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下平 滋隆 シモダイラ シゲタカ

■所属部署名再生医療学, 再生医療センター, 先端医療研究領域
■職名教授
 
 

研究者基本情報

学位

  • 博士(医学)

研究活動情報

論文

  • Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA‑A2‑restricted WT1‑reactive CD8+ T cells, Kan S, Bito T, Shimabuku M, Taguchi J, Ohkusa T, Shimodaira S, Sugiyama H, Koido S, International Journal of Oncology, 57:1047-1056, 2020年10月
  • Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA-A2-restricted WT1-reactive CD8(+) T cells, Kan, Shin;Bito, Tsuuse;Shimabuku, Masamori;Taguchi, Junichi;Ohkusa, Toshifumi;Shimodaira, Shigetaka;Sugiyama, Haruo;Koido, Shigeo, INTERNATIONAL JOURNAL OF ONCOLOGY, 57:1047-1056, 2020年10月
  • Complete measurable residual disease response after combination chemotherapy with AML-type and ALL-type regimens in pediatric B/myeloid acute bilineal leukemia, (Shoji Saito), Chiaki Taira, Kazuyuki Matsuda, Ryu Yanagisawa, Daisuke Morita, Tomonari Shigemura, Kentaro Yoshikawa, Miyuki Tanaka, Kazuo Sakashita, Saki Mukai, Shigetaka Shimodaira, Kenichi Koike, Yozo Nakazawa, Leukemia & Lymphoma, 61:967-970, 2020年04月
  • Dendritic Cells Pre-Pulsed with Wilms' Tumor 1 in Optimized Culture for Cancer Vaccination, Koya, Terutsugu;Date, Ippei;Kawaguchi, Haruhiko;Watanabe, Asuka;Sakamoto, Takuya;Togi, Misa;Kato, Tomohisa;Yoshida, Kenichi;Kojima, Shunsuke;Yanagisawa, Ryu;Koido, Shigeo;Sugiyama, Haruo;Shimodaira, Shigetaka, PHARMACEUTICS, 12, 2020年04月
  • Dendritic Cells Pre-Pulsed With Wilms' Tumor 1 in Optimized Culture for Cancer Vaccination, Terutsugu Koya, Ippei Date, Haruhiko Kawaguchi, Asuka Watanabe, Takuya Sakamoto, Misa Togi, Tomohisa Kato Jr, Kenichi Yoshida, Shunsuke Kojima, Ryu Yanagisawa, Shigeo Koido, Haruo Sugiyama , Shigetaka Shimodaira, Pharmaceutics, 12:305, 2020年03月
  • Dendritic Cells Pre-Pulsed with Wilms' Tumor 1 in Optimized Culture for Cancer Vaccination., Koya Terutsugu;Date Ippei;Kawaguchi Haruhiko;Watanabe Asuka;Sakamoto Takuya;Togi Misa;Kato Tomohisa;Yoshida Kenichi;Kojima Shunsuke;Yanagisawa Ryu;Koido Shigeo;Sugiyama Haruo;Shimodaira Shigetaka, Pharmaceutics, 12, 2020年
  • Investigation of factors associated with allergic transfusion reaction due to platelet transfusion and the efficacy of platelets resuspended in BRS‐A in adult patients, (Manjiro Yamanaka), Ryu Tanagisawa, Shunsuke Kojima, Hideyuki Nakazawa, Shigetaka Shimodaira, Transfusion, 59:3405-3412, 2019年12月
  • Predicted Markers of Overall Survival in Pancreatic Cancer Patients Receiving Dendritic Cell Vaccinations Targeting WT1, (Ito Z), Kan S, Bito T, Horiuchi S, Akasu T, Yoshida S, Kajihara M, Hokari A, Saruta M, Yoshida N, Kobayashi M, Ohkusa T, Shimodaira S, Okamoto M, Sugiyama H, Koido S, Oncology, 97:135-148, 2019年09月
  • In Vivo Administration of Recombinant Human Granulocyte Colony-Stimulating Factor Increases the Immune Effectiveness of Dendritic Cell-Based Cancer Vaccination, Shimodaira S, Yanagisawa R, Koya T, Hirabayashi K, Higuchi Y, Sakamoto T, Togi M, Kato T Jr, Kobayashi T, Koizumi T, Koido S, Sugiyama H, Vaccines (Basel), 7:120, 2019年09月
  • Comparison of administration of platelet concentrates suspended in M-sol or BRS-A for pediatric patients, (Shunsuke Kojima), Ryu Yanagisawa, Miyuki Tanaka, Yozo Nakazawa, Shigetaka Shimodaira, TRANSFUSION, 58:2952-2958, 2018年12月
  • Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma, (Tomoya Kanai), Zensho Ito, Yusuke Oji, Machi Suka, Sumiyuki Nishida, Kazuki Takakura, Mikio Kajihara, Masayuki Saruta, Shuichi Fujioka, Takeyuki Misawa, Tadashi Akiba, Hiroyuki Yanagisawa, Shigetaka Shimodaira, Masato Okamoto, Haruo Sugiyama, Shigeo Koido, Oncology Letters, 16:2682-2692, 2018年08月
  • WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study, (Yanagisawa R), Koizumi T, Koya T, Sano K, Koido S, Nagai K, Kobayashi M, Okamoto M, Sugiyama H, Shimodaira S, ANTICANCER RESEARCH, 38:2217-2225, 2018年04月
  • Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors, (Hirabayashi K), Yanagisawa R, Saito S, Higuchi Y, Koya T, Sano K, Koido S, Okamoto M, Sugiyama H, Nakazawa Y, Shimodaira S, ANTICANCER RESEARCH, 38:2227-2234, 2018年04月
  • Evaluation of Gelatin-Hybridized Chelate-Setting Calcium Phosphate Cements in Alveolar Bone Defects of Canine Mandible, Goichi Matsumoto, Yoshihiko Sugita, Katsutoshi Kubo, Waka Yoshida, Hatsuhiko Maeda, Mamoru Aizawa, Shigetaka Shimodaira, Yukihiko Kinoshita, Biomedical Journal of Scientific & Technical Research, 3:3420-3426, 2018年04月
  • Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions, (Kobayashi J), Yanagisawa R, Ono T, Tatsuzawa Y, Tokutake Y, Kubota N, Hidaka E, Sakashita K, Kojima S, Shimodaira S, Nakamura T, VOX SANGUINIS, 113:128-135, 2018年02月
  • Significance of Wilms tumor 1 antigen as a canser vaccine for pancreatic cancer, Koido.S, Okamoto.M ,Kobayashi.M, Shimodaira.S, Sugiyama.H, Discovery Medicine, 130:41-49, 2017年08月
  • Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas LIgand Pathway-mediated Killer Activity, Terutsugu Koya,Ryu Yanagisawa,Yumiko Higuchi,Kenji Sano&Shigetaka Shimodaira, SCIENTIFIC REPORTS, 7:42145, 2017年02月
  • Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathwaymediated Killer Activity, (T.Koya), R.Yanagisawa, Y.Higuchi, K.Sano, S.Shimodaira, Scientific Reports, 3:1-4, 2017年02月
  • Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based immunotherapy: A report of two cases., Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K., Interdisciplinary Neurosurgery, 9:24-29, 2017年
  • WT1 Peptide Vaccine is Unaffected by Airport Screening X-Irradiation, (Y.Higuchi), M.Kawakubo, M.Yuzawa, K.Sano, S.Shimodaira, Austin Journal of Vaccines & Immunotherapeutics, 3:1010-1010, 2016年09月
  • Predictive factors of poor blood collecting flow during leukocyte apheresis for cellular therapy, (Saori Konno), Ryu Yanagisawa, Noriko Motoki, Shigetaka Shimodaira, Therapeutic Apheresis and Dialysis, 25:1001-1011, 2021年02月
  • Quality Verification with a Cluster-Controlled Manufacturing System to Generate Monocyte-Derived Dendritic Cells, Haruhiko Kawaguchi, Takuya Sakamoto, Terutsugu Koya, Misa Togi, Ippei Date, Asuka Watanabe, Kenichi Yoshida, Tomohisa Kato, Yuka Nakamura, Yasuhito Ishigaki, Shigetaka Shimodaira, Vaccines, 9:533, 2021年05月
  • Identification of CD56 dim subpopulation marked with high expression of GZMB/PRF1/PI-9 in CD56 + interferon-α-induced dendritic cells, Asuka Watanabe, Misa Togi, Terutsugu Koya, Makoto Taniguchi , Takuya Sakamoto, Kuniyoshi Iwabuchi, Tomohisa Kato, Shigetaka Shimodaira, Genes to cells, 26:313-327, 2021年05月
  • Interferon-α-Induced Dendritic Cells Generated with Human Platelet Lysate Exhibit Elevated Antigen Presenting Ability to Cytotoxic T Lymphocytes, Date I, Koya T, Sakamoto T, Togi M, Kawaguchi H, Watanabe A, Kato T Jr, Shimodaira S, Vaccines, 9:10, 2021年
  • The Detection of Immunity against WT1 and SMAD4P130L of EpCAM+ Cancer Cells in Malignant Pleural Effusion, Terutsugu Koya, Yo Niida, Misa Togi, Kenichi Yoshida, Takuya Sakamoto, Hiroki Ura, Sumihito Togi, Tomohisa Kato Jr, Sohsuke Yamada, Haruo Sugiyama, Shigeo Koido, Shigetaka Shimodaira, International Journal of Molecular Sciences, 23:12177, 2022年10月
  • Evaluation of the usefulness of human adipose-derived stem cell spheroids formed using SphereRing® and the lethal damage sensitivity to synovial fluid in vitro, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Hironori Kitajima, Takashi Takaki, Terutsugu Koya, Ikuhiro Tanida, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara, Cells, 11:337, 2022年01月
