Japanese

ITO Tohru

■Faculty	Department of Gastroenterological Endoscopy
■Position	Professor

Researcher Profile & Settings

Research

Overview of research:

It is about 18% of lyphnode metastases for sm invasive early gastric cancer , but of which80% is no lympnode metastases. At least, if we know the metastasis at preoperative condtion, we think to make a large contribution to treatment course. We are going to perform to be wave analysis by nucleic analysis technique and positive appearance of gene for immunohistochemistry by an experiment on resected specimens of sm-invasive early gastric cancer and preoperative hiopsy of its cancers.

Education

Kanazawa Medical University Graduate School Division of Medicine

Degree

Ph.D in Medicine

Research Activities

Published Papers

A Case of multiple solitary neurofibromas located in the hypopharynx and cervical esophagus, Hamada Kazu, Shimode Yuzo, Hata Yoshiyuki, Kunou Hiroaki, Kobayashi Rika, Matsunaga Kazuhiro, Kawaura Ken, Mukai Tsuyoshi, Kitakata Hidekazu, Itoh Tohru, Okuro Masashi, Yamada Sohsuke, 3:1, Jun. 2022
Review of Biliary Drainage in the Management for Preoperative and Unresectable Malignant Distal Biliary Obstructions, Tsuyoshi Mukai, Hiroaki Kunou, Rika Kobayashi, Junji Kamai, Sadafumi Azukisawa, Ken Kawaura, Hidekazu Kitakata, Tasuku Hayashi, Hikaru Takano, Naoko Sakurai, Ranji Hayashi, Toshimi Otsuka, Tohru Ito, 47:7-12, Jun. 2022
Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report., Miura S, Niida Y, Hashizume C, Fujii A, Takagaki Y, Kusama K, Akazawa S, Minami T, Mukai T, Furuichi K, Tsuchishima M, Ueda N, Takamura H, Koya D, Ito T., 9:25, Mar. 2022
Bleeding Risk Factors after Endoscopic Submucosal Dissection in early Gastric Cancer and the Necessity of "Second-Look" Endoscopic Examination om the following Day, Rika Kobayashi, Ken Kawaura, Tohru Ito, Sadafumi Azukisawa, Hiroaki Kunou, Junji Kamai, Kazu Hamada, Tsuyoshi Mukai, Hidekazu kitakata, and Yasuhito Ishigaki, 11:914, Feb. 2022
Examination of Endoscopic Ultrasonographic Diagnosis for the Depth of Early Gastric Cancer, Kazu Hamada, Tohru Itoh, Ken Kawaura, Hidekazu Kitakata, Hiroaki Kuno, Junji Kamai, Rika Kobayasi, Sadahumi Azukisawa, Taishi Ishisaka, Yuta Igarashi, Kumie Kodera, Tazuo Okuno, Takuro Morita, Taroh Himeno, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Masashi Okuro, Journal of Clinical Medicine Research, 13:222-229, Apr. 2021
A Case of Refractory Esophageal Ulcer Caused by Radiotherapy for Hepatocellular Carcinoma, Kazu Hamada, Tohru Itoh, Ken Kawaura, Hiroaki Kuno, Junji Kamai, Rika Kobayasi,Sadahumi Azukisawa, Hidekazu Kitakata, Taishi Ishisaka, Yuta Igarashi, Kumie Kodera, Tazuo Okuno, Takuro Morita, Tarou Himeno, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Munetaka Matoba, Masashi Okuro, World Journal of Oncology, 12:67-72, Jun. 2021
A Case of Secondary Rectal Intramural Hematoma Triggered by Aspiration for Endoscopic Mucosal Resection, Kazu Hamada, Tohru Itoh, Ken Kawaura, Hiroaki Kuno, Junji Kamai, Rika Kobayasi,Sadahumi Azukisawa, Hidekazu Kitakata, Yuta Igarashi, Kumie Kodera, Tazuo Okuno,Takuro Morita, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Masashi Okuro, Gastroenterology Medicine & Research, 5:471-474, Apr. 2021
