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岡崎 俊朗 オカザキ トシロウ

所属部署名血液免疫内科学, 先端医療研究領域
職名教授
 
 

研究者基本情報

専門分野

  • 血液内科学

学位

  • 医学博士

所属学協会

  • 1997年- 2015年日本癌治療学会 編集委員
  • 1995年- 2015年日本血液学会 代議員
  • 2005年- 2015年日本検査医学会 評議員
  • - 2015年日本脂質生化学会 幹事
  • 2010年- 2015年日本自動化学会 評議員
  • 2008年- 2015年日本生化学会 評議員

経歴

  • 1979年06月- 1980年05月京都大学医学部附属病院 内科系研修医
  • 1980年06月静岡県島田市民病院内科 医員
  • 1987年04月- 1987年09月京都大学医学部第一内科 研修員
  • 1987年01月- 1991年07月米国デューク大学生化学・内科学教室 研究員
  • 1991年08月- 1995年07月大阪歯科大学内科学講座 助手
  • 1995年08月- 1996年09月大阪歯科大学内科学講座 講師
  • 1996年01月京都大学大学院医学研究科血液病態学(第一内科) 助手
  • 1998年07月京都大学大学院医学研究科血液病態学(第一内科) 講師
  • 2002年04月京都大学大学院医学研究科内科学講座 血液・腫瘍内科学 講師
  • 2005年01月鳥取大学医学部病態解析医学講座臨床検査医学・血液内科 教授
  • 2007年05月- 2011年05月鳥取大学医学部病態解析医学講座臨床検査医学・血液腫瘍科 教授
  • 2011年06月金沢医科大学血液免疫内科学 教授(現職)

