HIGUCHI Masaya

FacultyDepartment of Microbiology
PositionProfessor

Researcher Profile & Settings

Profile & Settings

    Birthday:  19681029

Contact

Research

    Overview of research:
    USP10 is a member of the ubiquitin specific peptidase family that we identified as a HTLV-I Tax interacting protein. USP10 is involved in many cellular stress responses such as DNA damage response, stress granules formation, and the regulation of metabolic pathway. We made USP10 KO mice and they show severe anemia due to the loss of hematopoietic stem cells. Thus, USP10 is an essential ubiquitinase for hematopoiesis.

Education

  • Tohoku University Graduate School Division of Medical Science

Degree

  • Ph.D in Medicine

Academic & Professional Experience

  • Apr. 2010Apr. 2016Niigata University Department of Medicine Associate Professor
  • Apr. 2006Mar. 2010Niigata University Department of Medicine Senior Assistant Professor
  • Jun. 2001Mar. 2006Niigata University Department of Medicine Assistant
  • Jun. 1998May 2001Harvard University Medical School Project Postdoctoral Fellow
  • Apr. 1997May 1998Japan Science and Technology Agency Project Postdoctoral Fellow

Research Activities

Research Areas

  • Medicine,dentistry, and pharmacy / Basic medicine / Functional analyses of a deubiquitinating enzyme USP10
    Hematology
    Research Project: Mechanism of the maintenance of hematopoietic stem and leukemia stem cells by a deubiquitinating enzyme USP10

Published Papers

  • USP10 is an essential deubiquitinase for hematopoiesis and inhibits apoptosis of long-term hematopoietic stem cells., M.Higuchi, H.Kawamura, H.Matsuki, T.Hara, M.Takahashi, S.Saito, K.Saito, S.Jiang, M.Naito, H.Kiyonari, M.Fujii, Stem Cell Reports7:1116-1129Dec. 2016
  • Induction of cell death in growing human T-cells and cell survival in resting cells in response to the human T-cell leukemia virus type 1 tax., (M.Mizuguchi), Y.Sasaki, T.Hara, M.Higuchi, Y.Tanaka, N.Funato, N.Tanaka, M.Fujii, M.Nakamura, PLoS One11:e0148217-e0148217Feb. 2016
  • Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB., (Y.Motai), M.Takahashi, T.Takachi, M.Higuchi, T.Hara, M.Mizuguchi, Y.Aoyagi, S.Terai, Y.Tanaka, M.Fujii, Virus Genes52:4-13Feb. 2016
  • Regulation of intracellular stress responses by the pleiotropic deubiquitinase USP1042:41-47Sep. 2017
  • Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer., (Yamawaki Kaoru);Ishiguro Tatsuya;Mori Yutaro;Yoshihara Kosuke;Suda Kazuaki;Tamura Ryo;Yamaguchi Masayuki;Sekine Masayuki;Kashima Katsunori;Higuchi Masaya;Fujii Masahiro;Okamoto Koji;Enomoto Takayuki, Cancer science108:632-6402017
  • USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis, (Masahiko Takahashi), Hiroki Kitaura, Akiyoshi Kakita, Taichi Kakihana, Yoshinori Katsuragi, Masaaki Nameta, Lu Zhang, Yuriko Iwakura, Hiroyuki Nawa, Masaya Higuchi, Masaaki Komatsu, Masahiro Fujii, iScience9:433-450Nov. 2018
  • MAGI‐1 expression is decreased in several types of human T‐cell leukemia cell lines, including adult T‐cell leukemia, (Takashi Kozakai), Masahiko Takahashi, Masaya Higuchi, Toshifumi Hara, Kousuke Saito, Yuetsu Tanaka, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Masahiro Fujii, International Journal of Hematology107:337-344Mar. 2018


Copyright (c) MEDIA FUSION Co.,Ltd. All rights reserved.