Japanese

FUKUDA Masamichi

■Faculty	Department of Ophthalmology, Division of Vision Research for Environmental Health
■Position	Associate Professor

Researcher Profile & Settings

Research

Overview of research:

We developed a cornea resistance experiment newly and tried quantification of the cornea disorder in this device. Conclusion :We attached cornea CL electrode to the cornea, and the possibility of quantification of the cornea disorder was suggested by measuring cornea resistance. This device will become a useful method that can measure cornea disorder characteristics with living body eyes.

Special Field

Ophthalmology
Molecular Pharmaceutics
Biopharmaceutics

Education

Josai University Faculty of Pharmaceutical Science

Degree

Doctor of Pharmacy

Academic & Professional Experience

1988- 2001Ophthalmology, Kanazawa　Medical University Associate Professor

Research Activities

Published Papers

Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment, Masamichi Fukuda, Shinsuke Shibata, Naoko Shibata, Nobuyuki Fujita, Hisanori Miyashita, Naoki Tanimura, Hidetoshi Ishida, Eri Kubo , Hiroshi Sasaki, PLOS ONE, 13:e0208198, 2018
An ease eith successful treatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Nobuyuki Fujita,Teppei Shibata,Masamichi Fukuda,Kazuyuki Sasaki, Hiroshi Sasaki, Folia Japanica de Ophthalmologica Clinica, 10:1007-1010, 2017
In vivo meaurement of human corneal impedance value, M.Fukuda, H.Sasaki, Cornea, 35:1305-1307, 2016
In vitro and in vivo corneal effects of latanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide, M.Fukuda, N.Takeda, S.Shibata, N.Shibata, T.Shibata, K.Sugiyama, H.Sasaki, European Journal of Pharmacology, 787:43-46, 2016
Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing, M.Fukuda, H.Sasak, Journal of Ocular Pharmacology and Therapeutics, 31:536-540, Sep. 2015
The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes, M.Fukuda, H.Sasaki, Journal of Ocular Pharmacology and Therapeutics, 31:57-60, 2015
Safety of rebamipide ophthalmic suspension for corneal epithelial cells: In vitro and In vivo study., M.Fukuda, H.Nakashima, J.Haruta, S.Shibata, N.Shibata, H.Osada, Y.Seki, N.Mita, H.Sasaki, 30:1467-1471, Oct. 2013
Safety comparison of additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations., M.Fukuda, S.Shibata, N.Shibata, K.Hagihara, H.Osada, N.Takahashi, E.Kubo, H.Sasaki, Clinical ophthalmology., 7:515-520, 2013
Generic versions of latanoprost ophthalmic solution evaluated for safety to corneal epithelial cells, M.Fukuda, I.Shibata, K.Hagiwara, H.Yaguchi, H.Sasaki, 28:849-854, Jun. 2011
Vitreous and aqueous penetration of orally and topically administered moxifloxacin, M.Fukuda, N.Shibata, H.Osada, Y.Yamashiro, H.Sasaki, Ophthalmic research., 46:113-117, Jun. 2011
Effect of sodium hyaluronate eyedrops on corneal cells, M.Fukuda, H.Yaguchi, N.Fujita, I.Shibata, H.Osada, N.Shibata, H.Sasaki, 28:549-552, Apr. 2011
Cytotocic effect of ofluoxacin ophthalmic solutions and timolol maleate ophthalmic solutions on cultured rabbit corneal cell line and ocular pharmacokinetics of ophthalmic solutions in rabbits, M.Fukuda, H.Sasaki, 26:977-981, Jul. 2009
Cytotoxic effects of new quinolone antibiotic ophthalmic solutions nad nonsteroidal anti-inflammatory ophthalmic solutions on cultured rabbit corneal cell line, M.Fukuda, H.Sasaki, 26:399-403, Mar. 2009
Intraocular penetration of astaxanthin in rabbit eyes, M.Fukuda, J.Takahashi, Y.Nishida, H.Sasaki, 25:1461-1464, Oct. 2008
A comparison of moxifloxacin and levofloxacin topical prophylaxis in a fluoroquinolone-resistant staphylococcus aureus rabbit model, (R.P.Kowalski), E.G.Romanowski, F.S.Mah, H.Sasaki, M.Fukuda, Y.J.Gordpm, Japanese journal of ophthalmology., 52:211-216, Jan. 2008
Corneal disorder quantification by corneal resistance, M.Fukuda, K.Yamamoto, N.Takahashi, H.Sasaki, M.Yoshikawa, 24:521-525, Apr. 2007
Intraocular penetration of moxifloxacin ophthlamic solution in rabbit eyes -calculaation of maximum drug concentration in aqueous-, M.Fukuda, H.Sasaki, Y.Ohashi, 23:1353-1357, Oct. 2006
Role of P-glycoprotein in restricting ofloxacin transport in cultured rabbit corneal epithelial cells., FUKUDA Masamichi, The Association for Research in Vision and Ophthalmology., 2001
Studies on the binding mechanism of fluoroquinolones to melanin., FUKUDA Masamichi, J. Infect. Chemother. (Japanease Society of Chemotherapy and the Japanease Association for Infections Diseases.), 2000
The Uptake of Fluoroquinolone Agent Drugs by Cultured Human Conjunctival Epithelial Cells and Cultured SIRC Rabbit Corneal Cells., FUKUDA Masamichi, Journal of Japanese Ophthalmological Society, 1999
An Animal Model of Corneal Bacterial Infection Induced by Intra-corneal Injection of staphylococcus Epidermidis., FUKUDA Masamichi, Journal of Japanese Ophthalmological Society., 1999
Intraocular Penetration of Biapenem into Rabbit Eyes., FUKUDA Masamichi, Atarashii Ganka(J. Eye), 1998
Intraocular Dynamics of S-1090, a New Cephem Antibiotic, in the Rabbit Eye., FUKUDA Masamichi, Folia Ophthalmol Jpn, 1997
The effects of antiglaucoma ophthalmic solutions on the cornea revealed by a corneal electrical resistance devi., Nobuo Takeda, Masamichi Fukuda, Hiroshi Sasaki, Kazuhisa Sugiyama, Journal of Ocular Pharmacology and Therapeutics, 37:97-103, Mar. 2021
Benzalkonium Chloride-Induced Corneal Epithelial Injury in Rabbit Reduced by Rebamipide, Masamichi Fukuda, Nobuo Takeda, Hidetoshi Ishida, Yusuke Seki, Naoko Shibata, Nobuo Takahashi, Kazuhisa Sugiyama, Eri Kubo, Hiroshi Sasaki, 38:85-91, Jan. 2022
DOI:https://doi.org/10.1089/jop.2021.0052
Preventative Effect of Topical Rebamipide Against Corneal Epithelium Disorders Caused by Diclofenac Sodium, Fukuda Masamichi, Kiyoi Takeshi, Takeda Shun, Sasaki Yu, Masuoka Naoyoshi, Kubo Eri, Sasaki Hiroshi., J Ocul Pharmacol Ther, 40:428-434, Sep. 2024
DOI:https://doi.org/10.1089/jop.2024.002
Effect of silver nitrate solution on corneal epithelial barrier function in rabbits, Masamichi Fukuda, Takeshi Kiyoi, Shun Takeda, Yu Sasaki, Takayoshi Masuoka, Tsuyoshi Mito, Makoto Sasaki, Eri Kubo, Hiroshi Sasaki, Cutaneous and Ocular Toxicology, 44:536-543, Dec. 2025
DOI:doi: 10.1080/15569527.2025.2570204

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.