Japanese

SAKAI Tomoyuki

■Faculty	Department of Hematology and Immunology
■Position	Senior Assistant Professor

Researcher Profile & Settings

Research

Overview of research:

Hematology and Immunology

Degree

Ph.D in Medicine

Research Activities

Published Papers

Impaired expression of innate immunity-related genes in IgG4-related disease: A possible mechanism in the pathogenesis of IgG4-RD, Takuji Nakamura, Tomomi Satoh-Nakamura, Akio Nakajima, Takafumi Kawanami, Tomoyuki Sakai, Yoshimasa Fujita, Haruka Iwao, Miyuki Miki, Yasufumi Masaki, Toshiro Okazaki, Yasuhito Ishigaki, Mitsuhiro Kawano, Kazunori Yamada, Shoko Matsui, Takako Saeki, Terumi Kamisawa, Motohisa Yamamoto, Hideaki Hamano, Tomoki Origuchi, Shintaro Hirata, Yoshiya Tanaka, Hiroto Tsuboi, Takayuki Sumida, Kazuichi Okazaki, Masao Tanaka, Tsutomu Chiba, Tsuneo Mimori, Hisanori Umehara, Modern Rheumatology, 30:551-557, May 2020
Osteosarcoma Manifesting Systemic Inflammation and Histological Features Mimicking Plasma Cell-type Castleman Disease, Shino Fujimoto, Tomoyuki Sakai, Hiroshi Kawabata, Nozomu Kurose, Sohsuke Yamada, Mariko Doai, Munetaka Matoba, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Hiroki Mizumaki, Masaki Yamaguchi, Yasufumi Masaki, Internal Medicine, 58:2555-2560, Sep. 2019
Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-ell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation, (Koji Kato), Takehiko Mori, Sung-Won Kim, Masashi Sawa, Tomoyuki Sakai, Hisako Hashimoto, Jun Taguchi, Tatsuo Oyake, Shingo Kurahashi, Kazunori Imada, Hitoshi Ohno, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta, Ritsuro Suzuki, Junji Suzumiya, Bone Marrow Transplantation, 54:1515-1517, Sep. 2019
Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease?, Shino Fujimoto, Tomoyuki Sakai, Hiroshi Kawabata, Nozomu Kurose, Sohsuke Yamada, Kazue Takai, Sadao Aoki, Junya Kuroda, Makoto Ide, Keigo Setoguchi, Norifumi Tsukamoto, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki, American Journal of Hematology, 94:975-983, Sep. 2019
High-Dose chemotherapy with autologous stem cell transplantaion in primary central nervous system lymphoma: data from the Japan society for hematopoietic cell transplantation registry, (Eisei Kondo), Takashi Ikeda, Koji Izutsu, Dai Chihara, Risa Shimizu-Koresawa, Nobuharu Fujii, Tomoyuki Sakai, Tadakazu Kondo, Kohmei Kubo, Yuichi Kato, Takashi Akasaka, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Astuta, Junji Suzumiya, Ritsuro Suzuki, for the Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation, Biology of Blood and Marrow Transplantation, 25:899-905, May 2019
Natural History and Predictors of Progression to Sjögren's Syndrome Among Participants of the Sjögren's International Collaborative Clinical Alliance Registry., Caroline H Shiboski, Alan N Baer, Stephen C Shiboski, Mi Lam, Stephen Challacombe, FDSRCS, FRCPath, FMedSci, Hector E Lanfranchi, Morten Schiødt, Penelope Shirlaw, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Esen Akpek, Vatinee Bunya, Cristina F Vollenweider, John S Greenspan, Troy E Daniels, Lindsey A Criswell, and for the Sjögren’s International Collaborative Clinical Alliance (SICCA) Research Groups, Arthritis care & research., 70:284-294, Feb. 2018
The treatment strategy of IgG4-related disease - from the result of prospective clinical study -, Yasufumi.Masaki, Shino.Fujimoto, Haruka.Kawanami (Iwao), Tomoyuki.Sakai, Takafumi.Kawanami, Yopshimasa.Fujita, Hiroshi.Kawabata, Toshihiro.Fukushima, 29:140-146, Jun. 2017
A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease, Yasufumi.Masaki, shoko.Matsui, Takako.Saeki, Hiroto.Tsuboi, Shintaro.Hirata, Yasumori.Izumi, Taiichiro.Miyashita, Keita.Fujikawa, Hiroaki.Dobashi, Kentaro.Susaki, Hisanori.Morimoto, Kasutaka.Takagi, Mitsuhiro.Kawano,Tomoki.Origuchi, Yoko.Wada, Naoki.Takahashi, Masanobu.Horikashi, Hiroshi.Ogishima, Yasunori.Suzuki, Takafumi.Kawanami, Haruka.Kawanami Iwao, Tomoyuki.Sakai, Yoshimasa.Fujita, Toshihiro.Fukushima, Masatoshi.Saito, Ritsuro.Suzuki, Yuko.Morikawa, Tadashi.Yoshino, Shigeo.Nakamura, Masaru.Kojima, Nozomu.Kurose, Yasuharu.Sato, Yoshiya.Tanaka, Susumu.Sugai, Takayuki.Sumida, Modern Rheumatology, 27:849-854, May 2017
