HATTA Toshihisa

FacultyDepartment of Anatomy Ⅰ

Researcher Profile & Settings


    Overview of research:
    Contribution of neurogenic cytokines and growth factors to the development of central nervous system are investigated using the mouse exo utero development system and/or complete artifical rearing system for rodent infants.


  • Shimane University


  • Ph.D in Medicine

Research Activities

Published Papers

  • Exposure to Maternal Immune Activation Causes Congenital Unfolded Protein Response Defects and Increases the Susceptibility to Postnatal Inflammatory Stimulation in Offspring, Yo Shimizu, Tsuyoshi Tsukada, Hiromi Sakata-Haga, Daisuke Sakai, Hiroki Shoji, Yutaka Saikawa, Toshihisa Hatta, Journal of Inflammation Research14:355-365Feb. 2021
  • The impact of ovariectomy on olfactory neuron regeneration in mice, Kentaro Yamada, Hideaki Shiga, Takuya Noda, Masayuki Harita, Tomoko Ishikura, Yukari Nakamura, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses45:203-209Feb. 2020
  • Leukemia inhibitory factor induces corticotropin-releasing hormone in mouse trophoblast stem cells, He Wang, Tsuyoshi Tsukada, Hiroki Shimada, Hiromi Sakata-Haga, Yasuo Iida, Shitai Zhang, Hiroki Shoji, Toshihisa Hatta, Biochemical and biophysical research communications522:81-87Jan. 2020
  • Direct evidence of the relationship between brain metastatic adenocarcinoma and white matter fibers: A fiber dissection and diffusion tensor imaging tractography study, (Xiaoliang Liu), Masashi Kinoshita, Harumichi Shinohara, Osamu Hori ,Noriyuki Ozaki, Toshihisa Hatta, Satoru Honma, Mitsutoshi Nakada, Journal of Clinical Neuroscience77:55-61Jul. 2020
  • Molecular mechanisms underlying the models of neurodevelopmental disorders in maternal immune activation relevant to the placenta, Tsuyoshi Tsukada, Hiroki Shimada, Hiromi Sakata-Haga, Hideaki Iizuka, Toshihisa Hatta, Congenital anomalies59:81-87May 2019
  • Effects of tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro, Takuya Noda, Hideaki Shiga, Kentaro Yamada, Masayuki Harita, Yukari Nakamura, Tomoko Ishikura, Masami Kumai, Zenji Kawakami, Atsushi Kaneko, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, Takaki Miwa, Chemical Senses44:327-338May 2019
  • Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice, (Yoshihara T), Satake H, Nishie T, Okino N, Hatta T, Otani H, Naruse C, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K, Fururkawa K, Ito M, Asano M, PLOS Genetics14:e1007574Aug. 2018
  • A rapid and nondestructive protocol for whole-mount bone staining of small fish and Xenopus, Sakata-Haga Hiromi, Uchishiba Maimi, Shimada Hiroki, Tsukada Tsuyoshi, Mitani Mayumi, Arikawa Tomohiro, Shoji Hiroki, Hatta Toshihisa, SCIENTIFIC REPORTS8:7453May 2018
  • Extracranial outflow of particles solved in cerebrospinal fluid: Fluorescein injection study, (Akai Takuya);Hatta Toshihisa;Shimada Hiroki;Mizuki Keiji;Kudo Nae;Hatta Taizo;Otani Hiroki, Congenital Anomalies58:93-98Oct. 2017
  • JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science130:916-926Jan. 2017
  • Galectin-4 expression is down-regulated in response to autophagy during differentiation of rat trophoblast cells, T.Arikawa, S.Liao, H.Shimada, T.Inoue, H.Sakata-Haga, T.Nakamura, T.Hatta, H.Syoji, SCIENTIFIC REPORTS6:1-11Sep. 2016
  • Three-dimensional structure of seminiferous tubules in the adult mouse, (N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki, Journal of Anatomy227:686-6942015
  • Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One10:e0123232-e01232322015
  • In vivo analysis of Arg-Gly-Asp Sequence/Integrin α5β1-mediated signai involvement in embryonic enchondral ossification by exo utero development system., (T.Inoue), RHashimoto, A.Matsumoto, E.Jahan, AM.Rafiq, J.Udagawa, T.Hatta, H.Otani, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.29:1554-63Jul. 2014
