SASAGAWA Toshiyuki

FacultyDepartment of Obstetrics and Gynecology, Division of Gynecology and Obstetrics Research in Microbiology and Cancer Immunology

Researcher Profile & Settings


    Overview of research:
    Human papilllomavirus infection, host immunity and urogenital cancer, Development of cancer immune-therapy, Treatment of Obstet/ Gynecologic disorders with Chinese medicine.


  • Osaka University Graduate School Division of Medicine
  • Kanazawa University School of Medicine Medicine


  • Ph.D in Medicine

Association Memberships

  • 1998American Association for Cancer Research member
  • 2004International Papillomavirus Society Board member
  • 1989Japanese Cancer Association member
  • 1983Japanese Society of Obstetrics and Gynecology Member
  • 20082015Japanese Society of Adolescentology Councilor
  • 2006Japanese Society of Sexually Transmitted Infection councilor
  • 2009The Japanese Society for Oriental Medicine member

Academic & Professional Experience

  • Jun. 1983Jun. 1986Toyonaka Municipal Hospital Medical Doctor for Obstetrics and Gynecology
  • Jul. 1987Mar. 1988Hospital of Institute for Microbial Disease in Osaka University Medical Doctor for Gynecology
  • Sep. 1992Dec. 1992Suita Municipal Hospital Medical Doctor for Obstetrics and Gynecology
  • Feb. 1993Jun. 1995Imperial Cancer Research Fund, Tumour Virus Group Reseracher

