FacultyMedical Science, Department of Anatomy Ⅰ

Researcher Profile & Settings


    Overview of research:
    1. Cytochemical study of the cytotoxicity by reactive oxygen species. 2. Mechanism of mitochondrial damage induced by paraquat.

Special Field

  • General anatomy(includes histology/embryology)


  • Tokyo University of Agriculture and Technology Graduate School Division of Agricultural Science
  • Tokyo University of Agriculture and Technology Faculty of Agriculture


  • Philosophiae Doctor

Association Memberships

  • 2002The Japanese Society of Mitochondrial Research and Medicine
  • 1990The Japanese Association of Anatomists
  • 1992The Japanese Society of Microscopy

Academic & Professional Experience

  • Apr. 1988Mar. 1993Research Institute of Nippon Meat Packer Inc. Research worker
  • May 1988Mar. 1995Kanazawa Medical University Research fellow
  • Apr. 1995Mar. 1999Kanazawa Medical University Teaching assistant
  • Apr. 1999Kanazawa Medical University Assistant professor

Research Activities

Published Papers

  • Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One10:e0123232-e01232322015
  • Effects of melanocortins on fetal development, E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta, Congenital anomalies51:47-542011
  • Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway, E.Simamura, H.Shimada, N.Higashi, M.Uchishiba, H.Otani, T.Hatta, Endocrinology.151:1853-1862Apr. 2010
  • Branching patterns of the celiac artery as the hepato-gastro-splenic trunk, N.Higashi, H.Shimada, E.Simamura, T.Hatta84:7-10Mar. 2009
  • Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase, H.Shimada, K-I.Hirai, E.Simamura, T.Hatta, H.Iwakiri, K.Mizuki, T.Hatta, T.Sawasaki, S.Matsunaga, Y.Endo, S.Shimizu, The Journal of biological chemistry.284: 28642-286492009
  • Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents, E.Simamura, H.Shimada, T.Hatta, K-I.Hirai, Journal of bioenergetics and biomembranes.40:213-217Sep. 2008
  • Right vertebral artery as the fourth branch of the aortic arch, N.Higashi, H.Shimada, E.Simamura, T.Hatta, Anatomical science international / Japanese Association of Anatomists83:314-318Aug. 2008
  • Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1, E.Simamura, H.Shimada, Y.Ishigaki, T.Hatta, N.Higashi, K-I.Hirai, Anatomical science international / Japanese Association of Anatomists83:261-266Aug. 2008
  • Mouse exo utero development system, T.Hatta, M.Yamada, E.Simamura, H.Shimada, M.Nimura, A.Matsumoto, J.Udagawa, R.Hashimoto, N.Higashi, H.Otani32:16-22Jun. 2007
  • Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel, E.Simamura, K.-I.Hirai, H.Shimada, J.Koyama, Y.Niwa, S.Shimizu, Cancer biology & therapy5:1523-1529Nov. 2006
  • Defense of UV-induced cell death by antioxidant nutrients, K.Furuta, H.Shimada, Y-B.Shui31:157-164Oct. 2006
  • Mitochondrial injury followed by apoptosis and necrosis in 2-methylnaphtho[2, 3-b]furan-4, 9-dione-treated human lung adenocarcinoma cells, SHIMADA Hiroki, 7th Asia-Pacific Electron Microscopy Conference2000
  • Energy-filter analytical electron microscopy applied to cancer research, SHIMADA Hiroki, 3rd Japanese-Polish Joint Seminar on Materials Analysis2000
  • Defence of UV-Induced cell death by antioxidant nutrients, SHIMADA Hiroki, 10th Biennial Meeting of the International Society for Free Radical Research2000
  • Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells, K.-I. Hirai, J. Koyama, J. Pang, SHIMADA Hiroki, E. Simamura, T. Yamori, S. Sato, K. Tagahara, T. Tsuruo, Cancer Detection & Prevention23:539-550Jun. 1999
  • Cytochemical energy-filtering transmission electron microscopy of mitochondrial free radical formation in paraquant cytotoxicity, K.-I. Hirai, J. Pang, SHIMADA Hiroki, T. Izuhara, T. Kurihara, K. Moriguchi, Journal of Electron Microscopy48:289-296Jun. 1999
