na+ channel expression on the lateral membrane of cardiomyocytes causes fatal arrhythmias in Brugada syndrome, Kunichika Tsumoto, Takashi Ashihara, Narumi Naito, Takao Shimamoto, Akira Amano, Yasutaka Kurata, Yoshihisa Kurach, Scientific Reports, 10:19964, Nov. 2020
  DOI:10.1038/s41598-020-76681-3
• Angiopoietin-2 is released during anaphylactic hypotension in anesthetized and unanesthetized rats, Tao Zhang, Toshishige Shibamoto, Mamoru Tanida, Makoto Taniguchi,Yuhichi Kuda, Wei Yang, Yasutaka Kurata, PLOS ONE, 15:e0242026, Nov. 2020
• Pretreatment with cilnidipine attenuates hypoxia/reoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening, (Minato Hiroyuki), Hisatome Ichiro, Kurata Yasutaka, Notsu Tomomi, Nakasone Naoe, Ninomiya Haruaki, Hamada Toshihiro, Tomomori Takuya, Okamura Akihiro, Miake Junichiro, Tsuneto Motokazu, Shirayoshi Yasuaki, Endo Ryo, Otsuki Akihiro, Okada Futoshi, Inagaki Yoshimi, Hypertension Research, 43:380-388, May 2020
  DOI:10.1038/s41440-019-0391-7
• Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock, (Otani Naoyuki), Kurata Yasutaka, Maharani Nani, Kuwabara Masanari, Ikeda Nobuhito, Notsu Tomomi, Li Peili, Miake Junichiro, Yoshida Akio, Sakaguchi Hiromi, Higaki Katsumi, Nakasone Naoe, Tsuneto Motokazu, Shirayoshi Yasuaki, Ouchi Motoshi, Ninomiya Haruaki, Yamamoto Kazuhiro, Anzai Naohiko, Hisatome Ichiro, Circulation Reports, 2:425-432, Jul. 2020
  DOI:10.1253/circrep.CR-20-0016
• Integrative and theoretical research on the architecture of a biological system and its disorder, (Shinichi Uchida), Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano, Ryuji Inoue, Yoshihisa Kurachi, Journal of Physiological Sciences, 69:433-451, May 2019
  DOI:10.1007/s12576-019-00667-8
• β-Adrenergic Blocker, Carvedilol, Abolishes Ameliorating Actions of Adipose-Derived Stem Cell Sheets on Cardiac Dysfunction and Remodeling After Myocardial Infarction., (Adachi Maya),Watanabe Mai,Kurata Yasutaka,Inoue Yumiko,Notsu Tomomi,Yamamoto Kenshiro,Horie Hiromu,Tanno Shogo,Morita Maki,Miake Junichiro,Hamada Toshihiro,Kuwabara Masanari,Nakasone Naoe,Ninomiya Haruaki,Tsuneto Motokazu,Shirayoshi Yasuaki,Yoshida Akio,Nishimura Motonobu,Yamamoto Kazuhiro,Hisatome Ichiro, Circulation Journal, 83:2282-2291, Dec. 2019
  DOI:10.1253/circj.CJ-19-0261
• Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes, (Taufiq Fikri), Maharani Nani, Li Peili, Kurata Yasutaka, Ikeda Nobuhito, Kuwabara Masanari, Otani Naoyuki, Miake Junichiro, Hasegawa Akira, Tsuneto Motokazu, Shirayoshi Yasuaki, Ninomiya Haruaki, Saitoh Tatsuya, Nakai Akira, Yamamoto Kazuhiro, Hisatome Ichiro, Circulation Journal, 83:718-726, Apr. 2019
  DOI:10.1253/circj.CJ-18-1088
• Inhibitory effects of class I antiarrhythmic agents on Na+ and Ca2+ currents of human iPS cell-derived cardiomyocytes, (Yonemizu Sayaka),Masuda Keiichiro,Kurata Yasutaka,Notsu Tomomi,Higashi Yuhei,Fukumura Kenta,Li Peili,Ninomiya Haruaki,Miake Junichiro,Tsuneto Motokazu,Shirayoshi Yasuaki,Hisatome Ichiro, Regenerative Therapy, 10:104-111, Feb. 2019
  DOI:10.1016/j.reth.2018.12.002
• Tonic contraction develops in the colon during anaphylactic hypotension in anesthetized rats, Tao Zhang, Toshishige Shibamoto, Mamoru Tanida, Yuhichi Kuda, Wei Yang, Yasutaka Kurata, Journal of Physiological Sciences, 69:953-960, 2019
