KANDA Tsugiyasu

■FacultyCommunity Medicine
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    My major research is to investigate the therapeutic approach of cytokines in cardiovascular diseases including heart failure and cardiomyopathy. Until now, I tried interleukin-6, 8 and 10, moreover, TNF-α, lepton, adiponectin as therapeutic tools. I am using animal model of murine viral myocarditis, rat myocardial infarction and murine diabetes mellitus.

Special Field

  • Cardioangiology
  • Internal Medicine in General

Degree

  • Ph.D in Medicine

Research Activities

Published Papers

  • The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Toshihide Izumida, Shinya Yamada, Ryusho Sangen, Kazu Hamada, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Hitoshi Saito, Tsugiyasu Kanda, Masashi Okuro, Acta Medica Okayama, 76:705-713, Dec. 2022
  • A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Shinichiro Nakao, Kazu Hamada, Susumu Takagi, Nao Terada, Kento Takeshima, Shinya Yamada, Ryusho Sangen, Toshihide Izumida, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Hiroyuki Wato, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Oku, Medicine, 101:e31614., Nov. 2022
  • Postoperative Urinary Retention in Japanese Elderly Males with a Femoral Neck or Trochanteric Fracture, Toshihiro Higashikawa, Kenji Shigemoto, Kenichi Goshima, Shintarou Iwai, Manabu Moriyama, Daisuke Usuda, Masahiro Hangyou, Hiromi Inujima, Kakeru Nozaki, Miyako Yamaguchi, Kimiko Usuda, Takeshi Nakahashi, Tadami Matsumoto, Shigeki Takashima, Tsugiyasu Kanda, Takeshi Horii, Masashi Okuro, Takeshi Sawaguchi, Acta Medica Okayama, 76:409-414, Aug. 2022
  • Effects of tofogliflozin on adrenocorticotropic hormone, renin and aldosterone, and cortisol levels in elderly patients with diabetes mellitus: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Takuro Morita, Kazu Hamada, Susumu Takagi, Kento Takeshima, Shinya Yamada, Ryusho Sangen, Toshihide Izumida, Hideyuki Mori, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Medicine, 100:e27638, Nov. 2021
  • The 12-Month Administration of Tofogliflozin for Glycemic Control with Monitoring Electrolytes, Renal and Cardiac Function in Japanese Elderly Patients with Type 2 Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kazu Hamada, Takuro Morita, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, International Journal of Geriatrics and Gerontology, 5:1-8, Feb. 2021
  • Effects of a Lower Lipid Diet and Exercise on Cognitive Disturbances with the Induction of Calcineurin 1 and Brain-derived Neurotrophic Factor Expressions in the Hippocampi of Obese Apolipoprotein E Knockout Mice, Shuo Wang, Haicong Li, Mineko Nishijo, Yoshikazu Nishino, Nobuo Kato, Yuji Kasamaki, Tadashi Ueda, Tsugiyasu Kanda, JMA Journal, 4:409-414, 2021
  • Perioperative Complications,Urinary Retention and Aspiration Pneumonia in Patients with Femoral Neck and Trochanter Fractures Under the Multidisciplinary Program:A Study at Bone Femoral Neck and Trochanter Fracture Center,Toyama Municipal Hospital, Toshihiro Higashikawa, Kenji Shigemoto, Daisuke Usuda, Hiromi Inushima, Kazu Hamada, Kenichi Goshima, Takuro Morita, Kimiko Usuda, Miyako Yamaguchi, Manabu Moriyama, Masahiro Hangyou, Shigeki Takashima, Tadami Matsumoto, Takeshi Horii, Tugiyasu Kanda, Masashi Okuro, Takeshi Sawaguchi, International Journal of Geriatrics and Gerontology, 4:1-5, Dec. 2020
  • Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change in RCAN1 expression, Wang Shuo, Haicong Li, Nishijo Muneko, Nishino Yoshikazu, Nobuo Kato, Yuji Kasamaki, Tadashi Ueda, Tsugiyasu Kanda, Journal of International Medical Research, 48:300060520964016, Nov. 2020