Tocilizumab and PMX-DHP have efficacy for severe COVID-19 pneumonia., Shinomiya Shohei, Nakase Keisuke, Fujii Ai, Takahara Yutaka, Adachi Hiroki, Okuro Masashi, Iinuma Yoshitsugu, Yokoyama Hitoshi, Ito Toru, Mizuno Shiro, SAGE open medical case reports, 9:1-5, Feb. 2021
DOI:10.1177/2050313X21991063
nPTD classification: an updated classification of gastric cancer location for function preserving gastrectomy based on physiological lymphatic flow., Shinichi Kinami, Naohiko Nakamura, Tomoharu Miyashita, Hidekazu Kitakata, Sachio Fushida, Takashi Fujimura, Tohru Itoh, Hiroyuki Takamura, BMC cancer, 21:1231, Nov. 2021
DOI:10.1186/s12885-021-08936-9
Life prognosis of sentinel node navigation surgery for early-stage gastric cancer: Outcome of lymphatic basin dissection, Shinichi Kinami, Naohiko Nakamura, Tomoharu Miyashita, Hidekazu Kitakata, Sachio Fushida, Takashi Fujimura, Yasuo Iida, Noriyuki Inaki, Toru Ito, Hiroyuki Takamura, World Journal of Gastroenterology, 27:8010-8030, Dec. 2021
DOI:10.3748/wjg.v27.i46.8010
The differential expression of perilipin-2 in hepatoblastoma and its association with prognosis, Sadafumi Azukisawa, Jianbo zheng, Xin Guo, Hiroki Ura, Yo Niida, Tohru Itoh, Sohsuke Yamada, Histology and Histopathology, 36:1169-1178, Dec. 2021
Gastrointestinal endoscopy in the era of the acute pandemic of coronavirus disease 2019:Recommendations by Japan Gastroenterological Endoscopy society(Issued on April 9th,2020), (A Irisawa), T Furuta, T Matsumoto, T Kawai, T Inaba, A Kanno, A Katanuma, Y Kawahara, K Matuda, K Misukami, T Otsuka, I Yasuda, S Tanaka, K Fujimoto, S Fukuda, H Iishi, Y Igarashi, K Inui, T Ueki, H Ogata, M Kato, A Shiotani, K Higuchi, N Fujita, K Murakami, H Yamamoto, T Ito, K Okazaki, Y Kitagawa, T Mine, H Tajiri, H Inoue, Digestive Endoscopy, 32:648-650, Jul. 2020
Clinical Question and Answers on Gastrointestinal Endoscopy during the Novel Coronavirus Disease2019 pandemic, (T Furuta), A Irisawa, T Matsumoto, T Kawai, T Inaba, A Kanno, A Katanuma, Y Kawahara, K Matsuda, K Mizukami, T Otsuka, I Yasuda, M Fujishiro, S Tanaka, K Fujimoto, S Fukuda, H Iishi, Y Igarashi, K Inui, T Ueki, H Ogata, M Kato, A Shiotani, K Higuchi, N Fujita, K Murakami, H Yamamoto, T Ito, K Okazaki ,Y Kitagawa, T Mine, H Tajiri , H Inoue, Digestive Endoscopy, 32:651-657, Jul. 2020
Relationship Between Gastroesophageal Reflux Disease and Endoscopic Finding "lodine-Unstained Streak", Kazu Hamada, Tohru Itoh, Ken Kawaura, Hidekazu Kitakata, Hiroaki Kuno, Junji Kamai, Rika Kobayasi, Sadahumi Azukisawa, Taishi Ishisaka, Yuta Igarashi, Kumie Kodera, Tazuo Okuno, Takuro Morita, Taroh Himeno, Hiroshi Yano, Toshihiro Higashikawa, Osamu Iritani, Kunimitsu Iwai, Shigeto Morimoto, Masashi Okuro, Journal of Clinical Medicine Research, 12:699-704, 2020
Sealed endoscopy full-thickness resection for gastric cancer: a pilot study in an ex vivo and in vivo porcine model, Hidekazu Kitakata, Tohru Itoh, Shinichi Kinami, Ken Kawaura, Kazu Hamada, Sadafumi Azukisawa, Rika Kobayashi, Jumji Kamai, Takeo Kosaka, Endoscopy International Open, 07:E36-E42, Jan. 2019
Selection of Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on the Patients., K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki, CLINICAL INVESTIGATION, 7:111-118, Sep. 2017
