SASAKI Hiroshi

Researcher Profile & Settings

Research

Overview of research:
Epidemiological studies of the ocular diseases in climatically different places. Effect of ultraviolet radiation and radio-frequency exposure on the eye. Visual function of the eyes with transparent lens, lens opacities and intraocular lens.

Special Field

• Ophthalmology

Education

• Kanazawa University Faculty of Medicine Ophthalmology

Degree

• Doctor of Medicine

Association Memberships

• 1997International Congress of Eye Reseaech

Academic & Professional Experience

• May 2005Kanazawa Medical University Professor
• Apr. 2007China Medical University visiting professor
• Apr. 2009Memoirs of the Tohoku Bunka Gakuen University visiting professor
• May 2005Kanazawa Medical University Medical Reserch Institute Professor

Research Activities

Published Papers

• Initial response to the 2024 Noto earthquake by the university hospital closest to the disaster area., Uramoto H, Shimasaki T, Sasaki H, Iinuma Y, Kawasaki Y, Kawahara N., Scientific Reports., 14:25013, Oct. 2024
  DOI:10.1038/s41598-024-75844-w
• Role of Decorin in the Lens and Ocular Diseases, Eri Kubo, Shinsuke Shibata, Teppei Shibata, Hiroshi Sasaki, Dhirendra P. Singh., cells, 12:74, Jan. 2023
• Role of Decorin in the Lens and Ocular Diseases, Eri Kubo, Shinsuke Shibata, Teppei Shibata, Hiroshi Sasaki, Dhirendra P Singh., 12:74, Dec. 2022
  DOI:https://doi.org/10.3390/cells12010074
• Vision With Retrodots and Factors for Declining Visual Function, Natsuko Hatsusaka, Naoki Tanimura, Mai Yamazaki, Norihiro Mita, Yuki Ukai, Yusuke Seki, Hisanori Miyashita, Tsuyoshi Mito, Eri Kubo, Hiroshi Sasaki, 63:17, Nov. 2022
  DOI:https://doi.org/10.1167/iovs.63.12.17
• Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats, (Saori Deguchi), Reita Kadowaki, Hiroko Otake, Atsushi Taga, Yosuke Nakazawa, Manju Misra, Naoki Yamamoto, Hiroshi Sasaki, Noriaki Nagai, 14:1520, Jul. 2022
  DOI:https://doi.org/10.3390/pharmaceutics14071520
• Positive dysphotopsia after intrascleral intraocular lens fixation: a case report, Tsuyoshi Mito, Honoka Kawakami, Toru Ikoma, Yuki Ukai, Mizuho Tsuchiya, Eri Kubo, Hiroshi Sasaki, 22:263, Jun. 2022
  DOI:https://doi.org/10.1186/s12886-022-02474-z
• Acute cataract by a high-intensity focused ultrasound procedure: a case report, Toru Ikoma, Teppei Shibata, Naoko Shibata, Tsuyoshi Mito, Eri Kubo, Hiroshi Sasaki, 22:164, Apr. 2022
  DOI:https://doi.org/10.1186/s12886-022-02390-2
• Analyzing Effect of Waterclefts on Visual Functions Via Optical Simulations, Yusuke Seki, Takushi Kawamorita, Naoki Yamamoto, Takashi Tanigawa, Norihiro Mita, Natsuko Hatsusaka, Eri Kubo, Hiroshi Sasaki, 63:22, Feb. 2022
  DOI:https://doi.org/10.1167/iovs.63.2.22
• Benzalkonium Chloride-Induced Corneal Epithelial Injury in Rabbit Reduced by Rebamipide, Masamichi Fukuda, Nobuo Takeda, Hidetoshi Ishida, Yusuke Seki, Naoko Shibata, Nobuo Takahashi, Kazuhisa Sugiyama, Eri Kubo, Hiroshi Sasaki, 38:85-91, Jan. 2022
  DOI:https://doi.org/10.1089/jop.2021.0052
• Threshold for Millimeter‑Wave (60 GHz)‑Induced Ocular Injury, Masami Kojima, Takafumi Tasaki, Yukihisa Suzuki, Toshio Kamijo, Aki Hada, Alfred Kik, Masateru Ikehata, Hiroshi Sasaki, Journal of Infrared Millimeter and Terahertz Waves, 43:260-271, Apr. 2022
  DOI:https://doi.org/10.1007/s10762-022-00850-w
• Role of Decorin in Posterior Capsule Opacification and Eye Lens Development., Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Cells, 10:863, Apr. 2021
• Atezolizumab-induced bilateral anterior uveitis: A case report, Tsuyoshi Mito, Shun Takeda, Nozomu Motono, Hiroshi Sasaki, American Journal of Ophthalmology Case Reports, 24:101205, Dec. 2021
• Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats., (Ryoka Goto), Shigehiro Yamada, Hiroko Otake, Yosuke Nakazawa, Mikako Oka, Naoki Yamamoto, Hiroshi Sasaki, Noriaki Nagai, Pharmaceutics, 13:1999, Nov. 2021
