KIYOI Takeshi

■FacultyDepartment of Pharmacology
■PositionSenior Assistant Professor

Research Activities

Published Papers

  • Preventative Effect of Topical Rebamipide Against Corneal Epithelium Disorders Caused by Diclofenac Sodium, Fukuda Masamichi, Kiyoi Takeshi, Takeda Shun, Sasaki Yu, Masuoka Naoyoshi, Kubo Eri, Sasaki Hiroshi., J Ocul Pharmacol Ther, 40:428-434, Sep. 2024
  • Corneal acetylcholine regulates sensory nerve activity via nicotinic receptors., Takayoshi Masuoka, Takeshi Kiyoi, Shijie Zheng, Qiang He, Li Liu, Junsuke Uwada, Ikunobu Muramatsu, 32:60-70, Jan. 2024
  • “Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of oxidative stress.“, Takeshi Kiyoi, Shuang Liu, Erika Takemasa, Naohito Hato, Masaki Mogi, Geriatrics & gerontology international, 23:304, Feb. 2023
  • “Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21.“, (Jun Muto), Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, Masamoto Murakami, Takeshi Imamura, Shigeki Higashiyama, Yasuhiro Fujisawa, Yoichi Mizukami, Koji Sayama, 6:13, Jan. 2023
  • Voluntary wheel-running activities ameliorate depressive-like behaviors in mouse dry eye model, Katsuya Nakano, Hitomi Nakazawa, Qiang He, Junsuke Uwada, Takeshi Kiyoi, Takaharu Ishibashi, Takayoshi Masuoka, 16:01-12, Sep. 2022
  • Perinatal low-fat dietary intervention affects glucose metabolism in female adult and aging offspring, (Megumi Ueno), Shuang Liu, Takeshi Kiyoi, Takashi Sugiyama, Masaki Mogi, 22:441-448, Mar. 2022
  • Long-term impact of maternal dietary intervention on metabolic homeostasis in male offspring in mice, (Megumi Ueno), Shuang Liu, Takeshi Kiyoi, Masaki Mogi, Takashi Sugiyama, 104:108971, Jan. 2022
  • CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP., Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada, Shigeki Higashiyama., Life science alliance, 4:e202101095, Sep. 2021
  • PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state., Ryuta Watanabe, Masashi Maekawa, Takeshi Kiyoi, Mie Kurata, Noriyoshi Miura, Tadahiko Kikugawa, Shigeki Higashiyama, Takashi Saika, The Prostate, 81:1390-1401, Sep. 2021
  • Mast cell activation markers for in vitro study, Muhammad Novrizal Abdi Sahid , Takeshi Kiyoi, J Immunoassay Immunochem, 41:778-816, Jul. 2020
  • Inhibition of Histamine Release from RBL-2H3 Cells by Zoledronate Did Not Affect Rab27a/Doc2a Interaction., Muhammad N A Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi, Biological & pharmaceutical bulletin, 44:1902-1906, Aug. 2021
  • Denervation‐induced loss of skeletal muscle mass influences immune homeostasis and accelerates the disease progression of lupus nephritis, Shuang Liu, Takeshi Kiyoi, Erika Takemasa, Masaki Mogi, JCSM Clinical Reports, 5:108-120, Jul. 2020
  • Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice., Yoshiyuki Kimura, Maho Sumiyoshi, Takeshi Kiyoi, Kimiye Baba, European journal of pharmacology, 886:173445, Nov. 2020
  • Assessment and Comparison of the Efficacy of Methotrexate, Prednisolone, Adalimumab, and Tocilizumab on Multipotency of Mesenchymal Stem Cells., Shuang Liu, Takeshi Kiyoi, Marina Ishida, Masaki Mogi, Frontiers in pharmacology, 11:1004, Aug. 2020
  • Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress., Takeshi Kiyoi, Shuang Liu, Erika Takemasa, Hirotomo Nakaoka, Naohito Hato, Masaki Mogi, PloS one, 15:e0227582, Apr. 2020