Findings of the margin around lesions by magnifying endoscopy with narrow-band imaging in early gastric carcinoma and intestinal metaplasia., K.Hamada, T.Itoh, K.Kawaura, S.Azukisawa, R.Kobayashi, H.Okamura, H.Kitakata, S.Urashima, T.Nojima, M.Fujino, Journal of digestive diseases, 17:377-382, 2016
DOI:10.1111/1751-2980.12352
New treatment strategy for submucosa-infiltrating gastric cancer without sentinel node metastasis: A pilot study of laparoscopy-assisted endoscopic full-thickness resection in an IN VIVO porcine model., T.Itoh, H.Kitakata, S.Kinami, K.Kawaura, K.Hamada, S.Azukisawa, R.Itoh, K.Omote, T.Kosaka, M.A.Fujino, ENDOSCOPIC FORUM for digestive disease, 31:17-26, May 2015
Examination of dark reddish-brown urine (RBU) caused by endoscopic submucosal dissection (ESD), K.Hamada, T.Itoh, H.Kitakata, K.Kawaura, S.Azukisawa, R.Itoh, H.Okamura, S.Urashima, ENDOSCOPIC FORUM for digestive disease, 31:33-39, May 2015
An electron microscopic analysis of intestinal spirochetosis in a patient with acute phase of ischemic colitis, J Electr. Microsc. Technol. Med. Biol., 24:91, Nov. 2010
Effect of hot-spring hydrotherapy on lymphocyte subsets expressing β２-adrenergic receptors, M.Sakuma, S.Matsuba, H.Matsuno, K.Uchikawa, T.Itou, S.Shimizu, N.Yamaguchi, 73:101-108, Feb. 2010
The lymphatic infiltration identified by D2-40 monoclonal antibody predicts lymph node metastasis in submucosal invasive colorectal cancer., K.Kawaura, S.Fujii, Y.Murata, T.Hasebe, G.Ishii, T.Itou, Y.Sano, N.Saito, A.Ochiai, Pathobiology : journal of immunopathology, molecular and cellular biology, 74-328-335, Dec. 2007
Prostate cancer producing carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki, 32：29-31, Jun. 2007
Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression, S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy., 21:155-160, Jun. 2007
Effectiveness of goshajinkigan on the cold sensation and dysthesia in a case of nodular multiple angiitis, J.Yamakawa, J.Moriya, K.Kusaka, T.Itoh, Y.Motoo, T.Kanda, 57：651-654, Sep. 2006
Advanced oesophageal carcinoma in an 84- year-old treated with chemoradiotherapy, K.Kusaka, T.Itoh, K.Kawaura, J.Moriya, J.Yamakawa, T.Takahashi, M.Oguchi, H.Tonami, I.Yamamoto, T.Kanda, The Journal of international medical research., 34:437-440, Jul. 2006
Traditional chinese medicine and kampo: a review from the distant past for the future, F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda, The Journal of international medical research., 34:231-239, May 2006
Angiotensin-Ⅱ receptor antagonist alleviates non-alcoholic fatty liver in kkay obese mice with type2 diabetes, F.Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, H.Sumino, S.Morimoto, T.Kanda, The Journal of international medical research., 34:297-302, May 2006
Globalization of kampo medicine, T.Kanda, J.Yamakawa, J.Moriya, S.Saegusa, K.Kawaura, F.Yu, K.Kusaka, T.Takahashi, T.Itoh, 30:297-301, Dec. 2005
Kampo medicines minimized a variety of complaints treated with twenty-eight western medicines: a case of 81-year-old woman, J.Moriya, T.Takahashi, J.Yamakawa, S.Saegusa, T.Itoh, K.Kusaka, K.Kawaura, F.Yu, T.Kanda, 30:12-15, Jun. 2005
Three-point fixation of stomach to abdominal wall in the percutaneous endoscopic gastrostomy procedure, K.Kusaka, T.Itoh, K.Kawaura, J.Yamakawa, T.Takahashi, T.Kanda, 37:494, Mar. 2005
