Late-onset Hypertension Is Associated with Improved Clinical Outcomes in Cancer Patients Treated with Sunitinib, (Kadowaki H), Ishida J, Shindo A, Ueda T, Yagi H, Umei M, Matsuoka R, Okamura S, Liu Q, Sato Y, Kume H, Takeda N, Komuro I, Akazawa H, Circulation Reports, 8:1326-1336, 2026年08月
Multiple saccular aneurysm formation in a patient with bilateral coronary artery fistula: a case report and review of the literature, (Takahashi M), Sekiguchi H, Fujikawa H, Mizuno O, Akazawa H, Kuroki S, Ikeda U, Shimada K, Cardiology, 86:174-176, 1995年
Plasma endothelin-1 levels in Takayasu's arteritis, (Akazawa H), Ikeda U, Kuroda T, Shimada K, Cardiology, 87:303-305, 1996年07月
Hypercoagulable state in patients with Takayasu's arteritis, (Akazawa H), Ikeda U, Yamamoto K, Kuroda T, Shimada K, Thrombosis and Haematostasis, 75:712-716, 1996年05月
Plasma cytokine levels in cardiac chambers of patients with mitral stenosis with congestive heart failure, (Ikeda U), Yamamoto K, Akazawa H, Hojo Y, Ohkawa F, Fujikawa H, Sekiguchi H, Shimada K, Cardiology, 87:476-480, 1996年11月
Molecular cloning and characterization of human cardiac homeobox gene CSX1, (Shiojima I), Komuro I, Mizuno T, Aikawa R, Akazawa H, Oka T, Yamazaki T, Yazaki Y, Circulation Research, 79:920-929, 1996年11月
Specific heart muscle disease associated with glycogen storage disease type III: clinical similarity to the dilated phase of hypertrophic cardiomyopathy, (Akazawa H), Kuroda T, Kim S, Mito H, Kojo T, Shimada K, European Heart Journal, 18:532-533, 1997年03月
Malignant hyperthermia induced by general anesthesia for bone marrow harvesting, (Hosoya N), Miyagawa K, Mimura T, Hoshide S, Akazawa H, Kanda Y, Takahashi N, Hirai H, Maekawa K, Yazaki Y, Bone Marrow Transplantation, 19:509-511, 1997年03月
Autoregulation of human cardiac homeobox gene CSX1: mediation by the enhancer element in the first intron, (Oka T), Komuro I, Shiojima I, Hiroi Y, Mizuno T, Aikawa R, Akazawa H, Yamazaki T, Yazaki Y, Heart and Vessels, Suppl 12:10-14, 1997年
Right ventricular dysplasia with complete atrioventricular block: necessity and limitation of left ventricular epicardial pacing, (Akazawa H), Ikeda U, Minezaki KK, Hayashi Y, Kuroki S, Shimada K, Clinical Cardiology, 21:604-606, 1998年08月
Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4, (Shiojima I), Komuro I, Oka T, Hiroi Y, Mizuno T, Takimoto E, Monzen K, Aikawa R, Akazawa H, Yamazaki T, Kudoh S, Yazaki Y, Journal of Biological Chemistry, 274:8231-8239, 1999年03月
Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation, (Akazawa H), Komuro I, Sugitani Y, Yazaki Y, Nagai R, Noda T, Genes to Cells, 5:499-513, 2000年06月
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease, (Zhu W), Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I, Journal of Biological Chemistry, 275:35291-35296, 2000年11月
Reactive oxygen species in mechanical stress-induced cardiac hypertrophy, (Aikawa R), Nagai T, Tanaka M, Zou Y, Ishihara T, Takano H, Hasegawa H, Akazawa H, Mizukami M, Nagai R, Komuro I, Biochemical and Biophysical Research Communications, 289:901-907, 2001年12月
Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation, (Monzen K), Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, Ishii S, Yazaki Y, Nagai R, Komuro I, Journal of Cell Biology, 153:687-698, 2001年05月
Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene, (Hasegawa S), Sato T, Akazawa H, Okada H, Maeno A, Ito M, Sugitani Y, Shibata H, Miyazaki J, Katsuki M, Yamauchi Y, Yamamura Ki K, Katamine S, Noda T, Proceedings of the National Academy of Sciences of the United States of America, 99:297-302, 2002年01月
Integrins play a critical role in mechanical stress-induced p38 MAPK activation, (Aikawa R), Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R, Komuro I, Hypertension, 39:233-238, 2002年02月
Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload, (Takimoto E), Yao A, Toko H, Takano H, Shimoyama M, Sonoda M, Wakimoto K, Takahashi T, Akazawa H, Mizukami M, Nagai T, Nagai R, Komuro I, FASEB Journal, 16:373-378, 2002年03月
Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart, (Toko H), Zhu W, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I, Journal of Biological Chemistry, 277:24735-24743, 2002年07月
Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats, (Zou Y), Yamazaki T, Nakagawa K, Yamada H, Iriguchi N, Toko H, Takano H, Akazawa H, Nagai R, Komuro I, Hypertension Research, 25:117-124, 2002年01月
Molecular and cellular mechanisms of mechanical stress-induced cardiac hypertrophy, (Zou Y), Takano H, Akazawa H, Nagai T, Mizukami M, Komuro I, Endocrine Journal, 49:1-13, 2002年02月
Inhibitory molecules in signal transduction pathways of cardiac hypertrophy, (Takano H), Zou Y, Akazawa H, Toko H, Mizukami M, Hasegawa H, Asakawa M, Nagai T, Komuro I, Hypertension Research, 25:491-498, 2002年07月
Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes, (Monzen K), Zhu W, Kasai H, Hiroi Y, Hosoda T, Akazawa H, Zou Y, Hayashi D, Yamazaki T, Nagai R, Komuro I, Biochemical and Biophysical Research Communications, 298:493-500, 2002年11月
Too much Csx/Nkx2-5 is as bad as too little?, (Akazawa H), Komuro I, Journal of Molecular and Cellular Cardiology, 35:227-229, 2003年03月
Stretch-modulation of second messengers: effects on cardiomyocyte ion transport, Kudoh S, Akazawa H, Takano H, Zou Y, Toko H, Nagai T, Komuro I, Progress in Biophysics and Molecular Biology, 82:57-66, 2003年05月
Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes, (Iijima Y), Nagai T, Mizukami M, Matsuura K, Ogura T, Wada H, Toko H, Akazawa H, Takano H, Nakaya H, Komuro I, FASEB Journal, 17:1361-1363, 2003年07月
Pleiotropic Effects of Cytokines on Acute Myocardial Infarction: G-CSF as A Novel Therapy for Acute Myocardial Infarction, (Takano H), Ohtsuka M, Akazawa H, Toko H, Harada M, Hasegawa H, Nagai T, Komuro I, Current Pharmaceutical Design, 9:1121-1127, 2003年
Roles of cardiac transcription factors in cardiac hypertrophy, (Akazawa H), Komuro I, Circulation Research, 92:1079-1088, 2003年05月
Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction, (Zou Y), Takano H, Mizukami M, Akazawa H, Qin Y, Toko H, Sakamoto M, Minamino T, Nagai T, Komuro I, Circulation, 108:748-753, 2003年08月
Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases, (Takano H), Zou Y, Hasegawa H, Akazawa H, Nagai T, Komuro I, Antioxidants & Redox Signaling, 5:789-794, 2003年12月
Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury, (Zou Y), Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I, Circulation, 108:3024-3030, 2003年12月