  • Functional Decline Status for the Development of Aspiration Pneumonia in Elderly Patients with Femoral Neck and Trochanteric Fractures, Toshihiro Higashikawa, Takuro Morita, Manabu Moriyama, Hiromi Inujima, Masahiro Hangyou, Kimiko Usuda, Shigeto Morimoto, Masashi Okuro, Tadami Matsumoto, Kenji Shigemoto, Kenichi Goshima, Takeshi Sawaguchi, Daisuke Usuda, Shigeki Takashima, Tsugiyasu Kanda, Open Access Journal of Biomedical Science, 3:679-682, Oct. 2020
  • Mortality and the Risk Factors in Elderly Female Patients With Femoral Neck and Trochanteric Fractures, Toshihiro Higashikawa, Kenji Shigemoto, Kenichi Goshima, Takeshi Horii, Daisuke Usuda, Takuro Morita, Manabu Moriyama, Hiromi Inujima, Masahiro Hangyou, Kimiko Usuda, Shigeto Morimoto, Tadami Matsumoto, Shigeki Takashima, Tsugiyasu Kanda, Masashi Okuro, Takashi Sawaguchi, Journal of Clinical Medicine Research, 12:668-673, Sep. 2020
  • Gender Differences in Cardiac Function Following Three-Month Administration of Tofogliflozin in Patients With Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Shinya Yamada, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Journal of Clinical Medicine Research, 12:530-538, Aug. 2020
  • New score including daily life independence levels with dementia is associated with the onset of deep vein thrombosis in frail older adults, Keisuke Nakanishi, Tsugiyasu Kanda, Takashi Kobata, Masayuki Mori, Shinya Yamada, Yuji Kasamaki, Geriatrics & Gerontology International, 20:414-421, May 2020
  • Effects of Tofogliflozin on Cardiac Function in Elderly Patients With Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Susumu Takagi, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Journal of Clinical Medicine Research, 12:165-171, Mar. 2020
  • Urinary retention as a postoperative complication associated with functional decline in elderly female patients with femoral neck and trochanteric fractures A retrospective study of a patient cohort, Higashikawa Toshihiro, Shigemoto Kenji, Goshima Kenichi, Usuda Daisuke, Okuro Masashi, Moriyama Manabu, Inujima Hiromi, Hangyou Masahiro, Usuda Kimiko, Morimoto Shigeto, Matsumoto Tadami, Takashima Shigeki, Kanda Tsugiyasu, Sawaguchi Takeshi, MEDICINE, 98:e16023, Jun. 2019
  • The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus., Higashikawa Toshihiro;Ito Tomohiko;Mizuno Takurou;Ishigami Keiichirou;Kohori Masaru;Mae Kunihiro;Sangen Ryusho;Usuda Daisuke;Saito Atsushi;Iguchi Masaharu;Kasamaki Yuji;Fukuda Akihiro;Saito Hitoshi;Kanda Tsugiyasu;Okuro Masashi, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 46:5117-5126, Dec. 2018
  • Atypical lipomatous tumor in the ligamentum teres of liver: A case report and review of the literature, Usuda Daisuke, Takeshima Kento, Sangen Ryusho, Nakamura Kisuke, Hayashi Kei, Okamura Hideyuki, Kawai Yasuhiro, Kasamaki Yuji, Iinuma Yoshitsugu, Saito Htoshi, Kanda Tsugiyasu, Urashima Sachio, World Journal of Clinical Cases, 6:548-553, Oct. 2018
  • Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection., Higashikawa Toshihiro;Okuro Masashi;Ishigami Keiichirou;Mae Kunihiro;Sangen Ryusho;Mizuno Takurou;Usuda Daisuke;Saito Atushi;Kasamaki Yuji;Fukuda Akihiro;Saito Hitoshi;Morimoto Shigeto;Kanda Tsugiyasu, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 46:2606-2614, Jul. 2018
  • Interleukin-18 as a diagnostic marker of adult-onset Still's disease in older patients: a case report and review of the literature., Usuda Daisuke, Furumura Yoshiki, Takeshima Kento, Sangen Ryusho, Kawai Yasuhiro, Kasamaki Yuji, Iinuma Yoshitugu, Kanda Tsugiyasu., Journal of medical case reports, 12:10.1186/s13256-018-1735-7., Jul. 2018
  • Evaluation of B-type natriuretic peptide as prognostic marker in patients with pneumonia: An observational study, Daisuke Usuda , Yoshiki Furumura, Ryusho Sangen, Yu Hashimoto, Jun Kawamukai, Emiri Muranaka, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda, Internal Medicine Review, 4:1-28, Mar. 2018
