KANDA Tsugiyasu

Researcher Profile & Settings

Research

Overview of research:
My major research is to investigate the therapeutic approach of cytokines in cardiovascular diseases including heart failure and cardiomyopathy. Until now, I tried interleukin-6, 8 and 10, moreover, TNF-α, lepton, adiponectin as therapeutic tools. I am using animal model of murine viral myocarditis, rat myocardial infarction and murine diabetes mellitus.

Special Field

• Cardioangiology
• Internal Medicine in General

Degree

• Ph.D in Medicine

Research Activities

Published Papers

• Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection., Higashikawa Toshihiro;Okuro Masashi;Ishigami Keiichirou;Mae Kunihiro;Sangen Ryusho;Mizuno Takurou;Usuda Daisuke;Saito Atushi;Kasamaki Yuji;Fukuda Akihiro;Saito Hitoshi;Morimoto Shigeto;Kanda Tsugiyasu, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 46:2606-2614, Jul. 2018
  DOI:10.1177/0300060518766640
• The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus., Higashikawa Toshihiro;Ito Tomohiko;Mizuno Takurou;Ishigami Keiichirou;Kohori Masaru;Mae Kunihiro;Sangen Ryusho;Usuda Daisuke;Saito Atsushi;Iguchi Masaharu;Kasamaki Yuji;Fukuda Akihiro;Saito Hitoshi;Kanda Tsugiyasu;Okuro Masashi, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 46:5117-5126, Dec. 2018
  DOI:10.1177/0300060518790870
• Atypical lipomatous tumor in the ligamentum teres of liver: A case report and review of the literature, Usuda Daisuke, Takeshima Kento, Sangen Ryusho, Nakamura Kisuke, Hayashi Kei, Okamura Hideyuki, Kawai Yasuhiro, Kasamaki Yuji, Iinuma Yoshitsugu, Saito Htoshi, Kanda Tsugiyasu, Urashima Sachio, World Journal of Clinical Cases, 6:548-553, Oct. 2018
  DOI:10.12998/wjcc.v6.i12.548
• Interleukin-18 as a diagnostic marker of adult-onset Still's disease in older patients: a case report and review of the literature., Usuda Daisuke, Furumura Yoshiki, Takeshima Kento, Sangen Ryusho, Kawai Yasuhiro, Kasamaki Yuji, Iinuma Yoshitugu, Kanda Tsugiyasu., Journal of medical case reports, 12:10.1186/s13256-018-1735-7., Jul. 2018
• Evaluation of B-type natriuretic peptide as prognostic marker in patients with pneumonia: An observational study, Daisuke Usuda , Yoshiki Furumura, Ryusho Sangen, Yu Hashimoto, Jun Kawamukai, Emiri Muranaka, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda, Internal Medicine Review, 4:1-28, Mar. 2018
• Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda, Journal Clinical Case Reports, 7:10001021　, 2017
  DOI:10.4172/2165-7920.10001021
• Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic erythroderma: a case report., Mizuno Takuro;Kiyosawa Jun;Fukuda Akihiro;Watanabe Seiji;Kurose Nozomu;Nojima Takayuki;Kanda Tsugiyasu, Journal of medical case reports, 11:35, 2017
  DOI:10.1186/s13256-016-1130-1
• Diagnosis of myxedema coma complicated by renal failure: a case report, Akiteru.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda, Clinical Case Reports, 5:399-402, Feb. 2017
  DOI:10.1002/ccr3.850
• Validation of a B-type natriuretic peptide as a prognostic marker in pneumonia patients: a prospective cohort study., D.Usuda, R.Sangen, Y.Hashimoto, E.Muranaka, Y.Iinuma, T.Kanda, BMJ open, 6:e010440-e010440, Feb. 2016
  DOI:10.1136/bmjopen-2015-010440
• Autopsy-proven intravascular lymphoma presenting as rapidly recurrent strokes, D.Usuda, M.Arahata, R.Temaru, Y.Iinuma, T.Kanda, S.Hayashi, Case reports in oncology, 9:148-153, Mar. 2016
  DOI:10.1159/000444632
• Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic elderly patients receiving antihypertensive treatment, T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda, S.Morimoto, Geriatrics Gerontology International, 16:365-373, Feb. 2015
• Implementation report of screening investigation of dementia for inhabitants of rural areas in Himi,Toyama, Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura, Y.Kawasaki, 39:67-74, Dec. 2014
