Japanese

HASHIMOTO Mitsumasa

■Faculty	Natural Sciences
■Position	Associate Professor

Researcher Profile & Settings

Research

Overview of research:

The main study of mine is the PKU-beta/TLK1 that is related to the cell cycle progression, espacially mitosis. It is being done by the means and the views of cell biology, biochemistry and molecular biology. In addition, the mechanism of phenomena that PKU-beta/TLK1 contributes to DNA repair is also studyed.

Education

Kanazawa University Graduate School Division of National Science and Technology
Doshisha University Faculty of Engineering

Degree

Doctor of Pharmacy

Academic & Professional Experience

Apr. 1999Emory University
Jul. 2001New York University

Research Activities

Published Papers

Calibrated scintigraphic imaging procedures improve quantitative assessment of the cardiac sympathetic nerve activity, Koichi Okuda, Kenichi Nakajima, Chiemi Kitamura, Yumiko Kirihara, Mitsumasa Hashimoto, Seigo Kinuya, Scientific reports, 10:21834, Dec. 2020
Preliminary quantitative evaluation of radiation-induced DNA damage in peripheral blood lymphocytes after cardiac dual-isotope imaging, Koichi Okuda, Naoto Watanabe, Mitsumasa Hashimoto, Mariko Doai, Yasuyuki Kawai, Tomoko Takahashi, Tomohiro Arikawa, Kazumasa Ooiso, Yumi Sunatani, Kuniyoshi Iwabuchi, Koji Kajinami, Munetaka Matoba, Applied Radiation and Isotopes, 154:108890, Dec. 2019
Caspase-mediated cleavage of X-ray repair cross-complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase-activated DNase., Yumi.Sunatani, Radhika Pankaj Kamdar, Mukesh Kumar Sharma, Tadashi.Matsui, Ryo.Sakasai, Mitsumasa.Hashimoto, Yasuhito.Ishigaki, Yoshihisa.Matsumoto, Kuniyoshi.Iwabuchi, Experimental cell research, 362:450, Jan. 2018
DOI:10.1016/j.yexcr.2017.12.009
Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT, Okuda, Koichi;Nakajima, Kenichi;Matsuo, Shinro;Kashiwaya, Soichiro;Yoneyama, Hiroto;Shibutani, Takayuki;Onoguchi, Masahisa;Hashimoto, Mitsumasa;Kinuya, Seigo, EJNMMI RESEARCH, 7:---, Mar. 2017
DOI:10.1186/s13550-017-0274-3
Cardiac and Respiratory Motion-induced Artifact in Myocardial Perfusion SPECT, Okuda Koichi;Nakajima Kenichi;Kikuchi Akihiro;Onoguchi Masahisa;Hashimoto Mitsumasa, Annals of Nuclear Cardiology, 3:88-93, 2017
DOI:10.17996/anc.17-00005
Development and validation of a direct-comparison method for cardiac I-123-metaiodobenzylguanidine washout rates derived from late 3-hour and 4-hour imaging, K.Okuda, K.Nakajima, S.Sugino, Y.Kirihara, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya, European Journal of Nuclear Medicine and Molecular Imaging, 43:319-325, Feb. 2016
DOI:10.1007/s00259-015-3173-8
Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution recovery in myocardial perfusion SPECT/CT., K.Okuda, K.Nakajima, M.Yamada, H.Wakabayashi, H.Ichikawa, H.Arai, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya, Annals of nuclear medicine., 28:60-68, Jan. 2014
Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi, Experimental biology and medicine (Maywood, N.J.), 238:889-897, 2013
DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: Implications for DNA double-strand break repair., (A.Kurosawa), S.Saito, S.So, M.Hashimoto, K.Iwabuchi, H.Watabe, N.Adachi, PloS one, 8:e72253;1-11, 2013
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1, (K.Watanabe), K.Iwabuchi, J.Sun, Y.Tsuji, T.Tani, K.Tokunaga, T.Date, M.Hashimoto, M.Yamaizumi, S.Tateishi, Nucleic acids research, 37:2176-2193, Jan. 2009
PKU-β/TLK1　regulates myosin Ⅱ activities, and is required for accurate equaled chromosome segregation, M.Hashimoto, T.Matsui, K.Iwabuchi, T.Date, Mutation research, 657:63-67, Sep. 2008
Characterization of a cancer cell line that expresses a splicing variant form of 53BP1:Separation of checkpoint and repair functions in 53BP1, K.Iwabuchi, T.Matsui, M.Hashimoto, Y.Matsumoto, T.Kurihara, T.Date, Biochemical and biophysical research communications, 376:509-513, Sep. 2008
Cell sorting analysis of cell cycle-dependent X-ray sensitivity in end joining-deficient human cells, K.Iwabuchi, M.Hashimoto, T.Matsui, A.Kurosawa, N.Adachi, T.Date, Biochemical and biophysical research communications, 372:662-667, May 2008
53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis., K.Iwabuchi, M.Hashimoto, T.Matsui, T.Kurihara, H.Shimizu, N.Adachi, M.Ishiai, K-I.Yamamoto, H.Tauchi, M.Takata, H.Koyama, T.Date, Genes to cells : devoted to molecular & cellular mechanisms, 11: 935-948, Aug. 2006
Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure, K.Kawamura, N.Morita, C.Domiki, K.Fujikawa-Yamamoto, M.Hashimoto, K.Iwabuchi, K.Suzuki, Cancer science., 97:252-258, 2006
HU protein of Escherichia coli has a role in the repair of closely opposed lesions in DNA, HASHIMOTO Mitsumasa, J. Biol. chem., 2003
DNA-PK: the major target for Wortmanniu mediated radiosensitization by the inhibitor of DSB repair uia NHEJ pathway, HASHIMOTO Mitsumasa, J. Radiat. Res (Tokyo), 2003
The 2-deoxyribonolactone lesion produced in DNA by neocarzinostatin and other damaging agents forms cross-links with the base-excision repair enzyme endonuclease III., J Am Chem Soc., 123(13):3161-3162, Apr. 2001
A Possible role for Ku in mediating sequential repair of closely opposed lesions, HASHIMOTO Mitsumasa, J. Biol. chem, 2001

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.