Japanese

ONAI Nobuyuki

■Faculty	Department of Immunology
■Position	Professor

Researcher Profile & Settings

Profile & Settings

http://www.kanazawa-med.ac.jp/~serol/Immunology/Top_Page.html

Research

Overview of research:

Dendritic cells, monocytes and macrophages belong to mononuclear phagocyte system (MPS). These cells regulate immune response against pathogen and tissue hemostasis. Our group investigate the regulation of dendritic cell and macrophage development and tissue homeostasis.

Research Activities

Research Areas

Medicine,dentistry, and pharmacy

Published Papers

PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR, Toshiki Yabe-Wada , Caroline C Philpott, Nobuyuki Onai, FEBS open bio, 10:407-413, Mar. 2020
Crystal structure of the ligand-free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH, T. Yabe-Wada, S. Matsuba, M. Unno, N. Onai, FEBS Letters, 592:2647-2657, Aug. 2018
DOI:10.1002/1873-3468.13181
Commitment to dendritic cells and monocytes, (Toshiaki Ohteki), Shunsuke Kawamura, Nobuyuki Onai, International Immunology, 33:815-819, Dec. 2021
Detailed structure of mouse interferon α2 and its interaction with Sortilin, (Honoka Watanabe), Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno, The Journal of Biochemistry, 170:265-273, Aug. 2021
A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties, (Kamio N), Yokota A, Tokuda Y, Ogasawara C, Nakano M, Nagao M, Tashiro K, Maekawa T, Onai N, Hirai H, Journal of Immunology, 209:498-509, Aug. 2022
PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocytederived macrophages into the inflamed colon, Xinquan Yang, Toshiki Yabe-Wada, Jia Han, Fumiji Saito, Chie Ogasawara, Sohsuke Yamada, Nobuyuki Onai, International Immunology, 35:287-299, Jan. 2023
An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture., Shintaro Matsuba, Hiroki Ura, Fumiji Saito, Chie Ogasawara, Shigetaka Shimodaira, Yo Niida, Nobuyuki Onai, Frontiers in Immunology, 14:1264609, Oct. 2023

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.