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes, (Matsuura K), Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, Sano M, Toko H, Akazawa H, Sato T, Nakaya H, Kasanuki H, Komuro I, Journal of Biological Chemistry, 279:11384-11391, 2004年03月
Role of Na(+)-Ca(2+) exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na(+)-Ca(2+) exchanger knockout mouse model, (Ohtsuka M), Takano H, Suzuki M, Zou Y, Akazawa H, Tamagawa M, Wakimoto K, Nakaya H, Komuro I, Biochemical and Biophysical Research Communications, 314:849-853, 2004年02月
Direct measurement of Ca(2+) concentration in the SR of living cardiac myocytes, (Kasai H), Yao A, Oyama T, Hasegawa H, Akazawa H, Toko H, Nagai T, Kinugawa K, Kohmoto O, Maruyama K, Takahashi T, Nagai R, Miyawaki A, Komuro I, Biochemical and Biophysical Research Communications, 314:1014-1020, 2004年02月
A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5, (Akazawa H), Kudoh S, Mochizuki N, Takekoshi N, Takano H, Nagai T, Komuro I, Journal of Cell Biology, 164:395-405, 2004年02月
Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization, (Ohtsuka M), Takano H, Zou Y, Toko H, Akazawa H, Qin Y, Suzuki M, Hasegawa H, Nakaya H, Komuro I, FASEB Journal, 18:851-853, 2004年05月
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II, (Zou Y), Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I, Nature Cell Biology, 6:499-506, 2004年06月
Diphtheria toxin-induced autophagic cardiomyocyte death plays a pathogenic role in mouse model of heart failure, (Akazawa H), Komazaki S, Shimomura H, Terasaki F, Zou Y, Takano H, Nagai T, Komuro I, Journal of Biological Chemistry, 279:41095-41103, 2004年09月
Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle, (Matsuura K), Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I, Journal of Cell Biology, 167:351-363, 2004年10月
Cardiac transcription factor Csx/Nkx2-5; its role in cardiac development and diseases, (Akazawa H), Komuro I, Pharmacology & Therapeutics, 107:252-268, 2005年08月
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes, (Harada M), Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi JI, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I, Nature Medicine, 11:305-311, 2005年03月
Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling, (Naito AT), Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I, Circulation Research, 97:144-151, 2005年07月
Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia, (Urano A), Endoh M, Wada T, Morikawa Y, Itoh M, Kataoka Y, Taki T, Akazawa H, Nakajima H, Komuro I, Yoshida N, Hayashi Y, Handa H, Kitamura T, Nosaka T, Molecular and Cellular Biology, 25:6834-6845, 2005年08月
Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization, (Tateno K), Minamino T, Toko H, Akazawa H, Shimizu N, Takeda S, Kunieda T, Miyauchi H, Oyama T, Matsuura K, Nishi J, Kobayashi Y, Nagai T, Kuwabara Y, Iwakura Y, Nomura Y, Saito Y, Komuro I, Circulation Research, 98:1194-1202, 2006年05月
A novel mechanism of mechanical stress-induced hypertrophy, (Akazawa H), Zou Y, Komuro I, Novartis Foundation Symposium, 274:20-31, 2006年
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis, (Naito AT), Shiojima I, Akazawa H, Hidaka K, Morisaki T, Kikuchi A, Komuro I, Proceedings of the National Academy of Sciences of the United States of America, 103:19812-19817, 2006年12月
Coronary aneurysm reduced after coronary stenting, (Ohtsuka M), Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Funabashi N, Kobayashi Y, Shiojima I, Komuro I, International Journal of Cardiology, 121:76-77, 2007年09月
Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo, (Oyama T), Nagai T, Wada H, Naito AT, Matsuura K, Iwanaga K, Takahashi T, Goto M, Mikami Y, Yasuda N, Akazawa H, Uezumi A, Takeda S, Komuro I, Journal of Cell Biology, 176:329-341, 2007年01月
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload, (Sano M), Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I, Nature, 446:444-448, 2007年03月
Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice, (Yamamoto R), Akazawa H, Ito K, Toko H, Sano M, Yasuda N, Qin Y, Kudo Y, Sugaya T, Chien KR, Komuro I, Circulation Journal, 71:1958-1964, 2007年12月
A novel mechanism of mechanical stress-induced angiotensin II type 1 receptor activation without the involvement of angiotensin II, (Yasuda N), Akazawa H, Qin Y, Zou Y Komuro I, Naunyn-Schmiedeberg's Archives of Pharmacology, 377:393-399, 2008年06月
Takayasu arteritis evaluated by multi-slice computed tomography in an old man, (Fujita T), Ohtsuka M, Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Takano H, Nakaya H, Komuro I, International Journal of Cardiology, 125:286-287, 2008年04月
Abdominal aortic pseudoaneurysm caused by prolonged methicillin-resistant Staphylococcus aureus sepsis, (Utsumi T), Ohtsuka M, Uchida E, Yamaguchi H, Nakajima T, Akazawa H, Takano H, Nakaya H, Komuro I, International Journal of Cardiology, 128:294-295, 2008年08月
Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation, (Yasuda N, Miura S, Akazawa H, Tanaka T, Qin Y, Kiya Y, Imaizumi S, Fujino M, Ito K, Zou Y, Fukuhara S, Kunimoto S, Fukuzaki K, Sato T, Ge J, Mochizuki N, Nakaya H, Saku K, Komuro I, EMBO Reports, 9:179-186, 2008年02月
Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations, (Ajima R), Akazawa H, Kodama M, Takeshita F, Otsuka A, Kohno T, Komuro I, Ochiya T, Yokota J, Genes to Cells, 13:987-999, 2008年10月
“Change Can Happen” by PKA: Proteasomes in in vivo Hearts, (Akazawa H), Komuro I, Journal of Molecular and Cellular Cardiology, 46:445-447, 2009年04月
Mechanisms and functions of agonist-independent activation in the angiotensin II type 1 receptor, (Akazawa H), Yasuda N, Komuro I, Molecular and Cellular Endocrinology, 302:140-147, 2009年04月
PDK1 coordinates survival pathways and -adrenergic response in the heart, (Ito K), Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I, Proceedings of the National Academy of Sciences of the United States of America, 106:8689-8694, 2009年05月
Multivalent ligand-receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation, (Qin Y), Yasuda N, Akazawa H, Ito K, Kudo K, Liao CH, Yamamoto R, Miura S, Saku K, Komuro I, Hypertension Research, 32:875-883, 2009年10月
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts, (Liao CH), Akazawa H, Tamagawa M, Ito K, Yasuda N, Kudo Y, Yamamoto R, Ozasa Y, Fujimoto M, Wang P, Nakauchi H, Nakaya H, Komuro I, Journal of Clinical Investigation, 120:242-253, 2010年01月