  • A morphological study of adipose-derived stem cell sheets created with temperature-responsive culture dishes using scanning electron microscopy, Yasuhiko Taki, Atsushi Fuku, Yuka Nakamura, Terutsugu Koya, Hironori Kitajima, Ikuhiro Tanida, Takashi Takaki, Kaori Nozaki, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Takeo Shimasaki, Togen Masauji, Naoki Yamamoto, Yasuhito Ishigaki, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa, Norio Kawahara, Medical Molecular Morphology, 55:187-198, 2022年09月
  • Certificate of acceptance for the manuscript (ijms-1913863) titled: Adaptive immunity against WT1 and SMAD4P130L of EpCAM+ cancer cells in malignant pleural effusion, Koya T, Niida Y, Togi M, Yoshida K, Sakamoto T, Ura H, Togi S, Kato T Jr, Yamada S, Sugiyama H, Koido S, Shimodaira S., Int J Mol Sci., 23:12177, 2022年10月
  • Analysis of Clinical Factors Associated with the Occurrence Time of AllergicTransfusion Reactions or Febrile Non-HemolyticTransfusion Reactions., (Yanagisawa R), Yamanaka R, Shimodaira S, Annals of Clinical & Laboratory Science, 52:382-390, 2022年05月
  • Different in vitro-generated MUTZ-3-derived dendritic cell types secrete dexosomes with distinct phenotypes and antigen presentation potencies., Sakamoto T, Koya T, Togi M, Yoshida K, Kato T Jr, Ishigaki Y, Shimodaira S., International Journal of Molecular Sciences, 11:8362, 2022年07月
  • Synovial fluid derived from human knee osteoarthritis increases the viability of human adipose-derived stem cells through upregulation of FOSL1, Hironori Kitajima, Takuya Sakamoto, Tetsuhiro Horie, Ayane Kuwano, Atsushi Fuku, Yasuhiko Taki, Yuka Nakamura, Ikuhiro Tanida, Hiroshi Sunami, Hiroaki Hirata, Yoshiyuki Tachi, Naoki Yamamoto, Yasuo Iida, Yasuhito Ishigaki, Sohsuke Yamada, Shigetaka Shimodaira, Yusuke Shimizu, Toru Ichiseki, Ayumi Kaneuji, Satoshi Osawa and Norio Kawahara, Cells, 12:330, 2023年01月
  • An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture., Shintaro Matsuba, Hiroki Ura, Fumiji Saito, Chie Ogasawara, Shigetaka Shimodaira, Yo Niida, Nobuyuki Onai, Frontiers in Immunology, 14:1264609, 2023年10月
  • Clinical Trial on the Safety and Tolerability of Personalized Cancer Vaccines Using Human Platelet Lysate-Induced Antigen-Presenting Cells, Terutsugu Koya, Kenichi Yoshida, Misa Togi, Yo Niida, Sumihito Togi, Hiroki Ura, Shuichi Mizuta, Tomohisa Kato Jr, Sohsuke Yamada, Takeo Shibata, Yi-Chang Liu, Shyng-Shiou Yuan, Deng-Chyang Wu, Hirohito Kobayashi, Taiju Utsugisawa, Hitoshi Kanno, Shigetaka Shimodaira, Cancers, 15:3627, 2023年07月
  • Dendritic cell vaccination in combination with erlotinib in a patient with inoperable lung adenocarcinoma: a case report, (Takuya Kosumi), Masanori Kobayashi, Shigetaka Shimodaira, Haruo Sugiyama, Shigeo Koido, Journal of Medical Case Reports, 18:88, 2024年02月
  • Dendritic cells pulsed with multifunctional Wilms' tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in pancreatic cancer, (Shigeo Koido), Junichi Taguchi, Masamori Shimabuku, Shin Kan, Tuuse Bito, Takeyuki Misawa, Zensho Ito, Kan Uchiyama, Masayuki Saruta, Shintaro Tsukinaga, Machi Suka, Hiroyuki Yanagisawa, Nobuhiro Sato, Toshifumi Ohkusa, Shigetaka Shimodaira, Haruo Sugiyama, Journal for ImmunoTherapy of Cancer, 12:e009765, 2024年12月
  • Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation, (Shyng-Shiou F. Yuan), Leong-Perng Chan, Hieu D. H. Nguyen, Chang-Wei Su, Yuk-Kwan Chen, Jeff Yi-Fu Chen, Shigetaka Shimodaira, Stephen Chu-Sung Hu, Steven Lo, Yen-Yun Wang, Journal of Experimental & Clinical Cancer Research, 43:233, 2024年08月
  • Predictors of patients with advanced pancreatic cancer undergoing conversion surgery via chemoimmunotherapy with a multifunctional Wilms' tumor 1 (WT1) peptide cocktail-pulsed dendritic cell vaccine, (Shigeo Koido), Junichi Taguchi, Masamori Shimabuku, Tuuse Bito, Soyoko Morimoto, Yusuke Oji, Yoshihiro Oka, Masaki Ito, Yoko Shimizu, Zensho Ito, Kan Uchiyama, Masayuki Saruta, Nobuhiro Sato, Toshifumi Ohkusa, Shigetaka Shimodaira, Haruo Sugiyama, Journal for ImmunoTherapy of Cancer, 13:e011426, 2025年07月

