SHIMADA Hiroki

■FacultyMedical Science, Department of Anatomy Ⅰ
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    1. Cytochemical study of the cytotoxicity by reactive oxygen species. 2. Mechanism of mitochondrial damage induced by paraquat.

Special Field

  • General anatomy(includes histology/embryology)

Education

  • Tokyo University of Agriculture and Technology Graduate School Division of Agricultural Science
  • Tokyo University of Agriculture and Technology Faculty of Agriculture

Degree

  • Philosophiae Doctor

Association Memberships

  • 2002The Japanese Society of Mitochondrial Research and Medicine
  • 1990The Japanese Association of Anatomists
  • 1992The Japanese Society of Microscopy

Academic & Professional Experience

  • Apr. 1988- Mar. 1993Research Institute of Nippon Meat Packer Inc. Research worker
  • May 1988- Mar. 1995Kanazawa Medical University Research fellow
  • Apr. 1995- Mar. 1999Kanazawa Medical University Teaching assistant
  • Apr. 1999Kanazawa Medical University Assistant professor

Research Activities

Published Papers

  • The impact of ovariectomy on olfactory neuron regeneration in mice, Kentaro Yamada, Hideaki Shiga, Takuya Noda, Masayuki Harita, Tomoko Ishikura, Yukari Nakamura, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses, 45:203-209, Feb. 2020
  • Leukemia inhibitory factor induces corticotropin-releasing hormone in mouse trophoblast stem cells, He Wang, Tsuyoshi Tsukada, Hiroki Shimada, Hiromi Sakata-Haga, Yasuo Iida, Shitai Zhang, Hiroki Shoji, Toshihisa Hatta, Biochemical and biophysical research communications, 522:81-87, Jan. 2020
  • Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta, Tsuyoshi Tsukada, Hiroki Shimada, Hiromi Sakata-Haga, Hideaki Iizuka, Toshihisa Hatta, Congenital anomalies, 59:81-87, May 2019
  • Effects of tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro, Takuya Noda, Hideaki Shiga, Kentaro Yamada, Masayuki Harita, Yukari Nakamura, Tomoko Ishikura, Masami Kumai, Zenji Kawakami, Atsushi Kaneko, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses, 44:327-338, May 2019
  • A rapid and nondestructive protocol for whole-mount bone staining of small fish and Xenopus, Sakata-Haga Hiromi, Uchishiba Maimi, Shimada Hiroki, Tsukada Tsuyoshi, Mitani Mayumi, Arikawa Tomohiro, Shoji Hiroki, Hatta Toshihisa, SCIENTIFIC REPORTS, 8:7453, May 2018
  • Extracranial outflow of particles solved in cerebrospinal fluid: Fluorescein injection study, (Akai Takuya);Hatta Toshihisa;Shimada Hiroki;Mizuki Keiji;Kudo Nae;Hatta Taizo;Otani Hiroki, Congenital Anomalies, 58:93-98, Oct. 2017
  • Galectin-4 expression is down-regulated in response to autophagy during differentiation of rat trophoblast cells, T.Arikawa, S.Liao, H.Shimada, T.Inoue, H.Sakata-Haga, T.Nakamura, T.Hatta, H.Syoji, SCIENTIFIC REPORTS, 6:1-11, Sep. 2016
  • Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One, 10:e0123232-e0123232, 2015
  • Effects of melanocortins on fetal development, E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta, Congenital anomalies, 51:47-54, 2011
  • Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway, E.Simamura, H.Shimada, N.Higashi, M.Uchishiba, H.Otani, T.Hatta, Endocrinology., 151:1853-1862, Apr. 2010