• Anaphylaxis stimulates afferent vagal nerve activity and efferent sympathetic nerve activity in the stomach of anesthetized rats, Kuda Y, Tanida M, Chen F, Kurata Y, Shibamoto T, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSI, 317:R337-R345, Aug. 2019
• Renal response to anaphylaxis in anesthetized rats and isolated perfused rat kidneys: roles of nitric oxide., Mukai K, Kuda Y, Shibamoto T, Tanida M, Kurata Y, Yokoyama H., The Journal of Physiological Sciences, 68:689-697, Sep. 2018
• Restoration of mutant hERG stability by inhibition of HDAC6., Li P, Kurata Y, Endang M, Ninomiya H, Higaki K, Taufiq F, Morikawa K, Shirayoshi Y, Horie M, Hisatome I., J Mol Cell Cardiol., 115:158-169, Feb. 2018
• Protective effects of topiroxostat on an ischemia-reperfusion model of rat hearts., Tanno S, Yamamoto K, Kurata Y, Adachi M, Inoue Y, Otani N, Mishima M, Yamamoto Y, Kuwabara M, Ogino K, Miake J, Ninomiya H, Shirayoshi Y, Okada F, Yamamoto K, Hisatome I., CIRCULATION JOURNAL, 82:1101-1111, Mar. 2018
• Pretreatment with an angiotensin II receptor blocker abolished ameliorating actions of adipose-derived stem cell sheets on cardiac dysfunction and remodeling after myocardial infarction., Yamamoto K, Kurata Y, Inoue Y, Adachi M, Tsuneto M, Miake J, Ogino K, Ninomiya H, Yoshida A, Shirayoshi Y, Suyama Y, Yagi S, Nishimura M, Yamamoto K, Hisatome I., Regenerative Therapy, 9:79-88, Sep. 2018
• Gastric vascular and motor responses to anaphylactic hypotension in anesthetized rats, in comparison to those with hemorrhagic or vasodilator-induced hypotension, Kuda Y, Shibamoto T, Zhang T, Yang W, Tanida M, Kurata Y, Journal of Physiological Sciences, 68:253-260, May 2018
  DOI:10.1007/s12576-017-0527-y
• Anaphylactic hypotension causes renal and adrenal sympathoexcitaion and induces c-fos in the hypothalamus and medulla oblongata, Tanida M, Zhang T, Sun L, Song J, Yang W, Kuda Y, Kurata Y, Shibamoto T., EXPERIMENTAL PHYSIOLOGY, 103:790-806, Jun. 2018
• β2-adrenoceptor blockade deteriorates systemic anaphylaxis by enhancing hyperpermeability in anesthetized mice, Yang W, Shibamoto T, Kuda Y, Zhang T, Tanida M, Kurata Y., Allergy Asthma & Immunology Research, 10:52-61, Jan. 2018
• Biphasic Renal Sympathetic Response to Hemorrhagic Hypotension in Mice., Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T., Shock, 48:576-582, 2017
  DOI:10.1097/SHK.0000000000000889
• Hysteretic dynamics of multi-stable early afterdepolarisations with repolarisation reserve attenuation: a potential dynamical mechanism for cardiac arrhythmias., (Tsumoto K), Kurata Y, Furutani K, Kurachi Y., Scientific Reports, 7:10771, 2017
• Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts., (Ikeda N), Nakazawa N, Kurata Y, Yaura H, Taufiq F, Minato H, Yoshida A, Ninomiya H, Nakayama Y, Kuwabara M, Shirayoshi Y, Hisatome I., Biomed Res, 38:229-238, 2017
• Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by Sustained Renal Sympathoexcitation., Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T., frontiers in Physiology, 8:669, 2017
• Molecular mechanism underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells., (Ohnohara T), Hisatome I, Kurata Y, Li P, Notsu T, Morikawa K, Otani N, Yoshida A, Iitsuka K, Kato M, Miake J, Ninomiya H, Higaki K, Shirayoshi Y, Nishihara T, Itoh T, Nakamura Y, Nishimura M., J Arrhythm, 33:226-233, 2017
• Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models., Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T., Am J Physiol Heart Circ Physiol, 312:H106-H127, 2017
• Blockade of β2-adrenoceptor, rather than β1-adrenoceptor, deteriorates cardiac anaphylaxis in isolated blood-perfused rat hearts., Kuda Y, Shibamoto T, Yang W, Zhang T, Tanida M, Kurata Y., Cardiol J, 24:403-408, 2017
• M3 muscarinic receptor signaling stabiling stabilizes a novel mutant human ether-a-go-go-related gene channel protein via phosphorylation of heat shock factor 1 in transfected cells., (E.Mahati), P.Li, Y.Kurata, N.Maharani, N.Ikeda, S.Sakata, K.Ogura, J.Miake, T.Aiba, W.Shimizu, N.Nakasone, H.Ninomiya, K.Higaki, K.Yamamoto, A.Nakai, Y.Shirayoshi, I.Hisatome, Circulation Journal, 80:2443-2452, 2016
• L-Ornithine intake affects sympathetic nerve outflows and reduces body weight and food intake in rats., (Y.Konishi), Y.Koosaka, R.Maruyama, K.Imanishi, K.Kasahara, A.Matsuda, S.Akiduki, Y.Hishida, Y.Kurata, T.Shibamoto, J.Satomi, M.Tanida, Brain Research Bulletin, 111:48-52, 2015
• Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized rats. , M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, Y.Kurata, Experimental Lung Research, 41:324-334, 2015
• Stabilization of Kv1.5 channel protein by the inotropic agent olprinone., (R.Endo), Y.Kurata, T.Notsu, P.Li, K.Morikawa, T.Kondo, K.Ogura, J.Miake, A.Yoshida, Y.Shirayoshi, H.Ninomiya, K.Higaki, M.Kuwabara, K.Yamamoto, Y Inagaki, I.Hisatome, European Journal of Pharmacology, 765:488-494, 2015
• Pulmonary vascular and airway responses to systemic vasoconstrictors in anesthetized BALB/c mice. , M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.Toga, Journal of cardiovascular pharmacology, 65:325-334, 2015
• Molecular mechanisms underlying urate-induced enhancement of Kv1.5 channel expression in HL-1 atrial myocytes., (N.Maharani), YK.Ting, J.Cheng, A.Hasegawa, Y.Kurata, P.Li, Y.Nakayama, H.Ninomiya, N.Ikeda, K.Morikawa, K.Yamamoto, N.Makita, T.Yamashita, Y.Shirayoshi, I.Hisatome, Circulation Journal, 79:2659-2668, 2015
• Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase., M.Tanida, N.Yamamoto, DA.Morgan, Y.Kurata, T.Shibamoto, K.Rahmouni, The Journal of Neuroscience, 35:474-484, 2015
• Hypothalamic nesfatin-1 stimulates sympathetic nerve activity via hypothalamic ERK signaling. , M.Tanida, H.Gotoh, N.Yamamoto, M.Wang, Y.Kuda, Y.Kurata, M.Mori, T.Shibamoto, Diabetes, 64:3725-3736, 2015
• Exercise attenuates ischemia-reperfusion injury of nonalcoholic fatty liver of OLETF rat. , T.Shibamoto, Y.Kuda, M.Tanida, M.Wang, Y.Kurata, Journal of Gastroenterology, Pancreatology & Liver Disorders, 2:1-6, 2015
• E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in mammalian cells., (P.Li), Y.Kurata, N.Maharani, E.Mahati, K.Higaki, A.Hasegawa, Y.Shirayoshi, A.Yoshida, T.Kondo, Y.Kurozawa, K.Yamamoto, H.Ninomiya, I.Hisatome, Journal Molecular and Cellular Cardiology, 86:138-146, 2015
• VEGF secretion by adipose tissue-derived regenerative cells is impaired under hyperglycemic conditions via glucose transporter activation and ROS increase, (H.Matsugami), Y.Harada, Y.Kurata, Y.Yamamoto, Y.Otsuki, H.Yaura, Y.Inoue, K.Morioka, A.Yoshida, Y.Shirayoshi, Y.Suyama, B.Nakayama, H.Iwaguro, K.Yamamoto, I.Hisatome, Biomedical research (Tokyo, Japan), 35:397-405, 2014
