MAEDA Masayo

Researcher Profile & Settings

Research

Overview of research:
Rho guanine nucleotide dissociation inhibitors(RhoGDIs) regulate the activity of Rho family GTPases. Our studies have indicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis. Further investigation of the details of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to a better treatment for cancer.

Special Field

• Pathological medical chemistry

Education

• Kanazawa University Faculty of Pharmaceutical Science Pharmaceutical Sciences

Academic & Professional Experience

• Jul. 1989Kanazawa Medical University Research Associate
• Apr. 2007Kanazawa Medical University Senior Assistant Professor

Research Activities

Published Papers

• Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs, T.Ota, M.Maeda, M.Okamoto, M.Tatsuka, BMC Systems Biology, 9:3, 2015
  DOI:10.1186/s12918-015-0143-5
• Centrosomal localization of RhoGDIβ and its relevance to mitotic processes in cancer cells., Y.-S. Jiang, M.Maeda, M.Okamoto, M.Fujii, R.Fukutomi, M.Hori, M.Tatsuka, T.Ota, International journal of oncology, 42:460-468, Jan. 2013
• Activation of Rac1 by Rho-guanine nucleotide dissociation inhibitor-β with defective isoprenyl-binding pocket, T.Ota, M.Maeda, M.Murakami, T.Takegami, S.Suto, M.Tatsuka, Cell biology international., 31:92-96, Sep. 2006
• Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis, (M. Tatsuka), S. Sato, S. Kitajima, S. Suto, H. Kawai, M. Miyauchi, I. Ogawa, M. Maeda, T. Ota, T. Takata, Oncogene., 24:1122-1127, Feb. 2005
• LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane, *T.Ota, M.Maeda, et al., Molecular carcinogenesis, 39:206-220, 2004
• Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes ot chromosome number instability., OTA Takahide, S. Suto, H. Katayama, Z. B. Han, F. Suzuki, M. Maeda, M. Tanino, Y. Terada, M. Tatsuka, Cancer research., 62:5168-5177, 2002
• Cationic liposomes with plasmid DNA influence cancer metastatic capability, *T. Ota, M. Maeda, et al., Anticancer research., 22 : 4049-4052, 2002
• Functional suppression of integrin β4-mediated adhesion caused by in vivo sequential selection for cancer cell intravasation, T. Ota, M. Maeda, M. Tanino, M.Tatsuoka, Anticancer research., 21: 205-211, 2001
• Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh2, (M. Tatsuka), M. Maeda, T. Ota, Japanese journal of cancer research : Gann., 92: 1184-1189, 2001
• Decrease of metastatic ability after selection for intravasating ability in Lewis Lung Carcinoma(3LL)cell line., OTA Takahide, M. Maeda, M.Tatsuka, T. Matsui, M. Tanino, Cancer letters., 139:105-108, 1999
• G1 phase-specific suppressino of the Cdk2 activity by ginsenoside Rh2 in cultured murine cells., OTA Takahide, M. Maeda, S. Odashima, J. Ninomiya-Tsuji, M. Tatsuka, Life Science, 60:PL 39-44, 1997
• A BALB/c 3T3-transformed cell line suitable for transfection assay of metastasis-inducing genes., (M. Tatsuka), OTA Takahide, M. Maeda, M. Wada, N. Yamagishi, S. Taniguchi, M. Seiki, S. Odashima, International journal of cancer. Journal international du cancer., 71:88-93, 1997
• Inhibition of metastasis by a dialysable factor in fetal bovine serum in B16 melanoma cells., OTA Takahide, M. Maeda, T. Matsui, M. Tanino, S. Odashima, Cancer Letters, 110:201-205, 1996
• CD44 participates in the tumor cell adhesion to endothelial cells in the experimental metastatic process in B16BL6 melanoma cells., OTA Takahide, T. Matsui, M. Maeda, M. Tanino, S. Odashima, Anticancer research., 15:1215-1219, 1995
• Involvement of peanut agglutinin-binding sugar chains in experimental metastasis of B16 melanoma cells., OTA Takahide, M. Maeda, M. Tanino, S. Odashima, Oncology Research, 5:235-243, 1993
• Mechanism and action of ginsenoside Rh2 : Uptake and metabolism of ginsenoside Rh2 by cultured B16 melanoma cells., OTA Takahide, M. Maeda, S. Odashima, Journal of Pharmaceutical Sciences, 80:1141-1146, 1991