• Morphological comparison between three-dimensional structure of immortalized human lens epithelial cells and Soemmering's ring., (Noriko Hiramatsu), Noriaki Nagai, Masashi Kondo, Kazuyoshi Imaizumi, Hiroshi Sasaki, Naoki Yamamoto, Medical Molecular Morphology, 54:216-226, Jan. 2021
• Balance of Drug Residence and Diffusion in Lacrimal Fluid Determine Ocular Bioavailability in In Situ Gels Incorporating Tranilast Nanoparticles., (Misa Minami), Hiroko Otake, Yosuke Nakazawa, Norio Okamoto, Naoki Yamamoto, Hiroshi Sasaki, Noriaki Nagai, Pharmaceutics, 13:1425, Sep. 2021
• Transdermal System Based on Solid Cilostazol Nanoparticles Attenuates Ischemia/Reperfusion-Induced Brain Injury in Mice., Hiroko Otake, Mizuki Yamaguchi, Fumihiko Ogata, Saori Deguchi, Naoki Yamamoto, Hiroshi Sasaki, Naohito Kawasaki, Noriaki Nagai, Nanomaterials, 11:1009, Apr. 2021
• Energy‐Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and L‐Menthol in Rat and Göttingen Minipig., Hiroko Otake, Mizuki Yamaguchi, Fumihiko Ogata, Saori Deguchi, Naoki Yamamoto, Hiroshi Sasaki, Naohito Kawasaki, Noriaki Nagai, International Journal of Molecular Sciences, 22:5137, May 2021
• Lens–specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity., Teppei Shibata, Masahito Ikawa, Ryo Sakasai, Yasuhito Ishigaki, Etsuko Kiyokawa, Kuniyoshi Iwabuchi, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Mechanisms of Ageing and Development, 196:111492, Apr. 2021
• The effects of antiglaucoma ophthalmic solutions on the cornea revealed by a corneal electrical resistance devi., Nobuo Takeda, Masamichi Fukuda, Hiroshi Sasaki, Kazuhisa Sugiyama, Journal of Ocular Pharmacology and Therapeutics, 37:97-103, Mar. 2021
• Quantitative assessment of photic phenomena in the presbyopia-correcting intraocular lens., Yuki Ukai, Hajime Okemoto, Yusuke Seki, Yui Nakatsugawa, Akane Kawasaki, Teppei Shibata, Tsuyoshi Mito, Eri Kubo, Hiroshi Sasaki, PLoS One, 16:e0260406, Dec. 2021
• Novel Technique for Retinal Nerve Cell Regeneration with Electrophysiological Functions Using Human Iris-Derived iPS Cells., Naoki Yamamoto, Noriko Hiramatsu, Mahito Ohkuma, Natsuko Hatsusaka, Shun Takeda, Noriaki Nagai, Ei-ichi Miyachi, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi, Eri Kubo, Hiroshi Sasaki, Cells, 10:743, Mar. 2021
• Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan., Natsuko Hatsusaka, Naoki Yamamoto, Hisanori Miyashita, Eri Shibuya, Norihiro Mita, Mai Yamazaki, Teppei Shibata, Hidetoshi Ishida, Yuki Ukai, Eri Kubo, Hong-Ming Cheng, Hiroshi Sasaki, PLoS ONE, 16:e0253093, Jun. 2021
• UV Index Does Not Predict Ocular Ultraviolet Exposure., Natsuko Hatsusaka, Yusuke Seki, Norihiro Mita, Yuki Ukai, Hisanori Miyashita, Eri Kubo, David Sliney, Hiroshi Sasaki, Translational Vision Science & Technology, 10:1, Jun. 2021
• The Visual Acuity Measurement and its Multiple Testing for Patients Implanted with Intraocular Lenses During the Cataract Surgery, Norihiro Mita, Hiroshi Sasaki, Tomofusa Yamauchi, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara, Statistica Applicata-Italian Journal of Applied Statistics, 32:269-284, 2020
• Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2), Naoki Yamamoto, Shun Takeda, Natsuko Hatsusaka, Noriko Hiramatsu, Noriaki Nagai, Saori Deguchi, Yosuke Nakazawa, Takumi Takata, Sachiko Kodera, Akimasa Hirata, Eri Kubo, Hiroshi Sasaki, Cells, 9:2670, Dec. 2020
  DOI:10.3390/cells9122670
• Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat, Hidetoshi Ishida, Teppei Shibata, Yuka Nakamura, Yasuhito Ishigaki, Dhirendra P.Singh, Hiroshi Sasaki, Eri Kubo, BioMed Research International, 2020:7319590, Nov. 2020
  DOI:10.1155/2020/7319590
• Degradation of connexin 50 protein causes waterclefts in human lens, (Yosuke Nakazawa), Teppei Shibata, Noriaki Nagai, Eri Kubo, Hiroomi Tamura, Hiroshi Sasaki, Open Medicine, 15:1163-1171, Oct. 2020
