IWAI Kunimitsu

FacultyHealth Evaluation Center, Department of Geriatric Medicine

Researcher Profile & Settings


    Overview of research:
    1. Nuclear matrix has a role of architectural support for the transcriptional apparatus at the promotor regions of the gene. I study the role of nuclear matrix in the microenvironment for transcription of the tissue specific genes in the cardiac hypertorophy and failure and physiological aging of the hippocampal memory formation. 2. I study the role of mental stress in the process of coronary arteriosclerosis and in the onset of acute coronary syndrome from the view point of detrimenral effects of monocyte-derived tissue macrophages.

Special Field

  • Cardioangiology
  • Cardioangiology
  • Cardioangiology
  • Cardioangiology
  • Cell biology
  • General medical chemistry
  • Cardioangiology
  • Cardioangiology


  • Osaka University Graduate School Division of Medicine
  • Osaka University Faculty of Medicine


  • Ph.D in Medicine

Association Memberships

  • 2006The Japan society for biomedical gerontology

Academic & Professional Experience

  • Sep. 2009Kanazawa Medical University. Department of Nursing Professor

Research Activities

Published Papers

  • Relationship Between Blood Pressure Levels on Admission and the Onset of Acute Pneumonia in Elderly Patients With Cerebral Hemorrhage, Taishi Ishisaka, Yuta Igarashi, Kumie Kodera, Tazuo Okuno, Takuro Morita, Taroh Himeno, Kazu Hamada, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Masashi Okuro, Journal of Clinical Medicine Research12:693-6982020
  • Relationship Between Gastroesophageal Reflux Disease and Endoscopic Finding "lodine-Unstained Streak", Kazu Hamada, Tohru Itoh, Ken Kawaura, Hidekazu Kitakata, Hiroaki Kuno, Junji Kamai, Rika Kobayasi, Sadahumi Azukisawa, Taishi Ishisaka, Yuta Igarashi, Kumie Kodera, Tazuo Okuno, Takuro Morita, Taroh Himeno, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Masashi Okuro, Journal of Clinical Medicine Research12:699-7042020
  • Association between blood pressure and disability-free survival among community-dwelling elderly patients receiving antihypertensive treatment, O.Iritani, Y.Koizumi, Y.Hamazaki, H.Yano, T.Morita, T.Himeno, T.Okuno, M.Okuro, K.Iwai, S.Morimoto, Hypertension research : official journal of the Japanese Society of Hypertension.37:772-778Mar. 2014
  • Association between hypertension status and the screening test for frailty in elderly community-dwelling Japanise, Y.Koizumi, Y.Hamazaki, M.Okuro, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto, Hypertension research : official journal of the Japanese Society of Hypertension.36:639-644Feb. 2013
  • The effects of a PPARα agonist on myocardial damage in obese diabetic mice with heart failure, R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda, International Heart Journal51:199-206May 2010
  • Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi, T.Kanda, Evidence-based complementary and alternative medicine : eCAM.7:341-3492010
  • Effect of collagen tripeptide of typeⅠcollagen on migration, proliferation and collagen synthesis of human aortic smooth muscle cells, T.Lihua, Y.Sakai, K.Iwai, S.Katsuda34:93-100Oct. 2009
  • Silent information regulator, sirtuin 1, and age-related diseases, L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto, Nature clinical practice. Rheumatology.9:7-152009
  • Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, International journal of cardiology129:414-421Nov. 2008
  • Association between seroprevalence of human metapneumovirus and c-reactive protein level and apolipoprotein e-ε4 allele in elderly inpatients in Japan, T.Takahashi, K.Nomura, H.Honda, T.Nakahashi, K.Iwai, M.Atsumi, K.Ishigami, T.Inamatsu, S.Morimoto, Journal of the American Geriatrics Society.56:1758-1760Sep. 2008
  • Association seroprevalence of human metapneumovirus with small vessel disease with dementia in elderly inpatients in Japan, K.Nomura, H.Murai, T.Nakahashi, H.Tsuchiya, K.Iwai, S.Morimoto33:86-90Aug. 2008
  • Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda, Neurochemical research33:1759-1767Mar. 2008
  • Reduced-energy diet improves survival of obses KKAy mice with viral myocarditis:induction of cardiac adiponectin expression, T.Kanda, S.Saegusa, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, International journal of cardiology119:310-318Jul. 2007
  • Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression, S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy.21:155-160Jun. 2007
  • Hepatocyte growth factor and visfatin in elderly bedridden patients, T.Kanda, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Matsumoto, Journal of the American Geriatrics Society.55:963-965Jun. 2007
  • Angiotensin Ⅰ-converting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans, M.Okuro, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, H.Murai, K.Iwai, T.Kanda, Hypertension research : official journal of the Japanese Society of Hypertension.29:655-663Sep. 2006
  • A ninety-eight-year-old woman with ruptured pancreatic anaplastic mucinous cystadenocarcinoma, H.Murai, S.Morimoto, I.Ohashi, K.Okaishi, H.Tsuchiya, K.Iwai, T.Nakahashi, Y.Nishimura, M.Okuro, E.Miyauchi, T.Nojima, M.Matsumoto43:246-251Feb. 2006
  • Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis, T.Takahashi, F.Yu, S.Saegusa, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Kurabayashi, T.Kanda, International Heart Journal47:107-123Jan. 2006
  • Disruption of Microtubules as an early Sign of Irreversible Ischemic Injury. Immunohistochemical Study of in Situ Canine Hearts., K.Iwai, M.Hori, A.Kitabatake, A.Kurihara, K.Uchida, Circ Res67:694-706Mar. 1990
  • Increased expression of DNA cointroduced with nuclear protein in adult rat liver., (Y.Kaneda), K.Iwai, T.Uchida, Science243:375-3781989

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