  • Diagnosis of myxedema coma complicated by renal failure: a case report, Akiteru.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda, Clinical Case Reports, 5:399-402, Feb. 2017
  • Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda, Journal Clinical Case Reports, 7:10001021　, 2017
  • Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic erythroderma: a case report., Mizuno Takuro;Kiyosawa Jun;Fukuda Akihiro;Watanabe Seiji;Kurose Nozomu;Nojima Takayuki;Kanda Tsugiyasu, Journal of medical case reports, 11:35, 2017
  • Autopsy-proven intravascular lymphoma presenting as rapidly recurrent strokes, D.Usuda, M.Arahata, R.Temaru, Y.Iinuma, T.Kanda, S.Hayashi, Case reports in oncology, 9:148-153, Mar. 2016
  • Validation of a B-type natriuretic peptide as a prognostic marker in pneumonia patients: a prospective cohort study., D.Usuda, R.Sangen, Y.Hashimoto, E.Muranaka, Y.Iinuma, T.Kanda, BMJ open, 6:e010440-e010440, Feb. 2016
  • Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic elderly patients receiving antihypertensive treatment, T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda, S.Morimoto, Geriatrics Gerontology International, 16:365-373, Feb. 2015
  • Implementation report of screening investigation of dementia for inhabitants of rural areas in Himi,Toyama, Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura, Y.Kawasaki, 39:67-74, Dec. 2014
  • Endocardial invasion of lung cancer undiagnosable before autopsy, T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito, N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda, N.Takekoshi, T.Kanda, Case reports in oncology [electronic resource], 7:144-148, Mar. 2014
  • Cardiac BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice, Rui Chen, Takuro Mizuno, T.Kanda, Internet J of Cardiovasc Res, 18;1617-1620, Aug. 2013
  • Cardiac BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino, The Internet Journal of Cardiovascular Research, 8, 2013
  • The anxiety and types of problems encountered by homecare patients during an intermittent self-catheterization, K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, 38(supplⅠ): 103-105, Dec. 2011
  • A study of the goods supply system from hospital to outpatients with intermittent self-catheterization(ISC), S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji, 38(supplⅠ):109-111, Dec. 2011
  • Self purchase of catheter supplies and the hardship associated with urinary homecare patients, Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji, 38(supplⅠ):106-108, Dec. 2011
  • Two types of Brugada-like ST-elevation in patients with febrile infection, T.Mizuno, K.Ishigami, D. Sakamoto, R.Isahii, T.Kanda, 36:124-126, 2011
  • Interleukin-6 expressing colon cancer with multiple hepatic metastases, A.Tempaku, T.Mizuno, M.Hasegawa, A.Saito, N.Yamashita, H.Atsumi, T.Ito, K.Ishigami, M.Miura, Y.Izumi, N.Kurose, H.Minato, T.Nojima, T.Kanda, N.Takekoshi, 36:106-110, 2011
  • Hypernatremia, rhabdomyolysis and acute renal failure, K.Ishigami, N.Yamashita, K.Konishi, A.Saito, M.Fukura, M.Hasegawa, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi, N.Takekoshi, 35:68-69, Aug. 2010
  • Clinical risk factors in regional brain ischemia using single photon emission computed tomography, R.Chen, F.Liang, K.Ishigami, T.Kanda, L.Zeng, A.Saito, M.Hasegawa, N.Yamashita, T.Itoh, T.Kigoshi, Y.Izumi, N.Takekoshi, S.Morimoto, Journal of the American Geriatrics Society., 58：1411-1412, Jul. 2010
  • Hypoglycemia in elderly diabetes mellitus-free patients :Case reports and a review of literature, K.Konishi, A.Saito, K.Ishigami, M.Fukura, M.Hasegawa, N.Yamashita, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi, N.Takekoshi, 35:13-15, Jun. 2010
