TAKATA Takanobu

FacultyDepartment of Life Sciences
PositionSenior Assistant Professor

Researcher Profile & Settings

Profile & Settings

Contact

Research

    Overview of research:
    The sugars (e.g. glucose, fructose) and proteins generate advanced glycation end-products (AGEs). We investigate AGEs derived from glyceraldehyde (GA) which is the glucose/fructose metabolism intermediate, called GA-AGEs. More, we named GA-AGEs to toxic AGEs (TAGE) because of such cytotoxicity and that GA-AGEs had been closely associated with Lifestyle-related diseases such as insulin resistanse, hypertension, diabetic complications, cardiovascular diseases, dementia, non-alcoholic steatohepatitis, Alzheimer's disease, and cancer. Actually, we investigate the quanitity of the intracellular GA-AGEs (TAGE) in the cultured cells and organs of human and rat, and identification of them.

Special Field

  • Health Science
  • General medical chemistry
  • Pathological medical chemistry
  • Laboratory animal science

Education

  • Kanazawa University Graduate School Division of Bioscience
  • Gifu Pharmaceutical University Graduate School Division of Pharmacy
  • Gifu Pharmaceutical University Faculty of Pharmaceutical Science

Degree

  • Doctor of Pharmacy

Association Memberships

  • Nov. 2018Japanese Association on Sarcopenia and Frailty member
  • Apr. 2019Japan Society for Biomedical Gerontology member
  • Nov. 2018Japanese College of Cardiology member
  • Jun. 2016The Japan Society of Diabetic Complications menmber
  • Jan. 2018Japan Mibyou System Asscosiation member
  • Oct. 2010Japanese Society of Anti-Aging Medicine member
  • Sep. 2016The Japan Society for Oriental Medicine member
  • Dec. 2004The Pharmacutical Society of Japan member

Academic & Professional Experience

  • Apr. 2008Mar. 2011Medical Research Institute of Kanazawa Medical University Research Fellow
  • Apr. 2011Mar. 2018Medical Research Institute of Kanazawa Medical University Assistant Professor
  • Apr. 2018Medical Research Institute of Kanazawa Medical University Senior Assistant Professor