研究活動情報

論文

  • Analysis of lipid-composition changes in plasma membrane microdomainsH.Ogiso, M.Taniguchi, T.OkazakiJournal of Lipid Research56:1594-16052015年08月
  • Role of sphingolipids and metabolizing enzymes in hematological malignancies(K.Kitatani), M.Taniguchi, T.OkazakiMolecules and Cells38:482-4952015年06月
  • Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide(H.Yazama), K.Kitatani, K.Fujiwara, M.Kato, M.Hashimoto-Nishimura, K.Kawamoto, K.Hasegawa, H.Kitano, A.Beilawska, J.Bielawski, T.OkazakiInternational Journal Clinical Oncology20:438-4462015年06月
  • Lysososomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosisM.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.OkazakiCell Death and Disease6:1-122015年04月
  • Prospective clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku Hematology Oncology Study GroupT.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.UedaMedical Oncology32:232-2382015年
  • Differential changes in sphingolipids between TNF-induced necroptosis and apoptosis in U937 cells and necroptosis-resistant sublines(H.Sawai), H.Ogiso, T.OkazakiLeukemia Research39:964-9702015年
  • Long-term heat exposure prevents hypoxia-induced apoptosis in mouse fibroblast cells(N.Sugimoto), O.Shido, K.Matsuzaki, M.Katakura, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.UmeharaCell biochemistry and biophysics.70:301-3072014年09月
  • Infiltration of the thyroid Gland by T-cell prolymphocytic leukemia(K.Fujiwara), T.Fukuhara, H.Kitano, T.OkazakiThyroid : official journal of the American Thyroid Association.24:1314-13182014年08月
  • The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration ? from cell and animal models to human disorders-M.Taniguchi, T.OkazakiBiochimica et biophysica acta-molecular and cell biology of lipids1841:692-7032014年05月
  • スフィンゴミエリンとスフィンゴミエリン合成酵素谷口 真, 岡崎 俊朗医学のあゆみ248:1084-10902014年03月
  • Comparative analysis of biological sphingolipids with glycerophospholipids and diacylglycerol by LC-MS/MSH.Ogiso, M.Taniguchi, S.Araya, S.Aoki, LO.Wardhani, Y.Yamashita, Y.Ueda, T.OkazakiMetabolites [electronic resource]4:98-1142014年03月
  • スフィンゴミエリン合成酵素1遺伝子欠損マウスにおける血小板減少の解明高 栄芬, 上田善文, 小木曽英夫, 谷口 真, 荒谷信一, 山下優香, L.Wardhani, 竹内光恵, 塚原 完, 岡崎俊朗脂質生化学研究56:168-1712014年
  • Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Faslpr miceY.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.UmeharaJournal of immunology (Baltimore, Md. : 1950)192:979-9842014年
  • Clot retraction is mediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts.(K.Kasahara), M.Kaneda, T.Miki, K.Iida, N.Sekino-Suzuki, I.kawashima, H.Suzuki, M.Shimonaka, M.Arai, Y.Ohno-Iwashita, S.Kojima, M.Abe, T.Kobayashi, T.Okazaki, M.Souri, A.Ichinose, N.YamamotoBlood.122:3340-33482013年11月
  • Japanese variant of multicentirc cattleman's disease associated with serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a distinct clinicopathological entity?Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.UmeharaJournal of clinical and experimental hematopathology : JCEH.53:79-852013年06月
  • Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice.(M.Yano), T.Yamamoto, N.Nishimura, T.Gotoh, K.Watanabe, K.Ikeda, Y.Garan, R.Taguchi, K.Node, T.Okazaki, Y.OikePloS one8:e61380;1-122013年04月
  • Upregulation of aquaporin expression in the salivary glands of heat-acclimated rats.(N.Sugimoto), K.Matsuzaki, H.Ishibashi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki, J.Sekine, S.Koizumi, A.Yachie, H.Umehara, O.ShidoScientific reports3:1763;1-82013年
  • Possible mechanisms of lymphoma development in Sjoguren's syndrome.(L.Dong), Y.Chen, Y.Masaki, T.Okazaki, H.UmeharaCurrent immunology reviews9:13-222013年