  • The effects of a PPARα agonist on myocardial damage in obese diabetic mice with heart failure, R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda, International Heart Journal, 51:199-206, May 2010
  • Traditional chinese medicine for chronic fatigue syndrome, R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:3-10, Mar. 2010
  • A Kampo medicine, boiogito, inhibits obesity in ovariectomized rats, J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:87-95, Jan. 2010
  • Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi, T.Kanda, Evidence-based complementary and alternative medicine : eCAM., 7:341-349, 2010
  • Suicides in aged patients; Case reports and review of the literature, M.Fukura, A.Saito, K.Ishigami, K.Konishi, M.Hasegawa, JL.Wu, H.Kawahara, T.Kanda, T.Kigoshi, N.Takekoshi, 34:14-16, Jun. 2009
  • Silent information regulator, sirtuin 1, and age-related diseases, L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto, Nature clinical practice. Rheumatology., 9:7-15, 2009
  • Candesartan improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, International journal of cardiology, 129:414-421, Nov. 2008
  • Chronic fatigue syndrome and the central nervous system, R.Chen, FX.Liang, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi, The Journal of international medical research., 36:867-874, Sep. 2008
  • A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor(vaspin),and obesity, Q.Li, R.Chen, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi, The Journal of international medical research., 36:625-629, Jul. 2008
  • A large ovarian tumor mimicking the accumulation of ascites, J.Moriya, J.Yamakawa, R.Chen, H.Takagi, S.Makinoda, T.Takahashi, T.Kanda, 33:31-32, Jun. 2008
  • Peroxisome proliferator-activated receptors(ppars) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?, R.Chen, F.Liang, J.Moriya, J.Yamakawa, T.Takahashi, L.Shen, T.Kanda, International journal of cardiology, 130:131-139, Mar. 2008
  • Brain atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda, Neurochemical research, 33:1759-1767, Mar. 2008
  • Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats, K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto, Hypertension research : official journal of the Japanese Society of Hypertension., 31:977-986, 2008
  • A kampo medicine, boi-ogi-to, inhibits obesity in ovariectomized rats, J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda, eCAM, 42013, Nov. 2007
  • Relationship between brachial arterial endothelial function and lumber spine bone mineral density in postmenopausal women, (H.Sumino), S.Ichikawa, S.Kusama, T.Takahashi, H.Sakamoto, H.Kumakura, Y.Takayama, T.Kanda, M.Murakami, M.Kurabayashi, Circulation journal : official journal of the Japanese Circulation Society, 71:1555-1559, Oct. 2007
  • Bariatric surgery for morbid obesity, R.Chen, T.Takahashi, T.Kanda, The New England journal of medicine, 357:1158-1160, Sep. 2007
  • Reduced-energy diet improves survival of obses KKAy mice with viral myocarditis:induction of cardiac adiponectin expression, T.Kanda, S.Saegusa, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, International journal of cardiology, 119:310-318, Jul. 2007
  • Prostate cancer producing carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki, 32：29-31, Jun. 2007
  • Oral administration of candesartan improves the survival of mice with viral myocarditis through modification of cardiac adiponectin expression, S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda, Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy., 21:155-160, Jun. 2007
  • Influenza Vaccines, T.Takahashi, T.Kanda, N.Yamaguchi, The New England journal of medicine, 356:1172-1173, Mar. 2007