Research Activities

Published Papers

  • Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Mirotubule-Associated Protein 1 Light Chain 3 and p62, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi14:332Jan. 2022
  • Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi12:615Jul. 2022
  • Effects of Toxic AGEs (TAGE) on Human Health, Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata11:2178Jul. 2022
  • Effects of toxic AGEs (TAGE) on human health.11:2178Jul. 2022
  • The association between accumulation of toxic advanced glycation end-products and cytotoxic effect in MC3T3-E1 cells.14:990Feb. 2022
  • Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease, Takafumi Kawanami, Haruka Kawanami-Iwao, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Tsutomu Takegami, Hiroto Yanagisawa, Shino Fujimoto, Tomoyuki Sakai, Yoshimasa Fujita, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Yuko Hirose, Yasufumi Masaki, Clinica Chimica Acta523:45-572021
  • Accumulation of toxic advanced glycation end-products induces cytotoxicity and inflammation in hepatocyte-like cells differentiated from human induced pluripotent stem cells., (Kikuchi C), Sakasai-Sakai A, Okimura R, Tanaka H, Takata T, Takeuchi M, Matsunaga T, Biol. Pharm. Bull.44:1399-1402Oct. 2021
  • Intracellular toxic AGEs (TAGE) triggers numerous types of cell damage., Takeuchi M, Sakasai-Sakai A, Takata T, Takino J, Koriyama Y, Furukawa A, Kikuchi C, Nagamine K, Hori T, Matsunaga T, Biomolecules11:387Mar. 2021
  • Potential of an interorgan network mediated by toxic advanced glycation end-products in a rat model, Shinya Inoue, Takanobu Takata, Yusuke Nakazawa, Yuka Nakamura, Xin Guo, Sohsuke Yamada, Yasuhito Ishigaki, Masayoshi Takeuchi, Katsuhito Miyazawa, Nutrients13:802020
  • Intracellular toxic advanced glycation end-products promote the production of reactive oxygen species in HepG2 cells, Sakasai-Sakai A, Takata T, Takeuchi M, International Journal of Molecular Sciences21:4861Jul. 2020
  • Impact of intracellular toxic advanced glycation end-products (TAGE) on murine myoblast cell death, Takata Takanobu, Sakasai-Sakai Akiko, Takeuchi Masayoshi, Diabetology & Metabolic Syndrome12:54Jun. 2020
  • Exploration of the mystery of the third glycogen metabolite 1,5-anhydro-D-fructose (1,5-AF), Akiko Sakasai-Sakai, Takanobu Takata, Hirokazu Suzuki, Ikuro Maruyama, Kenji Tanaka, Yoshihiro Motomiya, Masayoshi Takeuchi, The Journal of Japan Mibyou Association26:67-72Jan. 2020
  • Evidence for toxic advanced glycation end-products generated in the normal rat liver, Takata Takanobu, Sakasai-Sakai Akiko, Takino Jun-ichi, Takeuchi Masayoshi, Nutrients11:1612Jul. 2019
  • Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite, Sakasai-Sakai Akiko, Takata Takanobu, Suzuki Hirokazu, Maruyama Ikuro, Motomiya Yoshihiro, Takeuchi Masayoshi, Scientific Reports9:10194Jul. 2019
  • GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells, (Zentaro Kiuchi), YukinoNishibori, Satoru Kutsuna, Masashi Kotani, Ichiro Hada, Toru Kimura, Toshiyuki Fukutomi, Daisuke Fukuhara, Noriko Ito-Nitta, Akihiko Kudo, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Hirotoshi Tanaka, Satsuki Matsushima, Shinya Ogasawara, Yoshiaki Hirayama, Hiromu Takematsu, Kunimasa Yan, FASEB JOURNAL33:7387-7402Jun. 2019
  • Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease, Takata Takanobu, Sakasai-Sakai Akiko, Ueda Tadashi, Takeuchi Masayoshi, Scientific Reports9:2121Feb. 2019
  • The relevance of toxic AGEs (TAGE) cytotoxicity to NASH pathogenesis: A mini-review, Sakasai-Sakai Akiko, Takata Takanobu, Takino Jun-Ichi, Takeuchi Masayoshi, Nutrients11:462Feb. 2019
  • Novel biomarker toxic AGEs (TAGE) in the onset / progression of lifestyle-related (LSRD), Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, The journal of Japan Mibyo System Association24:27-33Aug. 2018
  • Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD, Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi, The journal of Japan Mibyo System Association24:19-25Mar. 2018
  • Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death, Akiko Sakasai-Sakai,Takanobu Takata,Jun-ichi Takino,Masayoshi Takeuchi, Scientific Reports7:14282Oct. 2017
  • Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion, Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi, World Journal of Gastroenterology23:4910-4919Jul. 2017
  • Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi, Nutrients9:634Jun. 2017
  • Involvement of toxic AGEs(TAGE) in the onset / progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy, Masayoshi Takeuchi,Akiko Sakasai-Sakai,Takanobu Takata23:20-302017
