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宇和田　淳介　ウワダ　ジュンスケ

■所属部署名薬理学
■職名講師
 
 

研究者基本情報

研究

    研究の概要:
    ムスカリン受容体を含むGタンパク質共役型受容体（GPCR）は細胞表面に局在して機能するとされている。私は細胞内にも機能的なムスカリン受容体が存在することを明らかにしており、その機能性や細胞内シグナリング、局在制御メカニズムについて研究を進めることで、その生体における重要性を探っている。

学位

  • 博士（理学）

研究活動情報

論文

  • PIKFYVE inhibition induces endosome- and lysosome-derived vacuole enlargement via ammonium accumulation, Junsuke Uwada, Hitomi Nakazawa, Takeshi Kiyoi, Takashi Yazawa, Ikunobu Muramatsu, Takayoshi Masuoka, Journal of Cell Science, 138:262236, 2025年01月
  • Morphological aberration of corneal nerves in hyposecretory dry eye guinea pigs, Takeshi Kiyoi, Qiang He, Li Liu, Shijie Zheng, Hitomi Nakazawa, Junsuke Uwada, Takayoshi Masuoka, MEDICAL MOLECULAR MORPHOLOGY, 58:34-42, 2025年03月
  • Tear deficiency transforms spatial distribution of corneal calcitonin gene-related peptide-positive nerves in rats., Takeshi Kiyoi*, Akihiro Nakajima, Qiang He, Li Liu, Shijie Zheng, Shizuka Kobayashi, Junsuke Uwada and Takayoshi Masuoka, Front Cell Neurosci, 19:1619310, 2025年07月
  • Corneal acetylcholine regulates sensory nerve activity via nicotinic receptors., Takayoshi Masuoka, Takeshi Kiyoi, Shijie Zheng, Qiang He, Li Liu, Junsuke Uwada, Ikunobu Muramatsu, The Ocular Surface, 32:60-70, 2024年01月
  • “Role of Muscarinic Acetylcholine Receptors in Intestinal Epithelial Homeostasis: Insights for the Treatment of Inflammatory Bowel Disease “, Junsuke Uwada, Hitomi Nakazawa, Ikunobu Muramatsu, Takayoshi Masuoka, Takashi Yazawa, International Journal of Molecular Sciences, 24:6508, 2023年03月
  • Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum., Muramatsu I, Uwada J, Chihara K, Sada K, Wang MH, Yazawa T, Taniguchi T, Ishibashi T, Masuoka T., Journal of Neurochemistry, 160:342-355, 2022年02月
  • Voluntary wheel-running activities ameliorate depressive-like behaviors in mouse dry eye model, Katsuya Nakano, Hitomi Nakazawa, Qiang He, Junsuke Uwada, Takeshi Kiyoi, Takaharu Ishibashi, Takayoshi Masuoka, Frontiers in Behavioral Neuroscience, 16:925128, 2022年09月
  • Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum, Ikunobu Muramatsu, Junsuke Uwada, Kazuyasu Chihara, Kiyonao Sada, Mao-Hsien Wang, Takashi Yazawa, Takanobu Taniguchi, Takaharu Ishibashi, Takayoshi Masuoka, Journal of Neurochemistry, 160:342-355, 2022年02月
  • 神経伝達様式の多様化と受容体表現型, 村松郁延, 宇和田淳介, 益岡尚由, 応用薬理, 103:1-5, 2022年10月
  • 11-Ketotestosterone is a major androgen produced in porcine adrenal glands and testes., Yazawa T, Sato T, Nemoto T, Nagata S, Imamichi Y, Kitano T, Sekiguchi T, Uwada J, Islam MS, Mikami D, Nakajima I, Takahashi S, Khan MRI, Suzuki N, Umezawa A, Ida T, The Journal of Steroid Biochemistry and Molecular Biology, 210:105847, 2021年01月
  • Profiles of 5α-Reduced Androgens in Humans and Eels: 5α-Dihydrotestosterone and 11-Ketodihydrotestosterone Are Active Androgens Produced in Eel Gonads, Yazawa T, Inaba H, Imamichi Y, Sekiguchi T, Uwada J, Islam MS, Orisaka M, Mikami D, Ida T, Sato T, Miyashiro Y, Takahashi S, Khan MRI, Suzuki N, Umezawa A, Kitano T, Frontiers in Endocrinology, 12:657360, 2021年03月
  • Pleiotropic effects of probenecid on three-dimensional cultures of prostate cancer cells, Uwada J, Mukai S, Terada N, Nakazawa H, Islam MS, Nagai T, Fujii M, Yamasaki K, Taniguchi T, Kamoto T, Yazawa T, Life Sciences, 1:119554, 2021年08月