• Endocardial invasion of lung cancer undiagnosable before autopsy, T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito, N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda, N.Takekoshi, T.Kanda, Case reports in oncology [electronic resource], 7:144-148, Mar. 2014
• Cardiac BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice, Rui Chen, Takuro Mizuno, T.Kanda, Internet J of Cardiovasc Res, 18;1617-1620, Aug. 2013
• Cardiac BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino, The Internet Journal of Cardiovascular Research, 8, 2013
• The anxiety and types of problems encountered by homecare patients during an intermittent self-catheterization, K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, 38(supplⅠ): 103-105, Dec. 2011
• A study of the goods supply system from hospital to outpatients with intermittent self-catheterization(ISC), S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji, 38(supplⅠ):109-111, Dec. 2011
• Self purchase of catheter supplies and the hardship associated with urinary homecare patients, Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji, 38(supplⅠ):106-108, Dec. 2011
• Two types of Brugada-like ST-elevation in patients with febrile infection, T.Mizuno, K.Ishigami, D. Sakamoto, R.Isahii, T.Kanda, 36:124-126, 2011
• Interleukin-6 expressing colon cancer with multiple hepatic metastases, A.Tempaku, T.Mizuno, M.Hasegawa, A.Saito, N.Yamashita, H.Atsumi, T.Ito, K.Ishigami, M.Miura, Y.Izumi, N.Kurose, H.Minato, T.Nojima, T.Kanda, N.Takekoshi, 36:106-110, 2011
• Hypernatremia, rhabdomyolysis and acute renal failure, K.Ishigami, N.Yamashita, K.Konishi, A.Saito, M.Fukura, M.Hasegawa, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi, N.Takekoshi, 35:68-69, Aug. 2010
• Clinical risk factors in regional brain ischemia using single photon emission computed tomography, R.Chen, F.Liang, K.Ishigami, T.Kanda, L.Zeng, A.Saito, M.Hasegawa, N.Yamashita, T.Itoh, T.Kigoshi, Y.Izumi, N.Takekoshi, S.Morimoto, Journal of the American Geriatrics Society., 58：1411-1412, Jul. 2010
• Hypoglycemia in elderly diabetes mellitus-free patients :Case reports and a review of literature, K.Konishi, A.Saito, K.Ishigami, M.Fukura, M.Hasegawa, N.Yamashita, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi, N.Takekoshi, 35:13-15, Jun. 2010
• The effects of a PPARα agonist on myocardial damage in obese diabetic mice with heart failure, R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda, International Heart Journal, 51:199-206, May. 2010
• Traditional chinese medicine for chronic fatigue syndrome, R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:3-10, Mar. 2010
• A Kampo medicine, boiogito, inhibits obesity in ovariectomized rats, J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:87-95, Jan. 2010
• Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:341-349, 2010
• Suicides in aged patients; Case reports and review of the literature, M.Fukura, A.Saito, K.Ishigami, K.Konishi, M.Hasegawa, JL.Wu, H.Kawahara, T.Kanda, T.Kigoshi, N.Takekoshi, 34:14-16, Jun. 2009
• Silent information regulator, sirtuin 1, and age-related diseases, L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto, Nature clinical practice. Rheumatology., 9:7-15, 2009
• Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, International journal of cardiology, 129:414-421, Nov. 2008
• Chronic fatigue syndrome and the central nervous system, R.Chen, FX.Liang, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi, The Journal of international medical research., 36:867-874, Sep. 2008
• A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor(vaspin),and obesity, Q.Li, R.Chen, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi, The Journal of international medical research., 36:625-629, Jul. 2008
• A large ovarian tumor mimicking the accumulation of ascites, J.Moriya, J.Yamakawa, R.Chen, H.Takagi, S.Makinoda, T.Takahashi, T.Kanda, 33:31-32, Jun. 2008
