IWAWAKI Takao

■FacultyDepartment of Life Sciences
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Physiological and pathological function of cellular stress response

Special Field

  • Basic medicine
  • Cell biology
  • Laboratory animal science

Degree

  • Ph. D

Research Activities

Published Papers

  • Paneth cell TNF signaling induces gut bacterial translocation and sepsis, (Wallaeys C), Garcia-Gonzalez N, Timmermans S, Vandewalle J, Vanderhaeghen T, De Beul S, Dufoor H, Eggermont M, Moens E, Bosteels V, De Rycke R, Thery F, Impens F, Verbanck S, Lienenklaus S, Janssens S, Blumberg RS, Iwawaki T, Libert C, Cell Host Microbe, 32:1725-1743, Oct. 2024
  • High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils, (Emmanuelli A), Salvagno C, Hwang SM, Awasthi D, Sandoval TA, Chae CS, Cheong JG, Tan C, Iwawaki T, Cubillos-Ruiz JR, Oncoimmunology, 13:2411070, Oct. 2024
  • Exposure to volatile ferroptosis inhibitor, TEMPO, reduced cutaneous ischemia-reperfusion injury progression to pressure ulcer formation in a mouse model, (Ishikawa M), Uchiyama A, Kosaka K, Nishio M, Ogino S, Yokoyama Y, Torii R, Akai R, Iwawaki T, Torii S, Motegi SI, J Dermatol Sci, 115:130-140, Sep. 2024
  • The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle, (Joshi AS), Tomaz da Silva M, Roy A, Koike TE, Wu M, Castillo MB, Gunaratne PH, Liu Y, Iwawaki T, Kumar A, EMBO Rep, 25:3627-3650, Aug. 2024
  • Unconventional Activation of IRE1 Enhances Th17 Responses and Promotes Airway Neutrophilia, (Wu D), Zhang X, Zimmerly KM, Wang R, Livingston A, Iwawaki T, Kumar A, Wu X, Campen M, Mandell MA, Liu M, Yang XO, Am J Respir Cell Mol Biol, 71:169-181, Aug. 2024
  • Protein translation rate determines neocortical neuron fate, (Borisova E), Newman AG, Couce Iglesias M, Dannenberg R, Schaub T, Qin B, Rusanova A, Brockmann M, Koch J, Daniels M, Turko P, Jahn O, Kaplan DR, Rosário M, Iwawaki T, Spahn CMT, Rosenmund C, Meierhofer D, Kraushar ML, Tarabykin V, Ambrozkiewicz MC, Nat Commun, 15:4879, Jun. 2024
  • Deletion of IRE1α in podocytes exacerbates diabetic nephropathy in mice, (Cybulsky AV), Papillon J, Guillemette J, Navarro-Betancourt JR, Chung CF, Iwawaki T, Fantus IG, Sci Rep, 14:11718, May 2024
  • IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis, (Jiang D), Guo Y, Wang T, Wang L, Yan Y, Xia L, Bam R, Yang Z, Lee H, Iwawaki T, Gan B, Koong AC, Nat Commun, 15:4114, May 2024
  • A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages, (Sasaki I), Fukuda-Ohta Y, Nakai C, Wakaki-Nishiyama N, Okamoto C, Okuzaki D, Morita S, Kaji S, Furuta Y, Hemmi H, Kato T, Yamamoto A, Tosuji E, Saitoh SI, Tanaka T, Hoshino K, Fukuda S, Miyake K, Kuroda E, Ishii KJ, Iwawaki T, Furukawa K, Kaisho T, Cell Rep, 43:113981, Mar. 2024
  • Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6α and ATF6β, Akai R, Hamashima H, Saito M, Kohno K, Iwawaki T, Cell Stress Chaperones, 29:34-48, Feb. 2024
  • Keratinocytes-specific SOX2 overexpression suppressed pressure ulcer formation following cutaneous I/R injury via enhancement of amphiregulin production, (Inoue Y), Uchiyama A, Amalia SN, Ishikawa M, Kosaka K, Sekiguchi A, Ogino S, Yokoyama Y, Torii R, Hosoi M, Akai R, Iwawaki T, Morasso MI, Motegi SI, J Invest Dermatol, 144:142-151, Jan. 2024
  • Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation, Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T, Miyazawa K., Free Radic Biol Med, 207:120-132, 2023
  • Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis, Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR, J Clin Invest, 133:e167359, 2023
  • The Unfolded Protein Response Sensor IRE1 Regulates Activation of In Vitro Differentiated Type 1 Conventional DCs with Viral Stimuli, Medel B, Bernales JI, Lira A, Fernández D, Iwawaki T, Vargas P, Osorio F, Int J Mol Sci, 24:10205, 2023
  • Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity, Flores-Santibañez F, Rennen S, Fernández D, De Nolf C, Van De Velde E, Gaete González S, Fuentes C, Moreno C, Figueroa D, Lladser Á, Iwawaki T, Bono MR, Janssens S, Osorio F, Front Immunol, 14:1209588, 2023
  • Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration, Massoudi D, Gorman S, Kuo YM, Iwawaki T, Oakes SA, Papa FR, Gould DB, Invest Ophthalmol Vis Sci, 64:30, 2023
  • ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions, Jeong H, Hong EH, Ahn JH, Cho J, Jeong JH, Kim CW, Yoon BI, Koo JH, Park YY, Yang YM, Iwawaki T, Vallance BA, Chang SY, Ko HJ, Exp Mol Med, 55:401-412, 2023
  • Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain, Nomura R, Takasugi N, Hiraoka H, Iijima Y, Iwawaki T, Kumagai Y, Fujimura M, Uehara T., Int J Mol Sci, 23:15412, 2022
  • Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane, Kriston-Vizi J, Lenart I, Iwawaki T, Gould K, Nesbeth D, Powis SJ, Antoniou AN, J Immunol Res, 2022:9493019, 2022
  • The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes, Navarro-Betancourt JR, Papillon J, Guillemette J, Chung CF, Iwawaki T, Cybulsky AV, Biochim Biophys Acta Mol Basis Dis, 1868:166391, 2022
  • Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression, Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR 3rd, Walter P, Erbay E, EMBO Mol Med, 14:e15344, 2022
  • Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis, Marek-Iannucci S, Yildirim AD, Hamid SM, Ozdemir AB, Gomez AC, Kocatürk B, Porritt RA, Fishbein MC, Iwawaki T, Noval Rivas M, Erbay E, Arditi M, JCI Insight, 7:e157203, 2022
  • Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1, Liu X, Taylor SA, Gromer KD, Zhang D, Hubchak SC, LeCuyer BE, Iwawaki T, Shi Z, Rockey DC, Green RM, PLoS One, 17:e0261789, 2022
  • The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism, Roy A, Tomaz da Silva M, Bhat R, Bohnert KR, Iwawaki T, Kumar A, Elife, 10:e73215, 2021
  • Inhibition of skin fibrosis in systemic sclerosis by botulinum toxin B via the suppression of oxidative stress, Baral H, Sekiguchi A, Uchiyama A, Nisaa Amalia S, Yamazaki S, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, J Dermatol, 48:1052-1061, 2021
  • Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α, Duwaerts CC, Siao K, Soon RK Jr, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ, Cell Death Differ, 28:1455-1465, 2021
  • Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain, Hiraoka H, Nomura R, Takasugi N, Akai R, Iwawaki T, Kumagai Y, Fujimura M, Uehara T, Arch Toxicol, 95:1241-1250, 2021
  • Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions, Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X, Nat Cell Biol, 22:1162-1169, 2020
  • Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia-reperfusion injury, Inoue Y, Uchiyama A, Sekiguchi A, Yamazaki S, Fujiwara C, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Wound Repair Regen, 28:600-608, 2020
  • Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescenceafter Cre/loxP-mediated recombination, Akai R, Saito M, Kohno K, Iwawaki T, Exp Anim, 69:306-318, 2020
  • IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival, Batista A, Rodvold JJ, Xian S, Searles SC, Lew A, Iwawaki T, Almanza G, Waller TC, Lin J, Jepsen K, Carter H, Zanetti M, PLoS Biol, 18:e3000687, 2020
  • AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity, Aguilà M, Bellingham J, Athanasiou D, Bevilacqua D, Duran Y, Maswood R, Parfitt DA, Iwawaki T, Spyrou G, Smith AJ, Ali RR, Cheetham ME, Hum Mol Genet, 29:1310-1318, 2020
  • IRE1α Promotes Zika Virus Infection via XBP1, Kolpikova EP, Tronco AR, Hartigh ABD, Jackson KJ, Iwawaki T, Fink SL, Viruses, 12:278, 2020
  • Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model, Yamazaki S, Sekiguchi A, Uchiyama A, Fujiwara C, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI, Sci Rep, 10:1349, 2020
  • Role of IRE1α in podocyte proteostasis and mitochondrial health, Navarro-Betancourt JR, Papillon J, Guillemette J, Iwawaki T, Chung CF, Cybulsky AV, Cell Death Discov, 6:128, 2020
  • Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD, Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR, Blood, 134:1670-1682, 2019
  • Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress, Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci, 96:8-17, 2019
  • Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin, Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI, J Dermatol Sci, 95:62-69, 2019
  • MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites, Takeda K, Nagashima S, Shiiba I, Uda A, Tokuyama T, Ito N, Fukuda T, Matsushita N, Ishido S, Iwawaki T, Uehara T, Inatome R, Yanagi S, EMBO J, 38:e100999, 2019
  • IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain, Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR, Science, 365:eaau6499, 2019
  • Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1, Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K, Kawaguchi SI, Iwawaki T, Adachi S, Suda H, Morita M, Uchida K, Baird L, Yamamoto M, Cell Rep, 28:746-758, 2019
  • ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin, Kim MS, Yi EJ, Kim YI, Kim SH, Jung YS, Kim SR, Iwawaki T, Ko HJ, Chang SY, Front Immunol, 10:1249, 2019
  • Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells, Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q, Nat Cell Biol, 21:328-337, 2019
  • Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients, Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G, Front Immunol, 10:506, 2019
  • IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming, Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F, Front Immunol, 9:3050, 2019
  • Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication, Antoniou AN, Lenart I, Kriston-Vizi J, Iwawaki T, Turmaine M, McHugh K, Ali S, Blake N, Bowness P, Bajaj-Elliott M, Gould K, Nesbeth D, Powis SJ, Ann Rheum Dis, 78:74-82, 2019
  • Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha, Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB, Nat Commun, 9:5340, 2018
  • IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A, Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C, Nat Cell Biol, 20:942-953, 2018
  • Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress, Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, J Dermatol Sci, 90:144-153, 2018
  • Activation of host IRE1α-dependent signaling axis contributes the intracellular parasitism of Brucella melitensis, Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM, Front Cell Infect Microbiol, 8:103, 2018
  • ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response, Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D, Elife, 7:e31159, 2018
  • IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells., Tsuchiya Y, Saito M, Kadokura H, Miyazaki JI, Tashiro F, Imagawa Y, Iwawaki T, Kohno K, 217:1287-1301, 2018
  • Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis, (Tschurtschenthaler M), Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A, J Exp Med, 214:401-422, 2017
  • Deletion of Inositol-Requiring Enzyme-1α in Podocytes Disrupts Glomerular Capillary Integrity and Autophagy, Kaufman DR, Papillon J, Larose L, Iwawaki T, Cybulsky AV, Mol Biol Cell, 28:1636-1651, 2017
  • IRE1 signaling exacerbates Alzheimer's disease pathogenesis, Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJ, Hetz C, Acta Neuropathol, 134:489-506, 2017
  • IRE1α promotes viral infection by conferring resistance to apoptosis, Fink SL, Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A, Sci Signal, 10:eaai7814, 2017
  • Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by Human Dendritic Cells, Márquez S, Fernández JJ, Terán-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, Cubillos-Ruiz JR, Fernández N, Crespo MS, Front Immunol, 8:639, 2017