  • Acupuncture regulates leukocyte subpopulations in human peripheral blood, N.Yamaguchi, T.Takahashi, M.Sakuma, T.Sugita, K.Uchikawa, S.Sakaihara, T.Kanda, M.Arai, K.Kawakita, Evidence-based complementary and alternative medicine : eCAM., 4:447-453, Feb. 2007
  • Acupuncture regulates leukocyte subpopulations in human peripheral blood, Nobuo Yamaguchi, Takashi Takahashi, Masahiro Sakuma, Toshiroh Sugita, Kumiko Uchikawa, Satoshi Sakaihara, Tsugiyasu Kanda, Matsuo Arai, Kenji Kawakita, Evidence-based complementary and alternative medicine : eCAM., 4:447-453, Feb. 2007
  • Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly inpatients:effects of azelnidipine, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino, M.Matsumoto, Hypertension research : official journal of the Japanese Society of Hypertension., 29:943-949, Dec. 2006
  • Angiotensin Ⅰ-converting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans, M.Okuro, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, H.Murai, K.Iwai, T.Kanda, Hypertension research : official journal of the Japanese Society of Hypertension., 29:655-663, Sep. 2006
  • Advanced oesophageal carcinoma in an 84- year-old treated with chemoradiotherapy, K.Kusaka, T.Itoh, K.Kawaura, J.Moriya, J.Yamakawa, T.Takahashi, M.Oguchi, H.Tonami, I.Yamamoto, T.Kanda, The Journal of international medical research., 34:437-440, Jul. 2006
  • Expression of ephrin in retinal neovascularization and iris rubeosis, (T.Yuuki), T.Kanda, S.Kishi, The Journal of international medical research., 34:485-494, Jun. 2006
  • Traditional chinese medicine and kampo: a review from the distant past for the future, F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda, The Journal of international medical research., 34:231-239, May 2006
  • Angiotensin-Ⅱ receptor antagonist alleviates non-alcoholic fatty liver in kkay obese mice with type2 diabetes, F.Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, H.Sumino, S.Morimoto, T.Kanda, The Journal of international medical research., 34:297-302, May 2006
  • Elevated arterial stiffness in postmenopausal women with osteoporosis, (H.Sumino), S.Ichikawa, S.Kasama, T.Takahashi, H.Kumakura, Y.Takayama, T.Kanda, T.Sakamaki, M.Kurabayashi, Maturitas, 55:212-218, Feb. 2006
  • Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women, (H.Sumino), S.Ichikawa, S.Kasama, T.Takahashi, H.Kumakura, Y.Takayama, T.Kanda, M.Kurabayashi, Atherosclerosis., 189:436-442, Feb. 2006
  • Conjugated estrogen plus medroxyprogesterone does not impair blood rheological properties in hypertensive postmenopausal women, (H.Sumino), S.Ichikawa, T.Takahashi, H.Sakamoto, K.Goto-Onozato, S.Koya, T.Kanda, M.Nara, K.Seki, M.Murakami, M.Kurabayashi, Maturitas, 53:306-314, Feb. 2006
  • Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis, T.Takahashi, F.Yu, S.Saegusa, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Kurabayashi, T.Kanda, International Heart Journal, 47:107-123, Jan. 2006
  • Beneficial effect of brewers' yeast extract on daily activity in a murine model o f chronic fatigue syndrome, T.Takahashi, Y.Fei, Z.Shi-jie, J.Moriya, H.Sumino, S.Morimoto, N.Yamaguchi, T.Kanda, eCAM, 3:109-115, Jan. 2006
  • Effect of interleukin-18 on viral myocarditis : enhancement of interferon-gamma and natural killer cell activity, KANDA Tsugiyasu, Journal of Molecular and Cellular Cardiology, 2000
  • Induction of virus-induced IDOM in virus resistant mice without lymphocyte maturation, KANDA Tsugiyasu, Life Sciences, 1998
  • Modification of viral myocarditis in mice by lnterleukin-6, KANDA Tsugiyasu, Circulation Research, 1996
  • Interleukin-8 as a sensitive marker of unstable coronary artery disease, KANDA Tsugiyasu, The American Journal of Cardiology, 1996
  • Interleukin-6 secreted from human myxoma reduces murine viral myocarditis, KANDA Tsugiyasu, Lefe Sciences, 1996