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload, (Shimizu I), Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I, Journal of Clinical Investigation, 120:1506-1514, 2010年05月
Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury, (Naito AT), Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I, Circulation Research, 106:1692-1702, 2010年06月
Assessment of inverse agonism for the angiotensin II type 1 receptor, (Akazawa H), Yasuda N, Miura S, Komuro I, Methods in Enzymology, 485:25-35, 2010年
Navigational error in the heart leads to premature ventricular excitation, (Akazawa H), Komuro I, Journal of Clinical Investigation, 121:513-516, 2011年02月
Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus, (Yamamoto R), Akazawa H, Fujihara H, Ozasa Y, Yasuda N, Ito K, Kudo Y, Qin Y, Ueta Y, Komuro I, Journal of Biological Chemistry, 286:21458-21465, 2011年06月
Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy, (Zou Y), Liang Y, Zhou N, Ma H, Guan A, Gong H, Sun A, Wang P, Niu Y, Jiang H, Takano H, Toko H, Yao A, Takeshima H, Akazawa H, Shiojima I, Wang Y, Komuro I, Ge J, Hypertension, 58:1099-1110, 2011年12月
A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure, (Fukushima N), Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Yamato M, Okano T, Kasanuki H, Hagiwara N, Komuro I, PLoS One, 6:e27901, 2011年12月
Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes, (Iwashita M), Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T, American Journal of Physiology-Endocrinology and Metabolism, 302:E286-E296, 2012年02月
Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice, (Yasuda N), Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Paradis P, Nemer M, Komuro I, Hypertension, 59:627-633, 2012年03月
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes, (Naito AT), Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I, Cell, 149:1298-1313, 2012年06月
ARB and Cardioprotection, (Akazawa H), Yabumoto C, Yano M, Kudo-Sakamoto Y, Komuro I, Cardiovascular Drugs and Therapy, 27:155-160, 2013年04月
Angiotensin II type 1 and type 2 receptor-induced cell signaling, (Akazawa H), Yano M, Yabumoto C, Kudo-Sakamoto Y, Komuro I, Current Pharmaceutical Design, 19:2988-2995, 2013年01月
Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system, (Yoshizawa T), Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang,L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T, Hypertension, 61:341-351, 2013年02月
Notch activation mediates angiotensin II-induced vascular remodeling by promoting proliferation and migration of vascular smooth muscle cells, (Ozasa Y), Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I, Hypertension Research, 36:859-865, 2013年10月
High incidence of Aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure: A cross-sectional study, (Murakami M), Suzuki J, Yamazaki S, Ikezoe M, Matsushima R, Ashigaki N, Aoyama N, Kobayashi N, Wakayama K, Akazawa H, Komuro I, Izumi Y, Isobe M, BMC Infectious Diseases, 13:557, 2013年11月
Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure, (Oka T), Akazawa H, Naito AT, Komuro I, Circulation Research, 114:565-571, 2014年01月
Dickkopf-3: a stubborn protector of cardiac hypertrophy, (Akazawa H), Komuro I, Cardiovascular Research, 102:6-8, 2014年04月
Periodontitis in cardiovascular disease patients with or without Marfan syndrome - a possible role of Prevotella intermedia., (Suzuki J), Imai Y, Aoki M, Fujita D, Aoyama N, Tada Y, Wakayama K, Akazawa H, Izumi Y, Isobe M, Komuro I, Nagai R, Hirata Y, PLoS One, 9:e95521, 2014年04月
High incidence of periodontitis in Japanese patients with abdominal aortic aneurysm, (Suzuki J), Aoyama N, Aoki M, Tada Y, Wakayama K, Akazawa H, Shigematsu K, Hoshina K, Izumi Y, Komuro I, Miyata T, Hirata Y, Isobe M, International Heart Journal, 55:268-270, 2014年05月
Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling, (Kudo-Sakamoto Y), Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Sakata Y, Suzuki J, Saido TC, Komuro I, Journal of Biological Chemistry, 289:19408-19419, 2014年07月
Excitation propagation in three-dimensional engineered hearts using decellularized extracellular matrix, (Yasui H), Lee JK, Yoshida A, Yokoyama T, Nakanishi H, Miwa K, Naito AT, Oka T, Akazawa H, Nakai J, Miyagawa S, Sawa Y, Sakata Y, Komuro I, Biomaterials, 35:7839-7850, 2014年09月
Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice, (Sun A), Zou Y, Wang P, Xu D, Gong H, Wang S, Qin Y, Zhang P, Chen Y, Harada M, Isse T, Kawamoto T, Fan H, Yang P, Akazawa H, Nagai T, Takano H, Ping P, Komuro I, Ge J, Journal of the American Heart Association, 3:e000779, 2014年09月
High incidence and severity of periodontitis in Marfan syndrome patients in Japan, (Suzuki J), Imai Y, Aoki M, Fujita D, Aoyama N, Tada Y, Akazawa H, Izumi Y, Isobe M, Komuro I, Nagai R, Hirata Y, Heart and Vessels, 30:692-695, 2015年09月
Incidence of periodontitis in Japanese patients with cardiovascular diseases: a comparison between abdominal aortic aneurysm and arrhythmia, (Suzuki J), Aoyama N, Aoki M, Tada Y, Wakayama K, Akazawa H, Shigematsu K, Hoshina K, Izumi Y, Komuro I, Miyata T, Hirata Y, Isobe M, Heart and Vessels, 30:498-502, 2015年07月
Complement C1q-induced activation of β-catenin signaling causes hypertensive arterial remodeling, (Sumida T), Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Manabe I, Nagai T, Shiojima I, Morita H, Komuro I, Nature Communications, 6:6241, 2015年02月
A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice, (Hirakawa H), Zempo H, Ogawa M, Watanabe R, Suzuki J, Akazawa H, Komuro I, Isobe M, PLoS One, 10:e0119360, 2015年03月
Pleiotropic effects of angiotensin II receptor signaling in cardiovascular homeostasis and aging, (Kamo T), Akazawa H, Komuro I, International Heart Journal, 56:249-254, 2015年05月
Congenital contractural arachnodactyly without FBN1 or FBN2 Gene mutations complicated by dilated cardiomyopathy, (Yagi H), Hatano M, Takeda N, Harada S, Suzuki Y, Taniguchi Y, Shintani Y, Morita H, Kanamori N, Aoyama T, Watanabe M, Manabe I, Akazawa H, Kinugawa K, Komuro I, Internal Medicine, 54:1237-1241, 2015年05月
Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling, (Kumagai H), Ikeda Y, Motozawa Y, Fujishiro M, Okamura T, Fujio K, Okazaki H, Nomura S, Takeda N, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Yamamoto K, Komuro I, Yanagisawa M, PLoS One, 10:e0129394, 2015年05月
Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors, (Ikeda Y), Kumagai H, Okazaki H, Fujishiro M, Motozawa Y, Nomura S, Takeda N, Toko H, Takimoto E, Akazawa H, Morita H, Suzuki J, Yamazaki T, Komuro I, Yanagisawa M, PLoS One, 10:e0127445, 2015年06月
Wnt/β-catenin signaling contributes to skeletal myopathy in heart failure via direct interaction with FoxO, (Okada K), Naito AT, Higo T, Nakagawa A, Shibamoto T, Sakai T, Hashimoto A, Kuramoto Y, Sumida T, Nomura S, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Morimoto S, Sakata Y, Shiojima I, Komuro I, Circulation: Heart Failure, 8:799-808, 2015年07月
Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure overloaded hearts, (Yamagami K), Oka T, Wang Q, Ishizu T, Lee JK, Miwa K, Akazawa H, Naito AT, Sakata Y, Komuro I, American Journal of Physiology-Heart and Circulatory Physiology, 309:H512-H522, 2015年08月
Cardiac Non-myocytes in the Hub of Cardiac Hypertrophy, (Kamo T), Akazawa H #, Komuro I, Circulation Research, 117:89-98, 2015年06月
Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice, (Nakatani K), Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, Sairyo M, Zhu Y, Okada T, Kawase R, Nakaoka H, Naito A, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Hatazawa J, Yamashita S, Metabolism, 64:1165-1174, 2015年09月
Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis, (Arakawa S), Nakanomyo I, Kudo-SakamotoY, Akazawa H, Komuro I, Shimizu S, Biochemical and Biophysical Research Communications, 467:1006-1011, 2015年11月
Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD+ protects the heart against pressure overload, (Yano M), Akazawa H #, Oka T, Yabumoto C, Kudo-Sakamoto Y, Kamo T, Shimizu Y, Yagi H, Naito AT, Lee JK, Suzuki J, Sakata Y, Komuro I, Scientific Reports, 5:15857, 2015年11月
Mechanisms of cardiovascular homeostasis and pathophysiology: from gene expression, signal transduction to cellular communication, (Akazawa H), Circulation Journal, 79:2529-2536, 2015年11月
Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression, (Yabumoto C), Akazawa H #, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I, Scientific Reports, 5:14453, 2015年09月
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition, (Takamura C), Suzuki J, Ogawa M, Watanabe R, Tada Y, Maejima Y, Akazawa H, Komuro I, Isobe M, Journal of Cardiology, 68:253-260, 2016年09月
Cardiac arrest triggered by subepicardial aneurysm without cardiac rupture, (Hasumi E), Fujiu K, Imamura T, Iwata H, Sawaki D, Hosoya Y, Ando J, Kojima T, Shimizu Y, Oguri G, Matsubara T, Hatano M, Akazawa H, Watanabe M, Ono M, Komuro I, Circulation Journal, 80:538-540, 2016年01月
Direct left atrial ICE imaging guided ablation for atrial fibrillation without employing contrast medium, (Matsubara TJ), Fujiu K, Asada K, Kojima T, Makimoto H, Yamagata K, Shimizu Y, Hasumi E, Hatano M, Akazawa H, Komuro I, International Journal of Cardiology, 203:733-739, 2016年01月
Current therapies and investigational drugs for peripheral arterial disease, (Suzuki J), Shimamura M, Suda H, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Isobe M, Komuro I, Morishita R, Hypertension Research, 39:183-191, 2016年04月
Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure, (Watanabe R), Suzuki J, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Hypertension Research, 39:237-244, 2016年04月
Cacao polyphenols ameliorate autoimmune myocarditis in mice, (Zempo H), Suzuki J, Watanabe R, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Hypertension Research, 39:203-209, 2016年04月
A case of multiple coronary artery-left ventricular microfistulae complicated with hepatic arteriovenous fistulae, (Niwa R), Hasumi E, Fujiu K, Uehara M, Nitta D, Hatano M, Akazawa H, Watanabe M, Komuro I, International Heart Journal, 57:123-126, 2016年01月
Understanding vascular diseases: Lessons from premature aging syndromes, (Ikeda Y), Kumagai H, Motozawa Y, Suzuki J, Akazawa H, Komuro I, Canadian Journal of Cardiology, 32:650-658, 2016年05月
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture, (Shiheido Y), Maejima Y, Suzuki J, Aoyama N, Kaneko M, Watanabe R, Sakamaki Y, Wakayama K, Ikeda Y, Akazawa H, Ichinose S, Komuro I, Izumi Y, Isobe M, Journal of Molecular and Cellular Cardiology, 99:123-137, 2016年10月
Activation of endothelial β-catenin signaling induces heart failure, (Nakagawa A), Naito AT, Sumida T, Nomura S, Shibamoto M, Higo T, Okada K, Sakai T, Hashimoto A, Kuramoto Y, Oka T, Lee JK, Harada M, Ueda K, Shiojima I, Limbourg FP, Adams RH, Noda T, Sakata Y, Akazawa H, Komuro I, Scientific Reports, 6:25009, 2016年05月
Pathophysiology and management of cardiovascular manifestations in Marfan and Loeys-Dietz syndromes, (Takeda N), Yagi H, Hara H, Fujiwara T, Fujita D, Nawata K, Inuzuka R, Taniguchi Y, Harada M, Toko H, Akazawa H, Komuro I, International Heart Journal, 57:271-277, 2016年05月
Toll-like receptor 4 signaling plays a critical role in Porphyromonas gingivalis accelerated neointimal formation after arterial injury in mice, (Kobayashi N), Suzuki J, Aoyama N, Sato H, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M, Hypertension Research, 39:717-722, 2016年10月
Leukemia inhibitory factor enhances endogenous cardiomyocyte regeneration after myocardial infarction, (Kanda M), Nagai T, Takahashi T, Liu ML, Kondou N, Naito AT, Akazawa H, Sashida G, Iwama A, Komuro I, Kobayashi Y, PLoS One, 11:e0156562, 2016年05月
Periodontitis may deteriorate sinus of Valsalva dilatation in Marfan syndrome patients, (Suzuki J), Imai Y, Aoki M, Fujita D, Takeda N, Aoyama N, Wakayama K, Ikeda Y, Kumagai M, Akazawa H, Izumi Y, Isoba M, Komuro I, Hirata Y, International Heart Journal, 57:456-460, 2016年07月
Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes, (Kamo T), Akazawa H #, Suzuki J, Komuro I, Inflammation and Regeneration, 36:12, 2016年08月
Heart failure complicated by alveolar hemorrhage due to vascular collapse and amyloid deposits in wild-type transthyretin amyloidosis, (Kido Y), Takahashi M, Fukuma N, Kawata T, Tanaka A, Hayashi A, Shibahara J, Daimon M, Morita H, Akazawa H, Komuro I, Cardiology, 135:216-220, 2016年08月
A periodontal pathogen Porphyromonas gingivalis deteriorates isoproterenol-induced myocardial remodeling in mice, (Sato H), Suzuki J, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida Y, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y, Hypertension Research, 40:35-40, 2017年01月
An EP4 receptor agonist inhibits cardiac fibrosis through activation of PKA signaling in hypertrophied heart, (Wang Q), Oka T, Yamagami K, Lee JK, Akazawa H, Naito AT, Yasui T, Ishizu T, Nakaoka Y, Sakata Y, Komuro I, International Heart Journal, 58:107-114, 2017年02月