  • Identification and functional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto, Suizo31:76-842016
  • Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD, M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi, International Journal of Diabetes and Clinical Researsh2:1-5Jul. 2015
  • Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH., M.Takeuchi, A.Sakasai-Sakai, T.Takata, T.Ueda, J.Takino, M.Tsutsumi, H.Hyogo, S.Yamagishi, Medical Hypotheses84:490-4932015
  • Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi, World journal of hepatology [electronic resource]6:880-893Dec. 2014
  • Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts, T. Takata, Y. Motoo, N. Tomosugi, Journal of integrative medicine.12:495-503Nov. 2014
  • Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma., (S.Maru), Y.Ishigaki, N.Shinohara, T.Takata, N.Tomosugi, K.Nonomura, The Journal of urology.189:1921-1929.May 2013
  • Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity., N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna, Y.Motoo, Molecular and clinical oncology.1:100-104Jan. 2013
  • Chk1-mediated phosphorylation of receptor-associated late transducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami, Genes to cells : devoted to molecular & cellular mechanisms18:369-3862013
  • Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro, T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi, Oncology reports.28:1968-1976Dec. 2012
  • Glycogen synthase kinase 3βinhibition sensitizes pancreatic cancer cells to gemcitabine, T.Shimasaki, Y.Ishigaki, Y.Nakamura, T.Takata, N.Nakaya, H.Nakajima, I.Sato, X.Zhao, A.Kitano, K.Kawakami, T.Tanaka, T.Takegami, N.Tomosugi, T.Minamoto, Y.Motoo, Journal of gastroenterology.47:321-333Mar. 2012
  • Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision17:159-169Jan. 2011
  • Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa24:8-13Nov. 2010
  • Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology37:583-5932010
  • Introduction of OLS inNIBB, Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa8:15-18Dec. 2009
  • Isolation of N-acetylneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens., T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugi, F.Takano, T.Ohta, Journal of health science55:373-379Mar. 2009
  • The Kampo Medicines Orengedokuto, Bofutsuhosan and Boiogito Have Different Activities to Regulate Gene expressions in differentiated Rat White Adipocytes : Comprehensive Analysis of Genetic Profiles, J.Yamakawa, Y.Ishigaki, F. Takano, T. Takahashi, J. Yoshida, J.Moriya, T.Takata, T. Tatsuno, K. Sasaki, T. Ohta, T.Takegami, F. Yoshizaki, Biological & pharmaceutical bulletin31: 2083-2089Nov. 2008
  • The Liquid Culture of Entomogenous fungus Paecilomyces tenuipes and Its Glycoprotein Costituent Protects against Anemia in Mice Treated with 5-fluorouracil., T. Takata, T. Tanaka, N. Yahagi, R. Yahagi, H. Tsuchida, Y.Ishigaki, N.Tomosugi, S. Fushiya, F. Takano, T. Ohta, Biological & pharmaceutical bulletin31 : 1561-1573Aug. 2008
  • Bioactive monoterpene glycosides conjugated with galic acid from the leaves of Eucalyptus globulus, (T. Hasegawa), F. Takano, T.Takata, M. Niyama, T. Ohta, Phytochemistry.69 : 747-753Feb. 2008
  • Cytotoxic Fatty Acid from Pleurocybella porrigens, (T. Hasegawa), M. Ishibashi, T.Takata, F. Takano, T. Ohta, Chem. Pharm. Bull.55 : 1748-1749Dec. 2007
  • Aqueous Extract of Peanut Skin and Its main Constituent Procyanidin A1 Suppress Serum IgE and IgG1 Levels in Mice-Immunized with Ovalbumin, (F. Takano), T.Takata, A. Yoshihara, Y. Nakamura, Y. Arima, T. Ohta, Biological & pharmaceutical bulletin30 : 922-927May 2007
  • Melanogenesisi Stimulation in Murine B16 Melanoma Cells by Kava (Piper metysticum) Rhizome Extract and Kavalactonens., (H. Matsuda), N. Hirata, Y. Kawaguchi, S. Naruto, T.Takata, M. Oyama, M. Iinuma, M. Kubo, Biological & pharmaceutical bulletin294:834Apr. 2006

Awards & Honors

  • Nov. 2017 Japan Mibyou System Association Excellence Title Award Toxic AGEs (TAGE) for the novel biomarker against the development and promotion of the lifestyle-related disease.
    T.Takata
  • Oct. 2016 Hokuriku branch of The Japan Society for Oriental Medicine Encouragement award of Hokuriku branch of The Japan Society for Oriental Medicine
    Takanobu Takata
  • May 2008 The Japanese Society of Pharmacognosy The grant of overseas posting of Koshiro
    Takanobu Takata
  • Feb. 2008 Nikkan Kogyo Shinbun, LTD. Encouragement award of 5th Campus Venture Grand prix of Chubu
    Takanobu Takata et al.
  • Jan. 2007 Nikkan Kogyo Shinbun, LTD. Nikkan Kogyo Shinbun Award of the 4th Campus Venture Grand Prix Chubu
    Takanobu Takata