• Soy isoflavone affects the autonomic nervous system in a tissue-specific manner in anesthetized rats, M.Tanida, K.Imanishi, M.Komatsu, J.Satomi, N.Yamamoto, M.Wang, Y.Kurata, T.Shibamoto, Experimental biology and medicine (Maywood, N.J.), 239:477？483, 2014
• Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine., M.Wang, T.Shibamoto, M.Tanida, Y.Kuda, Y.Kurata, Life sciences., 116:98-105, 2014
• Major contribution of vasospasm-induced coronary blood flow reduction to anaphylactic ventricular dysfunction assessed in isolated blood-perfused rat heart, Y.Kuda, Y.Kurata, M.Wang, M.Tanida, T.Shibamoto, Cardiology journal., 21:11-17, 2014
• Instability of KCNE1-D85N that causes long QT syndrome: stabilization by verapamil., (S.Sakata), Y.Kurata, P.Li, T.Notsu, K.Morikawa, J.Miake, K.Higaki, Y.Yamamoto, A.Yoshida, Y.Shirayoshi, K.Yamamoto, M.Horie, H.Ninomiya, S.Kanzaki, I.Hisatome, Pacing and clinical electrophysiology : PACE, 37:853-863, 2014
• Injection of Lactobacillus casei strain Shirota affects autonomic nerve activities in a tissue-specific manner, and regulates glucose and lipid metabolism in rats., M.Tanida, K.Imanishi, H.Akashi, Y.Kurata, O.Chonan, E. Naito, S.Kunihiro, M.Kawai, A.Kato-Kataoka, T.Shibamoto, Journal of diabetes investigation, 5:153-161, 2014
• Effects of anesthetics on the renal sympathetic response to anaphylactic hypotension in rats., L.Sun, M.Tanida, M.Wang, Y.Kuda, Y.Kurata, T.Shibamoto, PloS one, 9:e113945;1-15, 2014
• Angiotensin II and vasopressin are involved in the defense system against anaphylactic hypotension in anesthetized rats., M.Wang, T.Shibamoto, Y.Kuda, L.Sun, M.Tanida, Y.Kurata., European journal of pharmacology., 731:38-43, 2014
• MRI Reveals edema in larynx (But not in brain) during anaphylactic hypotension in anesthetized rats., I.Toyota, M.Tanida, T.Shibamoto, Mofei Wang, Y.Kurata, H.Tonami, Allergy, asthma & immunology research., 5:389-396, Nov. 2013
• Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats., M.Wang, M.Tanida, T.Shibamoto, Y.Kurata, American journal of physiology. Regulatory, integrative and comparative physiology., 305:R900-:R907, Aug. 2013
• Effect of hyperpolarization-activated current I(f) on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na(+) concentration., Y.Kurata, I.Hisatome, M.Tanida, T.Shibamoto, American journal of physiology. Heart and circulatory physiology., 304:H1337-H1351, Mar. 2013
• Nitric oxide and β2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice., S.Shinomiya, T.Shibamoto, Y.Kurata, Y.Kuda, W..Zhang, M.Tanida, H.Toga, Experimental lung research., 39:119-129, Jan. 2013
• Rat hepatic and splanchnic vascular responses to anaphylactic shock, compared with hemorrhagic or vasodilator-induced shock., W.Zhang, T.Shibamoto, M.Tanida, M.Wang, L.Sun, Y.Kurata, In vivo (Athens, Greece), 27:485-494, 2013
• Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins., (C.Iwai), P.Li, Y.Kurata, Y.Hoshikawa, K.Morikawa, N.Maharani, K.Higaki, T.Sasano, T.Notsu, Y.Ishido, J.Miake, Yamamoto Y, Y.Shirayoshi, H.Ninomiya, A.Nakai, S.Murata, A.Yoshida, K.Yamamoto, M.Hiraoka, I.Hisatome, Cardiovascular research., 100:520-528, 2013
• Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner., M.Tanida, A.Hayata, N.Shintani, N.Yamamoto, Y.Kurata, T.Shibamoto, D.A.Morgan, Rahmouni K, H.Hashimoto, Neuroscience., 238:297-304., 2013