  • Modulation of Unfolded Protein Response by Methylmercury, Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T, Biol Pharm Bull, 40:1595-1598, 2017
  • Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles, Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J, Sci Rep, 7:12902, 2017
  • Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress, (Motegi SI), Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O, Sci Rep, 7:17186, 2017
  • Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity, Forootan SS, Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM, Sci Rep, 7:16084, 2017
  • Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival, Tavernier SJ, Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CA, Lambrecht BN, Janssens S, Nat Cell Biol, 19:698-710, 2017
  • Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo, Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K, Sci Rep, 7:46230, 2017
  • From property of IL-1β to imaging of inflammation, Takao.Iwawaki, Japanese Journal of Clinical Immunology, 40:329-336, 2017
  • Necrotic Cell Sensor Clec4e Promotes a Pro-Atherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response., Clément M, Basatemur G, Masters L, Baker L, Bruneval P, Iwawaki T, Kneilling M, Yamasaki S, Goodall J, Mallat Z, Circulation, 134:1039-1051, 2016
  • Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo., Ohba T, Ishisaka M, Tsujii S, Tsuruma K, Shimazawa M, Kubo K, Umigai N, Iwawaki T, Hara H, Eur J Pharmacol, 789:244-253, 2016
  • Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells., Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK, Cell Rep, 14:2611-2623, 2016
  • IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation., Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L, Nat Cell Biol, 17:1546-1555, 2015
  • Constitutive role of GADD34 and CReP in cancellation of phospho-eIF2α-dependent translational attenuation and insulin biosynthesis in pancreatic β cells., Akai R, Hosoda A, Yoshino M, Iwawaki T, Genes Cells, 20:871-886, 2015
  • 2-Phenyl-APB-144-Induced Retinal Pigment Epithelium Degeneration and Its Underlying Mechanisms., Hirai S, Kurashima H, Nakamura D, Komatsu T, Yasuda Y, Habashita-Obata S, Ichikawa S, Katsuta O, Iwawaki T, Kohno K, J Ocul Pharmacol Ther, 31:570-584, 2015
  • Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo., Iwawaki T, Akai R, Oikawa D, Toyoshima T, Yoshino M, Suzuki M, Takeda N, Ishikawa TO, Kataoka Y, Yamamura K, Sci Rep, 5:17205, 2015
  • In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse., Alavi MV, Chiang WC, Kroeger H, Yasumura D, Matthes MT, Iwawaki T, LaVail MM, Gould DB, Lin JH, Invest Ophthalmol Vis Sci, 56:6961-6970, 2015
  • Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress., Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T, Sci Rep, 5:14812, 2015
  • IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis., Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K, J Clin Invest, 125:3269-3279, 2015
  • Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury., Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T, Neurotox Res, 27:99-105, 2015
  • The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control., Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, Chapple JP, Cheetham ME, Hum Mol Genet, 23:6594-6606, 2014
  • Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice., Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H, Int J Parasitol, 44:681-685, 2014
  • Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice., Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y, Irie T, Pharmacol Res, 87:26-41, 2014
  • Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury., Takagi T, Kitashoji A, Iwawaki T, Tsuruma K, Shimazawa M, Yoshimura S, Iwama T, Hara H, Free Radic Biol Med, 72:124-133, 2014
  • Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells., Benhamron S, Hadar R, Iwawaki T, So JS, Lee AH, Tirosh B, Eur J Immunol, 44:867-876, 2014