Research Activities

Published Papers

  • Detection of HPV genotype in the cervicovaginal papilloma, Sumire YAMADA, Satoko FUJITA, Tsukasa YAMANOUCHI, Mayumi SAITO, Toshiyuki SASAGAWA, Japanese Journal of Sexually Transmitted Infections31:1-6Nov. 2020
  • Correlation between Human Papillomavirus Codetection Profiles and Cervical Intraepithelial Neoplasia in Japanese Women, (Okayama K), Kimura H, Teruya K, Ishii Y, Fujita K, Fujii M, Oda M, Sasagawa T, Okodo M, Microorganisms8:1863Nov. 2020
  • Therapeutic Effect of Dienogest in Patients with Chocolate Cysts, Hiroaki Takagi, Tsukasa Yamanouchi, Yoshihiko Saeki, Sumire Shimada, Emi Takata, Jinichi Sakamoto, Satoko Fujita, Masahiro Takakura, Toshiyuki Sasagawa, Journal of Kanazawa Medical University45:19-23Sep. 2020
  • Hemostatic effects of kyukikyogaito in dienogest treatment, Hiroaki Takagi, Sumire Yamada, Jinichi Sakamoto, Satoko Fujita, Toshiyuki Sasagawa, Clinical and Experimental Obstetrics & Gynecology47:560-564Aug. 2020
  • The prevalence of VAIN, CIN, and related HPV genotypes in Japanese women with abnormal cytology, Shitai Zhang, Mayumi Saito, Sumire Yamada, Jinichi Sakamoto, Masahiro Takakura, Hiroaki Takagi, Toshiyuki Sasagawa., Journal of Medical Virology92:364-371Mar. 2020
  • A Novel Liquid Biopsy Strategy to Detect Small Amounts of Cancer Cells Using Cancer-Specific Replication Adenoviruses, Takakura M, Takata E, Sasagawa T, Journal of Clinical Medicine9:4044Dec. 2020
  • Case report of large malignant pericardial effusion in a post-surgical setting of endometrial mixed carcinoma: A description of unique cytological, histological, and immunohistochemical findings, Seiya Mizuguchi, Akihiro Shioya, Toshiyuki Sasagawa , Sumire Yamada, Kenichi Mizutani, Nozomu Kurose, Sohsuke Yamada, SAGE Open Medical Case Reports8:2050313X20930919Jun. 2020
  • The promise of combining cancer vaccine and checkpoint blockade for treating HPV-related cancer, Takeo Shibata, Benjamin J Lieblong, Toshiyuki Sasagawa, Mayumi Nakagawa, Cancer Treatment Reviews78:8-16Aug. 2019
  • Adenosquamous carcinoma of the uterine cervix displaying tumor-associated tissue eosinophilia, Nozomu Kurose, Seiya Mizuguchi, Yoshiiku Ohkanemasa, Manabu Yamashita, Mariko Nakano, Xin Guo, Akane Aikawa, Satoko Nakada, Toshiyuki Sasagawa, Sohsuke Yamada, SAGE Open Medical Case Reports7:2050313X19828235Feb. 2019
  • Long-term treatment of endometriosis with dienogest for up to five years, Takagi H, Sakamoto J, Sasagawa T, Clinical and Experimental Obstetrics & Gynecology46:398-402Jun. 2019
  • Usefulness of the maximum standardized uptake value for the diagnosis and staging of patients with cervical cancer undergoing positron emission tomography/computed tomography, H.Takagi, J.Sakamoto, Y.Osaka, T.Shibata, S.Fujita, T.Sasagawa, Medicine97:e9856Feb. 2018
  • Utility of 18F-fluorodeoxyglucose-positron emission tomography in the differential diagnosis of benign and malignant gynaecological tumours, H.Takagi, J.Sakamoto, Y.Osaka, T.Shibata, S.Fujita and T.Sasagawa, Journal of medical imaging and radiation oncology62:471-479Aug. 2018
  • Malignant Transformation of an Ovarian Endometrioma during Endometriosis Treatment:A Case Report, H.Takagi, E.Takata, J.Sakamoto, S.Fujita, M.Takakura, T.Sasagawa, Case reports in obstetrics and gynecology4:6210172Sep. 2018
  • Comparison of the digene hybrid capture 2 and Roche cobas 4800 HPV tests for detection of CIN2+ in a referral population in Japan, T.Sasagawa, T.Maehama, Y.Osaka, J.Sakamoto, T.Shibata, S.Fujita, M.Takakura, Journal of medical virology90:972-980May 2018
