SASAKI Hiroshi

FacultyDepartment of Ophthalmology, Division of Vision Research for Environmental Health

Researcher Profile & Settings


    Overview of research:
    Epidemiological studies of the ocular diseases in climatically different places. Effect of ultraviolet radiation and radio-frequency exposure on the eye. Visual function of the eyes with transparent lens, lens opacities and intraocular lens.

Special Field

  • Ophthalmology


  • Kanazawa University Faculty of Medicine Ophthalmology


  • Doctor of Medicine

Association Memberships

  • 1997International Congress of Eye Reseaech

Academic & Professional Experience

  • May. 2005Kanazawa Medical University Professor
  • Apr. 2007China Medical University visiting professor
  • Apr. 2009Memoirs of the Tohoku Bunka Gakuen University visiting professor
  • May. 2005Kanazawa Medical University Medical Reserch Institute Professor

Research Activities

Published Papers

  • Roles of TGF β and FGF Signals in the Lens : Tropomyosin Regulation for Posterior Capsule Opacity, Eri Kubo, Teppei Shibata, Dhirendra P. Singh and Hiroshi Sasaki, International Journal of Molecular Sciences19:3093Oct. 2018
  • Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves, Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Masao Taki, Kanako Wake, Soichi Watanabe, Maya Mizuno, Takafumi Tasaki, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves39:912-925Sep. 2018
  • Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity, Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Mechanisms of Ageing and Development171:24-30Apr. 2018
  • Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment, Masamichi Fukuda, Shinsuke Shibata, Naoko Shibata, Nobuyuki Fujita, Hisanori Miyashita, Naoki Tanimura, Hidetoshi Ishida, Eri Kubo , Hiroshi Sasaki, PLOS ONE13:e02081982018
  • Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh, Scientific reports7:14130Oct. 2017
  • Issues behind Radiation Management of Workers at Fukushima Nuclear Power Plant of Tokyo Electric Power Company -From the Viewpoint of Radiation Exposure of the Ocular Lens and the Biological Effects to the Lens-, (Toshiyuki Hayashida), Hiroshi Sasaki, NobuyukiHamada, Hideo Ttsuzaki, Natsuko Hatsusaka, Keiichi Akahane, Sumi Yokoyama, Japanese Journal of Health Physics52:88-99Sep. 2017
  • An ease eith successful treatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Nobuyuki Fujita,Teppei Shibata,Masamichi Fukuda,Kazuyuki Sasaki, Hiroshi Sasaki, Folia Japanica de Ophthalmologica Clinica10:1007-10102017
  • Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients, (Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Investigative Ophthalmology & Visual Science58:3294-33022017
  • Primary and secondary preventions of cataracts, Hiroshi Sasaki, Rinsho Ganka71:52-602017
  • A positive feedback loop between nitric oxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, (Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Toxicology381:19-302017
  • FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity., E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh, Journal of Cellular and Molecular Medicine21:916-9282017
  • Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette, (Koji Kitazawa), Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru Kinoshita, British Journal Of Ophthalmology101:548-5502017
  • Multiple comparisons in two-factor testing of psychophysical thresholds by the delta test method, (Norihiro Mita), Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara, Communications in statistics-simulation and computation46:669-6782017
  • In vivo meaurement of human corneal impedance value, M.Fukuda, H.Sasaki, Cornea35:1305-13072016
  • In vitro and in vivo corneal effects of latanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide, M.Fukuda, N.Takeda, S.Shibata, N.Shibata, T.Shibata, K.Sugiyama, H.Sasaki, European Journal of Pharmacology787:43-462016
  • An adult case of fulminant mumps keratitis with positive viral RNA in aqueous humor detected by RT-PCR, T.Shibata, Y.Takahashi, A.Okamoto, H.Sasaki, K.Kitagawa, Cornea35:569-5712016