  • Myocardial uptake of an iodinated branched fatty acid analog assessing SPECT, may detect metabolic derangement of the myocardium in diabetic patients with coronary heart disease, KANDA Tsugiyasu, Cardiology, 1995
  • False positive activated protein C sensitivity ratio caused by freezing and contamination of plasma with platelets, KANDA Tsugiyasu, Therapeutic Research, 1995
  • Chronic effect of losartan in a murine model of dilated cardiomyopathy : Comparison with captopril, KANDA Tsugiyasu, Journal of Pharmacology and Experimental Therapeutics, 1995
  • Myocardial beta-receptor and cardiac angiotensin alterations during the acute and chronic phases of viral myocarditis, KANDA Tsugiyasu, European Heart Journal, 1994
  • Interleukin-6 and cardiacmytoma, KANDA Tsugiyasu, American Journal of Cardiology, 1994
  • Holter monitoring as a noninvasive indicator of cardiac involvement in sarcoidosis, KANDA Tsugiyasu, Chest, 1994
  • Dexamethasone inhibits production of interleukin-6 by cultured cardiac myxoma cells, KANDA Tsugiyasu, American Heart Journal, 1994
  • Myocardial atrial natriuretic factor gene expression after coronary ligation in rats, KANDA Tsugiyasu, Experimental and clinical Endocrinology, 1993
  • Enhancement of myocardial damage and alteration of lymphocyte subsets in murine model of postpartum myocarditis, KANDA Tsugiyasu, American Journal of Cardiovascular, 1993
  • The alpha and alpha 2 domains of H-2 class I molecules interact to form unique epitopes, KANDA Tsugiyasu, Immunogenetics, 1987
  • Physicians’ Resilience as a Positive Effect of COVID-19, Tomoyuki Ushimoto, Kenshi Murasaka, Masaru Sakurai, Masao Ishizaki, Yukihiro Wato, Tsugiyasu Kanda, and Yuji Kasamaki, JMA Journal, 6:365-370, Oct. 2023
  • Orthogeriatric co-management at a regional core hospital as a new multidisciplinary approach in Japanese hip fracture operation, Toshihiro Higashikawa, Kenji Shigemoto, Manabu Moriyama, Daisuke Usuda, Masahiro Hangyou, Hiromi Inujima, Kakeru Nozaki, Miyako Yamaguchi, Kimiko Usuda, Osamu Iritani, Shigeto Morimoro, Takeshi Horii, Takeshi Nakahashi, Tadami Matsumoto, Toga Hirohisa, Shigeki Takashima, Tsugiyasu Kanda, Masashi Okuro, Takeshi Sawaguchi, Journal of Orthopaedic Science, 29:273-277, Jan. 2024
  • Procalcitonin, brain natriuretic peptide and albumin as markers to predict prognosis in hospitalized older Japanese patients with a risk of infection, Toshihiro Higashikawa, Toru Ito, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Michiteru Yoshida, Takuro Morita, Kazu Hamada, Hiroshi Yano, Kento Takeshima, Takatoshi Haraguchi, Shinya Yamada, Sohsuke Yamada, Tomoyuki Ushimoto, Ryusho Sangen, Toshihide Izumida, Jun Kiyosawa, Taisuke Ono, Masaharu Iguchi, Yukihiro Wato, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Shigeto Morimoto, Masashi Okuro, Geriatrics & Gerontology International, 24:571-576, Jun. 2024
  • Effects of 6-month administration of tofogliflozin on cardiac function in elderly patients with heart failure with preserved ejection fraction: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Takatoshi Haraguchi, Shinya Yamada, Ryusho Sangen, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Medicine, 103:e38948, Aug. 2024
  • Fatigue in Long Coronavirus Disease 2019: A Review of its Mechanism and Management, Junji Moriya, Takeshi Nakahashi, Takuya Sakamoto, Tsugiyasu Kanda, Yuji Kasamaki, Electronic Journal of Biology, 20:1-7, Mar. 2024
  • Investigating the Unexpected Effect of Bulkheads in a Dementia Model of Mice Through Molecular Analysis of the Hippocampus, Takuya Sakamoto, Tadashi Ueda, Tetsuhiro Horie, Daisuke Sakamoto, Yasuo Yoshitomi, Yasuhito Ishigaki, Munenori Ono, Nobuo Kato, Tsugiyasu Kanda, Yuji Kasamaki, Cureus, 16:e72272, Oct. 2024