  • Uniplex E6/E7 PCR method detecting E6 or E7 genes in 39 human papillomavirus types, Mitsuaki Okodo, Kaori Okayama, Koji Teruya, Toshiyuki Sasagawa, Journal of medical virology90:981-988May 2018
  • Association between 18F-fluorodeoxyglucose-PET/CT and grade of uterine endometrial carcinoma, H.Takagi, T.Sasagawa, T.Shibata, H.Minato, T.Takahashi, Taiwanese Journal of Obstetrics and Gynecology57:283-288Apr. 2018
  • Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan, J.Sakamoto, S.Kamiura, K.Okayama, M.Okodo, T.Shibata, Y.Osaka, S.Fujita, E.Takata, H.Takagi, M.Takakura, T.Sasagawa, Papillomavirus Res.6:46-51Dec. 2018
  • Myeloperoxidase in blood neutrophils during normal and abnormal menstrual cycles in women ofreproductive age, T.Shibata J.Sakamoto Y.Osaka N.Neyatani S.Fujita Y.Oka T.akagi H.Mori H.Fujita Y.Tanaka T.Sasagawa, Int J Lab Hematol39:169-174Apr. 2017
  • Myeloperoxidase in blood neutrophils during normal and abnormal menstrual cycles in women of reproductive age, T.Shibata, J.Sakamoto, Y.Osaka, N.Neyatani, S.Fujita, Y.Oka, H.Takagi, H.Mori, H.Fujita, Y.Tanaka, T.Sasagawa, International Journal of Laboratory Hematology39:169-174Dec. 2016
  • Human papillomavirus infection and pathogenesis in urothelial cells: a mini-review, (K.Shigehara), T.Sasagawa, M.Namiki, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.20:741-747Dec. 2014
  • Cytological evaluation using liquid-based cytology in the male urogenital tract infected with human papillomavirus, (K.Shigehara), T.Sasagawa, S.Kawaguchi, K.Nakashima, T.Nakashima, M.Shimamura, K.Furubayashi, M.Namiki, Diagnostic cytopathology.42:491-497Jun. 2014
  • HPV infection as an STI:a review of the prophylaxis and treatment of HPV-related diseases from an immunological point of view, T.Sasagawa, N.Yamaguchi, S.Fujita, H.Takagi, S.Makinoda25:27-362014
  • Detection of high-risk human papillomavirus subtypes in cervical glandular neoplasia by in situ hybridization., Z.Shang, H.Minato, T.Sasagawa, S.Nakada, E.Kinoshita, N.Kurose, T.Nojima, S.Makinoda, International journal of clinical and experimental pathology6:2168-2177Oct. 2013
  • Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi, Evidence-based complementary and alternative medicine : eCAM.2013,746486;1-10Mar. 2013
  • Role of Kampo medicine in integrative cancer therapy., J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi, Evidence-based complementary and alternative medicine : eCAM.2013:570848;1-6Mar. 2013
  • Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection, (K.Shigehara), S.Kawaguchi, T.Sasagawa, K.Furubayashi, M.Shimamura, Y.Maeda, H.Konaka, A.Mizokami, E.Koh, M.Namiki, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.17:487-492Apr. 2011
  • Etiological role of human papillomavirus infection for inverted papilloma of the bladder, (K.Shigehara), T.Sasagawa, J.Doorbar, S.Kawaguchi, Y.Kobori, T.Nakashima, M.Shimamura, Y.Maeda, T.Miyagi, Y.Kitagawa, Y.Kadono, H.Konaka, A.Mizokami, E.Koh, M.Namiki, Journal of medical virology.83:277-285Feb. 2011
  • Oral and cervical human papillomavirus infection among female sex workers in Japan, (K.Matsushita), T.Sasagawa, M.Miyashita, A.Ishizaki, A.Morishita, N.Hosaka, K.Saikawa, S.Hoshina, X.Bi, H.Ichimura, Japanese journal of infectious diseases.64:34-39Jan. 2011
  • Etiologic role of human papillomavirus infection in bladder carcinoma, (K.Shigehara), T.Sasagawa, S.Kawaguchi, T.Nakashima, M.Shimamura, Y.Maeda, H.Konaka, A.Mizokami, E.Koh, M.Namiki, Cancer117:2067-20762010
  • Koilocytic changes are not elicited by human papillomavirus genotypes with higher oncogenic potential, (Okodo M), Okayama K, Teruya K, Kimura H, Noji N, Ishii Y, Fujii M, Oda M, Sasagawa T, Journal of Medical Virology92:3766-3773Dec. 2020
  • Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed, Takeo Shibata, Sumit Shah, Teresa Evans, Hannah Coleman, Benjamin J. Lieblong, Horace J. Spencer, Charles M. Quick, Toshiyuki Sasagawa, Owen W. Stephens, Erich Peterson, Donald Johann, Yong-Chen Lu, Mayumi Nakagawa, Frontiers in Immunology12:1-13Sep. 2021
  • Evaluation of DNA extraction protocols from liquid-based cytology specimens for studying cervical microbiota, Takeo Shibata, Mayumi Nakagawa, Hannah N. Coleman, Sarah M. Owens, William W. Greenfield, Toshiyuki Sasagawa, Michael S. Robeson II, PLOS ONE16:1-24Aug. 2021
  • Profiles of Human Papillomavirus Detection of the Multinucleated Cells in Cervical Smears, (Okayama K), Sasagawa T, Teruya K, Oda M, Fujii M, Kimura H, Okodo M, Microorganisms9:1-8Jul. 2021
  • HPV Genotyping by Molecular Mapping of Tissue Samples in Vaginal Intraepithelial Neoplasia (VaIN) and Vaginal Squamous Cell Carcinoma (VaSCC), Shitai Zhang, Mayumi Saito, Kaori Okayama, Mitsuaki Okodo, Nozomu Kurose, Jinichi Sakamoto, Toshiyuki Sasagawa, Cancers (Basel)13:3260Jul. 2021
  • Effects of kyukikyogaito for menorrhagia and irregular uterine bleeding28:538-542Jul. 2021
  • Hemostatic effects of Orengedokuto in dienogest treatment37:66-70Mar. 2021
  • Comparison of Aptima and hybrid capture‐2 HPV tests and Pap test in the referral population in Japan, (Hiroko Kuroki), Jinichi Sakamoto, Takeo Shibata, Masahiro Takakura, Toshiyuki Sasagawa, Journal of Medical Virology93:5076-5083Feb. 2021
  • Evaluation of the clinical performance of noninvasive prenatal testing at a Japanese laboratory., Yuna Sasaki, Takahiro Yamada, Shiro Tanaka, Akihiko Sekizawa, Tatsuko Hirose, Nobuhiro Suzumori, Takashi Kaji, Satoshi Kawaguchi, Yasuyuki Hasuo, Haruki Nishizawa, Keiichi Matsubara, Haruka Hamanoue, Akimune Fukushima, Masayuki Endo, Masayuki Yamaguchi, Yoshimasa Kamei, Hideaki Sawai, Kiyonori Miura, Masaki Ogawa, Shinya Tairaku, Hiroaki Nakamura, Ayako Sanui, Masahito Mizuuchi, Yoko Okamoto, Michihiro Kitagawa, Yukie Kawano, Hisashi Masuyama, Jun Murotsuki, Hisao Osada, Ryuhei Kurashina, Osamu Samura, Mayuko Ichikawa, Rumi Sasaki, Kazuhisa Maeda, Yasuyo Kasai, Tomomi Yamazaki, Reiko Neki, Naoki Hamajima, Yukiko Katagiri, Shunichiro Izumi, Setsuko Nakayama, Norio Miharu, Yuko Yokohama, Masaya Hirose, Kosuke Kawakami, Kiyotake Ichizuka, Masakatsu Sase, Kohei Sugimoto, Takeshi Nagamatsu, Tomomi Shiga, Lena Tashima, Takeshi Taketani, Mariko Matsumoto, Hironori Hamada, Takafumi Watanabe, Tetsuya Okazaki, Sadahiko Iwamoto, Daisuke Katsura, Nobuo Ikenoue, Toshiyuki Kakinuma, Hiromi Hamada, Makiko Egawa, Atsushi Kasamatsu, Akinori Ida, Naohiko Kuno, Naoaki Kuji, Mika Ito, Hiroko Morisaki, Shinji Tanigaki, Hiromi Hayakawa, Akinori Miki, Shoko Sasaki, Makoto Saito, Naoki Yamada, Toshiyuki Sasagawa, Toshitaka Tanaka, Fumiki Hirahara, Shinji Kosugi, Haruhiko Sago, The journal of obstetrics and gynaecology research47:3437-34462021
  • Determination of human papillomavirus type in archival tissue specimens of invasive cervical cancer using molecular mapping and E6/E7-based polymerase chain reaction, Jinichi Sakamoto, Mayumi Saito, Shitai Zhang, Masahiro Takakura, Hiroaki Takagi, Toshiyuki Sasagawa, PLoS One17:e0265996Apr. 2022
  • A retrospective study of immunotherapy using the cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guérin (BCG-CWS) for cervical cancer, Takeo Shibata, Emi Takata, Jinichi Sakamoto, Akihiro Shioya, Sohsuke Yamada, Masahiro Takakura, Toshiyuki Sasagawa, Medicine101:e32481Dec. 2022

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