ONAI Nobuyuki

■FacultyDepartment of Immunology
■PositionProfessor

Researcher Profile & Settings

Profile & Settings

Research

    Overview of research:
    Dendritic cells, monocytes and macrophages belong to mononuclear phagocyte system (MPS). These cells regulate immune response against pathogen and tissue hemostasis. Our group investigate the regulation of dendritic cell and macrophage development and tissue homeostasis.

Research Activities

Research Areas

  • Medicine,dentistry, and pharmacy

Published Papers

  • PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR, Toshiki Yabe-Wada , Caroline C Philpott, Nobuyuki Onai, FEBS open bio, 10:407-413, Mar. 2020
  • Crystal structure of the ligand-free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH, T. Yabe-Wada, S. Matsuba, M. Unno, N. Onai, FEBS Letters, 592:2647-2657, Aug. 2018
  • Commitment to dendritic cells and monocytes, (Toshiaki Ohteki), Shunsuke Kawamura, Nobuyuki Onai, International Immunology, 33:815-819, Dec. 2021
  • Detailed structure of mouse interferon α2 and its interaction with Sortilin, (Honoka Watanabe), Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno, The Journal of Biochemistry, 170:265-273, Aug. 2021
  • A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties, (Kamio N), Yokota A, Tokuda Y, Ogasawara C, Nakano M, Nagao M, Tashiro K, Maekawa T, Onai N, Hirai H, Journal of Immunology, 209:498-509, Aug. 2022
  • PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocytederived macrophages into the inflamed colon, Xinquan Yang, Toshiki Yabe-Wada, Jia Han, Fumiji Saito, Chie Ogasawara, Sohsuke Yamada, Nobuyuki Onai, International Immunology, 35:287-299, Jan. 2023
  • An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture., Shintaro Matsuba, Hiroki Ura, Fumiji Saito, Chie Ogasawara, Shigetaka Shimodaira, Yo Niida, Nobuyuki Onai, Frontiers in Immunology, 14:1264609, Oct. 2023
  • Potential of Natural Products in Hangeshashinto Water Extract on the Direct Suppression of Stomatitis Induced by Intra-/Extracellular Advanced Glycation End-Products, Takanobu Takata, Junji Moriya, Katsuhito Miyazawa, Shinya Inoue, Sohsuke Yamada, Jia Han, Qian Yang, Xin Guo, Shuichi Mizuta, Takeshi Nakahashi, Nobuyuki Onai, Hiroyuki Nakano, Togen Masauji, Motoo Yoshiharu, Internatinal Journal of Molecular Sciences, 26:9118-9118, Sep. 2025