How to diagnose and treat IgG4-related disease, Y.Masaki, S.Fujimoto, H.Kawanami(Iwao), T.Sakai, T.Kawanami, Y.Fujita, H.Kawabata, T.Fukushima, Journal of Kanazawa Medical University, 41:67-72, Dec. 2016
Isolation of vascular smooth muscle antigen-reactive CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice., Y.Fujita, T.Fujii, H.Shimizu, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, T.Mimori, Cellular immunology, 303:50-54, 2016
DOI:10.1016/j.cellimm.2016.03.004
Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version., Y.Masaki, H.Kawabata, K.Takai, M.Kojima, N.Tsukamoto, Y.Ishigaki , N.Kurose, M.Ide, J.Murakami, K.Nara, H.Yamamoto, Y.Ozawa, H.Takahashi, K.Miura, T.Miyauchi, S.Yoshida, A.Momoi, N.Awano, S.Ikushima, Y.Ohta, N.Furuta, S.Fujimoto, H.Kawanami, T.Sakai, T.Kawanami, Y.Fujita, T.Fukushima, S.Nakamura, T.Kinoshita, S.Aoki, International journal of hematology, 103:686-692, 2016
DOI:10.1007/s12185-016-1979-1
Decreased expression of innate immunity-related genes in peripheral blood mononuclear cells from patients with IgG4-related disease, A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto, S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano, T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara, PLoS One, 10:e0126582-e0126582, May 2015
DOI:10.1371/journal.pone.0126582
CD14+ follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease, T.Satoh-Nakamura, N.Kurose, T.Kawanami, T.Nakamura, H.Iwao-Kawanami, A.Nakajima, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki, Biomedical Research, 36:143-153, Feb. 2015
Prospective clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku Hematology Oncology Study Group, T.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.Ueda, Medical Oncology, 32:232-238, 2015
IgG4-related disease:Diagnostic methods and therapeutic strategies in Japan, Y.Masaki, H.Shimizu, T.Sato, T.Nakamura, A.Nakajima, H.Iwao, M.Miki, T.Sakai, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, Journal of clinical and experimental hematopathology : JCEH., 54:95-101, 2014
Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Faslpr mice, Y.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, Journal of immunology (Baltimore, Md. : 1950), 192:979-984, 2014
Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Faslpr mice, Y.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, Journal of immunology (Baltimore, Md. : 1950), 192:979-984, 2014
Japanese variant of multicentirc cattleman's disease associated with serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a distinct clinicopathological entity?, Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara, Journal of clinical and experimental hematopathology : JCEH., 53:79-85, Jun. 2013
Skewed production of IL-6 and TGFβ by cultured salivary gland epithelial cells from patients with Sjogren's syndrome, T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, T.Nakamura, T.Sato, Y.Fujita, M.Tanaka, Y.Masaki, T.Fukushima, Y.Hirose, M.Taniguchi, N.Sugimoto, T.Okazaki, H.Umehara, PloS one, 7:e45689 1-5, Nov. 2012
Once-weekly bortezomib plus dexamethasone therapy induced complete response, reducing severe gastrointestinal adverse events for a patient with relapsed multiple myeloma -a case report, T.Fukushima, HH.Iwao, T.Sakai, T.Sato, T.Nakamura, A.Nakajima, M.Miki, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki, H.Umehara, 39:805-807, May 2012
Low-dose cytarabine plus aclarubicin for patients with previously untreated acute myeloid leukemia or high-risk myelodysplastic syndrome ineligible for standard-dose cytarabine plus anthracline, T.Fukushima, H.Kawabata, T.Sawaki, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, M.Miki, Y.Fujita, M.Tanaka, T.Kawanami, Y.Masaki, T.Okazaki, H.Umehara, Anticancer research., 32:1347-1354, 2012
