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下平 滋隆 シモダイラ シゲタカ

所属部署名再生医療学, 再生医療センター, 先端医療研究領域
職名教授
 
 

研究者基本情報

学位

  • 博士(医学)

研究活動情報

論文

  • Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cellsKan S, Bito T, Shimabuku M, Taguchi J, Ohkusa T, Shimodaira S, Sugiyama H, Koido SInternational Journal of Oncology57:1047-10562020年10月
  • Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA-A2-restricted WT1-reactive CD8(+) T cellsKan, Shin;Bito, Tsuuse;Shimabuku, Masamori;Taguchi, Junichi;Ohkusa, Toshifumi;Shimodaira, Shigetaka;Sugiyama, Haruo;Koido, ShigeoINTERNATIONAL JOURNAL OF ONCOLOGY57:1047-10562020年10月
  • Complete measurable residual disease response after combination chemotherapy with AML-type and ALL-type regimens in pediatric B/myeloid acute bilineal leukemia(Shoji Saito), Chiaki Taira, Kazuyuki Matsuda, Ryu Yanagisawa, Daisuke Morita, Tomonari Shigemura, Kentaro Yoshikawa, Miyuki Tanaka, Kazuo Sakashita, Saki Mukai, Shigetaka Shimodaira, Kenichi Koike, Yozo NakazawaLeukemia & Lymphoma61:967-9702020年04月
  • Dendritic Cells Pre-Pulsed with Wilms' Tumor 1 in Optimized Culture for Cancer VaccinationKoya, Terutsugu;Date, Ippei;Kawaguchi, Haruhiko;Watanabe, Asuka;Sakamoto, Takuya;Togi, Misa;Kato, Tomohisa;Yoshida, Kenichi;Kojima, Shunsuke;Yanagisawa, Ryu;Koido, Shigeo;Sugiyama, Haruo;Shimodaira, ShigetakaPHARMACEUTICS122020年04月
  • Dendritic Cells Pre-Pulsed With Wilms' Tumor 1 in Optimized Culture for Cancer VaccinationTerutsugu Koya, Ippei Date, Haruhiko Kawaguchi, Asuka Watanabe, Takuya Sakamoto, Misa Togi, Tomohisa Kato Jr, Kenichi Yoshida, Shunsuke Kojima, Ryu Yanagisawa, Shigeo Koido, Haruo Sugiyama , Shigetaka ShimodairaPharmaceutics12:3052020年03月
  • Dendritic Cells Pre-Pulsed with Wilms' Tumor 1 in Optimized Culture for Cancer Vaccination.Koya Terutsugu;Date Ippei;Kawaguchi Haruhiko;Watanabe Asuka;Sakamoto Takuya;Togi Misa;Kato Tomohisa;Yoshida Kenichi;Kojima Shunsuke;Yanagisawa Ryu;Koido Shigeo;Sugiyama Haruo;Shimodaira ShigetakaPharmaceutics122020年
  • Investigation of factors associated with allergic transfusion reaction due to platelet transfusion and the efficacy of platelets resuspended in BRS‐A in adult patients(Manjiro Yamanaka), Ryu Tanagisawa, Shunsuke Kojima, Hideyuki Nakazawa, Shigetaka ShimodairaTransfusion59:3405-34122019年12月
  • Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1(Ito Z), Kan S, Bito T, Horiuchi S, Akasu T, Yoshida S, Kajihara M, Hokari A, Saruta M, Yoshida N, Kobayashi M, Ohkusa T, Shimodaira S, Okamoto M, Sugiyama H, Koido SOncology97:135-1482019年09月
  • In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer VaccinationShimodaira S, Yanagisawa R, Koya T, Hirabayashi K, Higuchi Y, Sakamoto T, Togi M, Kato T Jr, Kobayashi T, Koizumi T, Koido S, Sugiyama HVaccines (Basel)7:1202019年09月
  • Comparison of administration of platelet concentrates suspended in M-sol or BRS-A for pediatric patients(Shunsuke Kojima), Ryu Yanagisawa, Miyuki Tanaka, Yozo Nakazawa, Shigetaka ShimodairaTRANSFUSION58:2952-29582018年12月
  • Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma(Tomoya Kanai), Zensho Ito, Yusuke Oji, Machi Suka, Sumiyuki Nishida, Kazuki Takakura, Mikio Kajihara, Masayuki Saruta, Shuichi Fujioka, Takeyuki Misawa, Tadashi Akiba, Hiroyuki Yanagisawa, Shigetaka Shimodaira, Masato Okamoto, Haruo Sugiyama, Shigeo KoidoOncology Letters16:2682-26922018年08月
  • WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study(Yanagisawa R), Koizumi T, Koya T, Sano K, Koido S, Nagai K, Kobayashi M, Okamoto M, Sugiyama H, Shimodaira SANTICANCER RESEARCH38:2217-22252018年04月
  • Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors(Hirabayashi K), Yanagisawa R, Saito S, Higuchi Y, Koya T, Sano K, Koido S, Okamoto M, Sugiyama H, Nakazawa Y, Shimodaira SANTICANCER RESEARCH38:2227-22342018年04月
  • Evaluation of Gelatin-Hybridized Chelate-Setting Calcium Phosphate Cements in Alveolar Bone Defects of Canine MandibleGoichi Matsumoto, Yoshihiko Sugita, Katsutoshi Kubo, Waka Yoshida, Hatsuhiko Maeda, Mamoru Aizawa, Shigetaka Shimodaira, Yukihiko KinoshitaBiomedical Journal of Scientific & Technical Research3:3420-34262018年04月
  • Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions(Kobayashi J), Yanagisawa R, Ono T, Tatsuzawa Y, Tokutake Y, Kubota N, Hidaka E, Sakashita K, Kojima S, Shimodaira S, Nakamura TVOX SANGUINIS113:128-1352018年02月