Chronotropic Effect of the Anti-thrombotic Agent Cilostazol in a Patient with Sick Sinus Syndrome with Syncope, J Moriya, T Takahashi, Y Nomura, K Kawaura, K Kusaka, J Yamakawa, N Fujioka, S Okubo, T Itoh, T Kanda, The Journal of International Medical Research, 32:549-551, May 2004
Selective binding of sucralfate to endoscopic mucosal resection-induced gastric ulcer: evaluation of aluminum adherence., T.Itoh, K.Kusaka, K.Kawaura, J.Yamakawa, T.Takahashi, T.Kanda, et al., The Journal of international medical research., 32：520-529, 2004
Plasma adiponectin levels in post-menopausal women receiving hormone replacement therapy., (H.Sumino), T.Takahashi, T.Itoh, K.Kusaka, J.Yamakawa, T.Kanda, et al., The Journal of international medical research., 32：639-645, 2004
Panic attack symptoms in a patient with left temporal lobe epilepsy., S.Saegusa, T.Takahashi, J.Moriya, J.Yamakawa, T.Itoh, K.Kusaka, K.Kawaura, T.Kanda, The Journal of international medical research., 32：94-96, 2004
Effect of the serotonin blocker sarpogrelate on circulating interleukin-18 levels in patients with diabetes and arteriosclerosis obliterans, J.Yamakawa, T.Takahashi, S.Saegusa, J.Moriya, T.Itoh, K.Kusaka, K.Kawaura, XQ.Wang, T.Kanda, The Journal of international medical research., 32:166-169, 2004
Effect of hochu-ekki-to(TJ-41),a Japanese herbal medicine,on daily activity in a murine model of chronic fatigue syndrome., XQ.Wang, T.Takahashi, S.Zhu, J.Moriya, S.Saegusa, J.Yamakawa, K.Kusaka, T.Itoh, T.Kanda, eCAM, 1：203-206, 2004
Chronotropic effect of the anti-thrombotic agent cilostazol in a patient with sick sinus syndrome and syncope., J.Moriya, T.Takahashi, *Y.Nomura, K.Kawaura, K.Kusaka, J.Yamakawa, *N.Fujioka, *S.Okubo, T.Itoh, T.Kanda, The Journal of international medical research., 32：549-551, 2004
Upregulation of cardiac ghrelin mRNA in leptin-deficient and leptin receptor-deficient mice with viral myocarditis, T. Kanda, T. Takahashi, T. Itoh, K. Kusaka, J. Yamakawa, *S. Kudo, *T. Takeda, *H. Tsugawa, *N. Takekosi, The Journal of international medical research., 31: 503-508, 2003
Spontaneously identified gastric sarcoidosis: a report of three cases, K. Kawaura, T. Takahashi, K. Kusaka, J. Yamakawa, T. Itoh, T. Kanda, The Journal of international medical research., 31: 239-243, 2003
Insulin resistant state in type 2 diabetes is related to advanced autonomic neuropathy, S. Nakano, T. Ito, H. Hatakeyama, M. Nishizawa, A. Nakagawa, T. Kigoshi, K. Uchida, et al., Clinical and experimental hypertension : CHE., 25: 155-167, 2003
Herpes simplex esophagitis from 1307 autopsy cases, T. Itoh, T. Takahashi, K. Kusaka, K. Kawaura, J. Yamakawa, T. Kanda, Journal of gastroenterology and hepatology., 18: 1407-1411, 2003
Brugada-like electrocardiographic changes during influenza infection, K. Kusaka, J. Yamakawa, K. Kawaura, T. Itoh, T. Takahashi, T. Kanda, The Journal of international medical research., 31: 244-246, 2003
A novel serotonin blocker, sarpogrelate, increases circulating adiponectin levels in diabetic patients with arteriosclerosis obliterans, J. Yamakawa, T. Takahashi, T. Itoh, K. Kusaka, K. Kawaura, X-Q. Wang, T. Kanda, Diabetes Care., 26: 2477-2478, 2003
The effect of the herbal medicine dai-kenchu-to on post-operative ileus, T. Itoh, J. Yamakawa, T. Kanda, et al., The Journal of international medical research., 30: 428-432, 2002