  • The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells., Osorio F, Tavernier SJ, Hoffmann E, Saeys Y, Martens L, Vetters J, Delrue I, De Rycke R, Parthoens E, Pouliot P, Iwawaki T, Janssens S, Lambrecht BN, Nat Immunol, 15:248-257, 2014
  • Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway., Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S, Free Radic Biol Med, 65:778-788, 2013
  • Paneth cells as a site of origin for intestinal inflammation., Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS, Nature, 503:272-276, 2013
  • Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue., Kadokura H, Saito M, Tsuru A, Hosoda A, Iwawaki T, Inaba K, Kohno K, Biochem Biophys Res Commun, 440:245-250, 2013
  • ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells., Niederreiter L, Fritz TM, Adolph TE, Krismer AM, Offner FA, Tschurtschenthaler M, Flak MB, Hosomi S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser D, Rosenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS, Kaser A, J Exp Med, 210:2041-2056, 2013
  • Membrane lipid saturation activates IRE1α without inducing clustering., Kitai Y, Ariyama H, Kono N, Oikawa D, Iwawaki T, Arai H, Genes Cells, 18:798-809, 2013
  • CHOP is a critical regulator of acetaminophen-induced hepatotoxicity., Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O, J Hepatol, 59:495-503, 2013
  • Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST., Josekutty J, Iqbal J, Iwawaki T, Kohno K, Hussain MM, J Biol Chem, 288:14372-14383, 2013
  • The role of the unfolded protein response in diabetes mellitus., Iwawaki T, Oikawa D, Semin Immunopathol, 35:333-350, 2013
  • Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins., Oikawa D, Iwawaki T, Biochem Biophys Res Commun, 433:426-431, 2013
  • Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4., Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R, Am J Physiol Cell Physiol, 304:C342-53, 2013
  • Negative feedback by IRE1β optimizes mucin production in goblet cells., Tsuru A, Fujimoto N, Takahashi S, Saito M, Nakamura D, Iwano M, Iwawaki T, Kadokura H, Ron D, Kohno K, Proc Natl Acad Sci USA, 110:2864-2869, 2013
  • Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice., So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH, Cell Metab, 16:487-499, 2012
  • Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing., Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S, Blood Cancer J, 2:e79, 2012
  • IRE1α activation protects mice against acetaminophen-induced hepatotoxicity., Hur KY, So JS, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Iwawaki T, Glimcher LH, Lee AH, J Exp Med, 209:307-318, 2012
  • Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β., Oikawa D, Kitamura A, Kinjo M, Iwawaki T, PLoS ONE, 7:e51290, 2012
  • A transgenic mouse model for monitoring oxidative stress., Oikawa D, Akai R, Tokuda M, Iwawaki T, Sci Rep, 2:229, 2012
  • Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing., Iwawaki T, Tokuda M, Biochem Biophys Res Commun, 413:527-531, 2011
  • C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation., Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, Ogawa H, Oike Y, Arterioscler Thromb Vasc Biol, 31:1124-1132, 2011
  • A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression., Thorp E, Iwawaki T, Miura M, Tabas I, J Lipid Res, 52:1033-1038, 2011
  • The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix., Tohmonda T, Miyauchi Y, Ghosh R, Yoda M, Uchikawa S, Takito J, Morioka H, Nakamura M, Iwawaki T, Chiba K, Toyama Y, Urano F, Horiuchi K, EMBO Rep, 12:451-457, 2011
  • Detection of ER stress in vivo by Raman spectroscopy., Hosoda A, Maruyama A, Oikawa D, Oshima Y, Komachi Y, Kanai G, Sato H, Iwawaki T, Biochem Biophys Res Commun, 405:37-41, 2011
  • Identification of a consensus element recognized and cleaved by IRE1 alpha., Oikawa D, Tokuda M, Hosoda A, Iwawaki T, Nucleic Acid Res, 38:6265-6273, 2010