  • Significance of Wilms tumor 1 antigen as a canser vaccine for pancreatic cancerKoido.S, Okamoto.M ,Kobayashi.M, Shimodaira.S, Sugiyama.HDiscovery Medicine130:41-492017年08月
  • Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas LIgand Pathway-mediated Killer ActivityTerutsugu Koya,Ryu Yanagisawa,Yumiko Higuchi,Kenji Sano&Shigetaka ShimodairaSCIENTIFIC REPORTS7:421452017年02月
  • Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathwaymediated Killer Activity(T.Koya), R.Yanagisawa, Y.Higuchi, K.Sano, S.ShimodairaScientific Reports3:1-42017年02月
  • Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases.Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K.Interdisciplinary Neurosurgery9:24-292017年
  • WT1 Peptide Vaccine is Unaffected by Airport Screening X-Irradiation(Y.Higuchi), M.Kawakubo, M.Yuzawa, K.Sano, S.ShimodairaAustin Journal of Vaccines & Immunotherapeutics3:1010-10102016年09月
  • Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy(Saori Konno), Ryu Yanagisawa, Noriko Motoki, Shigetaka ShimodairaTherapeutic Apheresis and Dialysis25:1001-10112021年02月
  • Quality Verification with a Cluster-Controlled Manufacturing System to Generate Monocyte-Derived Dendritic CellsHaruhiko Kawaguchi, Takuya Sakamoto, Terutsugu Koya, Misa Togi, Ippei Date, Asuka Watanabe, Kenichi Yoshida, Tomohisa Kato, Yuka Nakamura, Yasuhito Ishigaki, Shigetaka ShimodairaVaccines9:5332021年05月
  • Identification of CD56 dim subpopulation marked with high expression of GZMB/PRF1/PI-9 in CD56 + interferon-α-induced dendritic cellsAsuka Watanabe, Misa Togi, Terutsugu Koya, Makoto Taniguchi , Takuya Sakamoto, Kuniyoshi Iwabuchi, Tomohisa Kato, Shigetaka ShimodairaGenes to cells26:313-3272021年05月
  • Interferon-α-Induced Dendritic Cells Generated with Human Platelet Lysate Exhibit Elevated Antigen Presenting Ability to Cytotoxic T LymphocytesDate I, Koya T, Sakamoto T, Togi M, Kawaguchi H, Watanabe A, Kato T Jr, Shimodaira SVaccines9:102021年
  • The Detection of Immunity against WT1 and SMAD4P130L of EpCAM+ Cancer Cells in Malignant Pleural EffusionTerutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato Jr, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka ShimodairaInternational Journal of Molecular Sciences23:121772022年10月
  • Evaluation of the usefulness of human adipose-derived stem cell spheroids formed using SphereRing® and the lethal damage sensitivity to synovial fluid in vitroAtsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Hironori Kitajima, Takashi Takaki, Terutsugu Koya, Ikuhiro Tanida, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio KawaharaCells11:3372022年01月
  • A morphological study of adipose-derived stem cell sheets created with temperature-responsive culture dishes using scanning electron microscopyYasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, Hironori Kitajima, Ikuhiro Tanida, Takashi Takaki, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio KawaharaMedical Molecular Morphology55:187-1982022年09月
  • Certificate of acceptance for the manuscript (ijms-1913863) titled: Adaptive immunity against WT1 and SMAD4P130L of EpCAM+ cancer cells in malignant pleural effusionKoya T, Niida Y, Togi M, Yoshida K, Sakamoto T, Ura H, Togi S, Kato T Jr, Yamada S, Sugiyama H, Koido S, Shimodaira S.Int J Mol Sci.23:121772022年10月
  • Analysis of Clinical Factors Associated with the Occurrence Time of AllergicTransfusion Reactions or Febrile Non-HemolyticTransfusion Reactions.(Yanagisawa R), Yamanaka R, Shimodaira SAnnals of Clinical & Laboratory Science52:382-3902022年05月
  • Different in vitro-generated MUTZ-3-derived dendritic cell types secrete dexosomes with distinct phenotypes and antigen presentation potencies.Sakamoto T, Koya T, Togi M, Yoshida K, Kato T Jr, Ishigaki Y, Shimodaira S.International Journal of Molecular Sciences11:83622022年07月
  • Synovial fluid derived from human knee osteoarthritis increases the viability of human adipose-derived stem cells through upregulation of FOSL1Hironori Kitajima, Takuya Sakamoto, Tetsuhiro Horie, Ayane Kuwano, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Naoki Yamamoto, Yasuo Iida, Yasuhito Ishigaki, Sohsuke Yamada, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa and Norio KawaharaCells12:3302023年01月