書籍等出版物

  • 第11章 第6節 癌に対するWT1ペプチドパルス樹状細胞ワクチンの開発
    ペプチド医薬品のスクリーニング・安定化・製剤化技術
    (岡本正人), 小井戸薫雄, 下平滋隆, 杉山治夫
    技術情報協会 2017年12月
  • 樹状細胞療法と樹状細胞
    細胞治療認定管理士制度指定カリキュラム 第2版(菅野 仁.長村 登紀子)
    (長村登紀子),掛江直子,西脇聡史,田野崎隆二,室井一男,小林博人,山口照英,内田恵理子,藤原康宏,髙橋敦子,長井一浩,伊藤経夫,横濱章彦,尾上和夫,髙橋恒夫,平井雅子,丸橋隆行,小屋照継,下平滋隆,中山享之,山崎理絵,岸野光司,高梨美乃子,池田和彦,菊田 敦,菅原 桂,畠賢一郎,加畑 馨,菅野 仁,高源ゆみ,坂本卓弥,硎 美紗,加藤栄史,高見太郎,坂井田功,各務秀明,小野寺雅史,金子 新
    中外医学社 2021年08月

競争的資金

  • がん抗原WT1特異的T細胞受容体を導入したγδ-T細胞の解析モデルの構築
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2025年04月 - 2028年03月  
  • 研究開発課題5:機能性細胞を用いた生体適合性担体の探索および製造システムに関する研究
    科学技術新興機構(JST):研究成果展開事業 産学共創プラットフォーム共同研究推進プログラム(OPERA)
    研究期間:2017年 - 2021年  
    代表者:下平滋隆
  • 北陸発再生医療等製品:ネオ抗原を標的としたIFN–樹状細胞を用いた個別化がんワクチン開発
    その他:(財)北國がん研究振興財団北國がん基金研究助成金
    研究期間:2020年 - 2020年  
    代表者:下平 滋隆