  • A sensitive cell-based method to screen for selective inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate(K.Zama), A.Mitsutake, K.Watanabe, T.Okazaki, Y.IgarashiChemistry and physics of lipids165:760-7682012年10月
  • Regulation of cell migration by sphingomyelin synthase : Sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway.(S.Asano), K.Kitatani, M.Taniguchi, M.Hashimoto, K.Zama, S.Mitustake, Y.Igarashi, H.Takeya, J.Kigawa, A.Hayashi, H.Umehara, T.OkazakiMolecular and cellular biology32:3242-32522012年08月
  • Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway(S.Asano), K.Kitatani, M.Taniguchi, M.Hashimoto, K.Zama, S.Mitsutake, Y.Igarashi, H.Takeya, J.Kigawa, A.Hayashi, H.Umehara, T.OkazakiMolecular and cellular biology32:3242-32522012年06月
  • Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation.(AB.Shakor), M.Taniguchi, K.Kitatani, M.Hashimoto, S.Asano, A.Hayashi, K.Nomura, J.Bielawski, A.Bielawska, K.Watanabe, T.Kobayashi, Y.Igarashi, H.Umehara, H.Takeya, T.OkazakiThe Journal of biological chemistry.286:36053-360622011年10月
  • Sphingomyelin synthase 1-generated sphingomyelin plays an important role in transferrin trafficking and cell proliferation(A.Shakor), M.Taniguchi, K.Kitatani, M.Hashimoto, S.Asano, A.Hayashi, K.Nomura, J.Bielawski, A.Bielawska, K.Watanabe, T.Kobayashi, Y.Igarashi, H.Umehara, H.Takeya, T.OkazakiThe Journal of biological chemistry.286:36053-360622011年10月
  • Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice(M.Yano), K.Watanabe, T.Yamamoto, K.Ikeda, T.Senokuchi, M.Lu, T.Kadomatsu, H.Tsukano, M.Ikawa, M.Okabe, S.Yamaoka, T.Okazaki, H.Umehara, T.Gotoh, W.Song, K.Node, R.Taguchi, K.Yamagata, Y.OikeThe Journal of biological chemistry.286:3992-40022011年
  • セラミドとシグナル伝達;セラミドによる血管新生阻害谷口 真, 杉本 優子, 橋本 真由美, 佐々木 栄二, 岡崎 俊朗分子心血管病9巻2008年09月
  • Isolation of vascular smooth muscle antigen-reactive CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice.Y.Fujita, T.Fujii, H.Shimizu, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, T.MimoriCellular immunology303:50-542016年
  • Long-term heat exposure prevents hypoxia-induced apoptosis in mouse fibroblast cells(N.Sugimoto), O.Shido, K.Matsuzaki, M.Katakura, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.UmeharaCell biochemistry and biophysics.70:301-3072014年09月
  • Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Faslpr miceY.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka, Y.Masaki, T.Fukushima, T.Okazaki, H.UmeharaJournal of immunology (Baltimore, Md. : 1950)192:979-9842014年
  • Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid(K.Kitatani), T.Usui, SK.Sriraman, M.Toyoshima, M.Ishibashi, S.Shigeta, S.Nagase, M.Sakamoto, H.Ogiso, T.Okazaki, YA.Hannun, VP.Torchilin, N.YaegashiOncogene35:2801-28122016年
  • Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow.(H.Watanabe), K.Okahara, Y.Naito-Matsui, M.Abe, S.Go, J.Inokuchi, T.Okazaki, T.Kobayashi, Y.Kozutsumi, S.Oka, H.TakematsuMolecular biology of the cell27:2037-20502016年
  • Negative role of Sphingomyelin Synthase 2 in EL4 cells infiltration due to the deterioration of ICAM1/LFA1 systemOKA WARDHANI Lusi;HASHIMOTO Mayumi;KITATANI Kazuyuki;TANIGUCHI Makoto;AOKI Shinya;OGISO Hideo;ARAYA Shinichi;HAYASHI Kazuhiko;UMEHARA Hisanori;OKAZAKI Toshiro脂質生化学研究55:101-1032013年05月
  • アミノ酸刺激によるmTORの活性化に対するスフィンゴミエリンの影響座間 宏太;光武 進;渡辺 研;岡崎 俊朗;五十嵐 靖之脂質生化学研究54:164-1662012年05月
  • スフィンゴミエリン合成酵素(SMS)制御による細胞増殖・遊走調節 : 悪性腫瘍の新規治療法開発に向けて岡崎 俊朗脂質生化学研究54:**-**2012年05月
  • 焼酎粕に含まれるスフィンゴ脂質の検出・半定量的評価とその由来の解析平田 みよ;浦野 義崇;稲葉 繁樹;北谷 和之;岡崎 俊朗;北垣 浩志日本醸造協会誌 = Journal of the Brewing Society of Japan106:848-8532011年12月
  • Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID miceFUJIWARA Kazunori;KITATANI Kazuyuki;FUKUSHIMA Kei;YAZAMA Hiroaki;UMEHARA Hisanori;KIKUCHI Mitsunori;IGARASHI Yasuyuki;KITANO Hiroya;OKAZAKI ToshiroInternational journal of clinical oncology16:133-1402011年04月
  • Cloning and expression of two human recombinant monoclonal Fab fragments specific for EBV viral capsid antigenDONG Lingli;MASAKI Yasufumi;TAKEGAMI Tsutomu;KAWANAMI Takafumi;ITOH Kunihiko;JIN Zhe-Xiong;HUANG Cheng-Ri;TONG Xiao-Peng;FUKUSHIMA Toshihiro;TANAKA Masao;SAWAKI Toshioki;SAKAI Tomoyuki;SUGAI Susumu;OKAZAKI Toshiro;HIROSE Yuko;UMEHARA HisanoriInternational immunology19:331-3362007年03月
  • Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cellsJIN Zhe-Xiong;HUANG Cheng-Ri;DONG Lingli;GODA Seiji;KAWANAMI Takafumi;SAWAKI Toshioki;SAKAI Tomoyuki;TONG Xiao-Peng;MASAKI Yasufumi;FUKUSHIMA Toshihiro;TANAKA Masao;MIMORI Tsuneyo;TOJO Hiromasa;BLOOM Eda T.;OKAZAKI Toshiro;UMEHARA HisanoriInternational immunology20:1427-14372008年11月
  • Japanese Variant of Multicentric Castleman's Disease Associated With Serositis and Thrombocytopenia-A Report of Two Cases : Is TAFRO Syndrome (Castleman-Kojima Disease) a Distinct Clinicopathological Entity?MASAKI Yasufumi;NAKAJIMA Akio;IWAO Haruka;KUROSE Nozomu;SATO Tomomi;NAKAMURA Takuji;MIKI Miyuki;SAKAI Tomoyuki;KAWANAMI Takafumi;SAWAKI Toshioki;FUJITA Yoshimasa;TANAKA Masao;FUKUSHIMA Toshihiro;OKAZAKI Toshiro;UMEHARA HisanoriJournal of clinical and experimental hematopathology53:79-852013年06月
  • Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virusM.Taniguchi, T.Tasaki, H.Ninomiya, Y.Ueda, K.Kuremoto, S.Mitsutake, Y.Igarashi, T.Okazaki, T.TakegamiScientific Reports6:37829-378292016年11月
  • セラミド代謝と造血器腫瘍谷口 真, 岡崎俊朗血液内科73:478-4852016年10月
  • Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1(M.Wu), M.Takemoto, M.Taniguchi, T.Takumi, T.Okazaki, W.J.SongAmerican Journal of Physiology Cell Physiology311:C15-C232016年07月
  • Comparative lipid analysis in the normal and cancerous organoids of MDCK cells.H.Yoshizaki, H.Ogiso, T.Okazaki, E.KiyokawaJournal of Biochemistry159:573-5842016年06月
  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).(DJ.Klionsky), K.Abdelmohsen, A.Abe, MJ.Abedin, H.Abeliovich, A.Acevedo Arozena, H.Adachi, CM.Adams, PD.Adams, K.Adeli, PJ.Adhihetty, SG.Adler, G.Agam, R.Agarwal, MK.Aghi, M.Agnello, P.Agostinis, PV.Aguilar, J.Aguirre-Ghiso, EM.Airoldi, S.Ait-Si-Ali, T.Akematsu, ET.Akporiaye, M.Al-Rubeai, GM.Albaiceta, C.Albanese, D.Albani, ML.Albert, J.Aldudo, H.Algül, M.Alirezaei, I.Alloza, A.Almasan, M.Almonte-Beceril, ES.Alnemri, C.Alonso, N.Altan-Bonnet, DC.Altieri, S.Alvarez, L.Alvarez-Erviti, S.Alves, G.Amadoro, A.Amano, C.Amantini, S.Ambrosio, I.Amelio, AO.Amer, M.Amessou, A.Amon, Z.An, FA.Anania, SU.Andersen, UP.Andley, CK.Andreadi, N.Andrieu-Abadie, A.Anel, DK.Ann, S.Anoopkumar-Dukie, M.Antonioli, H.Aoki, N.Apostolova, S.Aquila, K.Aquilano, K.Araki, E.Arama, A.Aranda, J.Araya, A.Arcaro, E.Arias, H.Arimoto, AR.Ariosa, JL.Armstrong, T.Arnould, I.Arsov, K.Asanuma, V.Askanas, E.Asselin, R.Atarashi, SS.Atherton, JD.Atkin, LD.Attardi, P.Auberger, G.Auburger, L.Aurelian, R.Autelli, L.Avagliano, ML.Avantaggiati, L.Avrahami, S.Awale, N.Azad, T.Bachetti, JM.Backer, DH.Bae, JS.Bae, ON.Bae, SH.Bae, EH.Baehrecke, SH.Baek, S.Baghdiguian, A.Bagniewska-Zadworna, H.Bai, J.Bai, XY.Bai, Y.Bailly, KN.Balaji, W.Balduini, A.Ballabio, R.Balzan, R.Banerjee, G.Bánhegyi, H.Bao, B.Barbeau, MD.Barrachina, E.Barreiro, B.Bartel, A.Bartolomé, DC.Bassham, MT.Bassi, RC Jr.Bast, A.Basu, MT.Batista, H.Batoko, M.Battino, K.Bauckman, BL.Baumgarner, KU.Bayer, R.Beale, JF.Beaulieu, GR