  DOI:10.1515/med-2020-0249
• Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents, (Sachiko Kodera), Akimasa Hirata, Fumiaki Miura, Essam A.Rashed, Natsuko Hatsusaka, Naoki Yamamoto, Eri Kubo, Hiroshi Sasaki, Computers in Biology and Medicine, 126:104009, Sep. 2020
  DOI:10.1016/j.compbiomed.2020.104009
• Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells, Naoko Shibata, Hidetoshi Ishida, Etsuko Kiyokawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo, Experimental Eye Research, 199:108194, Aug. 2020
  DOI:10.1016/j.exer.2020.108194
• Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats, (Noriaki Nagai), Kazuki Umachi, Hiroko Otake, Mikako Oka, Noriko Hiramatsu, Hiroshi Sasaki, Naoki Yamamoto, Pharmaceutics, 12:629, Jul. 2020
  DOI:10.3390/pharmaceutics12070629
• An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva, (Noriaki Nagai), Misa Minami, Saori Deguchi, Hiroko Otake, Hiroshi Sasaki, Naoki Yamamoto, 8:764, Jul. 2020
  DOI:10.3389/fbioe.2020.00764
• Hydrogel Formulations Incorporating Drug Nanocrystals Enhance the Therapeutic Effect of Rebamipide in a Hamster Model for Oral Mucositis, (Noriaki Nagai), Ryotaro Seiriki, Saori Deguchi, Hiroko Otake, Noriko Hiramatsu, Hiroshi Sasaki, Naoki Yamamoto, Pharmaceutics, 12:532, Jun. 2020
  DOI:10.3390/pharmaceutics12060532
• Clinical Course of High-Frequency Millimeter-Wave (162 GHz) Induced Ocular Injuries and Investigation of Damage Thresholds, Masami Kojima, Yukihisa Suzuki, Takafumi Tasaki, Yoshinori Tatematsu, Maya Mizuno, Masafumi Fukunari, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves, 41:834-845, Jun. 2020
  DOI:org/10.1007/s10762-020-00714-1
• Lutein plus Water Chestnut (Trapa bispinosa Roxb.) Extract Inhibits the Development of Cataracts and Induces Antioxidant Gene Expression in Lens Epithelial Cells, Hidetoshi Ishida, Teppei Shibata, Shinsuke Shibata, Yuki Tanaka, Hiroshi Sasaki, Eri Kubo, Biomed Research International, 2020:9204620, May 2020
  DOI:org/10.1155/2020/920-4620
• A statistical modelling of the visual acuity measurement and its multiple test procedure, Norihiro Mita, Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara, Electronic Journal of Applied Statistical Analysis, 13:1-15, May 2020
  DOI:10.1285/i20705948v13n1p1
• Enhancement of Amyloid β1-43 Production in the Lens Epithelium of Japanese Type 2 Diabetic Patients, (Yu Mano), Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Noriaki Nagai, Biomedicines, 8:87, Apr. 2020
  DOI:10.3390/biomedicines8040087
• Distribution of corneal spherical aberration in a Tanzanian population, (Asano H), Hiraoka T, Seki Y, Shibata T, Osada H, Saruta T, Hatsusaka N, Fujikake F, Tabata Y, Mhina C, Sanyiwa A, Oshika T, Sasaki H, PLoS ONE, 14:e0222297, Sep. 2019
  DOI:doi.org/10.1371/journal.pone.0222297
• Visual Function and Functional Decline in Patients With Waterclefts, Tanimura N, Hatsusaka N, Miyashita H, Shibata T, Ishida H, Kunisho A, Kubo E, Sasaki H, Investigative ophthalmology & visual science, 60:3652-3658, Aug. 2019
  DOI:doi.org/10.1167/iovs.19-26793
• Different thermoregulatory responses of people from tropical and temperate zones: A computational study, (Kamiya T), Kodera S, Hasegawa K, Egawa R, Sasaki H, Hirata A, Building and Environment, 159:106152, Jul. 2019
  DOI:doi.org/10.1016/j.buildenv.2019.05.030
• Creating a Stable Short-term Housing Environment for Rabbits in a Cargo Van, Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki, Journal of American Association for Laboratory Animal Science, 58:456-461, Jul. 2019
• Changes in mitochondrial cytochrome c oxidase mRNA levels with cataract severity in lens epithelia of Japanese Patients, (Nagai N), Mano Y, Otake H, Shibata T, Kubo E, Sasaki H, Molecular medicine reports, 19:5464-5472, Jun. 2019
  DOI:doi:10.3892/mmr.2019.10214