  • Analyses of Molecular Characteristics and Enzymatic Activities of Ovine HSD17B3., Islam MS, Uwada J, Hayashi J, Kikuya KI, Muranishi Y, Watanabe H, Yaegashi K, Hasegawa K, Ida T, Sato T, Imamichi Y, Kitano T, Miyashiro Y, Khan RI, Takahashi S, Umezawa A, Suzuki N, Sekiguchi T, Yazawa T., Animals, 11:2876, 2021年09月
  • Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation., Yazawa T, Imamichi Y, Uwada J, Sekiguchi T, Mikami D, Kitano T, Ida T, Sato T, Nemoto T, Nagata S, Islam Khan MR, Takahashi S, Ushikubi F, Suzuki N, Umezawa A, Taniguchi T., The Journal of Steroid Biochemistry and Molecular Biology, 196:105493, 2020年02月
  • β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells., Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, Nishikawa Y, Nishikawa S, Yokoi S, Taniguchi T, Iwano M., Journal of Pharmacological Sciences, 142:1-8, 2020年01月
  • Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways., Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, Nishikawa Y, Nishikawa S, Yokoi S, Kimura H, Kimura I, Taniguchi T, Iwano M., Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1865:158666, 2020年01月
  • AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition., Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, Nishikawa Y, Nishikawa S, Yokoi S, Taniguchi T, Iwano M., Therapeutic Advances in Medical Oncology, 12:1758835920913432, 2020年03月
  • PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK., Uwada J, Nakazawa H, Mikami D, Islam MS, Muramatsu I, Taniguchi T, Yazawa T, Biochemical Pharmacology, 182:114297, 2020年12月
  • Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition., Masuoka T, Uwada J, Kudo M, Yoshiki H, Yamashita Y, Taniguchi T, Nishio M, Ishibashi T, Muramatsu I., Neuroscience, 404:39-47, 2019年04月
  • β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells., Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, Nishikawa Y, Morikawa Y, Yokoi S, Takahashi N, Kasuno K, Taniguchi T, Iwano M, Life Sciences, 222:125-132, 2019年04月
  • Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer's disease drugs., Muramatsu I, Uwada J, Yoshiki H, Sada K, Lee KS, Yazawa T, Taniguchi T, Nishio M, Ishibashi T, Masuoka T., Journal of Neurochemistry, 149:605-623, 2019年06月
  • Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells., Yazawa T, Imamichi Y, Sekiguchi T, Miyamoto K, Uwada J, Khan MRI, Suzuki N, Umezawa A, Taniguchi T, BioMed Research International, 2019:8973076, 2019年04月
  • Cyclooxygenase-2 is acutely induced by CCAAT/enhancer-binding protein β to produce prostaglandin E 2 and F 2α following gonadotropin stimulation in Leydig cells., Yazawa T, Imamichi Y, Yuhki KI, Uwada J, Mikami D, Shimada M, Miyamoto K, Kitano T, Takahashi S, Sekiguchi T, Suzuki N, Rafiqul Islam Khan M, Ushikubi F, Umezawa A, Taniguchi T., Molecular Reproduction and Development, 86:786-797, 2019年07月
  • Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells., Uwada J, Yazawa T, Nakazawa H, Mikami D, Krug SM, Fromm M, Sada K, Muramatsu I, Taniguchi T., Cellular Signalling, 63:109358, 2019年11月
  • Differential recruitment of acetylcholine vesicle pools by electrical stimulation and KCl depolarization in cholinergic nerve terminals, Ikunobu Muramatsu, Junsuke Uwada, Itsumi Nagai-Arakawa, Noriyuki Matsukawa, Takayoshi Masuoka, FEBS Letters, 0:10.1002/1873-3468.70385, 2026年06月

競争的資金

  • リン脂質キナーゼPIKfyveを標的とした高アンモニア血症の新規治療法の開発
    文部科学省：科学研究費　基盤研究（Ｃ）
    研究期間：2025年04月 - 2028年03月  
  • 細胞内局在性ムスカリン受容体の生体における機能解析
    文部科学省：科学研究費　基盤研究（C）
    研究期間：2019年 - 2021年  
    代表者:宇和田　淳介