SHIMASAKI Takeo

■FacultyDepartment of Advanced Medicine, Division of Systems Bioscience for Drug Discovery Based on Intrinsically Disordered Proteins, Medical Research Institute, Department of Gastroenterological Endoscopy
■PositionAssociate Professor

Researcher Profile & Settings

Research

    Overview of research:
    Bioinfomatics

Education

  • Kanazawa University Graduate School

Degree

  • Ph.D in Medicine

Research Activities

Published Papers

  • Influence of MIF polymorphisms on CpG island hyper-methylation of CDKN2A in the patients with ulcerative colitis, Naoko Sakurai, Tomoyuki Shibata, Masakatsu Nakamura, Hikaru Takano, Tasuku Hayashi, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa, BMC Medical Genetics, 21:201, Oct. 2020
  • Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa, Takano Hikaru, Shibata Tomoyuki, Nakamura Masakatsu, Sakurai Naoko, Hayashi Tasuku, Ota Masafumi, Nomura-Horita Tomoe, Hayashi Ranji, Shimasaki Takeo, Otsuka Toshimi, Tahara Tomomitsu, Arisawa Tomiyasu, BMC Medical Genetics, 21:205, Oct. 2020
  • A Case of Severe Duodenitis in an Adult Patient with Hyper IgESyndrome, Tomoe Nomura-Horita, Tasuku Hayashi, Toshimi Otsuka, Naoko Sakurai, Hikaru Takano, Masafumi Ota, Ranji Hayashi, Takeo Shimasaki, Masakatsu Nakamura, Sohsuke Yamada, Takashi Mochizuki, Tomiyasu Arisawa, Japanese Journal of Gastroenterology and Hepatology, 4:1-3, Jul. 2020
  • Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan, Wu Jing, Otsuka T, Nakamura M, Sakurai N, Takano H, Hayashi T, Ota M, Nomura T, Hayashi R, Shimasaki T, Tahara T, Shibata T, Arisawa T, ONCOLOGY LETTERS, 17:3482-3488, Mar. 2019
  • Exosome Research and Co-culture Study, Takeo.Shimasaki, Satoko.Yamamoto, Tomiyasu.Arisawa, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 41:1311-1321, Sep. 2018
  • Polymorphism rs7521584 in miR-429 is associated with the severity of atrophic gastritis in patients with Helicobacter pylori infection, Toshimi Otsuka,Tomomitu Tahara,Masakatsu Nakamura, Wu Ging,Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Takeo Shimasaki, Tomoyuki Shibata, Tomiyasi Arisawa, Molecular Medicine Reports, 18:2381-2386, Aug. 2018
  • Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility, Masafumi Ota,Tomomitu Tahara, Toshimi Otsuka, Wu Jing,Tomoe Nomura,Ranji Hayashi,Takeo Shimasaki,Masakatsu Nakamura,Tomoyuki Shibata,Tomoyasu Arisawa, ONCOLOGY LETTERS, 15:3772-3778, Mar. 2018
  • Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan, Arisawa, Tomiyasu;Nakamura, Masakatsu;Otsuka, Toshimi;Jing, Wu;Sakurai, Naoko;Takano, Hikaru;Hayashi, Tasuku;Ota, Masafumi;Nomura, Tomoe;Hayashi, Ranji;Shimasaki, Takeo;Tahara, Tomomitsu;Shibata, Tomoyuki, WORLD JOURNAL OF GASTROENTEROLOGY, 23:5364-5370, Aug. 2017
  • Identification and functional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto, Suizo, 31:76-84, 2016
  • Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry, 413:155-164, 2016
  • Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy., (T.Domoto), Pyko Ilya V, T.Furuta, K.Miyashita, M.Uehara, T.Shimasaki, M.Nakada, T.Minamoto, Cancer science, 107:1363-1372, 2016
  • Long-term administration and efficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and the GSTP1 polymorphism., (H.Kitade), T.Shimasaki, S.Igarashi, H.Sakuma, M.Mori, N.Tomosugi, M.Nakai, Oncology letters, 7:1499-1502, May 2014
  • The *1244A>G polymorphism of MyD88(rs7744)is closely associated with susceptibility to ulcerative colitis, K.Matsunaga, T.Tahara, H.Shiroeda, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata, T.Arisawa, Molecular medicine reports., 9:28-32, Jan. 2014
  • Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy., (A.Kitano), T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai, K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto, PloS one, 8:e55289;1-12, Feb. 2013
  • Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity., N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna, Y.Motoo, Molecular and clinical oncology., 1:100-104, Jan. 2013
  • Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer., T.Arisawa, T.Tahara, H.Shiroeda, K.Yamada, T.Nomura, H.Yamada, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata, Oncology reports., 30:3013-3019, 2013
  • Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi, Experimental biology and medicine (Maywood, N.J.), 238:889-897, 2013
  • Characterization of proteins secreted by pancreatic cancer cells with anticancer drug treatment in vitro, T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi, Oncology reports., 28:1968-1976, Dec. 2012
  • A case of colon cancer with chronic renal dysfunction responding to effective retreatment with FOLFIRI., 39:1267-1270, Aug. 2012
  • The anxiety and types of problems encountered by homecare patients during an intermittent self-catheterization, K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, 38(supplⅠ): 103-105, Dec. 2011
  • A study of the goods supply system from hospital to outpatients with intermittent self-catheterization(ISC), S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji, 38(supplⅠ):109-111, Dec. 2011
  • Self purchase of catheter supplies and the hardship associated with urinary homecare patients, Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji, 38(supplⅠ):106-108, Dec. 2011
  • A Case of primary cardiac angiosarcoma associated with cardiac tamponade, N.Nakaya, I.Sato, T.Shimasaki, H.Nakajima, N.Kurose, T.Nojima, Y.Motoo, 38:1353-1355, Aug. 2011
  • Metabolic disorder, inflammation, and deregulated molecular pathways converging in pancreatic cancer development: Implications for new therapeutic strategies, Y.Motoo, T.Shimasaki, Y.Ishigaki, H.Nakajima, K.Kawakami, T.Minamoto, Cancers, 3:446-460, Jan. 2011
  • Human SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer PANC-1 cells, (QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo, Pancreas., 40:55-60, Jan. 2011
  • Scanning electron microscopy with an ionic liquid reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami, H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa, Microscopy research and technique, 74:1024-1031, 2011
  • Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses after dpwmstaging with S-1 monotherapy, I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo, 37:1341-1344, Jul. 2010
  • Molecular analysis on responses of TP53INP1-knockout mouse embryonic fibroblasts to anti-cancer agents, (Q.Bian), Y.Motoo, H.Nakajima, T.Shimasaki, Y.Ishigaki, 125-128, 2010
  • Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010
  • An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta., (K.Miyashita), M.Nakada, K.Shakoori, Y.Ishigaki, T.Shimasaki, Y.Motoo, Kawakami K, T.Minamoto, Anti-cancer agents in medicinal chemistry, 9:1114-1122, Dec. 2009
  • Deregulated GSK3β Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase, (W.Mai), K.Kawakami, A.Shakoori, S.Kyo, K.Miyashita, K.Yokoi, M.Jin, T.Shimasaki, Y.Motoo, T.Minamoto, Clinical cancer research : an official journal of the American Association for Cancer Research., 15：6810-6819, Nov. 2009
  • Apoptosis-related gene expression profile is changed by gemcitabine in pancreatic cancer cell line(PANC-1), T.Shimasaki, Y.Ishigaki, T.Minato, Y.Motoo, 22:14-20, Mar. 2007
  • MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa, Tasuku Hayashi, Tomoyuki Shibata, Masakatsu Nakamura, Naoko Sakurai, Hikaru Takano, Masafumi Ota, Tomoe Nomura-Horita, Ranji Hayashi, Takeo Shimasaki, Toshimi Ostuka, Tomomitsu Tahara, Tomiyasu Arisawa, GENETIC TESTING AND MOLECULAR BIOMARKERS, 25:255-262, 2021
  • Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate, Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T., micromachines, 12:1431, Nov. 2021
  • A morphological study of adipose-derived stem cell sheets created with temperature-responsive culture dishes using scanning electron microscopy, Yasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, Hironori Kitajima, Ikuhiro Tanida, Takashi Takaki, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara, Medical Molecular Morphology, 55:187-198, Sep. 2022