Jr.Beck, C.Becker, JD.Beckham, PA.Bédard, PJ.Bednarski, TJ.Begley, C.Behl, C.Behrends, GM.Behrens, KE.Behrns, E.Bejarano, A.Belaid, F.Belleudi, G.Bénard , G.Berchem, D.Bergamaschi, M.Bergami, B.Berkhout, L.Berliocchi, A.Bernard, M.Bernard, F.Bernassola, A.Bertolotti, AS.Bess, S.Besteiro, S.Bettuzzi, S.Bhalla, S.Bhattacharyya, SK.Bhutia, C.Biagosch, MW.Bianchi, M.Biard-Piechaczyk, V.Billes, C.Bincoletto, B.Bingol, SW.Bird, M.Bitoun, I.Bjedov, C.Blackstone, L.Blanc, GA.Blanco, HK.Blomhoff, E.Boada-Romero, S.Böckler, M.Boes, K.Boesze-Battaglia, LH.Boise, A.Bolino, A.Boman, P.Bonaldo, M.Bordi, J.Bosch, LM.Botana, J.Botti, G.Bou, M.Bouché, M.Bouchecareilh, MJ.Boucher, ME.Boulton, SG.Bouret, P.Boya, M.Boyer-Guittaut, PV.Bozhkov, N.Brady, VM.Braga, C.Brancolini, GH.Braus, Pedro JM.Bravo-San, LA.Brennan, EH.Bresnick, P.Brest, D.Bridges, MA.Bringer, M.Brini, GC.Brito, B.Brodin, PS.Brookes, EJ.Brown, K.Brown, HE.Broxmeyer, A.Bruhat, PC.Brum, JH.Brumell, N.Brunetti-Pierri, RJ.Bryson-Richardson, S.Buch, AM.Buchan, H.Budak, DV.Bulavin, SJ.Bultman, G.Bultynck, V.Bumbasirevic, Y.Burelle, RE.Burke, M.Burmeister, P.Bütikofer, L.Caberlotto, K.Cadwell, M.Cahova, D.Cai, J.Cai, Q.Cai, S.Calatayud, N.Camougrand, M.Campanella, GR.Campbell, M.Campbell, S.Campello, R.Candau, I.Caniggia, L.Cantoni, L.Cao, AB.Caplan, M.Caraglia, C.Cardinali, SM.Cardoso, JS.Carew, LA.Carleton, CR.Carlin, S.Carloni, SR.Carlsson, D.Carmona-Gutierrez, LA.Carneiro, O.Carnevali, S.Carra, A.Carrier, B.Carroll, C.Casas, J.Casas, G.Cassinelli, P.Castets, S.Castro-Obregon, G.Cavallini, I.Ceccherini, F.Cecconi, AI.Cederbaum, V.Ceña, S.Cenci, C.Cerella, D.Cervia, S.Cetrullo, H.Chaachouay, HJ.Chae, AS.Chagin, CY.Chai, G.Chakrabarti, G.Chamilos, EY.Chan, MT.Chan, D.Chandra, P.Chandra, CP.Chang, RC.Chang, TY.Chang, JC.Chatham, S.Chatterjee, S.Chauhan, Y.Che, ME.Cheetham, R.Cheluvappa, CJ.Chen, G.Chen, GC.Chen, G.Chen, H.Chen, JW.Chen, JK.Chen, M.Chen, M.Chen, P.Chen, Q.Chen, Q.Chen, SD.Chen, S.Chen, SS.Chen, W.Chen, WJ.Chen, WQ.Chen, W.Chen, X.Chen, YH.Chen, YG.Chen, Y.Chen, Y.Chen, Y.Chen, YJ.Chen, YQ.Chen, Y.Chen, Z.Chen, Z.Chen, A.Cheng, CH.Cheng, H.Cheng, H.Cheong, S.Cherry, J.Chesney, CH.Cheung, E.Chevet, HC.Chi, SG.Chi, F.Chiacchiera, HL.Chiang, R.Chiarelli, M.Chiariello, M.Chieppa, LS.Chin, M.Chiong, GN.Chiu, DH.Cho, SG.Cho, WC.Cho, YY.Cho, YS.Cho, AM.Choi, EJ.Choi, EK.Choi, J.Choi, ME.Choi, SI.Choi, TF.Chou, S.Chouaib, D.Choubey, V.Choubey, KC.Chow, K.Chowdhury, CT.Chu, TH.Chuang, T.Chun, H.Chung, T.Chung, YL.Chung, YJ.Chwae, V.Cianfanelli, R.Ciarcia, IA.Ciechomska, MR.Ciriolo, M.Cirone, S.Claerhout, MJ.Clague, J.Clària, PG.Clarke, R.Clarke, E.Clementi, C.Cleyrat, M.Cnop, EM.Coccia, T.Cocco, P.Codogno, J.Coers, EE.Cohen, D.Colecchia, L.Coletto, NS.Coll, E.Colucci-Guyon, S.Comincini, M.Condello, KL.Cook, GH.Coombs, CD.Cooper, JM.Cooper, I.Coppens, MT.Corasaniti, M.Corazzari, R.Corbalan, E.Corcelle-Termeau, MD.Cordero, C.Corral-Ramos, O.Corti, A.Cossarizza, P.Costelli, S.Costes, SL.Cotman, A.Coto-Montes, S.Cottet, E.Couve, LR.Covey, LA.Cowart, JS.Cox, FP.Coxon, CB.Coyne, MS.Cragg, RJ.Craven, T.Crepaldi, JL.Crespo, A.Criollo, V.Crippa, MT.Cruz, AM.Cuervo, JM.Cuezva, T.Cui, PR.Cutillas, MJ.Czaja, MF.Czyzyk-Krzeska, RK.Dagda, U.Dahmen, C.Dai, W.Dai, Y.Dai, KN.Dalby, Valle L.Dalla, G.Dalmasso, M.D'Amelio, M.Damme, A.Darfeuille-Michaud, C.Dargemont, VM.Darley-Usmar, S.Dasarathy, B.Dasgupta, S.Dash, CR.Dass, HM.Davey, 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  • Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancerToshio.Ohnishi, Chieko.Hashizume, Makoto.Taniguchi, Hidehiro.Furumoto, Jia.Han, Rongfen.Gao, Shinichi.Kinami, Takeo.Kosaka, Toshiro.OkazakiThe Faseb Journal31:3816-38302017年12月