• Peroxisome proliferator-activated receptors(ppars) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?, R.Chen, F.Liang, J.Moriya, J.Yamakawa, T.Takahashi, L.Shen, T.Kanda, International journal of cardiology, 130:131-139, Mar. 2008
• Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda, Neurochemical research, 33:1759-1767, Mar. 2008
• Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats, K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto, Hypertension research : official journal of the Japanese Society of Hypertension., 31:977-986, 2008
• A kampo medicine, boi-ogi-to, inhibits obesity in ovariectomized rats, J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda, eCAM, 42013, Nov. 2007
• Relationship between brachial arterial endothelial function and lumber spine bone mineral density in postmenopausal women, (H.Sumino), S.Ichikawa, S.Kusama, T.Takahashi, H.Sakamoto, H.Kumakura, Y.Takayama, T.Kanda, M.Murakami, M.Kurabayashi, Circulation journal : official journal of the Japanese Circulation Society, 71:1555-1559, Oct. 2007
• Bariatric surgery for morbid obesity, R.Chen, T.Takahashi, T.Kanda, The New England journal of medicine, 357:1158-1160, Sep. 2007
• Reduced-energy diet improves survival of obses KKAy mice with viral myocarditis:induction of cardiac adiponectin expression, T.Kanda, S.Saegusa, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, International journal of cardiology, 119:310-318, Jul. 2007
• Prostate cancer producing carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki, 32：29-31, Jun. 2007
• Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression, S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy., 21:155-160, Jun. 2007
• Influenza Vaccines, T.Takahashi, T.Kanda, N.Yamaguchi, The New England journal of medicine, 356:1172-1173, Mar. 2007
• Acupuncture regulates leukocyte subpopulations in human peripheral blood, N.Yamaguchi, T.Takahashi, M.Sakuma, T.Sugita, K.Uchikawa, S.Sakaihara, T.Kanda, M.Arai, K.Kawakita, Evidence-based complementary and alternative medicine : eCAM., 4:447-453, Feb. 2007
• Acupuncture regulates leukocyte subpopulations in human peripheral blood, Nobuo Yamaguchi, Takashi Takahashi, Masahiro Sakuma, Toshiroh Sugita, Kumiko Uchikawa, Satoshi Sakaihara, Tsugiyasu Kanda, Matsuo Arai, Kenji Kawakita, Evidence-based complementary and alternative medicine : eCAM., 4:447-453, Feb. 2007
• Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly inpatients:effects of azelnidipine, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino, M.Matsumoto, Hypertension research : official journal of the Japanese Society of Hypertension., 29:943-949, Dec. 2006
• Angiotensin Ⅰ-converting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans, M.Okuro, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, H.Murai, K.Iwai, T.Kanda, Hypertension research : official journal of the Japanese Society of Hypertension., 29:655-663, Sep. 2006
• Advanced oesophageal carcinoma in an 84- year-old treated with chemoradiotherapy, K.Kusaka, T.Itoh, K.Kawaura, J.Moriya, J.Yamakawa, T.Takahashi, M.Oguchi, H.Tonami, I.Yamamoto, T.Kanda, The Journal of international medical research., 34:437-440, Jul. 2006
• Expression of ephrin in retinal neovascularization and iris rubeosis, (T.Yuuki), T.Kanda, S.Kishi, The Journal of international medical research., 34:485-494, Jun. 2006
• Traditional chinese medicine and kampo: a review from the distant past for the future, F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda, The Journal of international medical research., 34:231-239, May. 2006
• Angiotensin-Ⅱ receptor antagonist alleviates non-alcoholic fatty liver in kkay obese mice with type2 diabetes, F.Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, H.Sumino, S.Morimoto, T.Kanda, The Journal of international medical research., 34:297-302, May. 2006
• Elevated arterial stiffness in postmenopausal women with osteoporosis, (H.Sumino), S.Ichikawa, S.Kasama, T.Takahashi, H.Kumakura, Y.Takayama, T.Kanda, T.Sakamaki, M.Kurabayashi, Maturitas, 55:212-218, Feb. 2006
• Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women, (H.Sumino), S.Ichikawa, S.Kasama, T.Takahashi, H.Kumakura, Y.Takayama, T.Kanda, M.Kurabayashi, Atherosclerosis., 189:436-442, Feb. 2006
• Conjugated estrogen plus medroxyprogesterone does not impair blood rheological properties in hypertensive postmenopausal women, (H.Sumino), S.Ichikawa, T.Takahashi, H.Sakamoto, K.Goto-Onozato, S.Koya, T.Kanda, M.Nara, K.Seki, M.Murakami, M.Kurabayashi, Maturitas, 53:306-314, Feb. 2006
• Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis, T.Takahashi, F.Yu, S.Saegusa, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Kurabayashi, T.Kanda, International Heart Journal, 47:107-123, Jan. 2006
• Beneficial effect of brewers' yeast extract on daily activity in a murine model o f chronic fatigue syndrome, T.Takahashi, Y.Fei, Z.Shi-jie, J.Moriya, H.Sumino, S.Morimoto, N.Yamaguchi, T.Kanda, eCAM, 3:109-115, Jan. 2006
• Effect of interleukin-18 on viral myocarditis : enhancement of interferon-gamma and natural killer cell activity, KANDA Tsugiyasu, Journal of Molecular and Cellular Cardiology, 2000
• Induction of virus-induced IDOM in virus resistant mice without lymphocyte maturation, KANDA Tsugiyasu, Life Sciences, 1998
• Modification of viral myocarditis in mice by lnterleukin-6, KANDA Tsugiyasu, Circulation Research, 1996
• Interleukin-8 as a sensitive marker of unstable coronary artery disease, KANDA Tsugiyasu, The American Journal of Cardiology, 1996
• Interleukin-6 secreted from human myxoma reduces murine viral myocarditis, KANDA Tsugiyasu, Lefe Sciences, 1996
• Myocardial uptake of an iodinated branched fatty acid analog assessing SPECT, may detect metabolic derangement of the myocardium in diabetic patients with coronary heart disease, KANDA Tsugiyasu, Cardiology, 1995
• False positive activated protein C sensitivity ratio caused by freezing and contamination of plasma with platelets, KANDA Tsugiyasu, Therapeutic Research, 1995
• Chronic effect of losartan in a murine model of dilated cardiomyopathy : Comparison with captopril, KANDA Tsugiyasu, Journal of Pharmacology and Experimental Therapeutics, 1995
• Myocardial beta-receptor and cardiac angiotensin alterations during the acute and chronic phases of viral myocarditis, KANDA Tsugiyasu, European Heart Journal, 1994
• Interleukin-6 and cardiacmytoma, KANDA Tsugiyasu, American Journal of Cardiology, 1994
• Holter monitoring as a noninvasive indicator of cardiac involvement in sarcoidosis, KANDA Tsugiyasu, Chest, 1994
• Dexamethasone inhibits production of interleukin-6 by cultured cardiac myxoma cells, KANDA Tsugiyasu, American Heart Journal, 1994
• Myocardial atrial natriuretic factor gene expression after coronary ligation in rats, KANDA Tsugiyasu, Experimental and clinical Endocrinology, 1993
• Enhancement of myocardial damage and alteration of lymphocyte subsets in murine model of postpartum myocarditis, KANDA Tsugiyasu, American Journal of Cardiovascular, 1993
• The alpha and alpha 2 domains of H-2 class I molecules interact to form unique epitopes, KANDA Tsugiyasu, Immunogenetics, 1987
• Urinary retention as a postoperative complication associated with functional decline in elderly female patients with femoral neck and trochanteric fractures A retrospective study of a patient cohort, Higashikawa Toshihiro, Shigemoto Kenji, Goshima Kenichi, Usuda Daisuke, Okuro Masashi, Moriyama Manabu, Inujima Hiromi, Hangyou Masahiro, Usuda Kimiko, Morimoto Shigeto, Matsumoto Tadami, Takashima Shigeki, Kanda Tsugiyasu, Sawaguchi Takeshi, MEDICINE, 98:e16023, Jun. 2019
  DOI:10.1097/MD.0000000000016023
• New score including daily life independence levels with dementia is associated with the onset of deep vein thrombosis in frail older adults, Keisuke Nakanishi, Tsugiyasu Kanda, Takashi Kobata, Masayuki Mori, Shinya Yamada, Yuji Kasamaki, Geriatrics & Gerontology International, 20:414-421, May. 2020