池田　崇之　イケダ タカユキ

研究者基本情報

研究

研究の概要:
１．可溶型VEGF受容体（可溶型Flt-1）を産生する選択的RNAプロセシング機構の解明 ２．血管形成における可溶型VEGF受容体（可溶型Flt-1）の役割

専門分野

• 医化学一般
• 病態医化学
• 人類遺伝学

学歴

• 東北大学 大学院 医学研究科

学位

• 博士(医学)
• 障害科学修士

所属学協会

• 2010年日本RNA学会 正会員
• 2004年日本生化学会 正会員

経歴

• 2006年04月- 2008年08月科学技術振興機構JSTイノベーションプラザ宮城 研究員
• 2008年09月金沢医科大学 助教
• 2004年04月- 2006年03月東北大学 ポスドク

研究活動情報

論文

• HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis, Takayuki Ikeda, Sungki Hong, Shota Yoshida, Swayam Prakash Srivastava, Abhiram Kunamneni, Yao Yao, 1 Om Khuperkar, Venkatesha Basrur, Henry Kuang, Maureen Kachman, Abraham Raskind, Heidi Baum, Arya Joshi, Vinamra Swaroop, Aaron Thurman, Oliviamae Kopasz-Gemmen, Siddharth Kandukuri, F.N.U. Pradeepa, Hideto Yonekura, Jiandie D. Lin, and Ken Inoki, Cell Reports, 44:116382, 2025年10月
• Transthyretin Is Commonly Upregulated in the Hippocampus of Two Stress-Induced Depression Mouse Models., Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Ryo Yamamoto, Takafumi Furuyama, Yasuhito Ishigaki, Nobuo Kato, Hideto Yonekura, Takayuki Ikeda, International Journal of Molecular Sciences, 24:3736, 2023年02月
• Metformin mitigates DPP-4 inhibitor-induced breast cancer metastasis via suppression of mTOR signaling, Emi Kawakita, Fan Yang, Asako Kumagai, Yuta Takagaki, Munehiro Kitada, Yasuo Yoshitomi, Takayuki Ikeda, Yuka Nakamura, Yasuhito Ishigaki, Keizo Kanasaki, Daisuke Koya, Molecular Cancer Research, 19:61-73, 2021年01月
  DOI:doi:10.1158/1541-7786.MCR-20-0115
• EAPC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells, Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura, Scientific reports, 11:19453, 2021年09月
• Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients, 13:2226, 2021年06月
• Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development, Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura, International Journal of Molecular Sciences, 22:2804, 2021年03月
• Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity, (Yao Yao), Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki, Molecular Cell, 80:437-451, 2020年11月
• Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA, Takayuki Ikeda, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Hideto Yonekura, International Journal of Molecular Sciences, 21:6460, 2020年09月
• Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open, 8:bio035691, 2019年02月
• Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis, Yang Fan, Takagaki Yuta, Yoshitomi Yasuo, Ikeda Takayuki, Li Jinpeng, Kitada Munehiro, Kumagai Asako, Kawakita Emi, Shi Sen, Kanasaki Keizo, Koya Daisuke, Cancer research, 79:735-746, 2019年02月
  DOI:10.1158/0008-5472.CAN-18-0620
• JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science, 130:916-926, 2017年01月
• Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry, 413:155-164, 2016年
• Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5, E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura, T.Hatta, PLoS One, 10:e0123232-e0123232, 2015年
  DOI:10.1371/journal.pone.0123232
• Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate, T.Ikeda, S.Takasawa, N.Noguchi, K.Nata, A.Yamauchi, I.Takahashi, T.Yoshikawa, A.Sugawara, H.Yonekura, H.Okamoto, Molecular and cellular biochemistry., 366:69-80, 2012年07月
• Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura, The Biochemical journal., 436:399-407, 2011年06月
• Identification of the COL2A1 mutation in patients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura, Genetic testing and molecular biomarkers., 15:231-237, 2011年04月
• Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, 2011年01月
• A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene, (S.Takasawa), M.Kuroki, K.Nata, N.Noguchi, T.Ikeda, A.Yamauchi, H.Ota, A.Itaya-Hironaka, S.Sakuramoto-Tsuchida, I.Takahashi, T.Yoshikawa, T.Shimosegawa, H.Okamoto, Biochemical and biophysical research communications, 397:140-145, 2010年06月
• Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010年
• Important role of heparan sulfate in postnatal islet growth and insulin secretion., (I.Takahashi), N.Noguchi, K.Nata, S.Yamada, T.Kaneiwa, S.Mizumoto, T.Ikeda, K.Sugihara, M.Asano, T.Yoshikawa, A.Yamauchi, N.J.Shervani, A.Uruno, I.Kato, M.Unno, K.Sugahara, S.Takasawa, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 383:113-118, 2009年05月
• Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells., (A.Yamauchi), I.Takahashi, S.Takasawa, K.Nata, N.Noguchi, T.Ikeda, T.Yoshikawa, N.J.Shervani, I.Suzuki, A.Uruno, M.Unno, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 379:743-748, 2009年02月
• FKBP12.6 disruption impairs glucose-induced insulin secretion, (N.Noguchi), T.Yoshikawa, T.Ikeda, I.Takahashi, N.J.Shervani, A.Uruno, A.Yamauchi, K.Nata, S.Takasawa, H.Okamoto, A.Sugawara, Biochemical and biophysical research communications, 371:735-740, 2008年07月
• Cyclin D1 activation through ATF-2 in Reg-induced pancreatic s-cell regeneration, (S.Takasawa), T.Ikeda, T.Akiyama, K.Nata, K.Nakagawa, N.J.Shervani, N.Noguchi, S.Murakami-Kawaguchi, A.Yamauchi, I.Takahashi, T.Tomioka-Kumagai, H.Okamoto, FEBS letters, 580:585-591, 2006年01月
• Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6, (T.Nakazawa), S.Takasawa, N.Noguchi, K.Nata, ATohgo, M.Mori, K.Nakagawara, T.Akiyama, T.Ikeda, A.Yamauchi, I.Takahashi, T.Yashikawa, H.Okamoto, Gene, 360: 55-64, 2005年10月
• Comparative genomic hybridization and mutation analyses of sporadic schwannomas, T.Ikeda, S.Hashimoto, S.Fukushige, H.Ohmori, A.Horii, Journal of Neuro-Oncology, 72:225-230, 2005年05月
• Autoantibodies to REG, a beta-cell regeneration factor, in diabetic patients, (N.J.Shervani), S.Takasawa, Y.Uchigata, T.Akiyama, K.Nakagawa, N.Noguchi, H.Takeda, I.Takahashi, A.Yamauchi, T.Ikeda, Y.Iwamoto, K.Nata, H.Okamoto, Eur J Clin Invest, 34: 752-758, 2004年11月
• Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III, (K.Nata), L.Yi, X.Liqing, T.Ikeda, T.Akiyama, N.Noguchi, S.Kawaguchi, A.Yamauchi, I.Takahashi, N.J.Shervani, T.Onogawa, S.Takasawa, H.Okamoto, Gene, 340: 161-170, 2004年09月
• Loss of heterozygosity on chromosome 16p and 18q in anaplastic thyroid carcinoma, (M.Kadota), Y.Tamaki, M.Sekimoto, Y.Fujiwara, N.Aritake, S.Hasegawa, T.kobayashi, T.Ikeda, A.Horii, M.Monden, Oncol Rep, 10: 35-38, 2003年01月
• Production and characterization of Reg knockout mice: Reduced proliferation of pancreatic s-cell in Reg knockout mice, (M.Unno), K.Nata, N.Noguchi, Y.Narushima, T.Akiyama, T.Ikeda, K.Nakagawa, S.Takasawa, H.Okamoto, Diabetes., 51: S478-S483, 2002年12月
• Germline mutation of the PTEN gene in a Japanese patient with Cowden’s disease, (N.kato), K.Kimura, H.Sugawara, S.Aoyagi, T.Ikeda, A.Horii, Int J Oncol, 18: 1017-1022, 2001年05月
• Activation of Reg gene, a gene for insulin-producing s-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation, (T.Akiyama), S.Takasawa, K.Nata, S.Kobayashi, M.Abe, N.J.Shervani, T.Ikeda, K.Nakagawa, M.Unno, S.Matsuno, H.Okamoto, Proceedings of the National Academy of Sciences of the United States of America, 98: 48-53, 2001年01月
• Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer, T.Ikeda, K.Yoshinaga, A.Suzuki, A.Sakurada, H.Ohmori, A.Horii, Oncol Rep, 7: 567-570, 2000年05月
• Mutational analysis of the CTNNB1 (s-catenin) gene in human endometrial cancer: Frequent mutations at codon 34 that cause nuclear accumulation, T.Ikeda, K.Yoshinaga, S.Semba, E.Kondo, H.Ohmori, A.Horii, Oncol Rep, 7: 323-326, 2000年03月
• Comparative genomic hybridization defines frequent loss on 16p in human anaplastic thyroid carcinoma, (Y.Komoike), Y.Tamaki, I.Sakita, N.Tomita, M.Ohue, M.Sekimoto, M.Miyazaki, M.Kadota, N.Masuda, M.Ooka, T.Ohnishi, Y.Nakano, T.Kozaki, T.Kobayashi, N.Matsuura, T.Ikeda, A.Horii, M.Monden, Int J Oncol, 14: 1157-1162, 1999年06月

受賞

• 2017年07月 金沢医科大学医学会 金沢医科大学医学会「論文表彰」 Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.
  池田崇之
• 2013年 金沢医科大学医学会 金沢医科大学医学会「論文表彰」 Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate. Mol Cell Biochem, 366(1-2):69-80, 2012.
  池田崇之,

競争的資金

• 健康寿命におけるsVEGFR-1の役割の解明と健康寿命延伸への応用
  文部科学省：科学研究費　基盤研究（B）
  研究期間：2024年04月 - 2028年03月  
• E3ユビキチンリガーゼHUWE1のRheb活性化における役割の解明
  その他：(公財)武田科学振興財団 2021年度研究助成
  研究期間：2021年 - 2021年  
  代表者:池田　崇之
• 敗血症における血管内皮細胞で産生されるsFlt-1の役割の解明
  文部科学省：科学研究費　基盤研究(C)
  研究期間：2021年 - 2023年  
  代表者:池田　崇之
• 眼内血管形成における可溶型ＶＥＧＦ受容体の役割：個体レベルでの解明
  文部科学省：科学研究費　若手研究（Ｂ）
  研究期間：2011年 - 2013年  
  代表者:池田崇之