  • The role of Prdx6 in the protection of cell of the crystalline lens from oxidative stress induced by UV exposure, S.Shibata, N.Shibata, T.Shibata, H.Sasaki, DP.Singh, E.Kubo, Japanese Journal of Ophthalmology60:408-4182016
  • Propolis, a constituent of honey, inhibits the development of sugar cataracts and high-glucose-induced reactive oxygen species in rat lenses, T.Shibata, S.Shinnsuke, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo, Journal of Ophthalmologydoi: 10.1155/2016/1917093.:0-02016
  • Optical simulation for subsurface nanoglistening, Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki, Journal of Cataract and Refractive Surgery41:193-198Oct. 2015
  • Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing, M.Fukuda, H.Sasak, Journal of Ocular Pharmacology and Therapeutics31:536-540Sep. 2015
  • Visual acuity and contrast visual acuity predicted from cataract type, S.Enta, N.Hatsusaka, Y.Sakamoto, N.Mita, M.Takahashi, H.Osada, E.Kubo, H.Sasaki, The Journal of the Japanese Society for Cataract Research27:68-73Jun. 2015
  • Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40 GHz), M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki, Journal of Infrared Millimeter and Terahertz Waves36:390-399Apr. 2015
  • Update no multifocal intraocular lenses' development, H.Sasaki, Journal of Japanese Ophthalmological Society119:3-5Jan. 2015
  • Use of a warmed ophthalmic viscoelastic device to accelerate the unfolding of 1-piece intraocular lenses in the capsular bag, (K.Minami), K.Miyata, N.Nagai, H.Sasaki, Journal of Cataract & Refractive surgery41:2332-23332015
  • The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes, M.Fukuda, H.Sasaki, Journal of Ocular Pharmacology and Therapeutics31:57-602015
  • Rapid survey of four asp isomers in disease-related proteins by LC-MS combined with commercial enzymes, (H.Maeda), T.Takata, N.Fujii, H.Sakaue, S.Nirasawa, S.Takahashi, H.Sasaki, N.Fujii, Analytical Chemistry87:561-5682015
  • Evaluation of casey eye Institute camera for photographic documentation of opaque crystalline lens, N.Hatsusaka, K.Sasaki, Y.Kawakami, M.Sasaki, H.Sasaki68:1413-1420Oct. 2014
  • Effect of rebamipide ophthalmic suspension on signs and symptoms of keratoconjunctivitis sicca in sjogren syndrome patients with or without punctal occlusions, A.Arimoto, K.Kitagawa, N.Mita, Y.Takahashi, E.Shibuya, H.Sasaki, Cornea.33:806-811Aug. 2014
  • Dosimetry using a localized exposure system in the Millimeter-Wave band for in vivo studies on ocular effects, (K.Sasaki), T.Sakai, T.Nagaoka, K.Wake, S.Watanabe, M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki, Y.Suzuki, M.Taki, Y.Kamimura, A.Hirata, H.Shirai, IEEE transactions on microwave theory and techniques62:1554-1564Jul. 2014
  • Multiple comparisons for a psychophysical test in bootstrap logistic regression, N.Mita, H.Sasaki, K.Kani, A.Tabuchi, H.Hara, Journal of algorithms & computational technology.8:339-355May. 2014
  • Pepeatability of visua acuity testing using a psychometric function, (T.Tokutake), T.Yamauchi, N.Mita, Ken-ichiro Kawamoto, H.Tabuchi, K.Kani, H.Hara, A.Tabuchi, H.Sasaki, Japanese journal of ophthalmology.58:381-3872014
  • Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis., (Y.Inoue), Y.Shimomura, M.Fukuda, D.Miyazaki, Y.Ohashi, H.Sasaki, Y.Tagawa, H.Shiota, N.Inada, S.Okamoto, K.Araki-Sasaki, T.Kimura, H.Hatano, H.Nakagawa, S.Nakamura, A.Hirahara, K.Tanaka, H.Sakuma, The British journal of ophthalmology.97:1108-1112Nov. 2013
  • Safety of rebamipide ophthalmic suspension for corneal epithelial cells: In vitro and In vivo study., M.Fukuda, H.Nakashima, J.Haruta, S.Shibata, N.Shibata, H.Osada, Y.Seki, N.Mita, H.Sasaki30:1467-1471Oct. 2013
  • Cases in which prescribed glaucoma medications were unnecessary., (N.Ibaraki), E.Kubo, H.Sasaki30:1472-1474Oct. 2013
  • Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens., E.Kubo, N.Hasanova, H.Sasaki, DP.Singh, Journal of cellular and molecular medicine.17:1146-1159Sep. 2013