• Ocular Response to Millimeter Wave Exposure Under Different Levels of Humidity, Masami Kojima, Cheng-Yu Tsai, Yukihisa Suzuki, Kensuke Sasaki, Takafumi Tasaki, Masao Taki, Soichi Watanabe, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves, 40:574-584, May 2019
  DOI:10.1007/s10762-019-00586-0
• Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study, Miyashita H, Hatsusaka N, Shibuya E, Mita N, Ymazaki M, Shibata T, Ishida H, Ukai Y, Kubo E, Sasaki H, PLoS One, 14:e0215338, Apr. 2019
  DOI:doi.org/10.1371/journal.pone.0215338
• Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open, 8:bio035691, Feb. 2019
• Roles of TGF β and FGF Signals in the Lens : Tropomyosin Regulation for Posterior Capsule Opacity, Eri Kubo, Teppei Shibata, Dhirendra P. Singh and Hiroshi Sasaki, International Journal of Molecular Sciences, 19:3093, Oct. 2018
  DOI:doi:10.3390/ijms19103093
• Ocular Effects of Exposure to 40, 75, and 95 GHz Millimeter Waves, Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Masao Taki, Kanako Wake, Soichi Watanabe, Maya Mizuno, Takafumi Tasaki, Hiroshi Sasaki, Journal of Infrared, Millimeter, and Terahertz Waves, 39:912-925, Sep. 2018
  DOI:doi.org/10.1007/s1062-018-0497-z
• Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity, Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Mechanisms of Ageing and Development, 171:24-30, Apr. 2018
  DOI:doi.org/10.1016/j.mad.2018.03.001
• Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment, Masamichi Fukuda, Shinsuke Shibata, Naoko Shibata, Nobuyuki Fujita, Hisanori Miyashita, Naoki Tanimura, Hidetoshi Ishida, Eri Kubo , Hiroshi Sasaki, PLOS ONE, 13:e0208198, 2018
• Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh, Scientific reports, 7:14130, Oct. 2017
• Issues behind Radiation Management of Workers at Fukushima Nuclear Power Plant of Tokyo Electric Power Company -From the Viewpoint of Radiation Exposure of the Ocular Lens and the Biological Effects to the Lens-, (Toshiyuki Hayashida), Hiroshi Sasaki, NobuyukiHamada, Hideo Ttsuzaki, Natsuko Hatsusaka, Keiichi Akahane, Sumi Yokoyama, Japanese Journal of Health Physics, 52:88-99, Sep. 2017
  DOI:10.5453/jhps.52.88
• An ease eith successful treatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Nobuyuki Fujita,Teppei Shibata,Masamichi Fukuda,Kazuyuki Sasaki, Hiroshi Sasaki, Folia Japanica de Ophthalmologica Clinica, 10:1007-1010, 2017
• Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients, (Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Investigative Ophthalmology & Visual Science, 58:3294-3302, 2017
  DOI:10.1167/iovs.17-22065
• Primary and secondary preventions of cataracts, Hiroshi Sasaki, Rinsho Ganka, 71:52-60, 2017
• A positive feedback loop between nitric oxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, (Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Toxicology, 381:19-30, 2017
  DOI:org/10.1016/j.tox.2017.02.014
• FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity., E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh, Journal of Cellular and Molecular Medicine, 21:916-928, 2017
  DOI:10.1111/jcmm.13030
• Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed disposable pipette, (Koji Kitazawa), Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru Kinoshita, British Journal Of Ophthalmology, 101:548-550, 2017
  DOI:10.1136/bjophthalmol-2016-309650
• Multiple comparisons in two-factor testing of psychophysical thresholds by the delta test method, (Norihiro Mita), Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara, Communications in statistics-simulation and computation, 46:669-678, 2017
  DOI:org/10.1080/03610918.2014.977917
• In vivo meaurement of human corneal impedance value, M.Fukuda, H.Sasaki, Cornea, 35:1305-1307, 2016
• In vitro and in vivo corneal effects of latanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide, M.Fukuda, N.Takeda, S.Shibata, N.Shibata, T.Shibata, K.Sugiyama, H.Sasaki, European Journal of Pharmacology, 787:43-46, 2016
