Japanese

TAKATA Takanobu

■Faculty	Department of Life Sciences
■Position	Senior Assistant Professor

Researcher Profile & Settings

Profile & Settings

http://researchmap.jp/read0139363/?lang=english

Contact

takajjjj@kanazawa-med.ac.jp

Research

Overview of research:

The sugars (e.g. glucose, fructose) and proteins generate advanced glycation end-products (AGEs). We investigate AGEs derived from glyceraldehyde (GA) which is the glucose/fructose metabolism intermediate, called GA-AGEs. More, we named GA-AGEs to toxic AGEs (TAGE) because of such cytotoxicity and that GA-AGEs had been closely associated with Lifestyle-related diseases such as insulin resistanse, hypertension, diabetic complications, cardiovascular diseases, dementia, non-alcoholic steatohepatitis, Alzheimer's disease, and cancer. Actually, we investigate the quanitity of the intracellular GA-AGEs (TAGE) in the cultured cells and organs of human and rat, and identification of them.

Special Field

Health Science
General medical chemistry
Pathological medical chemistry
Laboratory animal science

Education

Kanazawa University Graduate School Division of Bioscience
Gifu Pharmaceutical University Graduate School Division of Pharmacy
Gifu Pharmaceutical University Faculty of Pharmaceutical Science

Degree

Doctor of Pharmacy

Association Memberships

Nov. 2018- Japanese Association on Sarcopenia and Frailty member
Apr. 2019- Japan Society for Biomedical Gerontology member
Nov. 2018- Japanese College of Cardiology member
Jun. 2016- The Japan Society of Diabetic Complications menmber
Jan. 2018- Japan Mibyou System Asscosiation member
Oct. 2010- Japanese Society of Anti-Aging Medicine member
Sep. 2016- The Japan Society for Oriental Medicine member
Dec. 2004- The Pharmacutical Society of Japan member

Academic & Professional Experience

Apr. 2008- Mar. 2011Medical Research Institute of Kanazawa Medical University Research Fellow
Apr. 2011- Mar. 2018Medical Research Institute of Kanazawa Medical University Assistant Professor
Apr. 2018Medical Research Institute of Kanazawa Medical University Senior Assistant Professor