  • Significance of sugar chain recognition by galectins and its involvement in disease-associated glycosylation, T.Arikawa, E.Simamura, H.Shimada, T.Nakamura, T.Hatta, H.Shoji, Congenital anomalies54:77-812014
  • Expression pattern of Galectin 4 in rat placentation, Tomohiro Arikawa, Eriko Simamura, Hiroki Shimada, Nozomu Nishi, Takanori Tatsuno, Yasuhito Ishigaki, Naohisa Tomosugi, Chizu Yamashiro, Toshiyuki Hata, Tsutomu Takegami, Tomonori Nakamura, Haruta Mogami, Ken Yamaguchi, Hiroki Otani, Toshihisa Hatta, Hiroki Shoji, Placenta2012 Aug 6. [Epub ahead of print]Aug. 2012
  • Effects of melanocortins on fetal development, E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta, Congenital anomalies51:47-542011
  • Direct and indirect effects of neuropeptide Y and neurotrophin 3 on myelination in the neonatal brains, (R.Hashimoto), J.Udagawa, Y.Kagohashi, A.Matsumoto, T.Hatta, H.Otani, Brain research.1373:55-662011
  • Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway, E.Simamura, H.Shimada, N.Higashi, M.Uchishiba, H.Otani, T.Hatta, Endocrinology.151:1853-1862Apr. 2010
  • Ror2 is required for midgut elongation during mouse development, (M.Yamada), J.Udagawa, A.Matsumoto, R.Hashimoto, T.Hatta, M.Nishita, Y.Minami, H.Otani, Developmental dynamics : an official publication of the American Association of Anatomists239:941-953Mar. 2010
  • Individual variation in organ histogenesis as a causative factor in the developmental origins of health and disease: unnoticed congenital anomalies?, (H.Otani), J.Udagawa, T.Hatta, Y.Kagohashi, R.Hashimoto, A.Matsumoto, F.Satow, M.Nimura, Congenital anomalies50:205-2112010
  • Branching patterns of the celiac artery as the hepato-gastro-splenic trunk, N.Higashi, H.Shimada, E.Simamura, T.Hatta84:7-10Mar. 2009
  • Quantitative analysis of delayed neuronal death in the hippocampal subfields of SHRSP and SHR, (M.Daisu), T.Hatta, Y.Sakurai-Yamashita, T.Nabika, K.Moritake, Cellular and molecular neurobiology29:557-5622009
  • Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase, H.Shimada, K-I.Hirai, E.Simamura, T.Hatta, H.Iwakiri, K.Mizuki, T.Hatta, T.Sawasaki, S.Matsunaga, Y.Endo, S.Shimizu, The Journal of biological chemistry.284: 28642-286492009
  • Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents, E.Simamura, H.Shimada, T.Hatta, K-I.Hirai, Journal of bioenergetics and biomembranes.40:213-217Sep. 2008
  • Congenital deformities and developmental abnormalities of the mandibular condyle in the temporomandibular joint, K.Kaneyama, N.Segami, T.Hatta, Congenital anomalies48:118-125Sep. 2008
  • Right vertebral artery as the fourth branch of the aortic arch, N.Higashi, H.Shimada, E.Simamura, T.Hatta, Anatomical science international / Japanese Association of Anatomists83:314-318Aug. 2008
  • Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1, E.Simamura, H.Shimada, Y.Ishigaki, T.Hatta, N.Higashi, K-I.Hirai, Anatomical science international / Japanese Association of Anatomists83:261-266Aug. 2008
  • Morphometric study on the characteristic external features of normal and abnormal human embryos, H.Otani, J.Udagawa, T. Lundh, T.Hatta, R.Hashimato, A.Masumoto, F.Satow, Congenital anomalies48:18-28Feb. 2008
  • Mouse exo utero development system, T.Hatta, M.Yamada, E.Simamura, H.Shimada, M.Nimura, A.Matsumoto, J.Udagawa, R.Hashimoto, N.Higashi, H.Otani32:16-22Jun. 2007
  • Development of the pons in human fetuses, T.Hatta, F.Satow, J.Hatta, R.Hashimoto, J.Udagawa, A.Matsumoto, H.Otani, Congenital anomalies47:63-67Jun. 2007
  • Quantitative analyses of leukemia inhibitory factor in the cerebrospinal fluid in mouse embryos., Neuroreport.17:1863-1866Jan. 2006