Periodontitis and myocardial hypertrophy, (Suzuki J), Sato H, Kaneko M, Yoshida Y, Aoyama N, Akimoto S, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Izumi Y, Isobe M, Komuro I, Hypertension Research, 40:324-328, 2017年04月
Correct diagnosis of wild-type transthyretin-related amyloidosis followed by the introduction of a novel therapy in a patient with cardiac wall thickening of unknown cause, (Sawada N), Nakayama A, Takahashi M, Tanaka M, Morita H, Akazawa H, Komuro I, International Heart Journal, 58:147-150, 2017年02月
Cardiac sarcoidosis diagnosed by incidental lymph node biopsy, (Matsuda J), Fujiu K, Roh S, Tajima M, Maki H, Kojima T, Ushiku T, Nawata K, Takeda N, Watanabe M, Akazawa H, Komuro I, International Heart Journal, 58:140-143, 2017年02月
A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction, (Watanabe R), Suzuki J, Wakayama K, Maejima Y, Shimamura M, Koriyama H, Nakagami H, Kumagai H, Ikeda Y, Akazawa H, Morishita R, Komuro I, Isobe M, Scientific Reports, 7:43920, 2017年03月
Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure, (Kamo T), Akazawa H #, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki J, Honda K, Morita H, Hattori M, Komuro I, PLoS One, 12:e0174099, 2017年03月
Angiotensin II peptide vaccine protects brain through reducing oxidative stress, (Wakayama K), Shimamura M, Suzuki J, Watanabe R, Koriyama H, Akazawa H, Nakagami H, Mochizuki H, Isobe M, Morishita R, Stroke, 48:1362-1368, 2017年05月
DNA single-strand break-induced DNA damage response causes heart failure, (Higo T), Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa A, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, Mckinnon PJ, Sakata Y, Komuro I, Nature Communications, 8:15104, 2017年04月
MicroRNA-99a: A new kid on the block for cardioprotection, (Liu Q), Akazawa H, International Heart Journal, 58:310-312, 2017年05月
Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure, (Kamo T), Akazawa H, Suzuki JI, Komuro I, Korean Circulation Journal, 47:663-669, 2017年09月
Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation, (Aoyama N), Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M, Heart and Vessels, 32:1314-1319, 2017年11月
Detrimental effects of specific periodontopathic bacterial infection on tachyarrhythmia compared to bradyarrhythmia, (Aoyama N), Suzuki J, Kobayashi N, Hanatani T, Ashigaki A, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Minabe M, Izumi Y, Isobe M, BMC Cardiovascular Disorders, 17:267, 2017年10月
Cost-effectiveness analysis of cardiovascular disease treatment in Japan, (Kodera S), Kiyosue A, Ando J, Akazawa H, Morita H, Watanabe M, Komuro I, International Heart Journal, 58:847-852, 2017年12月
Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients, (Aoyama N), Suzuki JI, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Minabe M, Izumi Y, Isobe M, Heart and Vessels, 33:198-204, 2018年02月
Japanese cardiovascular disease patients with diabetes mellitus suffer increased tooth loss in comparison to those without diabetes mellitus - a cross-sectional study, (Aoyama N), Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiehido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Minabe M, Izumi Y, Isobe M, Internal Medicine, 57:777-782, 2018年03月
Coronary artery aneurysm caused by a stent fracture, (Oshima T), Minatsuki S, Myojo M, Kodera S, Nawata K, Ando J, Akazawa H, Watanabe M, Ono M, Komuro I, International Heart Journal, 59:203-208, 2018年01月
Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys-Dietz syndrome or multiple self-healing squamous epithelioma, (Fujiwara T), Takeda N, Hara H, Morita H, Kishihara J, Inuzuka R, Yagi, H, Maemura S, Toko H, Harada M, Ikeda Y, Kumagai H, Nomura S, Takimoto E, Akazawa H, Ako J, Komuro I, European Journal of Human Genetics, 26:1151-1158, 2018年08月
Impact of pathogenic FBN1 variant types on the progression of aortic disease in patients with Marfan syndrome, (Takeda N), Inuzuka R, Maemura S, Morita H, Nawata K, Fujita D, Taniguchi Y, Yamauchi H, Yagi H, Kato M, Nishimura H, Hirata Y, Ikeda Y, Kumagai H, Amiya E, Hara H, Fujiwara T, Akazawa H, Suzuki JI, Imai Y, Nagai R, Takamoto S, Hirata Y, Ono M, Komuro I, Circulation: Genomic and Precision Medicine, 11:e002058, 2018年06月
Periodontitis and diabetes mellitus: Be true to your teeth, (Akazawa H), International Heart Journal, 59:680-682, 2018年07月
A novel bioabsorbable sheet that delivers NF-κB decoy oligonucleotide restrains abdominal aortic aneurysm development in rats, (Akimoto S), Suzuki J, Aoyama N, Ikeuchi R, Watanabe H, Tsujimoto H, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, International Heart Journal, 59:1134-1141, 2018年09月
MicroRNAs as Biomarkers for Cardiac Sarcoidosis: No Matter How Small, (Umei M), Akazawa H, Journal of Cardiology, 72:449-451, 2018年12月
Activated β-catenin in Foxp3(+) regulatory T cells links inflammatory environments to autoimmunity, (Sumida T), Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA, Nature Immunology, 19:1391-1402, 2018年12月
Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure, (Nomura S), Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H Komuro I, Nature Communications, 9:4435, 2018年10月
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury, (Hara H), Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I, JACC: Basic to Translational Science, 3:639-653, 2018年11月
Pressure overload impairs cardiac function in long-chain fatty acid transporter CD36-knockout mice, (Nakatani K), Masuda D, Kobayashi T, Sairyo M, Zhu Y, Okada T, Naito AT, Ohama T, Koseki M, Oka T, Akazawa H, Nishida M, Komuro I, Sakata Y, Yamashita S, International Heart Journal, 60:159-167, 2019年01月
High-throughput single-molecule RNA imaging analysis reveals heterogenous responses of cardiomyocytes to hemodynamic overload, (Satoh M), Nomura S, Harada M, Yamaguchi T, Ko T, Sumida T, Toko H, Naito AT, Takeda N, Tobita T, Fujita T, Ito M, Fujita K, Ishizuka M, Kariya T, Akazawa H, Kobayashi Y, Morita H, Takimoto E, Aburatani H, Komuro I, Journal of Molecular and Cellular Cardiology, 128:77-89, 2019年03月
Overview of the 83rd Annual Scientific Meeting of the Japanese Circulation Society - Renaissance of Cardiology for the Creation of Future Medicine, (Akazawa H), Toko H, Harada M, Ueda K, Kodera S, Kiyosue A, Fujiu K, Hatano M, Daimon M, Ando J, Takimoto E, Morita H, Komuro I, Circulation Journal, 83:1829-1835, 2019年08月