• An adult case of fulminant mumps keratitis with positive viral RNA in aqueous humor detected by RT-PCR, T.Shibata, Y.Takahashi, A.Okamoto, H.Sasaki, K.Kitagawa, Cornea, 35:569-571, 2016
• The role of Prdx6 in the protection of cell of the crystalline lens from oxidative stress induced by UV exposure, S.Shibata, N.Shibata, T.Shibata, H.Sasaki, DP.Singh, E.Kubo, Japanese Journal of Ophthalmology, 60:408-418, 2016
• Propolis, a constituent of honey, inhibits the development of sugar cataracts and high-glucose-induced reactive oxygen species in rat lenses, T.Shibata, S.Shinnsuke, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo, Journal of Ophthalmology, doi: 10.1155/2016/1917093.:0-0, 2016
  DOI:doi: 10.1155/2016/1917093.
• Optical simulation for subsurface nanoglistening, Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki, Journal of Cataract and Refractive Surgery, 41:193-198, Oct. 2015
• Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing, M.Fukuda, H.Sasak, Journal of Ocular Pharmacology and Therapeutics, 31:536-540, Sep. 2015
• Visual acuity and contrast visual acuity predicted from cataract type, S.Enta, N.Hatsusaka, Y.Sakamoto, N.Mita, M.Takahashi, H.Osada, E.Kubo, H.Sasaki, The Journal of the Japanese Society for Cataract Research, 27:68-73, Jun. 2015
• Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40 GHz), M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki, Journal of Infrared Millimeter and Terahertz Waves, 36:390-399, Apr. 2015
  DOI:10.1007/s10762-014-0142-4
• Update no multifocal intraocular lenses' development, H.Sasaki, Journal of Japanese Ophthalmological Society, 119:3-5, Jan. 2015
• Use of a warmed ophthalmic viscoelastic device to accelerate the unfolding of 1-piece intraocular lenses in the capsular bag, (K.Minami), K.Miyata, N.Nagai, H.Sasaki, Journal of Cataract & Refractive surgery, 41:2332-2333, 2015
• The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes, M.Fukuda, H.Sasaki, Journal of Ocular Pharmacology and Therapeutics, 31:57-60, 2015
• Rapid survey of four asp isomers in disease-related proteins by LC-MS combined with commercial enzymes, (H.Maeda), T.Takata, N.Fujii, H.Sakaue, S.Nirasawa, S.Takahashi, H.Sasaki, N.Fujii, Analytical Chemistry, 87:561-568, 2015
• Evaluation of casey eye Institute camera for photographic documentation of opaque crystalline lens, N.Hatsusaka, K.Sasaki, Y.Kawakami, M.Sasaki, H.Sasaki, 68:1413-1420, Oct. 2014
• Effect of rebamipide ophthalmic suspension on signs and symptoms of keratoconjunctivitis sicca in sjogren syndrome patients with or without punctal occlusions, A.Arimoto, K.Kitagawa, N.Mita, Y.Takahashi, E.Shibuya, H.Sasaki, Cornea., 33:806-811, Aug. 2014
• Dosimetry using a localized exposure system in the Millimeter-Wave band for in vivo studies on ocular effects, (K.Sasaki), T.Sakai, T.Nagaoka, K.Wake, S.Watanabe, M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki, Y.Suzuki, M.Taki, Y.Kamimura, A.Hirata, H.Shirai, IEEE transactions on microwave theory and techniques, 62:1554-1564, Jul. 2014
• Multiple comparisons for a psychophysical test in bootstrap logistic regression, N.Mita, H.Sasaki, K.Kani, A.Tabuchi, H.Hara, Journal of algorithms & computational technology., 8:339-355, May 2014
• Pepeatability of visua acuity testing using a psychometric function, (T.Tokutake), T.Yamauchi, N.Mita, Ken-ichiro Kawamoto, H.Tabuchi, K.Kani, H.Hara, A.Tabuchi, H.Sasaki, Japanese journal of ophthalmology., 58:381-387, 2014
• Multicentre clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial keratitis., (Y.Inoue), Y.Shimomura, M.Fukuda, D.Miyazaki, Y.Ohashi, H.Sasaki, Y.Tagawa, H.Shiota, N.Inada, S.Okamoto, K.Araki-Sasaki, T.Kimura, H.Hatano, H.Nakagawa, S.Nakamura, A.Hirahara, K.Tanaka, H.Sakuma, The British journal of ophthalmology., 97:1108-1112, Nov. 2013