書籍等出版物

  • 第11章 第6節 癌に対するWT1ペプチドパルス樹状細胞ワクチンの開発
    ペプチド医薬品のスクリーニング・安定化・製剤化技術
    (岡本正人), 小井戸薫雄, 下平滋隆, 杉山治夫
    技術情報協会 2017年12月
  • 樹状細胞療法と樹状細胞
    細胞治療認定管理士制度指定カリキュラム 第2版(菅野 仁.長村 登紀子)
    (長村登紀子),掛江直子,西脇聡史,田野崎隆二,室井一男,小林博人,山口照英,内田恵理子,藤原康宏,髙橋敦子,長井一浩,伊藤経夫,横濱章彦,尾上和夫,髙橋恒夫,平井雅子,丸橋隆行,小屋照継,下平滋隆,中山享之,山崎理絵,岸野光司,高梨美乃子,池田和彦,菊田 敦,菅原 桂,畠賢一郎,加畑 馨,菅野 仁,高源ゆみ,坂本卓弥,硎 美紗,加藤栄史,高見太郎,坂井田功,各務秀明,小野寺雅史,金子 新
    中外医学社 2021年08月

競争的資金

  • 研究開発課題5:機能性細胞を用いた生体適合性担体の探索および製造システムに関する研究
    科学技術新興機構(JST):研究成果展開事業 産学共創プラットフォーム共同研究推進プログラム(OPERA)
    研究期間:2017年 - 2021年  
    代表者:下平滋隆
  • 北陸発再生医療等製品:ネオ抗原を標的としたIFN–樹状細胞を用いた個別化がんワクチン開発
    その他:(財)北國がん研究振興財団北國がん基金研究助成金
    研究期間:2020年 - 2020年  
    代表者:下平 滋隆