• Mast cells are not involved in the ischemia-reperfusion injury in perfused rat liver, T.Shibamoto, M.Tsutsumi, Y.Kuda, C.Ohmukai, W.Zhang, Y.Kurata, The Journal of surgical research, 174:114-119, May 2012
• Vascular perfusion limits mesenteric lymph flow during anaphylactic hypotension in rats, W.Zhang, T.Shibamoto, Y.Kuda, Y.Kurata, S.Shinomiya, H.Kida, H.Tsuchida, American journal of physiology. Regulatory, integrative and comparative physiology., 302:R1191-R1196, 2012
• The responses of the hepatic and splanchnic vascular beds to vasopressin in rats, W.Zhang, T.Shibamoto, Y.Kuda, S.Shinomiya, Y.Kurata, Biomedical research (Tokyo, Japan), 33:83-88, 2012
• Stabilization of Kv1.5 channel protein by bepridil through its action as a chemical chaperone, (S.Suzuki), Y.Kurata, P.Li, T.Notsu, A.Hasegawa, N.Ikeda, M.Kato, J.Miake, S.Sakata, G.Shiota, A.Yoshida, H.Ninomiya, K.Higaki, K.Yamamoto, Y.Shirayoshi, I.Hisatome, European journal of pharmacology., 696:28-34, 2012
• Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models, Y.Kurata, I.Hisatome, T.Shibamoto, American journal of physiology. Heart and circulatory physiology., 302:H2285-H2300, 2012
• Electrophysiological properties of prion-positive cardiac progenitors derived from murine embryonic stem cells, (H.Fujii), Y.Ikeuchi, Y.Kurata, N.Ikeda, U.Bahrudin, P.Li, Y.Nakayama, R.Endo, A.Hasegawa, K.Morikawa, J.Miake, A.Yoshida, K.Hidaka, T.Morisaki, H.Ninomiya, Y.Shirayoshi, K.Yamamoto, I.Hisatome, Circulation journal : official journal of the Japanese Circulation Society, 76:2875-2883, 2012
• Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability, (P.Li), H.Ninomiya, Y.Kurata, M.Kato, J.Miake, Y.Yamamoto, O.Igawa, A.Nakai, K.Higaki, F.Toyoda, J.Wu, M.Horie, H.Matsuura, A.Yoshida, Y.Shirayoshi, M.Hiraoka, I.Hisatome, Circulation research., 108:458-468, 2011
• Pulmonary vasoconstrictive and bronchoconstrictive responses to anaphylaxis are weakened via β2-adrenoceptor activation by endogenous epinephrine in anesthetized rats, W.Zhang, T.Shibamoto, Y.Kuda, C.Omukai, Y.Kurata, Anesthesiology., 114:614-623, 2011
• Portacaval shunting attenuates portal hypertension and systemic hypotension in rat anaphylactic shock, C.Kamikado, T.Shibamoto, W.Zhang, Y.Kuda, C.Omukai, Y.Kurata, The journal of physiological sciences : JPS, 61:161-166, 2011
• Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading to electrophysiological dysfunction, (U.Bahrudin), K.Morikawa, A.Takeuchi, Y.Kurata, J.Miake, E.Mizuta, K.Adachi, K.Higaki, Y.Yamamoto, Y.Shirayoshi, A.Yoshida, M.Kato, K.Yamamoto, E.Nanba, H.Morisaki, T.Morisaki, S.Matsuoka, H.Ninomiya, I.Hisatome, Journal of molecular biology., 413:857-878, 2011
• Ethanol predominantly constricts pre-sinusoids of isolated perfused livers of rat, guinea pig and mouse, T.Shibamoto, M.Tsutsumi, C.Omukai, Y.Kuda, W.Zhang, Y.Kurata, Alcohol and alcoholism : international journal of the Medical Council on Alcoholism., 46:117-122, 2011
• Enhancing effects of salicylate on quinidine-induced block of human wild type and LQT3 related mutant cardiac Na+ channels, (T.Urashima), Y.Kurata, J.Miake, M.Kato, K.Ogura, A.Yano, M.Adachi, Y.Tanaka, K.Yamada, T.Hamada, E.Mizuta, M.Kuwabara, M.Kato, Y.Yamamoto, K.Ogino, A.Yoshida, Y.Shirayoshi, I.Hisatome, Biomedical research (Tokyo, Japan), 32:303-312, 2011