OCT-Based Management of Nilotinib-Associated CAD in a Patient With Chronic Myeloid Leukemia, (Kiriyama H), Ishida J, Kadowaki H, Iwasa T, Kiyosue A, Kodera S, Ando J, Akazawa H, Komuro I, JACC: CardioOncology, 1:318-321, 2019年12月
Dawning of digital era in the management of hypertension, (Matsuoka R), Akazawa H, Kodera S, Komuro I, Hypertension Research, 43:1135-1140, 2020年11月
Cancer therapeutics-related cardiac dysfunction: insights from bench and bedside of onco-cardiology, (Kadowaki H), Akazawa H #, Ishida J, Komuro I, Circulation Journal, 84:1446-1453, 2020年08月
Transethnic Meta-analysis of Genome-wide Association Studies Identifies Three New Loci and Characterizes Population-specific Differences for Coronary Artery Disease, (Matsunaga H), Ito K, Akiyama M, Takahashi A, Koyama S, Nomura S, Ieki H, Ozaki K, Onouchi Y, Sakaue S, Suna S, Ogishima S, Yamamoto M, Hozawa A, Satoh M, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Tanaka K, Arisawa K, Ikezaki H, Takashima N, Naito M, Wakai K, Tanaka H, Sakata Y, Morita H, Sakata Y, Matsuda K, Murakami Y, Akazawa H, Kubo M, Kamatani Y, Komuro I, Circulation: Genomic and Precision Medicine, 13:e002670, 2020年06月
Diagnosing heart failure from chest X-ray images using deep learning, (Matsumoto T), Kodera S, Shinohara H, Ieki H, Yamaguchi T, Higashikuni Y, Kiyosue A, Ito K, Ando J, Takimoto E, Akazawa H, Morita H, Komuro I, International Heart Journal, 61:781-786, 2020年07月
A fetal case of myocarditis following myositis induced by pembrolizumab treatment for metastatic upper urinary tract urothelial carcinoma, (Matsui H), Kawai T, Sato Y, Ishida J, Kadowaki H, Akiyama Y, Yamada Y, Nakamura M, Yamada D, Akazawa H, Suzuki M, Komuro I, Kume H, International Heart Journal, 61:1070-1074, 2020年09月
Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease, (Koyama S), Ito K, Terao C, Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, Sawada N, Tsugane S, Koyama T, Ikezaki H, Takashima N, Tanaka K, Arisawa K, Kuriki K, Naito M, Wakai K, Suna S, Sakata Y, Sato H, Hori M, Sakata Y, Matsuda K, Murakami Y, Aburatani H, Kubo M, Matsuda F, Kamatani Y, Komuro I, Nature Genetics, 52:1169-1177, 2020年11月
Inhibition of transforming growth factor- signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome, (Hara H), Maemura S, Fujiwara T, Takeda N, Ishii S, Yagi H, Suzuki T, Harada M, Toko H, Kanaya T, Ijichi H, Moses HL, Takimoto E, Morita H, Akazawa H, Komuro I, PLoS One, 15:e0239908, 2020年11月
Cardio-Oncology in Japan: The Rapidly Rising Sun, (Oka T), Akazawa H, Sase K, Hatake K, Komuro I, JACC: CardioOncology, 2:815-818, 2020年12月
Factors associated with left ventricular reverse remodeling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction, (Adachi Y), Kiyosue A, Ando J, Kawahara T, Kodera S, Minatsuki S, Kikuchi H, Inaba T, Kiriyama H, Hirose K, Shinohara H, Saito A, Fujiwara T, Hara H, Ueda K, Sakakura K, Hatana M, Harada M, Takimoto E, Akazawa H, Morita H, Momomura S, Fujita H, Komuro I, Scientific Reports, 11:239, 2021年01月
Mechanisms and management of immune checkpoint inhibitors-related cardiac adverse events, (Kadowaki H), Akazawa H, Ishida J, Komuro I, JMA Journal, 4:91-98, 2021年04月
Axitinib induces and aggravates hypertension irrespectively of prior treatment with tyrosine kinase inhibitors, (Kadowaki H), Ishida J, Akazawa H, Yagi H, Saga-Kamo A, Umei M, Matsuoka R, Liu Q, Matsunaga H, Maki H, Sato Y, Kume H, Komuro I, Circulation Reports, 3:234-240, 2021年03月
Automatic detection of vessel structure by deep learning using intravascular ultrasound images of the coronary arteries, (Shinohara H), Kodera S, Ninomiya K, Nakamoto M, Katsushika S, Saito A, Minatsuki S, Kikuchi H, Kiyosue A, Higashikuni Y, Takeda N, Fujiu K, Ando J, Akazawa H, Morita H, Komuro I, PLOS One, 16:e0255577, 2021年08月
Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice, (Fujiwara T), Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Maemura S, Suzuki T, Takiguchi H, Kubota Y, Seo K, Sakata A, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Nishimura S, Komuro I, Circulation, 144:1452-1455, 2021年10月
The Effectiveness of a Deep Learning Model to Detect Left Ventricular Systolic Dysfunction from Electrocardiograms, (Katsushika S), Kodera S, Nakamoto M, Ninomiya K, noue S, Sawano S, Kakuda N, Takiguchi H, Shinohara H, Matsuoka R, Ieki H, Higashikuni Y, Nakanishi K, Nakao T, Seki T, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I, International Heart Journal, 62:1332-1341, 2021年12月
Deep learning algorithm to detect cardiac sarcoidosis from an echocardiographic movie, (Katsushika S), Kodera S, Nakamoto M, Ninomiya K, Kakuda N, Shinohara H, Matsuoka R, Ieki H, Uehara M, Higashikuni Y, Nakanishi K, Nakao T, Takeda N, Fujiu K, Daimon M, Ando J, Akazawa H, Morita H, Komuro I, Circulation Journal, 86:87-95, 2021年12月
Detection of profound myocardial damage by cardiac MRI in a patient with severe cardiotoxicity induced by anti-HER2 therapy, (Kadowaki H), Ishida J, Uehara M, Ishizuka M, Kiyosue A, Hatano M, Shimada S, Ono M, Akazawa H, Komuro I, International Heart Journal, 62:1436-1441, 2021年12月
Oral Administration of Euglena gracilis Z Alleviates Constipation and Cardiac Dysfunction in a Mouse Model of Isoproterenol-induced Heart Failure, (Umei M), Akazawa H, Saga-Kamo A, Yagi H, Liu Q, Matsuoka R, Kadowaki H, Shindo A, Nakashima A, Yasuda K, Suzuki K, Komuro I, Circulation Reports, 4:83-91, 2021年12月
Deep learning model to detect significant aortic regurgitation using electrocardiography: Detection model for aortic regurgitation, (Sawano S), Kodera S, Katsushika S, Nakamoto M, Ninomiya K, Shinohara H, Higashikuni Y, Nakanishi K, Nakao T, Seki T, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I, Journal of Cardiology, 79:334-341, 2022年03月
Oxidized LDL but not angiotensin II induces cardiomyocyte hypertrophic responses through the interaction between LOX-1 and AT1 receptors, (Lin L), Zhou N, Kang L, Wang Q, Wu J, Wang X, Yang C, Zhang G, Chen Y, Jiang H, Chen R, Yang X, Sun A, Gong H, Ren J, Akazawa H, Issei K, Ge J, Yang C, Zou Y, Journal of Molecular and Cellular Cardiology, 162:110-118, 2022年01月
Prospects for cardiovascular medicine using artificial intelligence, (Kodera S), Akazawa H, Morita H, Komuro I, Journal of Cardiology, 79:319-325, 2022年03月
Sick Sinus Syndrome: More Than a Needle-in-a-haystack Manifestation of Immune Checkpoint Inhibitor-associated Myocarditis, (Kadowaki H), Akazawa H, Internal Medicine, 61:2101-2102, 2022年07月