• Safety of rebamipide ophthalmic suspension for corneal epithelial cells: In vitro and In vivo study., M.Fukuda, H.Nakashima, J.Haruta, S.Shibata, N.Shibata, H.Osada, Y.Seki, N.Mita, H.Sasaki, 30:1467-1471, Oct. 2013
• Cases in which prescribed glaucoma medications were unnecessary., (N.Ibaraki), E.Kubo, H.Sasaki, 30:1472-1474, Oct. 2013
• Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens., E.Kubo, N.Hasanova, H.Sasaki, DP.Singh, Journal of cellular and molecular medicine., 17:1146-1159, Sep. 2013
• FDTD analysis of temperature elevation in the lens of human and rabbit models due to near-field and far-field exposures at 2.45 GHz., (T.Oiszmi), I.Laakso, A.Hirata, O.Fujiwara, S.Watanabe, M.Taki, M.Kojima, H.Sasaki, K.Sasaki, Radiation protection dosimetry., 155:284-291, Jul. 2013
• Corrected near and intermediate vfisual acuity in eyes with aspheric mono focal intraocular lens., M.Sasaki, M.Takahashi, E.Shibuya, A.Okamoto, N.Mita, Y.Takahashi, E.Kubo, H.Sasaki, 25:61-64, Jun. 2013
• Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells., E.Kubo, N.Hasanova, N.Fatma, H.Sasaki, DP.Singh, Journal of cellular and molecular medicine., 17:212-221, Jan. 2013
• Twelve-year incidence of exfoliation syndrome in the Reykjavik eye study., (A.Arnarsson), H.Sasaki, F.Jonasson, Acta ophthalmologica., 91:157-162, 2013
• Safety comparison of additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations., M.Fukuda, S.Shibata, N.Shibata, K.Hagihara, H.Osada, N.Takahashi, E.Kubo, H.Sasaki, Clinical ophthalmology., 7:515-520, 2013
• Assessing predictive accuracy of lens transparency property via 10-year follow-up in Japanese, N.Mita, N.Hatsusaka, E.Shibata, Y.Sakamoto, H.Osada, I.Shibata, N.Shibata, H.Yaguchi, K.Sasaki, H.Sasaki, 28:1503-1507, Oct. 2011
• Simultaneous stereoinversion and isomerization at the Asp-4 residue in βB2-crystallin from the aged human eye lenses, (N.Fujii), T.Kawaguchi, H.Sasaki, N.Fujii, Biochemistry., 50:8628-8635, Oct. 2011
• Generic versions of latanoprost ophthalmic solution evaluated for safety to corneal epithelial cells, M.Fukuda, I.Shibata, K.Hagiwara, H.Yaguchi, H.Sasaki, 28:849-854, Jun. 2011
• Vitreous and aqueous penetration of orally and topically administered moxifloxacin, M.Fukuda, N.Shibata, H.Osada, Y.Yamashiro, H.Sasaki, Ophthalmic research., 46:113-117, Jun. 2011
• Effect of sodium hyaluronate eyedrops on corneal cells, M.Fukuda, H.Yaguchi, N.Fujita, I.Shibata, H.Osada, N.Shibata, H.Sasaki, 28:549-552, Apr. 2011
• UV-B exposure to the eye depending on solar altitude, H.Sasaki, Y.Sakamoto, C.Schnider, N.Fujita, N.Hatsusaka, DH.Sliney, K.Sasaki, Eye & contact lens., 37:191-195, Apr. 2011
• Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers., 15:231-237, Apr. 2011
• Cyclin-dependent kinase inhibitor p16 and p21 expression, and cell cycle change in human lens epithelial cell line SRA 01/04 following contact inhibition in normal culture, Y.Yamashiro, H.Sasaki, N.Ibaraki, K.Nagai, Y.Kawakami, H.Yaguchi, N.Fujita, H.Osada, K.Sasaki, Ophthalmic research., 46:38-43, Mar. 2011
• Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, Jan. 2011
• Acute dosimetry and estimation of threshold-inducing behavioral signs of thermal stress in rabbits at 2.45-GHz microwave exposure, (A.Hirata), M.Kojima, H.Kawai, Y.Yamashiro, S.Watanabe, H.Sasaki, O.Fujiwara, IEEE transactions on microwave theory and techniques, 57:1234-1242, May 2010
• An　infant case of acute purulent dacryoadenitis due to MRSA, 26:1405-1408, Oct. 2009
• Effect of 5-S-GAD on UV-B-Induced cataracts in rats, H.Kawada, M.Kojima, T.Kimura, S.Natori, K.Sasaki, H.Sasaki, Japanese journal of ophthalmology., 53:531-535, Sep. 2009
• Acute ocular injuries cause by 60-GHz millimeter-wave exposure, Masami Kojima, Masahiro Hanazawa, Yoko Yamashiro, Hiroshi Sasaki, Soichi Watanabe, Masao Taki, Yukihisa Suzuki, Akimasa HIrata, Yoshitsugu Kamimura, Kazuyuki Sasaki, Health Physics, 97(3), Sep. 2009