• Effects of β-adrenoceptor antagonists on anaphylactic hypotension in conscious, W.Zhang, T.Shibamoto, Y.Kurata, H.Kohno, European journal of pharmacology., 650:303-308, 2011
• Roles of hyperpolarization-activated current If in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models., Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto, American journal of physiology. Heart and circulatory physiology., 298:H1748-H1760, 2010
• Liver volume, as assessed by four ultrasonic crystals arranged to form a tetrahedron, decreases during anaphylactic shock in anesthetized rats., H.Takano, T.Shibamoto, W.Zhang, Y.Kurata, Shock (Augusta, Ga.), 34:586-591, 2010
• Identification, isolation and characterization of HCN4-positive pacemaking cells derived from murine embryonic stem cells during cardiac differentiation, (K.Morikawa), U.Bahrudin, J.Miake, O.Igawa, Y.Kurata, Y.Nakayama, Y.Shirayoshi, I.Hisatome, Pacing and clinical electrophysiology : PACE, 33:290-303, 2010
• Exercise training attenuates anaphylactic venoconstriction in rat perfused liver, but does not affect anaphylactic hypotension in conscious rats., S.Cui, T.Shibamoto, W.Zhang, Y.Kurata, O.Kashimura, S.Miyamae, Clinical and experimental pharmacology & physiology., 37:889-893, 2010
• Mouse hepatic portal venoconstrictive response to vasoconstrictors is much weaker than that in rat, ZS.Zhao, T.Shibamoto, M.Tsutsumi, S.Cui, WM.Zhang, H.Takano, Y.Kurata, Journal of cardiovascular pharmacology., 54:421-426, 2009
• Hepatic microvascular pressure during anaphylactic shock in anesthetized rats, H.Takano, T.Shibamoto, W.Zhang, Y.Kurata, H.Toga, Microvascular research, 78:169-173, 2009
• 7-nitroindazole, but not L-name or aminoguanidine, attenuates anaphylactic hypotension in conscious rats, W.Zhang, T.Shibamoto, S.Cui, H.Takano, Y.Kurata, Shock (Augusta, Ga.), 31:201-206, 2009
• Venous resistance increases during rat anaphylactic shock., S.Cui, T.Shibamoto, W.Zhang, H.Takano, Y.Kurata, Shock (Augusta, Ga.), 29:733-739, 2008
• Regional difference in dynamical property of sinoatrial node pacemaking: role of Na+ channel current., Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto, 95:951-977, 2008
• PAF, rather than histamine, participates in mouse anaphylactic hypotension., T.Shibamoto, W.Liu, S.Cui, W.Zhang, H.Takano, Y.Kurata, Pharmacology., 82:114-120, 2008
• Functional stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines., (Y.Hirota), Y.Kurata, M.Kato, T.Notsu, S.Koshida, T.Inoue, Y.Kawata, J.Miake, U.Bahrudin, P.Li, Y.Hoshikawa, Y.Yamamoto, O.Igawa, Y.Shirayoshi, A.Nakai, H.Ninomiya, K.Higaki, M.Hiraoka, I.Hisatome, Biochemical and biophysical research communications, 372:469-474, 2008
• Changes of HCN gene expression and If currents in Nkx2.5-positive cardiomyocytes derived from murine embryonic stem cells during differentiation., (S.Yano), J.Miake, E.Mizuta, K.Manabe, U.Bahrudin, K.Morikawa, K.Arakawa, N.Sasaki, O.Igawa, C.Shigemasa, Y.Yamamoto, T.Morisaki, K.Hidaka, Y.Kurata, A.Yoshida, G.Shiota, K.Higaki, H.Ninomiya, JK.Lee, Y.Shirayoshi, I.Hisatome, Biomedical research (Tokyo, Japan), 29:195-203, 2008
• Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineering, Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto, American journal of physiology. Heart and circulatory physiology., 292:H701-718, Jan. 2007