  • Evaluation of the structure of the otoconial layer using micro-computed tomography., Eriko Nishihara, Masahiro Okada, Takeshi Kiyoi, Masachika Shudou, Yuuki Imai, Naohito Hato, Auris, nasus, larynx, 47:734-739, Oct. 2020
  • Genetic Manipulation of Calcium Release-Activated Calcium Channel 1 Modulates the Multipotency of Human Cartilage-Derived Mesenchymal Stem Cells., Shuang Liu, Minae Takahashi, Takeshi Kiyoi, Kensuke Toyama, Masaki Mogi, Journal of immunology research, 2019:7510214, Feb. 2019
  • SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9, Kazufumi Tanigawa, Masashi Maekawa, Takeshi Kiyoi, Jun Nakayama, Riko Kitazawa, Sohei Kitazawa, Kentaro Semba, Tomohiko Taguchi, Satoshi Akita, Motohira Yoshida,Kei Ishimaru Yuji Watanabe Shigeki Higashiyama, Journal of cellular physiology, 234:17280-17294, 2019
  • Morphological and functional analysis of beige (Chèdiak-Higashi syndrome) mouse mast cells with giant granules., Takeshi Kiyoi, Shuang Liu, Muhammad Novrizal Abdi Sahid, Masachika Shudou, Masahito Ogasawara, Masaki Mogi, Kazutaka Maeyama, International immunopharmacology, 69:202-212, Apr. 2019
  • High-throughput screening system for dynamic monitoring of exocytotic vesicle trafficking in mast cells., Takeshi Kiyoi, Shuang Liu, Muhammad Novrizal Abdi Sahid, Masachika Shudou, Kazutaka Maeyama, Masaki Mogi, PloS one, 133:e0198785, Jul. 2018
  • Efficacy of constant long-term delivery of YM-58483 for the treatment of rheumatoid arthritis., Maya Miyoshi, Shuang Liu, Asuka Morizane, Erika Takemasa, Yashuyuki Suzuki, Takeshi Kiyoi, Kazutaka Maeyama, Masaki Mogi, European journal of pharmacology, 824:89-98, Apr. 2018
  • Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins., Muhammad Novrizal Abdi Sahid, Shuang Liu, Takeshi Kiyoi, Kazutaka Maeyama, European journal of pharmacology, 814:255-263, Nov. 2017
  • Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models, Shuang Liu, Hitoshi Hasegawa, Erika Takemasa, Yasuyuki Suzuki, Keizou Oka, Takeshi Kiyoi, Hiroyuki Takeda, Tomio Ogasawara, Tatsuya Sawasaki, Masaki Yasukawa,Kazutaka Maeyama, Journal of immunology, 199:1584-1595, Sep. 2017
  • Intra-articular lentivirus-mediated gene therapy targeting CRACM1 for the treatment of collagen-induced arthritis, Liu Shuang, Kiyoi Takeshi, Takemasa Erika, Maeyama Kazutaka, Journal of Pharmacological Sciences, 133:130-138, Mar. 2017
  • The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell., Masahito Ogasawara, Mieko Otani, Masaoki Takano, Masachika Shudou, Yohei Inaba, Satoru Nirasawa, Saori Takahashi, Takeshi Kiyoi, Yuki Tanaka, Kenji Kameda,Naoki Kunugita Kazutaka Maeyama Keiji Sano Masahiro Yamashita Kohei Yamauchi, Experimental lung research, 42:245-262, Jun. 2016
  • CRACM3 regulates the stability of non-excitable exocytotic vesicle fusion pores in a Ca (2+)-independent manner via molecular interaction with syntaxin4., Shuang Liu, Muhammad Novrizal Abdi Sahid, Erika Takemasa, Takeshi Kiyoi, Miyuki Kuno, Yusuke Oshima, Kazutaka Maeyama, Scientific reports, 6:28133, Jun. 2016
  • The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice., Kenshi Takechi, Katsuya Suemaru, Takeshi Kiyoi, Akihiro Tanaka, Hiroaki Araki, European journal of pharmacology, 775:57-66, Mar. 2016
  • Evaluation of edaravone against radiation-induced oral mucositis in mice, Nakajima Noriko, Watanabe Shinichi, Kiyoi Takeshi, Tanaka Akihiro, Suemaru Katsuya, Araki Hiroaki, Journal of Pharmacological Sciences, 127:339-343, Mar. 2015
  • Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice, Tasaka Yuichi, Yasunaga Daiki, Kiyoi Takeshi, Tanaka Mamoru, Tanaka Akihiro, Suemaru Katsuya, Araki Hiroaki, Journal of Pharmacological Sciences, 127:275-283, Mar. 2015
  • Systemic lentivirus-mediated delivery of short hairpin RNA targeting calcium release-activated calcium channel 3 as gene therapy for collagen-induced arthritis., Shuang Liu, Takeshi Kiyoi, Erika Takemasa, Kazutaka Maeyama, Journal of immunology, 194:76-83, Jan. 2015
  • An ecological study on distributional pattern and characteristics of land snails (Gastropoda) of the shrine/temple forests in Shimane, Bulletin of the Hoshizaki Green Foundation, 10:277-287, Mar. 2007
  • Effect of silver nitrate solution on corneal epithelial barrier function in rabbits, Masamichi Fukuda, Takeshi Kiyoi, Shun Takeda, Yu Sasaki, Takayoshi Masuoka, Tsuyoshi Mito, Makoto Sasaki, Eri Kubo, Hiroshi Sasaki, Cutaneous and Ocular Toxicology, 44:536-543, Dec. 2025
  • PIKFYVE inhibition induces endosome- and lysosome-derived vacuole enlargement via ammonium accumulation, Junsuke Uwada, Hitomi Nakazawa, Takeshi Kiyoi, Takashi Yazawa, Ikunobu Muramatsu, Takayoshi Masuoka, Journal of Cell Science, 138:262236, Jan. 2025
  • Morphological aberration of corneal nerves in hyposecretory dry eye guinea pigs, Takeshi Kiyoi, Qiang He, Li Liu, Shijie Zheng, Hitomi Nakazawa, Junsuke Uwada, Takayoshi Masuoka, MEDICAL MOLECULAR MORPHOLOGY, 58:34-42, Mar. 2025
  • Changes in Corneal Epithelial Barrier Function and Zonula Occludens-1 Distribution with Concomitant Use of Silver Nitrate and Latanoprost in Rabbits., Fukuda M., Sasaki Y., Kiyoi T., Ishida H., Sasaki M., Masuoka T., Kubo E., Sasaki H., Journal of Ocular Pharmacology and Therapeutics, 00:10807683261469380, Jul. 2026
  • Tramadol Eye Drop Reduces Ocular Nocifensive Behavior Not Primarily Mediated by μ-Opioid Receptor Activation in a Rat Dry Eye Model, Shogo Nagaoka, Yoshihiro Takai, Takeshi Kiyoi, Takayoshi Masuoka, Biological and Pharmaceutical Bulletin, 49:794-801, May 2026
  • Transcriptome-Based Evaluation of Hydrogen Gas Effects for Preventing UVA-Induced Photoaging Using an Artificial Skin Model, Takeshi Kiyoi, Shuang Liu, Kentaro Uchida, Erika Takemasa, Naohito Hato, Masaki Mogi, Geriatrics & Gerontology International, 3:e70401, Mar. 2026

Books etc

  • Effect of lysed Enterococcus faecalis FK-23 as a tyndallized probiotic in allergic diseases.
    Functional Foods and Nutraceuticals in Metabolic and Non-communicable Diseases
    Elsevier  Jan. 2021
  • Histological Analysis of Arthritic Joints.
    Methods in Molecular Biology
    Kiyoi T
    springer nature  Sep. 2018
  • Histological Analyses of Arthritic Joints in Collagen-Induced Arthritis Model Mice
    Methods in Molecular Biology
    Takeshi Kiyoi
    Springer Nature  Jan. 2024
  • Scanning Electron Microscopic Analysis of the Bone-Resorption Activity in Mature Osteoclasts
    Methods in Molecular Biology
    Takeshi Kiyoi
    Springer Nature  Jan. 2024
  • Evaluation of Skin Damage Under UV Exposure
    Methods in Molecular Biology
    Takeshi Kiyoi
    Springer Nature  Jan. 2024
  • Bone Resorption Activity in Mature Osteoclasts.
    Methods in Molecular Biology
    Kiyoi T
    springer nature  Sep. 2018