  • Branching patterns of the celiac artery as the hepato-gastro-splenic trunk, N.Higashi, H.Shimada, E.Simamura, T.Hatta, 84:7-10, Mar. 2009
  • Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase, H.Shimada, K-I.Hirai, E.Simamura, T.Hatta, H.Iwakiri, K.Mizuki, T.Hatta, T.Sawasaki, S.Matsunaga, Y.Endo, S.Shimizu, The Journal of biological chemistry., 284: 28642-28649, 2009
  • Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents, E.Simamura, H.Shimada, T.Hatta, K-I.Hirai, Journal of bioenergetics and biomembranes., 40:213-217, Sep. 2008
  • Right vertebral artery as the fourth branch of the aortic arch, N.Higashi, H.Shimada, E.Simamura, T.Hatta, Anatomical science international / Japanese Association of Anatomists, 83:314-318, Aug. 2008
  • Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1, E.Simamura, H.Shimada, Y.Ishigaki, T.Hatta, N.Higashi, K-I.Hirai, Anatomical science international / Japanese Association of Anatomists, 83:261-266, Aug. 2008
  • Mouse exo utero development system, T.Hatta, M.Yamada, E.Simamura, H.Shimada, M.Nimura, A.Matsumoto, J.Udagawa, R.Hashimoto, N.Higashi, H.Otani, 32:16-22, Jun. 2007
  • Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel, E.Simamura, K.-I.Hirai, H.Shimada, J.Koyama, Y.Niwa, S.Shimizu, Cancer biology & therapy, 5:1523-1529, Nov. 2006
  • Defense of UV-induced cell death by antioxidant nutrients, K.Furuta, H.Shimada, Y-B.Shui, 31:157-164, Oct. 2006
  • Mitochondrial injury followed by apoptosis and necrosis in 2-methylnaphtho[2, 3-b]furan-4, 9-dione-treated human lung adenocarcinoma cells, SHIMADA Hiroki, 7th Asia-Pacific Electron Microscopy Conference, 2000
  • Energy-filter analytical electron microscopy applied to cancer research, SHIMADA Hiroki, 3rd Japanese-Polish Joint Seminar on Materials Analysis, 2000
  • Defence of UV-Induced cell death by antioxidant nutrients, SHIMADA Hiroki, 10th Biennial Meeting of the International Society for Free Radical Research, 2000
  • Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells, K.-I. Hirai, J. Koyama, J. Pang, SHIMADA Hiroki, E. Simamura, T. Yamori, S. Sato, K. Tagahara, T. Tsuruo, Cancer Detection & Prevention, 23:539-550, Jun. 1999
  • Cytochemical energy-filtering transmission electron microscopy of mitochondrial free radical formation in paraquant cytotoxicity, K.-I. Hirai, J. Pang, SHIMADA Hiroki, T. Izuhara, T. Kurihara, K. Moriguchi, Journal of Electron Microscopy, 48:289-296, Jun. 1999
  • Mitochondrial NADH-quinone oxidoreductase(NQOm)produces reactive oxygen species in the chemical injury of rat liver mitochondria, K.-I. Hirai, SHIMADA Hiroki, J. Pang, S. Kato, E. Simamura, Acta Histochemica et Cytochemica, 32:239-242, May 1999
  • Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers., SHIMADA Hiroki, K.-I. Hirai, E. Simamura, J. Pang, Archives of biochemistry and biophysics., 351:75-81, Mar. 1998
  • Mitochondrial damage by a new antitumour agent furanonaphthoquinone derivative in human cervical cancer Hela cells., (J. Pang), K.-I. Hirai, E. Simamura, SHIMADA Hiroki, S. Kuwabara, Journal of Electron Microscopy, 46:181-187, Apr. 1997