Daily 500mg valacyclovir is effective for prevention of varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib, T.Fukushima, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki, T.Okazaki, H.Nakajima, Y.Motoo, H.Umehara, Anticancer research., 32:5437-5440, 2012
Cutoff values of serum IgG4 and histopathological IgG4+ plasma cells for diagnosis of patients with IgG4-related disease, Y.Masaki, N.Kurose, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada, S.Matsui, T.Origuchi, S.Nishiyama, K.Yamada, M.Kawano, A.Hirabayashi, K.Fujikawa, T.Sugiura, M.Horikoshi, N.Umeda, H.Minato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.sawaki, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, K.Eguchi, S.Sugai, H.Umehara, International journal of rheumatology, e580814,1-5, 2012
CD4＋T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin syｎthase 1-knockout mice, L.Dong, K.Watanabe, M.Itoh, C.Huan, X.Tong, T.Nakamura, M.Miki, H.Iwao, A.Nakajima, T.Sakai, T.Kawanami, T.Sawaki, Y.Masaki, T.Fukushima, Y.Fujita, M.Tanaka, M.Yano, T.Okazaki, H.Umehara, International immunology., 24:327-337, 2012
Efficacy and safety of bortezomib plus dexamethasone therapy for refractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence of gastrointestinal adverse events, T.Fukushima, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sato, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki, H.Nakajima, Y.Motoo, H.Umehara, Anticancer research., 31:2297-2302, Sep. 2011
Intravascular large B-cell lymphoma: an important cause of fever of unknown origin, Y.Masaki, M.Miki, T.Sakai, T.Sawaki, T.Fukushima, H.Umehara, 63:435-441, May 2011
Iron chelation therapy with deferasirox induced complete remission in a patient with chemotherapy-resistant acute monocytic leukemia, T.Fukushima, H.Kawabata, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki, Y.Hirose, H.Umehara, Anticancer research., 31:1741-1744, May 2011
Prevention of fasting-mediated bone marrow atrophy by leptin administration, Y.Fujita, H.Yanagida, T.Mimori, Z.Jin, T.Sakai, T.Kawanami, T.Sawaki, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, Cellular immunology., 273:52-58, 2011
High-dose methotrexate with R-CHOP therapy for the treatment of patients with primary central nervous system lymphoma, Y.Masaki, M.Miki, Y.Sun, T.Nakamura, H.Iwao, A.Nakajima, N.Kurose, T.Sakai, Z.Jin, T.Sawaki, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara, International journal of hematology., 93:720-726, 2011
Prevention of fasting-mediated bone marrow atrophy by leptin administration, Y.Fujita, H.Yanagida, T.Mimori, Z.Jin, T.Sakai, T.Kawanami, T.Sawaki, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, Cellular immunology., 273:52-58, 2011
Primary neurolymphomatosis of the cervical nerve root, M.miki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, T.Sawaki, T.Kawanami, M.Kaito, N.Kurose, Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara, 51:564-567, Jul. 2010
Complete response obtained by bortezomib plus dexamethasone in a patient with relapsed multiple myeloma with multiple plasmacytomas, T.Fukushima, T.Nakamura, M.Miki, T.Sakai, H.Iwao, A.Nakajima, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki, Y.Hirose, H.Umehara, Anticancer research., 30:3791-3794, Jun. 2010
Palliative radiotherapy with 1 x 8 Gy using conformal radiotherapy for chemotherapy-refractory, recurrent, aggressive lymphomas, M.Matoba, K.Oota, H.Tonami, Y.Masaki, T.Sakai, H.Umehara, Japanese journal of radiology, 28:220-223, May 2010
Synergistic effects of topoisomerase I inhibitor, SN38, on Fas-mediated apoptosis, Y.Cao, Z.Jin, X.Tong, S.Yue, T.Sakai, T.Kawanami, T.Sawaki, M.Miki, H.Iwao, A.Nakajima, Y.Masaki, Y.Fukushima, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara, Anticancer research., 30:3911-3918, 2010
Cisplatin augments FAS-mediated apoptosis through lipid rafts, C.Huang, Z.Jin, L.Dong, X.Tong, S.Yue, T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, Y.Masaki, Y.Fukushima, M.Tanaka, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara, Anticancer research., 30:2065-2072, 2010
