HIGUCHI Masaya

Researcher Profile & Settings

Profile & Settings

Birthday:  19681029

Contact

mhiguchi@med.niigata-u.ac.jp

Research

Overview of research:
USP10 is a member of the ubiquitin specific peptidase family that we identified as a HTLV-I Tax interacting protein. USP10 is involved in many cellular stress responses such as DNA damage response, stress granules formation, and the regulation of metabolic pathway. We made USP10 KO mice and they show severe anemia due to the loss of hematopoietic stem cells. Thus, USP10 is an essential ubiquitinase for hematopoiesis.

Education

• Tohoku University Graduate School Division of Medical Science

Degree

• Ph.D in Medicine

Academic & Professional Experience

• Apr. 2010- Apr. 2016Niigata University Department of Medicine Associate Professor
• Apr. 2006- Mar. 2010Niigata University Department of Medicine Senior Assistant Professor
• Jun. 2001- Mar. 2006Niigata University Department of Medicine Assistant
• Jun. 1998- May 2001Harvard University Medical School Project Postdoctoral Fellow
• Apr. 1997- May 1998Japan Science and Technology Agency Project Postdoctoral Fellow

Research Activities

Research Areas

• Medicine,dentistry, and pharmacy / Basic medicine / Functional analyses of a deubiquitinating enzyme USP10
  Hematology
  Research Project: Mechanism of the maintenance of hematopoietic stem and leukemia stem cells by a deubiquitinating enzyme USP10

Published Papers

• USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis, (Masahiko Takahashi), Hiroki Kitaura, Akiyoshi Kakita, Taichi Kakihana, Yoshinori Katsuragi, Masaaki Nameta, Lu Zhang, Yuriko Iwakura, Hiroyuki Nawa, Masaya Higuchi, Masaaki Komatsu, Masahiro Fujii, iScience, 9:433-450, Nov. 2018
• MAGI‐1 expression is decreased in several types of human T‐cell leukemia cell lines, including adult T‐cell leukemia, (Takashi Kozakai), Masahiko Takahashi, Masaya Higuchi, Toshifumi Hara, Kousuke Saito, Yuetsu Tanaka, Masayoshi Masuko, Jun Takizawa, Hirohito Sone, Masahiro Fujii, International Journal of Hematology, 107:337-344, Mar. 2018
• Regulation of intracellular stress responses by the pleiotropic deubiquitinase USP10, 42:41-47, Sep. 2017
• Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer., (Yamawaki Kaoru);Ishiguro Tatsuya;Mori Yutaro;Yoshihara Kosuke;Suda Kazuaki;Tamura Ryo;Yamaguchi Masayuki;Sekine Masayuki;Kashima Katsunori;Higuchi Masaya;Fujii Masahiro;Okamoto Koji;Enomoto Takayuki, Cancer science, 108:632-640, 2017
  DOI:10.1111/cas.13196
• USP10 is an essential deubiquitinase for hematopoiesis and inhibits apoptosis of long-term hematopoietic stem cells., M.Higuchi, H.Kawamura, H.Matsuki, T.Hara, M.Takahashi, S.Saito, K.Saito, S.Jiang, M.Naito, H.Kiyonari, M.Fujii, Stem Cell Reports, 7:1116-1129, Dec. 2016
  DOI:10.1016/j.stemcr.2016.11.003.
• Induction of cell death in growing human T-cells and cell survival in resting cells in response to the human T-cell leukemia virus type 1 tax., (M.Mizuguchi), Y.Sasaki, T.Hara, M.Higuchi, Y.Tanaka, N.Funato, N.Tanaka, M.Fujii, M.Nakamura, PLoS One, 11:e0148217-e0148217, Feb. 2016
  DOI:10.1371/journal.pone.0148217. eCollection 2016.
• Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB., (Y.Motai), M.Takahashi, T.Takachi, M.Higuchi, T.Hara, M.Mizuguchi, Y.Aoyagi, S.Terai, Y.Tanaka, M.Fujii, Virus Genes, 52:4-13, Feb. 2016
  DOI:doi: 10.1007/s11262-015-1277-7.
• Generation of a recombinant Saffold Virus expressing UnaG as a marker for the visualization of viral infection., Takako Okuwa, Tosiki Himeda, koichi Utani, Masaya Higuchi, 20:175, Aug. 2023
  DOI:10.1186/s12985-023-02142-8
• Theilovirus 3C Protease Cleaves the C-Terminal Domain of the Innate Immune RNA Sensor, Melanoma Differentiation-Associated Gene 5, and Impairs Double-Stranded RNA-Mediated IFN Response, (Masahiko Miyamoto), Toshiki Himeda, Kazuki Ishihara, Takako Okuwa, Daiki Kobayashi, Masaaki Nameta, Yu Karasawa, Benyapa Chunhaphinyokul, Yutaka Yoshida, Nobuyuki Tanaka, Masaya Higuchi, Akihiko Komuro, The Journal of Immunology, 210:335, Feb. 2023
  DOI:10.4049/jimmunol.2200565
• Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry, (Kanako Watanabe), Tomoichiro Oka, Hirotaka Takagi, Sergei Anisimov, Shun-ichi Yamashita, Yoshinori Katsurag, Masahiko Takahashi, Masaya Higuchi, Tomotake Kanki, Akihiko Saitoh, Masahiro Fujii, Nature Communications, 14:1817, Mar. 2023