• Cytotocic effect of ofluoxacin ophthalmic solutions and timolol maleate ophthalmic solutions on cultured rabbit corneal cell line and ocular pharmacokinetics of ophthalmic solutions in rabbits, M.Fukuda, H.Sasaki, 26:977-981, Jul. 2009
• Measurement of AQCmax of five diffeｒnt ophthalmic solution and discussion of its new application, M.Fukuda, H.Sasaki, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 25:351-355, May 2009
• Cytotoxic effects of new quinolone antibiotic ophthalmic solutions nad nonsteroidal anti-inflammatory ophthalmic solutions on cultured rabbit corneal cell line, M.Fukuda, H.Sasaki, 26:399-403, Mar. 2009
• Assessment of pinguecuｌa and pterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey in Shanxi, China, K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki, 5:31-40, Mar. 2009
• Acute ocular injuries caudes by 60-GHz millimeter-wave exposure, M.Kojima, M.Hanazawa, Y.Yamashiro, H.Sasaki, S.Watanabe, M.Taki, Y.Suzuki, A.Hirata, Y.Kamimura, K.Sasaki, Health physics., 97:212-218, Mar. 2009
• Pseudoexfoliation in the Reykjavik eye study:five-year incidence and changes in related ophthalmologic variables, (A.Arnarsson), KF.Damji, H.Sasaki, T.Sverrinsson, F.Jonasson, American journal of ophthalmology., 148:291-297, Feb. 2009
• Obsevational cohort study : The Reykjavik eye study, H.Sasaki, 26:17-24, Jan. 2009
• Calculation of AQCmax:comparison of five ophthalmic fluoroquinolone solution, M.Fukuda, H.Sasaki, Current medical research and opinion, 24:3479-3486, Dec. 2008
• Intraocular penetration of astaxanthin in rabbit eyes, M.Fukuda, J.Takahashi, Y.Nishida, H.Sasaki, 25:1461-1464, Oct. 2008
• Investigation of wavelength-specific characteristics of quasi- and millimeter-waves, M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, A.Hirata, Y.Sakamoto, Y.Kawakami, S.Watanabe, K.Wake, M.Taki, Y.Kamimura, H.Sasaki, K.Sasaki, ⅩⅩⅤⅢth General Assembly of International Union Radio science, KP214:1-4, Aug. 2008
• Expression of matrix metalloproteinases in wound healing after glaucoma filtration surｇery in rabbits, I.Shima, S.Katsuda, Y.Ueda, N.Takahashi, H.Sasaki, Ophthalmic research., 39:315-324, Oct. 2007
• Corneal disorder quantification by corneal resistance, M.Fukuda, K.Yamamoto, N.Takahashi, H.Sasaki, M.Yoshikawa, 24:521-525, Apr. 2007
• On the ocular refractive components : the Reykjavik eye study, (T.Olsen), A.Arnarsson, H.Sasaki, K.Sasaki, F.Jonasson, Acta ophthalmologica Scandinavica., 85:361-366, Apr. 2007
• Efficacy of α-lipoic acid against diabetic cataract in rat, M.Kojima, L.Sun, I.Hata, Y.Sakamoto, H.Sasaki, K.Sasaki, Japanese journal of ophthalmology., 51:10-13, Jan. 2007
• Intraocular penetration of moxifloxacin ophthlamic solution in rabbit eyes -calculaation of maximum drug concentration in aqueous-, M.Fukuda, H.Sasaki, Y.Ohashi, 23:1353-1357, Oct. 2006
• Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study, (GM.Zoega), A.Fujisawa, H.Sasaki, A.Kubota, K.Sasaki, K.Kitagawa, F.Jonasson, Ophthalmology., 113:565-569, Mar. 2006
• Risk factors for five-year incident age-related macular degeneration: The Reykjavik Eye Study, (A.Arnarsson), T.Sverrisson, E.Stefansson, H.Sigurdsson, H.Sasaki, K.Sasaki, F.Jonasson, American journal of ophthalmology., 142:419-428, Jan. 2006
• Orientation of the intermediate-vision zone of rotationally asymmetric multifocal intraocular lenses and photic phenomena, Mito T, Ukai Y, Nakatsugawa Y, Shibata T, Shibata S, Kubo E, Sasaki H., Jpn J Ophthalmol, 67:318-325, Apr. 2023
• Early-stage corneal toxicity secondary to high-dose systemic cytarabine: a case report, Mito T, Takeda S, Miyashita H, Sasaki H., BMC Ophthalmol, 23:84, Mar. 2023
• Function of mitochondrial cytochrome c oxidase is enhanced in human lens epithelial cells at high temperatures, Takeda Shun, Yamamoto Naoki, Nagai Noriaki, Hiramatsu Noriko, Deguchi Saori, Hatsusaka Natsuko, Kubo Eri, Sasaki Hiroshi., Molecular Medicine Reports, 27:19, Jan. 2023