• l-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse, S.Cui, T.Shibamoto, Z.Zhao, H.Takano, Y.Kurata, Prostaglandins, leukotrienes, and essential fatty acids., 76:277-283, 2007
• The sinusoidal pressure during ischemia-reperfusion injury in perfused mouse liver pretreated with or without L-NAME, T.Shibamoto, Z.Ruan, S.Cui, W.Liu, Z-S.Zhao, H.Takano, Y.Kurata, T.Koizumi, K.Kubo, The Journal of surgical research, 139:30-35, 2007
• The roles of mast cells and Kupffer cells in rat systemic anaphylaxis, T.Shibamoto, T.Shimo, S.Cui, W.Zhang, H.Takano, Y.Kurata, H.Tsuchida, American journal of physiology. Regulatory, integrative and comparative physiology., 293:R2202-R2209, 2007
• Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers, S.Cui, T.Shibamoto, H.Takano, W.Zhang, Y.Kurata, European journal of pharmacology., 576:99-106, 2007
• Involvement of splanchnic vascular bed in anaphylactic hypotension in anesthetized BALB/c mice, W.Liu, H.Takano, T.Shibamoto, S.Cui, Z-S.Zhao, W.Zhang, Y.Kurata, American journal of physiology. Regulatory, integrative and comparative physiology., 293:R1947-1953, 2007
• Inhibition of β-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat cardiac cells, (K.Ogura), J.Miake, N.Sasaki, C.Iwai, U.Bahrudin, P.Li, M.Kato, K.Iitsuka, Y.Hirota, T.Koshida, Y.Yamamoto, Y.Inoue, A.Yano, M.Adachi, O.Igawa, Y.Kurata, T.Morisaki, G.Shiota, Y.Shirayoshi, H.Ninomiya, I.Hisatome, Journal of molecular and cellular cardiology., 43:648-652, 2007
• Hepatic pre-sinusoidal vessels contract in anaphylactic hypotension in rabbits, N.Karasawa, T.Shibamoto, S.Cui, H.Takano, Y.Kurata, H.Tsuchida, Acta physiologica Scandinavica., 189：15-22, 2007
• Head-down tilt posture attenuates anaphylactic hypotension in mice and rats, Z.Zhao, T.Shibamoto, S.Cui, H.Takano, W.Zhang, Y.Kurata, The journal of physiological sciences : JPS, 57:269-274, 2007
• Effects of L-NAME on thromboxane A2-induced venoconstriction in isolated perfused livers from rat, guinea pig and mouse, S.Cui, T.Shibamoto, Z.Zhao, W.Zhang, H.Takano, Y.Kurata, Vascular pharmacology., 47:215-221, 2007
• Delayed onset of beating and decreased expression of T-type Ca2+channel in mouse ES cell-derived cardiocytes carrying human chromosome 21, (E. Mizuta), H. Furuichi, Y. Kazuki, J. Miake, S. Yano, U. Bahrudin, Y. Yamamoto, O. Igawa, C. Shigemasa, K. Hidaka, T. Morisaki, Y. Kurata, H. Ninomiya, M. Kitakaze, Y. Shirayoshi, M. Oshimura, I. Hisatome, Biochemical and biophysical research communications, 351:126-132, Dec. 2006
• Spreading dilatation in small arteries, H.Takano, Y.Kurata, T.Shibamoto, 31:127-131, Aug. 2006
• Inhibition of inward rectifier K+ currents by angiotensin Ⅱ in rat atrial myocytes: Lack of effects in cells from spontaneous hypertensive rats, (K. Sonoyama), H. Ninomiya, O. Igawa, Y.Kaetsu, Y.Furuse, T.Hamada, J. Miake, P. Li, Y. Yamamoto, K. Ogino, A. Yoshida, S. Taniguchi, Y. Kurata, S. Matsuoka, T. Narahashi, G. Shiota, Y. Nozawa, H. Matsubara, M. Horiuchi, Y. Shirayoshi, I. Hisatome, Hypertension research : official journal of the Japanese Society of Hypertension., 29: 923-934, Aug. 2006
• Oxygen consumption, assessed with the oxygen absorption spectrophotometer, decreases independently of venoconstriction during hepatic anaphylaxis in perfused rat liver, S.Cui., T.Shibamoto, Z.Ruan, H.Takano, W.Liu, Y.Kurata, Shock (Augusta, Ga.), 26:62-68, 2006