Nonsyndromic arteriopathy and aortopathy and vascular Ehlers-Danlos syndrome causing COL3A1 variants, (Yagi H), Takeda N, Amiya E, Akiyama N, Chang H, Ishiura H, Sato J, Akazawa H, Morita H, Komuro I, American Journal of Medical Genetics Part A, 188:2777-2782, 2022年09月
Antihypertensive Drugs and Cancer Risk, (Kidoguchi S), Sugano N, Yokoo T, Kaneko H, Akazawa H, Mukai M, Node K, Yano Y, Nishiyama A, American Journal of Hypertension, 35:767-783, 2022年09月
Automatic Detection of Left Ventricular Dilatation and Hypertrophy from Electrocardiograms Using Deep Learning, (Kokubo T), Kodera S, Sawano S, Katsushika S, Nakamoto M, Takeuchi H, Kimura N, Shinohara H, Matsuoka R, Nakanishi K, Nakao T, Higashikuni Y, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Matsuyama Y, Komuro I, International Heart Journal, 63:939-947, 2022年09月
Age prediction from coronary angiography using a deep neural network: Age as a potential label to extract prognosis-related imaging features, (Sawano S), Kodera S, Sato M, Katsushika S, Sukeda I, Takeuchi H, Shinohara H, Kobayashi A, Takiguchi H, Hirose K, Kamon T, Saito A, Kiriyama H, Miura M, Minatsuki S, Kikuchi H, Higashikuni Y, Takeda N, Fujiu K, Ando J, Akazawa H, Morita H, Komuro I, PLoS One, 17:e0276928, 2022年10月
Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis, (Ieki H), Ito K, Saji M, Kawakami R, Nagatomo Y, Takada K, Kariyasu T, Machida H, Koyama S, Yoshida H, Kurosawa R, Matsunaga H, Miyazawa K, Ozaki K, Onouchi Y, Katsushika S, Matsuoka R, Shinohara H, Yamaguchi T, Kodera S, Higashikuni Y, Fujiu K, Akazawa H, Iguchi N, Isobe M, Yoshikawa T, Komuro I, Communications Medicine, 2:159, 2022年12月
Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction, (Miyazawa K), Ito K, Ito M, Zou Z, Kubota M, Nomura S, Matsunaga H, Koyama S, Ieki H, Akiyama M, Koike Y, Kurosawa R, Yoshida H, Ozaki K, Onouchi Y, BioBank Japan P, Takahashi A, Matsuda K, Murakami Y, Aburatani H, Kubo M, Momozawa Y, Terao C, Oki S, Akazawa H, Kamatani Y, Komuro I, Nature Genetics, 55:187-197, 2023年02月
Novel AGL variants in a patient with glycogen storage disease type IIIb and pulmonary hypertension caused by pulmonary veno-occlusive disease: A case report, (Shindo A), Ueda K, Minatsuki S, Nakayama Y, Hatsuse S, Fujita K, Nomura S, Hatano M, Takeda N, Akazawa H, Komuro I, Frontiers in Genetics, 14:1148067, 2023年03月
Pericardial grafting of cardiac progenitor cells in self-assembling peptide scaffold improves cardiac function after myocardial infarction, (Kanda M), Nagai T, Kondo N, Matsuura K, Akazawa H, Komuro I, Kobayashi Y, Cell Transplantation, 32:9636897231174078, 2023年01月
An explainable artificial intelligence-enabled electrocardiogram analysis model for the classification of reduced left ventricular function, (Katsushika S), Kodera S, Sawano S, Shinohara H, Setoguchi N, Tanabe K, Higashikuni Y, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I, European Heart Journal Digital Health, 4:254-264, 2023年04月
Coronary Periarteritis and Pericardial Thickening Could Be Predictors for Coronary Artery Events Complicated by IgG4-Related Disease, (Yagi H), Amiya E, Uehara M, Minatsuki S, Hatano M, Takeda N, Akazawa H, Komuro I, CJC Open, 5:480-489, 2023年05月
PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice, (Fujiwara T), Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Katoh M, Maemura S, Suzuki T, Takiguchi H, Yanase T, Kubota Y, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Nishimura S, Komuro I, JCI Insight, 8:e162632, 2023年09月
Deep Learning Models for Predicting Left Heart Abnormalities From Single-Lead Electrocardiogram for the Development of Wearable Devices, (Sato M), Kodera S, Setoguchi N, Tanabe K, Kushida S, Kanda J, Saji M, Nanasato M, Maki H, Fujita H, Kato N, Watanabe H, Suzuki M, Takahashi M, Sawada N, Yamasaki M, Sawano S, Katsushika S, Shinohara H, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I, Circulation Journal, 88:146-156, 2023年12月
A case of progressive right ventricular failure with ventricular arrhythmia and aortic insufficiency after implantable left ventricular assist device implantation, (Jimba T), Hatano M, Fujiwara T, Akazawa H, Watanabe M, Kinugawa K, Ono K, Komuro I, Journal of Cardiology Cases, 29:7-10, 2023年09月
Asymptomatic and symptomatic cardiac toxicity associated with immune checkpoint inhibitors: insights from a Japanese registry, (Tamura Y), Tamura Y, Ohtsu H, Nakamori S, Maruyama K, Muraoka N, Shoji M, Tajiri K, Tomita H, Iso Y, Sugimura K, Yamada H, Kinugawa K, Morimoto R, Akazawa H, Harada K, Nakano S, Tsujita K, Gunji T, Tsuruda T, Nakamura A, Maruyama M, Miyake Y, Hatanaka K, Kawano H, Sato W, Yano S, Imanaka-Yoshida K, Komuro I, European Heart Journal Open, 6:oeag079, 2026年05月
Shared and reciprocal mechanisms between heart failure and cancer: an emerging concept of heart-cancer axis, (Kadowaki H), Akazawa H, Shindo A, Ueda T, Ishida J, Komuro I, Circulation Journal, 88:182-188, 2024年01月
The potential of the transformer-based survival analysis model, SurvTrace, for predicting recurrent cardiovascular events and stratifying high-risk patients with ischemic heart disease, (Shinohara H), Kodera S, Nagae Y, Hiruma T, Kobayashi A, Sato M, Sawano S, Kamon T, Narita K, Hirose K, Kiriyama H, Saito A, Miura M, Minatsuki S, Kikuchi H, Takeda N, Akazawa H, Morita H, Komuro I, PLoS One, 19:e0304423, 2024年06月
Applying masked autoencoder-based self-supervised learning for high-capability vision transformers of electrocardiographies, (Sawano S), Kodera S, Setoguchi N, Tanabe K, Kushida S, Kanda J, Saji M, Nanasato M, Maki H, Fujita H, Kato N, Watanabe H, Suzuki M, Takahashi M, Sawada N, Yamasaki M, Sato M, Katsushika S, Shinohara H, Takeda N, Fujiu K, Daimon M, Akazawa H, Morita H, Komuro I, PLoS One, 19:e0307978, 2024年08月
Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy, (Inoue S), Ko T, Shindo A, Nomura S, Yamada T, Jimba T, Dai Z, Nakao H, Suzuki A, Kashimura T, Iwahana T, Goto K, Matsushima S, Ishida J, Amiya E, Zhang B, Kubota M, Sawami K, Heryed T, Yamada S, Katoh M, Katagiri M, Ito M, Nayakama Y, Fujiu K, Hatano M, Takeda N, Takimoto E, Akazawa H, Morita H, Yamaguchi J, Inomata T, Kobayashi Y, Minamino T, Tsutsui H, Kurokawa M, Aiba A, Aburatani H, Komuro I, JACC: Basic to Translational Science, 9:956-967, 2024年06月
