TAKEDA Kenji

Researcher Profile & Settings

Research

Overview of research:
Gene 33 (also known as RALT) is considered as a negative feedback regulator that can be induced by a vriety of external stimuli, including oxidative stress and vasoactive peptides. I am primarily interested in understanding at the molecular level the functional roles of gene33 in cardiovascular disease.Seeking potential theraputic targets for cardiovascular desease, my research particularly focuses on following two themes using neonatal rat cardiac myocytes and H9c2 cell line : identification of signaling molecules downstream of gene 33, and analysis of its transcriptional regulation.

Education

• Hokkaido University Graduate School Department of Biological Sciences

Degree

• Ph.D

Research Activities

Published Papers

• Involvement of intercellular TAGE and the TAGE-RAGE-ROS axis in the onset and progression of NAFLD/NASH., Sakasai-Sakai A, Takeda K, Takeuchi M, Antioxidants, 12:748, Mar. 2023
• Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients, (Nora Lee), Kazuya Maeda, Shinya Fukizawa, Ichiro Ieiri, Atsuko Tomaru, Hironobu Akao, Kenji Takeda, Mizuho Iwadare, Osamu Niwa, Tougen Masauji, Naoe Yamane, Kouji Kajinami, Hiroyuki Kusuhara, Yuichi Sugiyama, Drug Metabolism and Pharmacokinetics, 34:387-395, Dec. 2019
  DOI:10.1016/j.dmpk.2019.08.004
• A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients, (K.Sai), K.Kajinami, H.Akao, M.Iwadare, R.Sato-Ishida, Y.Kawai, K.Takeda, T.Tanimoto, T.Yamano, T.Akasaka, T.Ishida, K.Hirata, K.Saku, S.Yagi, T.Soeki, M.Sata, M.Ueno, S.Miyazaki, A.Shiraki, J.Oyama, K.Node, K.Sugamura, H.Ogawa, K.Kurose, K.Maekawa, Y.Matsuzawa, T.Imatoh, R.Hasegawa, Y.Saito, Drug metabolism and pharmacokinetics, 31:467-470, 2016
  DOI:10.1016/j.dmpk.2016.09.002
• Nutri-pharmacogenomics of warfarin anticoagulation therapy : VKORC1 genotype-dependent influence of dietary vitamin K intake, R.Saito, K.Takeda, K.Yamamoto, A.Nakagawa, H.Aoki, K.Fujibayashi, M.Wakasa, A.Motoyama, M.Iwadare, R.Ishida, N.Fujioka, T.Tsuchiya, H.Akao, Y.Kawai, M.Kitayama, K.Kajinami, Journal of thrombosis and thrombolysis., 38:105-114, Jul. 2014
• Regulation of pssitive feedback loop of HB-EGF signal by gene 33/ralt in H9c2 cells, K.Takeda, S.Akazawa, Y.Kawai, K.Kajinami, 33:76-85, Aug. 2008
• Current understandings and future perspective for gene therapy, Takeda K, Kawai Y, Kajinami K, Nippon Rinsho, 28:696-700, Jul. 2007
• A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model, Kenji Takeda, Akiko Sakai-Sakasai, Kouji Kajinami, Masayoshi Takeuchi, Cells, 12:2838-2838, Dec. 2023