  • Sciatic nerve regeneration navigated by laminin-fibronectin double coated biodegradable collagen grafts in rats., (X.-J. Tong), K.-I. Hirai, SHIMADA Hiroki, Y. Mizutani, T. Izumi, N. Toda, P. Yu, Brain research., 633:155-162, 1994
  • Induction of peripheral nerve regeneration using laminin-fibronectin double coated collagen fiber grafts., SHIMADA Hiroki, K.-I. Hirai, H. Seguchi, Artificial Organs Today, 4:1-11, 1993
  • Mitochondrial breakage induced by the herbicide paraquat in cultured human lung cells, (G.-Y. Wang), K.-I. Hirai, SHIMADA Hiroki, Journal of Electron Microscopy, 4:181-184, Jun. 1992
  • Behavior of axons, Schwann cells and perineurial cells in nerve grafts : effects of anti-laminin and anti-fibronectin antisera., (G.-Y. Wang), K.-I. Hrai, SHIMADA Hiroki, S.-Z. Zang, Brain research., 583:216-226, Jun. 1992
  • The role of laminin, a component of Schwann cell basal lamina in rat sciatic nerve regeneration within antiserum-treated nerve grafts., (G.-Y. Wang), K.-I. Hirai, SHIMADA Hiroki, Brain research., 570:116-125, Jan. 1992
  • The spread of human lung cancer cells on collagen and its inhibition by the type III collagen., K.-I. Hirai, SHIMADA Hiroki, T. Ogawa, S. Taji, Clinical and Experimental Metastasis, 9:515-525, Jun. 1991
  • Analysis of unsaturated disaccharides from glycosaminoglycans by high performance liquid chromatography., (Y. Nomura), SHIMADA Hiroki, K. Takahashi, K. Wada, Agricultural Biological Chemistry, 53:3313-3315, Dec. 1989
  • Leukemia inhibitory factor induces corticotropin-releasing hormone in mouse trophoblast stem cells, Wang, He;Tsukada, Tsuyoshi;Shimada, Hiroki;Sakata-Haga, Hiromi;Iida, Yasuo;Zhang, Shitai;Shoji, Hiroki;Hatta, Toshihisa, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 522:81-87, Jan. 2020
  • The Impact of Ovariectomy on Olfactory Neuron Regeneration in Mice, Yamada, Kentaro;Shiga, Hideaki;Noda, Takuya;Harita, Masayuki;Ishikura, Tomoko;Nakamura, Yukari;Hatta, Toshihisa;Sakata-Haga, Hiromi;Shimada, Hiroki;Miwa, Takaki, CHEMICAL SENSES, 45:203-209, Mar. 2020
  • Tissue clearing by RAP system is available for immunohistochemistry, SAKATA Hiromi;UCHISHIBA Maimi;TSUKADA Tsuyoshi;SAKAI Daisuke;SHIMADA Hiroki;SHOJI Hiroki;HATTA Toshihisa, Annual Meeting of the Japanese Society of Toxicology, 47:P-138, 2020
  • Leukemia inhibitory factor induces corticotropin-releasing hormone in mouse trophoblast stem cells., Wang He;Tsukada Tsuyoshi;Shimada Hiroki;Sakata-Haga Hiromi;Iida Yasuo;Zhang Shitai;Shoji Hiroki;Hatta Toshihisa, Biochemical and biophysical research communications, 522, 2020
  • The Impact of Ovariectomy on Olfactory Neuron Regeneration in Mice., Yamada Kentaro;Shiga Hideaki;Noda Takuya;Harita Masayuki;Ishikura Tomoko;Nakamura Yukari;Hatta Toshihisa;Sakata-Haga Hiromi;Shimada Hiroki;Miwa Takaki, Chemical senses, 45, 2020
  • MC5R Contributes to Sensitivity to UVB Waves and Barrier Function in Mouse Epidermis., Shintani Akari;Sakata-Haga Hiromi;Moriguchi Keiichi;Tomosugi Mitsuhiro;Sakai Daisuke;Tsukada Tsuyoshi;Taniguchi Makoto;Asano Masahide;Shimada Hiroki;Otani Hiroki;Shoji Hiroki;Hatta Junko;Mochizuki Takashi;Hatta Toshihisa, JID innovations, 1, 2021