書籍等出版物

  • 第8節 スフィンゴミエリン合成酵素・スフィンゴミエリナーゼ
    疾患モデルの作製と利用 脂質代謝異常と関連疾患 下巻(尾池雄一, 佐々木雄彦 )
    谷口 真, 岡崎俊朗
    エル・アイ・シー 2015年04月
  • Unraveling the specific role of sphingomyelins in cell physiology: Where are we?
    Sphingolipids: Biology, Synthesis and Functions (Angel Catalá)
    (J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn
    Nova Science Publishers 2015年01月
  • Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders
    Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao, Lina Marie Obeid)
    (H.Sawai), M.Taniguchi, T.Okazaki
    Springer 2015年

受賞

  • 2010年 日本セラミド研究会 JSC Award
    岡崎 俊朗,

競争的資金

  • 骨組織による血糖値調節機構の解明 -スフィンゴミエリンの重要性-
    文部科学省:科学研究費 分担研究 基盤研究(C)
    研究期間:2014年 - 2016年  
    代表者:吉川美弘(大阪歯科大学)分担・連携研究者:岡崎俊朗
  • スフィンゴミエリン合成酵素(SMS)1を標的とした難治性がんに対する次世代抗がん剤の開発
    その他公的機関:(独)科学技術振興機構 研究成果最適展開支援プログラム(A-STEP)FSステージシーズ顕在化タイプ 研究成果展開事業
    研究期間:2014年 - 2014年  
    代表者:岡崎俊朗
  • 難治性疾患に対するスフィンゴ脂質制御を標的とする膜ミクロドメイン療法の開発
    その他:公益財団法人武田科学振興財団特定研究助成
    研究期間:2012年 - 2012年  
    代表者:岡崎俊朗
  • スフィンゴ脂質を介した正常”骨髄微少環境”再生による新規白血病治療法の開発
    その他:先進医薬研究振興財団血液医学分野一般研究助成
    研究期間:2012年 - 2012年  
    代表者:岡崎俊朗
  • スフィンゴミエリン合成酵素による膜ミクロドメイン機能制御を介した悪性腫瘍の浸潤・転移抑制
    その他:(財)小野医学研究財団小野医学研究奨励助成
    研究期間:2012年 - 2012年  
    代表者:岡崎俊朗
  • さっぽろバイオクラスター構想“Bio-S”
    その他公的機関:公益財団法人北海道科学技術総合振興センター地域産学官連携科学技術振興事業
    研究期間:2011年 - 2011年  
    代表者:岡崎俊朗


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