  • The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques., Tsukano H, Gotoh T, Endo M, Miyata K, Tazume H, Kadomatsu T, Yano M, Iwawaki T, Kohno K, Araki K, Mizuta H, Oike Y, Arterioscler Thromb Vasc Biol, 30:1925-1932, 2010
  • IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level., Iwawaki T, Akai R, Kohno K, PLoS ONE, 5:e13052, 2010
  • Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes., Oikawa D, Akai R, Iwawaki T, FEBS Lett, 584:1066-1070, 2010
  • Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins., Oikawa D, Kimata Y, Kohno K, Iwawaki T, Exp Cell Res, 315:2496-2504, 2009
  • Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance., Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, Shimabukuro M, Sakaguchi K, Ito T, Nakagata N, Yamada T, Katagiri H, Kasuga M, Ando Y, Ogawa H, Mochizuki N, Itoh H, Suda T, Oike Y, Cell Metab, 10:178-188, 2009
  • Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland., Hosoda A, Tokuda M, Akai R, Kohno K, Iwawaki T, Biochem J, 425:117-125, 2009
  • Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability., Iwawaki T, Akai R, Yamanaka S, Kohno K, Proc Natl Acad Sci USA, 106:16657-16662, 2009
  • Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA., Yanagitani K, Imagawa Y, Iwawaki T, Hosoda A, Saito M, Kimata Y, Kohno K, Mol Cell, 34:191-200, 2009
  • Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice., Yoshiuchi K, Kaneto H, Matsuoka TA, Kasami R, Kohno K, Iwawaki T, Nakatani Y, Yamasaki Y, Shimomura I, Matsuhisa M, Endocr J, 56:1103-1111, 2009
  • An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis., Abarzua F, Kashiwakura Y, Takaoka M, Watanabe M, Ochiai K, Sakaguchi M, Iwawaki T, Tanimoto R, Nasu Y, Huh NH, Kumon H, Biochem Biophys Res Commun, 375:614-618, 2008
  • Direct monitoring of in vivo ER stress during the development of insulin resistance with ER stress-activated indicator transgenic mice., Yoshiuchi K, Kaneto H, Matsuoka TA, Kohno K, Iwawaki T, Nakatani Y, Yamasaki Y, Hori M, Matsuhisa M, Biochem Biophys Res Commun, 366:545-550, 2008
  • Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1., Oikawa D, Tokuda M, Iwawaki T, Biochem Biophys Res Commun, 360:122-127, 2007
  • Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators., Iwawaki T, Akai R, Biochem Biophys Res Commun, 350:709-715, 2006
  • Regulation of human STARD4 gene expression under endoplasmic reticulum stress., Yamada S, Yamaguchi T, Hosoda A, Iwawaki T, Kohno K, Biochem Biophys Res Commun, 343:1079-1085, 2006
  • A transgenic mouse model for monitoring endoplasmic reticulum stress., Iwawaki T, Akai R, Kohno K, Miura M, Nat Med, 10:98-102, 2004
  • Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy., Kiso S, Kawata S, Tamura S, Inui Y, Yoshida Y, Sawai Y, Umeki S, Ito N, Yamada A, Miyagawa J, Higashiyama S, Iwawaki T, Saito M, Taniguchi N, Matsuzawa Y, Kohno K, Gastroenterology, 124:701-707, 2003
  • Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice., Saito M, Iwawaki T, Taya C, Yonekawa H, Noda M, Inui Y, Mekada E, Kimata Y, Tsuru A, Kohno K, Nat Biotechnol, 19:746-750, 2001
  • Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress., Iwawaki T, Hosoda A, Okuda T, Kamigori Y, Nomura-Furuwatari C, Kimata Y, Tsuru A, Kohno K, Nat Cell Biol, 3:158-164, 2001
  • Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells., Iwawaki T, Kohno K, Kobayashi K, Biochem Biophys Res Commun, 274:590-595, 2000

Awards & Honors

  • Dec. 2003 Incentive award in the 4th Bio Business Competition Japan “Business strategy with new system for monitoring endoplasmic reticulum stress”
    Takao Iwawaki

Seeds

  • Genetic tools and model mice for visualization of endoplasmic reticulum stress
  • Genetic tools and model mice for visualization of oxidative stress
  • Genetic tools and model mice for visualization of inflammation
  • Genetic tools and model mice for visualization of integrated stress response