Intracellular toxic advanced glycation end-products promote the production of reactive oxygen species in HepG2 cells, Sakasai-Sakai A, Takata T, Takeuchi M, International Journal of Molecular Sciences, 21:4861, Jul. 2020
Nutritional conditions and oxygen concentration affect spontaneous occurrence of homologous recombination events but not spontaneous mutagenesis in Escherichia coli, (Lan Anh Thi Le), Phooi Yee Chang, Sayaka Ando, Thomas M. Conrad, Shohei Nunose, Akiko Sakai, Haruka Uefune, Asako Furukohri, Masahiro Tatsumi Akiyama, Hisaji Maki, Genes & Genetic Systems, 95:85-93, May 2020
Exploration of the mystery of the third glycogen metabolite 1,5-anhydro-D-fructose (1,5-AF), Akiko Sakasai-Sakai, Takanobu Takata, Hirokazu Suzuki, Ikuro Maruyama, Kenji Tanaka, Yoshihiro Motomiya, Masayoshi Takeuchi, The Journal of Japan Mibyou Association, 26:67-72, Jan. 2020
Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite, Sakasai-Sakai Akiko, Takata Takanobu, Suzuki Hirokazu, Maruyama Ikuro, Motomiya Yoshihiro, Takeuchi Masayoshi, Scientific Reports, 9:10194, Jul. 2019
Evidence for toxic advanced glycation end-products generated in the normal rat liver, Takata Takanobu, Sakasai-Sakai Akiko, Takino Jun-ichi, Takeuchi Masayoshi, Nutrients, 11:1612, Jul. 2019
The relevance of toxic AGEs (TAGE) cytotoxicity to NASH pathogenesis: A mini-review, Sakasai-Sakai Akiko, Takata Takanobu, Takino Jun-Ichi, Takeuchi Masayoshi, Nutrients, 11:462, Feb. 2019
Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease, Takata Takanobu, Sakasai-Sakai Akiko, Ueda Tadashi, Takeuchi Masayoshi, Scientific Reports, 9:2121, Feb. 2019
Novel biomarker toxic AGEs (TAGE) in the onset / progression of lifestyle-related (LSRD), Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, The journal of Japan Mibyo System Association, 24:27-33, Aug. 2018
Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD, Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi, The journal of Japan Mibyo System Association, 24:19-25, Mar. 2018
Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Masayoshi Takeuchi, 7:1, Oct. 2017
Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion, Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi, World Journal of Gastroenterology, 23:4910-4919, Jul. 2017
Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi, Nutrients, 9:634, Jun. 2017
Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function, (Jun-ichi Takino), Kentaro Nagamine, Mikoto Suzuki, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hori, American Journal of Molecular Biology, 7:87-98, Apr. 2017
Involvement of toxic AGEs(TAGE) in the onset / progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy, Masayoshi Takeuchi,Akiko Sakasai-Sakai,Takanobu Takata, 23:20-30, 2017
Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma, (J.Takino), K.Nagamine, T.Hori, A.Sakasai-Sakai, M.Takeuchi, World Journal of Hepatology, 7:2459-2469, Aug. 2015
Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD, M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi, International Journal of Diabetes and Clinical Researsh, 2:1-5, Jul. 2015
Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH., M.Takeuchi, A.Sakasai-Sakai, T.Takata, T.Ueda, J.Takino, M.Tsutsumi, H.Hyogo, S.Yamagishi, Medical Hypotheses, 84:490-493, 2015
Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi, World journal of hepatology [electronic resource], 6:880-893, Dec. 2014
Impact of Reactive Oxygen Species on Spontaneous Mutagenesis in Escherichia coli., Sakai A, Nakanishi M, Yoshiyama K, Maki H, 11:767-787, Jul. 2006
Impact of intracellular toxic advanced glycation end-products (TAGE) on murine myoblast cell death, Takata Takanobu, Sakasai-Sakai Akiko, Takeuchi Masayoshi, Diabetology & Metabolic Syndrome, 12:54, Jun. 2020
Accumulation of toxic advanced glycation end-products induces cytotoxicity and inflammation in hepatocyte-like cells differentiated from human induced pluripotent stem cells., (Kikuchi C), Sakasai-Sakai A, Okimura R, Tanaka H, Takata T, Takeuchi M, Matsunaga T, Biol. Pharm. Bull., 44:1399-1402, Oct. 2021
Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis., (Tanaka K), Sakasai-Sakai A, Motomiya Y, Yoneda T, Takeuchi M, 13:85, Aug. 2021
Intracellular toxic AGEs (TAGE) triggers numerous types of cell damage., Takeuchi M, Sakasai-Sakai A, Takata T, Takino J, Koriyama Y, Furukawa A, Kikuchi C, Nagamine K, Hori T, Matsunaga T, Biomolecules, 11:387, Mar. 2021
Suppression of hepatic stellate cell death by toxic advanced glycation end-products., (Takino J), Sato T, Nagamine K, Sakasai-Sakai A, Takeuchi M, Hori T, Biol. Pharm. Bull., 44:112-117, Jan. 2021
Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Mirotubule-Associated Protein 1 Light Chain 3 and p62, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, 14:332, Jan. 2022
Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, 12:615, Jul. 2022
Effects of Toxic AGEs (TAGE) on Human Health, Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, 11:2178, Jul. 2022
The association between accumulation of toxic advanced glycation end-products and cytotoxic effect in MC3T3-E1 cells., 14:990, Feb. 2022
Involvement of intercellular TAGE and the TAGE-RAGE-ROS axis in the onset and progression of NAFLD/NASH., Sakasai-Sakai A, Takeda K, Takeuchi M, Antioxidants, 12:748, Mar. 2023
A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model, Kenji Takeda, Akiko Sakai-Sakasai, Kouji Kajinami, Masayoshi Takeuchi, Cells, 12:2838-2838, Dec. 2023
Structures of Toxic Advanced Glycation End-Products Derived from Glyceraldehyde, A Sugar Metabolite, Akiko Sakai-Sakasai, Kenji Takeda, Hirokazu Suzuki, Masayoshi Takeuchi, 14:202-202, Feb. 2024
Major generation route of cytotoxic protein adducts derived from acetaldehyde, a metabolite of alcohol., Takeuchi M, Suzuki H, Sakai-Sakasai A, 189:111385, Aug. 2024
Structures of toxic advanced glycation end-products derived from glyceraldehyde, a sugar metabolite., Sakai-Sakasai A, Takeda K, Suzuki H, Takeuchi M., 14:202, Feb. 2024
Toxic advanced glycation end-products (TAGE) are major structures of cytotoxic AGEs derived from glyceraldehyde., Takeuchi M, Suzuki H, Takeda K, Sakai-Sakasai, 183:111248, Feb. 2024
Glycation stress induced by glyceraldehyde promotes vimentin accumulation and disrupts aggresome clearance in Hep3B cells, Akiko Sakai-Sakasai, Kenji Takeda, Masayoshi Takeuchi, Biochemical and Biophysical Research Communications, 829:154173-154173, Sep. 2026