  • FDTD analysis of temperature elevation in the lens of human and rabbit models due to near-field and far-field exposures at 2.45 GHz., (T.Oiszmi), I.Laakso, A.Hirata, O.Fujiwara, S.Watanabe, M.Taki, M.Kojima, H.Sasaki, K.Sasaki, Radiation protection dosimetry.155:284-291Jul. 2013
  • Corrected near and intermediate vfisual acuity in eyes with aspheric mono focal intraocular lens., M.Sasaki, M.Takahashi, E.Shibuya, A.Okamoto, N.Mita, Y.Takahashi, E.Kubo, H.Sasaki25:61-64Jun. 2013
  • Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells., E.Kubo, N.Hasanova, N.Fatma, H.Sasaki, DP.Singh, Journal of cellular and molecular medicine.17:212-221Jan. 2013
  • Twelve-year incidence of exfoliation syndrome in the Reykjavik eye study., (A.Arnarsson), H.Sasaki, F.Jonasson, Acta ophthalmologica.91:157-1622013
  • Safety comparison of additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations., M.Fukuda, S.Shibata, N.Shibata, K.Hagihara, H.Osada, N.Takahashi, E.Kubo, H.Sasaki, Clinical ophthalmology.7:515-5202013
  • Assessing predictive accuracy of lens transparency property via 10-year follow-up in Japanese, N.Mita, N.Hatsusaka, E.Shibata, Y.Sakamoto, H.Osada, I.Shibata, N.Shibata, H.Yaguchi, K.Sasaki, H.Sasaki28:1503-1507Oct. 2011
  • Simultaneous stereoinversion and isomerization at the Asp-4 residue in βB2-crystallin from the aged human eye lenses, (N.Fujii), T.Kawaguchi, H.Sasaki, N.Fujii, Biochemistry.50:8628-8635Oct. 2011
  • Generic versions of latanoprost ophthalmic solution evaluated for safety to corneal epithelial cells, M.Fukuda, I.Shibata, K.Hagiwara, H.Yaguchi, H.Sasaki28:849-854Jun. 2011
  • Vitreous and aqueous penetration of orally and topically administered moxifloxacin, M.Fukuda, N.Shibata, H.Osada, Y.Yamashiro, H.Sasaki, Ophthalmic research.46:113-117Jun. 2011
  • Effect of sodium hyaluronate eyedrops on corneal cells, M.Fukuda, H.Yaguchi, N.Fujita, I.Shibata, H.Osada, N.Shibata, H.Sasaki28:549-552Apr. 2011
  • UV-B exposure to the eye depending on solar altitude, H.Sasaki, Y.Sakamoto, C.Schnider, N.Fujita, N.Hatsusaka, DH.Sliney, K.Sasaki, Eye & contact lens.37:191-195Apr. 2011
  • Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers.15:231-237Apr. 2011
  • Cyclin-dependent kinase inhibitor p16 and p21 expression, and cell cycle change in human lens epithelial cell line SRA 01/04 following contact inhibition in normal culture, Y.Yamashiro, H.Sasaki, N.Ibaraki, K.Nagai, Y.Kawakami, H.Yaguchi, N.Fujita, H.Osada, K.Sasaki, Ophthalmic research.46:38-43Mar. 2011
  • Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision17:159-169Jan. 2011
  • Acute dosimetry and estimation of threshold-inducing behavioral signs of thermal stress in rabbits at 2.45-GHz microwave exposure, (A.Hirata), M.Kojima, H.Kawai, Y.Yamashiro, S.Watanabe, H.Sasaki, O.Fujiwara, IEEE transactions on microwave theory and techniques57:1234-1242May. 2010
  • An infant case of acute purulent dacryoadenitis due to MRSA26:1405-1408Oct. 2009
  • Effect of 5-S-GAD on UV-B-Induced cataracts in rats, H.Kawada, M.Kojima, T.Kimura, S.Natori, K.Sasaki, H.Sasaki, Japanese journal of ophthalmology.53:531-535Sep. 2009
  • Acute ocular injuries cause by 60-GHz millimeter-wave exposure, Masami Kojima, Masahiro Hanazawa, Yoko Yamashiro, Hiroshi Sasaki, Soichi Watanabe, Masao Taki, Yukihisa Suzuki, Akimasa HIrata, Yoshitsugu Kamimura, Kazuyuki Sasaki, Health Physics97(3)Sep. 2009
  • Cytotocic effect of ofluoxacin ophthalmic solutions and timolol maleate ophthalmic solutions on cultured rabbit corneal cell line and ocular pharmacokinetics of ophthalmic solutions in rabbits, M.Fukuda, H.Sasaki26:977-981Jul. 2009
  • Measurement of AQCmax of five differnt ophthalmic solution and discussion of its new application, M.Fukuda, H.Sasaki, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics25:351-355May. 2009
  • Cytotoxic effects of new quinolone antibiotic ophthalmic solutions nad nonsteroidal anti-inflammatory ophthalmic solutions on cultured rabbit corneal cell line, M.Fukuda, H.Sasaki26:399-403Mar. 2009
  • Assessment of pinguecula and pterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey in Shanxi, China, K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki5:31-40Mar. 2009