  • Mitochondrial NADH-quinone oxidoreductase(NQOm)produces reactive oxygen species in the chemical injury of rat liver mitochondria, K.-I. Hirai, SHIMADA Hiroki, J. Pang, S. Kato, E. Simamura, Acta Histochemica et Cytochemica32:239-242May 1999
  • Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers., SHIMADA Hiroki, K.-I. Hirai, E. Simamura, J. Pang, Archives of biochemistry and biophysics.351:75-81Mar. 1998
  • Mitochondrial damage by a new antitumour agent furanonaphthoquinone derivative in human cervical cancer Hela cells., (J. Pang), K.-I. Hirai, E. Simamura, SHIMADA Hiroki, S. Kuwabara, Journal of Electron Microscopy46:181-187Apr. 1997
  • Sciatic nerve regeneration navigated by laminin-fibronectin double coated biodegradable collagen grafts in rats., (X.-J. Tong), K.-I. Hirai, SHIMADA Hiroki, Y. Mizutani, T. Izumi, N. Toda, P. Yu, Brain research.633:155-1621994
  • Induction of peripheral nerve regeneration using laminin-fibronectin double coated collagen fiber grafts., SHIMADA Hiroki, K.-I. Hirai, H. Seguchi, Artificial Organs Today4:1-111993
  • Mitochondrial breakage induced by the herbicide paraquat in cultured human lung cells, (G.-Y. Wang), K.-I. Hirai, SHIMADA Hiroki, Journal of Electron Microscopy4:181-184Jun. 1992
  • Behavior of axons, Schwann cells and perineurial cells in nerve grafts : effects of anti-laminin and anti-fibronectin antisera., (G.-Y. Wang), K.-I. Hrai, SHIMADA Hiroki, S.-Z. Zang, Brain research.583:216-226Jun. 1992
  • The role of laminin, a component of Schwann cell basal lamina in rat sciatic nerve regeneration within antiserum-treated nerve grafts., (G.-Y. Wang), K.-I. Hirai, SHIMADA Hiroki, Brain research.570:116-125Jan. 1992
  • The spread of human lung cancer cells on collagen and its inhibition by the type III collagen., K.-I. Hirai, SHIMADA Hiroki, T. Ogawa, S. Taji, Clinical and Experimental Metastasis9:515-525Jun. 1991
  • Analysis of unsaturated disaccharides from glycosaminoglycans by high performance liquid chromatography., (Y. Nomura), SHIMADA Hiroki, K. Takahashi, K. Wada, Agricultural Biological Chemistry53:3313-3315Dec. 1989
  • Galectin-4 expression is down-regulated in response to autophagy during differentiation of rat trophoblast cells, T.Arikawa, S.Liao, H.Shimada, T.Inoue, H.Sakata-Haga, T.Nakamura, T.Hatta, H.Syoji, SCIENTIFIC REPORTS6:1-11Sep. 2016
  • Extracranial outflow of particles solved in cerebrospinal fluid: Fluorescein injection study, (Akai Takuya);Hatta Toshihisa;Shimada Hiroki;Mizuki Keiji;Kudo Nae;Hatta Taizo;Otani Hiroki, Congenital Anomalies58:93-98Oct. 2017
  • A rapid and nondestructive protocol for whole-mount bone staining of small fish and Xenopus, Sakata-Haga Hiromi, Uchishiba Maimi, Shimada Hiroki, Tsukada Tsuyoshi, Mitani Mayumi, Arikawa Tomohiro, Shoji Hiroki, Hatta Toshihisa, SCIENTIFIC REPORTS8:7453May 2018
  • Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta, Tsuyoshi Tsukada, Hiroki Shimada, Hiromi Sakata-Haga, Hideaki Iizuka, Toshihisa Hatta, Congenital anomalies59:81-87May 2019
  • Effects of tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro, Takuya Noda, Hideaki Shiga, Kentaro Yamada, Masayuki Harita, Yukari Nakamura, Tomoko Ishikura, Masami Kumai, Zenji Kawakami, Atsushi Kaneko, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses44:327-338May 2019
  • The impact of ovariectomy on olfactory neuron regeneration in mice, Kentaro Yamada, Hideaki Shiga, Takuya Noda, Masayuki Harita, Tomoko Ishikura, Yukari Nakamura, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses45:203-209Feb. 2020
  • Leukemia inhibitory factor induces corticotropin-releasing hormone in mouse trophoblast stem cells, He Wang, Tsuyoshi Tsukada, Hiroki Shimada, Hiromi Sakata-Haga, Yasuo Iida, Shitai Zhang, Hiroki Shoji, Toshihisa Hatta, Biochemical and biophysical research communications522:81-87Jan. 2020

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