Research Activities

Published Papers

Analysis of Crude, Diverse, and Multiple Advanced Glycation End-Product Patterns May Be Important and Beneficial, Takanobu Takata, Togen Masauji, Yoshiharu Motoo, Metabolites, 14:3, Dec. 2023
Potential of the Novel Slot Blot Method with PVDF Membrane for Protein Identification and Quantification in Kampo Medicines, Takanobu Takata, Togen Masauji, Yoshiharu Motoo, Membranes, 13:896, Dec. 2023
Novel In Vitro Assay of the Effects of Kampo Medicines against Intra/Extracellular Advanced Glycation End-Products in Oral, Esophageal, and Gstric Epithelial Cells, Takanobu Takata, Yoshiharu Motoo, Metabolites, 13:878, Jul. 2023
Is the Novel Slot Blot a Useful Method for Quantification of Intracellular Advanced Glycation End-Products?, Takanobu Takata, Metabolites, 13:564, Apr. 2023
Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, 12:615, Jul. 2022
Effects of toxic AGEs (TAGE) on human health., 11:2178, Jul. 2022
The association between accumulation of toxic advanced glycation end-products and cytotoxic effect in MC3T3-E1 cells., 14:990, Feb. 2022
Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Mirotubule-Associated Protein 1 Light Chain 3 and p62, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, 14:332, Jan. 2022
Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease, Takafumi Kawanami, Haruka Kawanami-Iwao, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Tsutomu Takegami, Hiroto Yanagisawa, Shino Fujimoto, Tomoyuki Sakai, Yoshimasa Fujita, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Yuko Hirose, Yasufumi Masaki, Clinica Chimica Acta, 523:45-57, 2021
Accumulation of toxic advanced glycation end-products induces cytotoxicity and inflammation in hepatocyte-like cells differentiated from human induced pluripotent stem cells., (Kikuchi C), Sakasai-Sakai A, Okimura R, Tanaka H, Takata T, Takeuchi M, Matsunaga T, Biol. Pharm. Bull., 44:1399-1402, Oct. 2021
Intracellular toxic AGEs (TAGE) triggers numerous types of cell damage., Takeuchi M, Sakasai-Sakai A, Takata T, Takino J, Koriyama Y, Furukawa A, Kikuchi C, Nagamine K, Hori T, Matsunaga T, Biomolecules, 11:387, Mar. 2021
Potential of an interorgan network mediated by toxic advanced glycation end-products in a rat model, Shinya Inoue, Takanobu Takata, Yusuke Nakazawa, Yuka Nakamura, Xin Guo, Sohsuke Yamada, Yasuhito Ishigaki, Masayoshi Takeuchi, Katsuhito Miyazawa, Nutrients, 13:80, 2020
Intracellular toxic advanced glycation end-products promote the production of reactive oxygen species in HepG2 cells, Sakasai-Sakai A, Takata T, Takeuchi M, International Journal of Molecular Sciences, 21:4861, Jul. 2020
Impact of intracellular toxic advanced glycation end-products (TAGE) on murine myoblast cell death, Takata Takanobu, Sakasai-Sakai Akiko, Takeuchi Masayoshi, Diabetology & Metabolic Syndrome, 12:54, Jun. 2020
DOI:10.1186/s13098-020-00561-z
Exploration of the mystery of the third glycogen metabolite 1,5-anhydro-D-fructose (1,5-AF), Akiko Sakasai-Sakai, Takanobu Takata, Hirokazu Suzuki, Ikuro Maruyama, Kenji Tanaka, Yoshihiro Motomiya, Masayoshi Takeuchi, The Journal of Japan Mibyou Association, 26:67-72, Jan. 2020
Evidence for toxic advanced glycation end-products generated in the normal rat liver, Takata Takanobu, Sakasai-Sakai Akiko, Takino Jun-ichi, Takeuchi Masayoshi, Nutrients, 11:1612, Jul. 2019
DOI:10.3390/nu11071612
Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite, Sakasai-Sakai Akiko, Takata Takanobu, Suzuki Hirokazu, Maruyama Ikuro, Motomiya Yoshihiro, Takeuchi Masayoshi, Scientific Reports, 9:10194, Jul. 2019
DOI:10.1038/s41598-019-46333-2
GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells, (Zentaro Kiuchi), YukinoNishibori, Satoru Kutsuna, Masashi Kotani, Ichiro Hada, Toru Kimura, Toshiyuki Fukutomi, Daisuke Fukuhara, Noriko Ito-Nitta, Akihiko Kudo, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Hirotoshi Tanaka, Satsuki Matsushima, Shinya Ogasawara, Yoshiaki Hirayama, Hiromu Takematsu, Kunimasa Yan, FASEB JOURNAL, 33:7387-7402, Jun. 2019
Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease, Takata Takanobu, Sakasai-Sakai Akiko, Ueda Tadashi, Takeuchi Masayoshi, Scientific Reports, 9:2121, Feb. 2019
DOI:10.1038/s41598-019-39202-5
The relevance of toxic AGEs (TAGE) cytotoxicity to NASH pathogenesis: A mini-review, Sakasai-Sakai Akiko, Takata Takanobu, Takino Jun-Ichi, Takeuchi Masayoshi, Nutrients, 11:462, Feb. 2019
DOI:10.3390/nu11020462
Novel biomarker toxic AGEs (TAGE) in the onset / progression of lifestyle-related (LSRD), Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, The journal of Japan Mibyo System Association, 24:27-33, Aug. 2018
Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD, Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi, The journal of Japan Mibyo System Association, 24:19-25, Mar. 2018
Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death, Akiko Sakasai-Sakai,Takanobu Takata,Jun-ichi Takino,Masayoshi Takeuchi, Scientific Reports, 7:14282, Oct. 2017
Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion, Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi, World Journal of Gastroenterology, 23:4910-4919, Jul. 2017
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi, Nutrients, 9:634, Jun. 2017
DOI:10.3390/nu9060634
Involvement of toxic AGEs(TAGE) in the onset / progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy, Masayoshi Takeuchi,Akiko Sakasai-Sakai,Takanobu Takata, 23:20-30, 2017
Identification and functional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto, Suizo, 31:76-84, 2016
Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD, M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi, International Journal of Diabetes and Clinical Researsh, 2:1-5, Jul. 2015
Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH., M.Takeuchi, A.Sakasai-Sakai, T.Takata, T.Ueda, J.Takino, M.Tsutsumi, H.Hyogo, S.Yamagishi, Medical Hypotheses, 84:490-493, 2015
Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi, World journal of hepatology [electronic resource], 6:880-893, Dec. 2014
Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts, T. Takata, Y. Motoo, N. Tomosugi, Journal of integrative medicine., 12:495-503, Nov. 2014
Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma., (S.Maru), Y.Ishigaki, N.Shinohara, T.Takata, N.Tomosugi, K.Nonomura, The Journal of urology., 189:1921-1929., May 2013
Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity., N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna, Y.Motoo, Molecular and clinical oncology., 1:100-104, Jan. 2013
Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami, Genes to cells : devoted to molecular & cellular mechanisms, 18:369-386, 2013
Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro, T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi, Oncology reports., 28:1968-1976, Dec. 2012
Glycogen synthase kinase 3βinhibition sensitizes pancreatic cancer cells to gemcitabine, T.Shimasaki, Y.Ishigaki, Y.Nakamura, T.Takata, N.Nakaya, H.Nakajima, I.Sato, X.Zhao, A.Kitano, K.Kawakami, T.Tanaka, T.Takegami, N.Tomosugi, T.Minamoto, Y.Motoo, Journal of gastroenterology., 47:321-333, Mar. 2012
Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, Jan. 2011
Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa, 24:8-13, Nov. 2010
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010
Introduction of OLS inNIBB, Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa, 8:15-18, Dec. 2009
Isolation of N-acetylneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens., T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugi, F.Takano, T.Ohta, Journal of health science, 55:373-379, Mar. 2009
The Kampo Medicines Orengedokuto, Bofutsuhosan and Boiogito Have Different Activities to Regulate Gene expressions in differentiated Rat White Adipocytes : Comprehensive Analysis of Genetic Profiles, J.Yamakawa, Y.Ishigaki, F. Takano, T. Takahashi, J. Yoshida, J.Moriya, T.Takata, T. Tatsuno, K. Sasaki, T. Ohta, T.Takegami, F. Yoshizaki, Biological & pharmaceutical bulletin, 31: 2083-2089, Nov. 2008
The Liquid Culture of Entomogenous fungus Paecilomyces tenuipes and Its Glycoprotein Costituent Protects against Anemia in Mice Treated with 5-fluorouracil., T. Takata, T. Tanaka, N. Yahagi, R. Yahagi, H. Tsuchida, Y.Ishigaki, N.Tomosugi, S. Fushiya, F. Takano, T. Ohta, Biological & pharmaceutical bulletin, 31 : 1561-1573, Aug. 2008
Bioactive monoterpene glycosides conjugated with galic acid from the leaves of Eucalyptus globulus, (T. Hasegawa), F. Takano, T.Takata, M. Niyama, T. Ohta, Phytochemistry., 69 : 747-753, Feb. 2008
Cytotoxic Fatty Acid from Pleurocybella porrigens, (T. Hasegawa), M. Ishibashi, T.Takata, F. Takano, T. Ohta, Chem. Pharm. Bull., 55 : 1748-1749, Dec. 2007
Aqueous Extract of Peanut Skin and Its main Constituent Procyanidin A1 Suppress Serum IgE and IgG1 Levels in Mice-Immunized with Ovalbumin, (F. Takano), T.Takata, A. Yoshihara, Y. Nakamura, Y. Arima, T. Ohta, Biological & pharmaceutical bulletin, 30 : 922-927, May 2007
Melanogenesisi Stimulation in Murine B16 Melanoma Cells by Kava (Piper metysticum) Rhizome Extract and Kavalactonens., (H. Matsuda), N. Hirata, Y. Kawaguchi, S. Naruto, T.Takata, M. Oyama, M. Iinuma, M. Kubo, Biological & pharmaceutical bulletin, 294:834, Apr. 2006

Awards & Honors

Nov. 2017 Japan Mibyou System Association Excellence Title Award Toxic AGEs (TAGE) for the novel biomarker against the development and promotion of the lifestyle-related disease.
T.Takata
Oct. 2016 Hokuriku branch of The Japan Society for Oriental Medicine Encouragement award of Hokuriku branch of The Japan Society for Oriental Medicine
Takanobu Takata
May 2008 The Japanese Society of Pharmacognosy The grant of overseas posting of Koshiro
Takanobu Takata
Feb. 2008 Nikkan Kogyo Shinbun, LTD. Encouragement award of 5th Campus Venture Grand prix of Chubu
Takanobu Takata et al.
Jan. 2007 Nikkan Kogyo Shinbun, LTD. Nikkan Kogyo Shinbun Award of the 4th Campus Venture Grand Prix Chubu
Takanobu Takata

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.