Clinical Research Activity Shown by Key Word Listings, J. Yamakawa, T. Itoh, K. Kawaura, K. Kusaka, T. Kanda, Kanazawa Ika Daigaku zasshi = Journal of Kanazawa Medical University. Links , 27: 143-146, 2002
Histochemical Study of Hyaluronatein Alcoholic Liver Disease., (S.Urashima), M.Tsutsumi, K.Shimanaka, Y.Ueshima, M.Tsushima, T.Itoh, H.Kawahara, S.Takase, Alcohol. Clini. Exp. Res., ；19-130-134, 1999
Effects of New Orally Active Dopamine Prodrug, Docarpamine, on Pefractory Ascites : A Pilot Study., M.Tsuchishima, T.Funasaki, M.Tsutsumi, S.Takase, Y.Ueshima, S.Urashima, K.Shimanaka, T.Itoh, H.Kawahara, Am J Gastroenterol, ；94：2475-2481, 1999
Clinico-pathological Study on Synchoronous Multiple Early Gastric Cancer-From the Standpoint of Surgery, Stomach and Intestine, 29:691-700, Jul. 1994
A Case Of Borrmann 4 Type Adenocarcinoma Of 18-Year-Old Man With Review Of 25 Cases Of gastric Carcinoma In The Young, ENDOSCOPIC FORUM for digestive disease, Vol.9 No.2 251-256, 1993
Clinicopathologic Study On The Intramucosal Gastric Cancer With Lymph Node Metastasis, (Hidehiro Nomura), Hideto Watanabe, Cheng-Dong Huang, Nakaba Fujioka, Yuri Tsuchiya, Kazuhiko Omote, Yasushi Deguchi, Toshihiro Fujimoto, Toru Ito, Yutaka Takahashi, Masayoshi Mai, ENDOSCOPIC FORUM for digestive disease, 8 No.2 282-286, 1992
The combination of the low immunohistochemical expression of peroxiredoxin 4 and perilipin 2 predicts longer survival in pancreatic ductal adenocarcinoma with peroxiredoxin 4 possibly playing a main role, Jia Han, Tohru Itoh, Akihiro Shioya, Masaru Sakurai, Takeru Oyama, Motona Kumagai, Hiroyuki Takamura , Masashi Okuro, Tsuyoshi Mukai, Hidekazu Kitakata, Masaru Inagaki, Michiyo Higashi, Xin Guo, Sohsuke Yamada, HISTOLOGY AND HISTOPATHOLOGY, 38:1415-1427, Dec. 2023
DOI:10.14670/HH-18-666
Report on the seventh national survey on gastrointestinal endoscopy-related adverse events for three years : from 2019 to 2021, Gastroenterological Endoscopy, 66:327-354, Mar. 2024
Laparoscope and endoscopy cooperative surgery with sentinel node navigation for early gastric cancer e\without indication for ESD, Hidekazu Kitkata, Shinichi Kinami, Tohru Itoh, Gastroenterological Endoscopy, 66:1258-1267, May 2024
Procalcitonin, brain natriuretic peptide and albumin as markers to predict prognosis in hospitalized older Japanese patients with a risk of infection, Toshihiro Higashikawa, Toru Ito, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Michiteru Yoshida, Takuro Morita, Kazu Hamada, Hiroshi Yano, Kento Takeshima, Takatoshi Haraguchi, Shinya Yamada, Sohsuke Yamada, Tomoyuki Ushimoto, Ryusho Sangen, Toshihide Izumida, Jun Kiyosawa, Taisuke Ono, Masaharu Iguchi, Yukihiro Wato, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Shigeto Morimoto, Masashi Okuro, Geriatrics & Gerontology International, 24:571-576, Jun. 2024
The immunohistochemical combination of low SGLT2 expression and high PRDX4 expression independently predicts shortened survival in patients undergoing surgical resection for hepatoblastoma, Yao Liu, Jia Han, Akihiro Shioya, Yang-Xian Zhang, Vu Anh Dung, Takeru Oyama, Xin Guo, Qian Yang, Tohru Ito, Sohsuke Yamada, Diagnostic Pathology, 20:2, Jan. 2025

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.