• Skin absorption of felbinac solid nanoparticles in gel formulation containing l-menthol and carboxypolymethylene, Kadowaki R, Ogata F, Fushiki A, Daimyo S, Deguchi S, Otake H, Nagata M, Sasaki H, Kawasaki N, Nagai N., J Pharm Health Care Sci, 9:20, Jun. 2023
• Orally disintegrating tablets containing famotidine nanoparticles provide high intestinal absorbability via the energy-dependent endocytosis pathway, Nagai N, Ogata F, Kadowaki R, Deguchi S, Otake H, Nakazawa Y, Nagata M, Sasaki H, Kawasaki N., Front Bioeng Biotechnol, 11:1167291, Mar. 2023
• Aquaporins contribute to vacuoles formation in Nile grass type II diabetic rats, (Aihara Kana), Nakazawa Yosuke, Takeda Shun, Hatsusaka Natsuko, Onouchi Takanori, Hiramatsu Noriko, Nagata Mayumi, Nagai Noriaki, Funakoshi-Tago Megumi, Yamamoto Naoki, Sasaki Hiroshi., Medical Molecular Morphology, 56:274-287, Sep. 2023
• Drug Delivery to Ocular Tissues by the Instillation of Nilvadipine Nano-suspension：Comparison with Drug Behavior between Ophthalmic and Oral Administration, Reita Kadowaki, Ryogo Meiwa, Seiji Iwai, Mayumi Nagata, Hiroyuki Matsushima, Yosuke Nakazawa, Naoki Yamamoto, Hiroshi Sasaki, Noriaki Nagai, 36:95-99, Jun. 2024
• Evaluation of Selenite-Induced Lens Hardening in Suckling Rats by Kinetics Analysis, Reita Kadowaki, Takumi Asai, Saori Deguchi, Hiroko Otake, Norio Okamoto, Yosuke Nakazawa, Hiroshi Sasaki, Noriaki Nagai, 36:104-109, Jun. 2024
• High ambient temperature may induce presbyopia via TRPV1 activation, (Nakazawa Y.), Kuno Y., Shimada H., Nagai N., Hiramatsu N., Takeda S., Yamamoto N., Funakoshi-Tago M., Sasaki H., Med Mol Morphol, 57:268-276, Jul. 2024
  DOI:https://doi.org/10.1007/s00795-024-00391-2
• Comparison of Postoperative Axial Rotation of the Toric Intraocular Lens in Cataract Surgery Combined with Vitrectomy Versus Cataract Surgery Alone, Mito Tsuyoshi, Ishida Hidetoshi, Seki Yusuke, Shirayama Takuro, Ukai Yuki, Sasaki Hiroshi, Ophthalmologica, 247:224-230, Jul. 2024
  DOI:https://doi.org/10.1159/000539986
• Prediction of low-addition segmented refractive intraocular lens position and deviation using anterior-segment optical coherence tomography, Mita N., Yamazaki M., Seki Y., Sasaki Y., Shibuya E., Mito T., Hatsusaka N., Kubo E., Sasaki H., PLoS One, 19:e0305076, Jun. 2024
  DOI:https://doi.org/10.1371/journal.pone.0305076
• Preventative Effect of Topical Rebamipide Against Corneal Epithelium Disorders Caused by Diclofenac Sodium, Fukuda Masamichi, Kiyoi Takeshi, Takeda Shun, Sasaki Yu, Masuoka Naoyoshi, Kubo Eri, Sasaki Hiroshi., J Ocul Pharmacol Ther, 40:428-434, Sep. 2024
  DOI:https://doi.org/10.1089/jop.2024.002
• Exacerbated Tourette syndrome diagnosed in adulthood after recurrent bilateral retinal detachment, Mito Tsuyoshi, Okemoto Hajime, Kawasaki Akane, Sasaki Hiroshi., Retinal Cases & Brief Reports, 18:488-490, Jul. 2024
  DOI:https://doi.org/10.1097/ICB.0000000000001421
• Anterior Segment Optical Coherence Tomography Findings in Capsular Block Syndrome with Improvement in Myopia following Neodymium-Yttrium Aluminum Garnet Laser Treatment, Okemoto H, Mito T, Kawamorita T, Sasaki H, 15:78-83, Jan. 2024
  DOI:https://doi.org/10.1159/000535861
• Effects of High Temperature and High Humidity on the Degree of Ocular Damage Caused by 60 GHz Millimeter Wave Exposure, Kojima M, Tasaki T, Kamijo T, Hada A, Suzuki Y, Ikehata M, Sasaki H., Health Phys, 127:557-564, Nov. 2024
  DOI:https://doi.org/10.1097/HP.0000000000001843
• Progressive hyperopic refractive changes after posterior capsule tear following blunt ocular trauma, Teppei Shibata, Yusuke Seki, Yukiya Seida, Tsuyoshi Yoshita, Shunsuke Tsuchiya, Hiroshi Sasaki, Eri Kubo, 34:102032, Jun. 2024
  DOI:https://doi.org/10.1016/j.ajoc.2024.102032