Mechanisms of bortezomib-induced apoptosis in T cell lines, T.Sakai, 34:125-132, Dec. 2009
Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome, Hiroshi Kawabata, Shino Fujimoto, Tomoyuki Sakai, Hiroto Yanagisawa, Toshio Kitawaki, Kenji Nara, Masao Hagihara, Hiroshi Yamamoto, Masakuni Tanimizu, Chikako Kato, Tomoki Origuchi, Kazutaka Sunami, Yoshitaka Sunami, Taro Masunari, Nobuhiko Nakamura, Masanori Kobayashi, Keiko Yamagami, Katsuhiro Miura, Kazue Takai, Sadao Aoki, Norifumi Tsukamoto, Yasufumi Masaki, International Journal of Hematology, 114:179-188, 2021
Optimal treatments for TAFRO syndrome: a retrospective surveillance study in Japan, Shino Fujimoto, Hiroshi Kawabata, Tomoyuki Sakai, Hiroto Yanagisawa, Momoko Nishikori, Kenji Nara, Shin Ohara Norifumi Tsukamoto, Nozomu Kurose, Sohsuke Yamada, Kazue Takai, Sadao Aoki, Yasufumi Masaki, International Journal of Hematology, 113:73-80, 2021
Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease, Takafumi Kawanami, Haruka Kawanami-Iwao, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Tsutomu Takegami, Hiroto Yanagisawa, Shino Fujimoto, Tomoyuki Sakai, Yoshimasa Fujita, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Yuko Hirose, Yasufumi Masaki, Clinica Chimica Acta, 523:45-57, 2021
Faggot cells in acute myeloid leukemia with t(7;11)(p15;p15) and NUP98-HOXA9 fusion, Hiroto Yanagisawa, Shuichi Mizuta, Hiroshi Kawabata, Shino Fujimoto, Tomoyuki Sakai, Haruka Iwao-Kawanami, Takafumi Kawanami, Kazunori Yamada, Toshihiro Fukushima, Katsunori Kyoda, Yasufumi Masaki, Annals of Hematology, 100:2121-2123, Aug. 2021
Prognostic impacts of serum levels of C-reactive protein, albumin, and total cholesterol in patients with myelodysplastic syndromes, Hiroto Yanagisawa, Hiroshi Kawabata, Yusuke Ueda, Kotaro Arita, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki, International Journal of Hematology, 116:81-88, 2022
Castleman disease and TAFRO syndrome, Yasufumi Masaki, Kotaro Arita, Tomoyuki Sakai, Kazue Takai, Sadao Aoki, Hiroshi Kawabata, Annals of Hematology, 101:485-490, 2022
TAFRO syndrome: A disease requiring immediate medical attention, Yasufumi Masaki, Yusuke Ueda, Hiroto Yanagisawa, Kotaro Arita, Tomoyuki Sakai, Kazunori Yamada, Shuichi Mizuta, Toshihiro Fukushima, Kazue Takai, Sadao Aoki, and Hiroshi Kawabawa, Internal Medicien, 62:27-32, Jan. 2023
Long-term survival by surgery and adjuvant chemotherapy in a patient with perforated extranodal NK/T-cell lymphoma of the small intestine: a retrospective case study, (Hiroshi Funaki), Naomi Nojima, Yutaka Takikawa, Kazutoshi Komori, Hajime Hasegawa, Tomoyuki Sakai, Sohsuke Yamada, and Yasufumi Masaki, Surgical Case Reports, 9:103, Jun. 2023
Prospective therapeutic studies of disseminated extranodal large B-cell lymphoma including intravascular large B-cell lymphoma, Tomoyuki Sakai, Yusuke Ueda, Hiroto Yanagisawa, Kotaro Arita, Haruka Iwao, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Katsunori Tai, Shinji Kishi, Koji Morinaga, Jun Murakami, Hiroyuki Takamatsu, Yasushi Terasaki, Nobuyuki Yoshio, Yukio Kondo, Hirokazu Okumura, Sadaya Matano, Masaki Yamaguchi, Hiroshi Tsutani, Yasufumi Masaki, Global Health & Medicine, 6:277-281, Aug. 2024
Fatal hemophagocytic lymphohistiocytosis with intravascular large B-cell lymphoma following coronavirus disease 2019 vaccination in a patient with systemic lupus erythematosus: an intertwined case, Yusuke Ueda, Tomoyuki Sakai, Kazunori Yamada, Kotaro Arita, Yoko Ishige, Daisuke Hoshi, Hiroto Yanagisawa, Haruka Iwao-Kawanami, Takafumi Kawanami, Shuichi Mizuta, Toshihiro Fukushima, Sohsuke Yamada, Akihiro Yachie, Yasufumi Masaki, Immunological Medicine, 47:192-199, Sep. 2024
DOI:DOI: 10.1080/25785826.2024.2338594
IgG4-related disease concomitant with diffuse large B-cell lymphoma, Hiroto Yanagisawa, Keita Mishima, Yaya Yamanouchi, Yusuke Ueda, Takahiro Yamano, Haruka Iwao-Kawanami, Tomoyuki Sakai, Takafumi Kawanami, Kazunori Yamada, Mitsuhiro Kawano, Shuichi Mizuta, Toshihiro Fukushima, Yasufumi Masaki, 64:953-957, 2025

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.