  • Acute ocular injuries caudes by 60-GHz millimeter-wave exposure, M.Kojima, M.Hanazawa, Y.Yamashiro, H.Sasaki, S.Watanabe, M.Taki, Y.Suzuki, A.Hirata, Y.Kamimura, K.Sasaki, Health physics.97:212-218Mar. 2009
  • Pseudoexfoliation in the Reykjavik eye study:five-year incidence and changes in related ophthalmologic variables, (A.Arnarsson), KF.Damji, H.Sasaki, T.Sverrinsson, F.Jonasson, American journal of ophthalmology.148:291-297Feb. 2009
  • Obsevational cohort study : The Reykjavik eye study, H.Sasaki26:17-24Jan. 2009
  • Calculation of AQCmax:comparison of five ophthalmic fluoroquinolone solution, M.Fukuda, H.Sasaki, Current medical research and opinion24:3479-3486Dec. 2008
  • Intraocular penetration of astaxanthin in rabbit eyes, M.Fukuda, J.Takahashi, Y.Nishida, H.Sasaki25:1461-1464Oct. 2008
  • Investigation of wavelength-specific characteristics of quasi- and millimeter-waves, M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, A.Hirata, Y.Sakamoto, Y.Kawakami, S.Watanabe, K.Wake, M.Taki, Y.Kamimura, H.Sasaki, K.Sasaki, ⅩⅩⅤⅢth General Assembly of International Union Radio scienceKP214:1-4Aug. 2008
  • Expression of matrix metalloproteinases in wound healing after glaucoma filtration surgery in rabbits, I.Shima, S.Katsuda, Y.Ueda, N.Takahashi, H.Sasaki, Ophthalmic research.39:315-324Oct. 2007
  • Corneal disorder quantification by corneal resistance, M.Fukuda, K.Yamamoto, N.Takahashi, H.Sasaki, M.Yoshikawa24:521-525Apr. 2007
  • On the ocular refractive components : the Reykjavik eye study, (T.Olsen), A.Arnarsson, H.Sasaki, K.Sasaki, F.Jonasson, Acta ophthalmologica Scandinavica.85:361-366Apr. 2007
  • Efficacy of α-lipoic acid against diabetic cataract in rat, M.Kojima, L.Sun, I.Hata, Y.Sakamoto, H.Sasaki, K.Sasaki, Japanese journal of ophthalmology.51:10-13Jan. 2007
  • Intraocular penetration of moxifloxacin ophthlamic solution in rabbit eyes -calculaation of maximum drug concentration in aqueous-, M.Fukuda, H.Sasaki, Y.Ohashi23:1353-1357Oct. 2006
  • Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study, (GM.Zoega), A.Fujisawa, H.Sasaki, A.Kubota, K.Sasaki, K.Kitagawa, F.Jonasson, Ophthalmology.113:565-569Mar. 2006
  • Risk factors for five-year incident age-related macular degeneration: The Reykjavik Eye Study, (A.Arnarsson), T.Sverrisson, E.Stefansson, H.Sigurdsson, H.Sasaki, K.Sasaki, F.Jonasson, American journal of ophthalmology.142:419-428Jan. 2006
  • Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open8:bio035691Feb. 2019
  • Distribution of corneal spherical aberration in a Tanzanian population, (Asano H), Hiraoka T, Seki Y, Shibata T, Osada H, Saruta T, Hatsusaka N, Fujikake F, Tabata Y, Mhina C, Sanyiwa A, Oshika T, Sasaki H, PLoS ONE14:e0222297Sep. 2019
  • Visual Function and Functional Decline in Patients With Waterclefts, Tanimura N, Hatsusaka N, Miyashita H, Shibata T, Ishida H, Kunisho A, Kubo E, Sasaki H, Investigative ophthalmology & visual science60:3652-3658Aug. 2019
  • Changes in mitochondrial cytochrome c oxidase mRNA levels with cataract severity in lens epithelia of Japanese Patients, (Nagai N), Mano Y, Otake H, Shibata T, Kubo E, Sasaki H, Molecular medicine reports19:5464-5472Jun. 2019
  • Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study, Miyashita H, Hatsusaka N, Shibuya E, Mita N, Ymazaki M, Shibata T, Ishida H, Ukai Y, Kubo E, Sasaki H, PLoS One14:e0215338Apr. 2019
  • Different thermoregulatory responses of people from tropical and temperate zones: A computational study, (Kamiya T), Kodera S, Hasegawa K, Egawa R, Sasaki H, Hirata A, Building and Environment159:106152Jul. 2019
  • Creating a Stable Short-term Housing Environment for Rabbits in a Cargo Van, Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki, Journal of American Association for Laboratory Animal Science58:456-461Jul. 2019
  • Ocular Response to Millimeter Wave Exposure Under Different Levels of Humidity, Masami Kojima, Cheng-Yu Tsai, Yukihisa Suzuki, Kensuke Sasaki, Takafumi Tasaki, Masao Taki, Soichi Watanabe, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves40:574-584May. 2019

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