• NG-nitro-L-arginine methyl ester potentiates anaphylactic venoconstriction in rat perfused livers, T.Shibamoto, T.Ishibashi, T.Shimo, S.Cui, H.Takano, H.Tsuchida, M.Nishio, Y.Kurata, Clinical and experimental pharmacology & physiology., 33:1073-1077, 2006
• Effects of Hct on L-NAME-induced potentiation of anaphylactic presinusoidal constriction in perfused rat livers, S.Cui., T.Shibamoto, W.Liu, H.Takano, Z.S.Zhao, Y.Kurata, Journal of cardiovascular pharmacology., 48:827-833, 2006
• L-cysteine prevents oxidation-induced block of the cardiac Na+cannel via interaction with heart-specific cysteiny 1 residues in the p-loop region , KURATA Yasutaka, Circulation Journal, 2002
• Analysis of Moricizine block of sodium current in isolated guinea-pig atrial myocytes : Atrio-ventricular difference of Moricizine block , KURATA Yasutaka, Vascul Pharmacol, 2002
• Block of sodium channels by divalent mercury : Role of specific cysteinyl residues in the P-loop region.(共著), KURATA Yasutaka, Biophysical Journal, 2000
• Mechanisms of cation permeation in cardiac sodium channel : description by dynamic pore model. (共著), KURATA Yasutaka, Biophysical Journal, 1999
• Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class (]G0001[) antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle.(共著), KURATA Yasutaka, Biochim Biophys Acta, 1999
• Effects of nicardipine and bupivacaine on early afterdepolarization in rabbit sinoatrial node cells : A possible mechanism of bupivacaine-induced arrhythmias.(共著), KURATA Yasutaka, General Pharmacology, 1999
• Agonist and potentiation actions of n-octanol on gamma-aminobutyric acid type A receptors. (共著), KURATA Yasutaka, Molecular Pharmacology, 1999
• Effect of sulfhydryl oxidoreduction on permeability of cardiac tetrodotoxin-insensitive sodium channel. (共著), KURATA Yasutaka, Life Sciences, 1998
• Selective effects of alcohols on γ-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells. (共著), KURATA Yasutaka, Journal of Pharmacology and Experimental Therapeutics, 1994
• Kinetic analysis of alcohol effects on GABAA receptor-channel complex(共著), KURATA Yasutaka, Biophysical Journal, 1994
• Alcohol modulation of cloned GABAA receptor-channel complex expressed in human kidney cell lines. (共著), KURATA Yasutaka, Brain Research, 1993
• Effect of a novel class I antiarrhythmic agent, TYB-3823, on the calcium current in single guinea pig ventricular myocytes. (共著), KURATA Yasutaka, Journal of Electrocardiology, 1992
• The effect of TYB-3823, a new antiarrhythmic drug, on sodium current in isolated cardiac cells. (共著), KURATA Yasutaka, British Journal of Pharmacology, 1991
• A mathematical model of cardiac Na-channel developed from Gyring rate theory, KURATA Yasutaka, Japanese Journal of Electrocardiology., 1991
• On mechanisms underlying development of intracellular Ca2+ oscillation in Ca-overloaded cardiac cell., KURATA Yasutaka, Japanese Journal of Electrocardiology, 1989
• Membrane action of ethanol on rabbit sino-atrial node studied by voltage clamp method. (共著), KURATA Yasutaka, Pharmacology and Toxicology, 1989
• Theoretical analysis of stability in cardiac cell system., KURATA Yasutaka, 1988
• Theoretical analysis of electrical stability in cardiac sino-atrial node cell., KURATA Yasutaka, 1988