Association of Multiple Nonhypertrophic Cardiomyopathy-Related Genetic Variants and Outcomes in Patients With Hypertrophic Cardiomyopathy, (Hiruma T), Inoue S, Dai Z, Nomura S, Kubo T, Sugiura K, Suzuki A, Kashimura T, Matsushima S, Yamada T, Tobita T, Katoh M, Ko T, Ito M, Ishida J, Amiya E, Hatano M, Takeda N, Takimoto E, Akazawa H, Morita H, Yamaguchi J, Inomata T, Tsutsui H, Kitaoka H, Aburatani H, Takeda N, Komuro I, JACC: Heart Failure, 12:2041-2052, 2024年12月
Deep Learning to Detect Pulmonary Hypertension from the Chest X-Ray Images of Patients with Systemic Sclerosis, (Shimbo M), Hatano M, Katsushika S, Kodera S, Isotani Y, Sawano S, Matsuoka R, Minatsuki S, Inaba T, Maki H, Sumida H, Takeda N, Akazawa H, Komuro I, International Heart Journal, 65:1066-1074, 2024年11月
Deep Learning-Based Identification of Echocardiographic Abnormalities from Electrocardiograms, (Fujiki G), Kodera S, Setoguchi N, Tanabe K, Kushida S, Saji M, Nanasato M, Maki H, Fujita H, Kato N, Watanabe H, Suzuki M, Takahashi M, Sawada N, MD, Ando J, Sato M, Sawano S, Katsushika S, Shinohara H, Takeda N, Fujiu K, Akazawa H, Morita H, Komuro I, JACC: Asia, 5:88-98, 2024年12月
XOR-Derived ROS in Tie2-Lineage Cells Including Endothelial Cells Promotes Aortic Aneurysm Progression in Marfan Syndrome, (Hiroki Yagi), Hiroshi Akazawa, Qing Liu, Kimiko Yamamoto, Kan Nawata, Akiko Saga-Kamo, Masahiko Umei, Hiroshi Kadowaki, Ryo Matsuoka, Akito Shindo, Shun Okamura, Haruhiro Toko, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Norihiko Takeda, Mehdi A Fini, Minoru Ono, Issei Komuro, Arteriosclerosis, Thrombosis, and Vascular Biology, 45:e63-e77, 2025年03月
An ensemble learning model for detection of pulmonary hypertension using electrocardiogram, chest X-ray, and brain natriuretic peptide, (Risa Kishikawa), Satoshi Kodera, Naoto Setoguchi, Kengo Tanabe, Shunichi Kushida, Mamoru Nanasato, Hisataka Maki, Hideo Fujita, Nahoko Kato, Hiroyuki Watanabe, Masao Takahashi, Naoko Sawada, Jiro Ando, Masataka Sato, Shinnosuke Sawano, Hiroki Shinohara, Koki Nakanishi, Shun Minatsuki, Junichi Ishida, Katsuhito Fujiu, Hiroshi Akazawa, Hiroyuki Morita, Norihiko Takeda, European Heart Journal Digital Health, 6:209-217, 2025年01月
Heart failure monitoring with a single‑lead electrocardiogram at home, (Eriko Hasumi), Katsuhito Fujiu, Ying Chen, Sumie Miyamoto, Mitsunori Oida, Yu Shimizu, Kunihiro Kani, Kohsaku Goto, Ryoko Uchida, Yuxiang Liu, Tsukasa Oshima, Jun Matsuda, Takumi J Matsubara, Junichi Sugita, Yukiteru Nakayama, Gaku Oguri, Toshiya Kojima, Yujin Maru, Satoshi Kodera, Hiroshi Akazawa, Morio Shoda, Issei Komuro, International Journal of Cardiology, 432:133203, 2025年08月
Prognostic Factors Associated With Early Recovery From Veno-Arterial Extracorporeal Membrane Oxygenation Support in Patients With Fulminant Myocarditis, (Tomomi Ueda), Eisuke Amiya, Masaru Hatano, Kosuke Inoue, Junichi Ishida, Shun Minatsuki, Hiroki Yagi, Chie Bujo, Yoshitaka Isotani, Nobutaka Kakuda, Takanobu Yamada, Norifumi Takeda, Hiroshi Akazawa, Koshiro Kanaoka, Kenji Onoue, Yoshihiko Saito, Shungo Hikoso, Issei Komuro, Norihiko Takeda, Journal of the American Heart Association, 14:e039673, 2025年06月
Perivascular inflammation in the progression of aortic aneurysms in Marfan syndrome, (Hiroyuki Sowa), Hiroki Yagi, Kazutaka Ueda, Masaki Hashimoto, Kohei Karasaki, Qing Liu, Atsumasa Kurozumi, Yusuke Adachi, Tomonobu Yanase, Shun Okamura, Bowen Zhai, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Nobuhiko Ito, Minoru Ono, Hiroshi Akazawa, Issei Komuro, JCI Insight, 10:e184329, 2025年08月
Clinical characteristics and in-hospital mortality of chronic myeloid leukemia patients with ischemic heart disease: insights from the JROAD-DPC registry, (Akito Shindo), Hiroshi Akazawa, Tomomi Ueda, Hiroshi Kadowaki, Junichi Ishida, Issei Komuro, European Heart Journal Open, 5:oeaf101, 2025年08月
Enhancing Chest Radiography Artificial Intelligence Model with Electrocardiogram for Improved Detection of Low Ejection Fraction, (Masataka Sato), Satoshi Kodera, Shogo Hamano, Naoto Setoguchi, Kengo Tanabe, Shunichi Kushida, Mike Saji, Mamoru Nanasato, Hisataka Maki, Hideo Fujita, Nahoko Kato, Hiroyuki Watanabe, Masao Takahashi, Naoko Sawada, Jiro Ando, Shinnosuke Sawano, Risa Kishikawa, Hiroki Shinohara, Norifumi Takeda, Katsuhito Fujiu, Koki Nakanishi, Hiroshi Akazawa, Hiroyuki Morita, Norihiko Takeda, International Heart Journal, 66:771-779, 2025年05月
Pregnant Patient With Infrarenal Abdominal Aortic Aneurysm Successfully Treated With EVAR, (Tomomi Ueda), Hiroki Yagi, Nana Akiyama, Naoya Akiba, Katsuyuki Hoshina, Hiroshi Akazawa, Norifumi Takeda, Norihiko Takeda, JACC: Case Reports, 30:105287, 2025年10月
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population, (Nobuyuki Enzan), Kazuo Miyazawa, Satoshi Koyama, Ryo Kurosawa, Hirotaka Ieki, Hiroki Yoshida, Fumie Takechi, Masashi Fukuyama, Ryosuke Osako, Kohei Tomizuka, Xiaoxi Liu, Kouichi Ozaki, Yoshihiro Onouchi, the BioBank Japan Project, Koichi Matsuda, Yukihide Momozawa, Hiroyuki Aburatani, Yoichiro Kamatani, Takanori Yamaguchi, Hiroshi Akazawa, Koichi Node, Patrick T Ellinor, Michael G Levin, Scott M Damrauer, Benjamin F Voight, Jacob Joseph, Yan V Sun, Chikashi Terao, Toshiharu Ninomiya, Issei Komuro, Kaoru Ito, Nature Communications, 16:9680, 2025年11月
Inverse Agonist Activity of Angiotensin II Receptor Blocker Is Crucial for Prevention of Progressive Aortic Dilatation in Marfan Syndrome, (Hiroki Yagi), Hiroshi Akazawa, Qing Liu, Sayo M. Ito, Masahiko Umei, Hiroshi Kadowaki, Ryo Matsuoka, Akito Shindo, Shun Okamura, Tomomi Ueda, Akiko Saga-Kamo, Kazutaka Ueda, Norifumi Takeda, Tappei Takada, Issei Komuro, Arteriosclerosis, Thrombosis, and Vascular Biology, 46:132-144, 2026年01月
Risk Factors and Prognostic Significance of Non-Perioperative Atrial Fibrillation in Lung Cancer Patients, (Tsukasa Oshima), Hiroshi Akazawa, Junichi Ishida, Hiroshi Kadowaki, Akito Shindo, Tomomi Ueda, Yosuke Amano, Kousuke Watanabe, Katsuhito Fujiu, Hidenori Kage, Issei Komuro, Circulation Reports, 7:1171-1180, 2025年10月
Feasibility study protocol for the evaluation of home blood pressure in patients receiving angiogenesis inhibitor therapy: a multicenter observational study, (Kaori Kitaoka), Satoshi Morimoto, Shintaro Minegishi, Hiroshi Kato, Yasuyuki Kitahara, Wataru Shioyama, Taro Shiga, Kazuko Tajiri, Masaaki Shoji, Mitsuhiro Fukata, Hiroshi Akazawa, Mikio Mukai, Yuichiro Yano, Koichi Node, Akira Nishiyama, Hypertension Research, Hypertension Research:1441-1447, 2026年04月