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芝本 利重 シバモト トシシゲ

所属部署名生理学Ⅱ
職名教授
 
 

研究者基本情報

研究

    研究の概要:
    循環生理学

専門分野

  • 生理学一般
    循環生理
  • 麻酔・蘇生学
    循環ショック
  • 救急医学
    循環ショック

学歴

  • 信州大学 医学部 医学科

学位

  • 医学博士

所属学協会

  • American Physiologial Society member
  • 2005年- 2015年日本Shock学会 理事
  • 1992年- 2015年日本自律神経学会 評議員
  • 2005年- 2015年日本循環制御医学会 理事
  • - 2015年日本生理学会 将来計画委員会委員
  • - 2015年日本生理学会 評議員
  • - 2015年日本病態生理学会 評議員
  • 2013年日本病態生理学会 理事
  • 2002年- 2015年日本臨床生理学会 評議員

経歴

  • 1985年- 1986年信州大学医学部第一解剖学講座 助手
  • 1987年- 1989年南アラバマ大学生理学教室 研究助手
  • 1988年- 1990年信州大学医学部第二生理学講座 助手
  • 1990年- 1992年信州大学医学部第二生理学講座 講師
  • 1992年- 2001年信州大学医学部第二生理学講座 助教授

研究活動情報

論文

  • L-Ornithine intake affects sympathetic nerve outflows and reduces body weight and food intake in rats.(Y.Konishi), Y.Koosaka, R.Maruyama, K.Imanishi, K.Kasahara, A.Matsuda, S.Akiduki, Y.Hishida, Y.Kurata, T.Shibamoto, J.Satomi, M.TanidaBrain Research Bulletin111:48-522015年
  • The effect of tolvaptan, a vasopressin V2 receptor antagonist, on the portal venous pressure in rats.T.Shibamoto, M.Wang Japanese Pharmacology & Therapeutics 43:1283-12942015年
  • Systemic vasoconstriction modulates the responses of pulmonary vasculature and airway to vasoconstrictors in anesthetized rats. M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, Y.KurataExperimental Lung Research41:324-3342015年
  • Pulmonary vascular and airway responses to systemic vasoconstrictors in anesthetized BALB/c mice. M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.TogaJournal of cardiovascular pharmacology65:325-3342015年
  • Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.M.Tanida, N.Yamamoto, DA.Morgan, Y.Kurata, T.Shibamoto, K.RahmouniThe Journal of Neuroscience35:474-4842015年
  • Hypothalamic nesfatin-1 stimulates sympathetic nerve activity via hypothalamic ERK signaling.M.Tanida, H.Gotoh, N.Yamamoto, M.Wang, Y.Kuda, Y.Kurata, M.Mori, T.ShibamotoDiabetes64:3725-37362015年
  • Exercise attenuates ischemia-reperfusion injury of nonalcoholic fatty liver of OLETF rat. T.Shibamoto, Y.Kuda, M.Tanida, M.Wang, Y.KurataJournal of Gastroenterology, Pancreatology & Liver Disorders2:1-62015年
  • Soy isoflavone affects the autonomic nervous system in a tissue-specific manner in anesthetized ratsM.Tanida, K.Imanishi, M.Komatsu, J.Satomi, N.Yamamoto, M.Wang, Y.Kurata, T.ShibamotoExperimental biology and medicine (Maywood, N.J.)239:477?4832014年
  • Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine.M.Wang, T.Shibamoto, M.Tanida, Y.Kuda, Y.KurataLife sciences.116:98-1052014年
  • Major contribution of vasospasm-induced coronary blood flow reduction to anaphylactic ventricular dysfunction assessed in isolated blood-perfused rat heartY.Kuda, Y.Kurata, M.Wang, M.Tanida, T.ShibamotoCardiology journal.21:11-172014年
  • Injection of Lactobacillus casei strain Shirota affects autonomic nerve activities in a tissue-specific manner, and regulates glucose and lipid metabolism in rats.M.Tanida, K.Imanishi, H.Akashi, Y.Kurata, O.Chonan, E. Naito, S.Kunihiro, M.Kawai, A.Kato-Kataoka, T.ShibamotoJournal of diabetes investigation5:153-1612014年
  • Effects of anesthetics on the renal sympathetic response to anaphylactic hypotension in rats.L.Sun, M.Tanida, M.Wang, Y.Kuda, Y.Kurata, T.ShibamotoPloS one9:e113945;1-152014年
  • Angiotensin II and vasopressin are involved in the defense system against anaphylactic hypotension in anesthetized rats.M.Wang, T.Shibamoto, Y.Kuda, L.Sun, M.Tanida, Y.Kurata.European journal of pharmacology.731:38-432014年
  • Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice.(H.Cui), Y.Okamoto, K.Yoshioka, W.Du, N.Takuwa, W.Zhang, M.Asano, T.Shibamoto, Y.TakuwaThe Journal of allergy and clinical immunology.132:1205-12142013年11月
  • MRI Reveals edema in larynx (But not in brain) during anaphylactic hypotension in anesthetized rats.I.Toyota, M.Tanida, T.Shibamoto, Mofei Wang, Y.Kurata, H.TonamiAllergy, asthma & immunology research.5:389-3962013年11月
  • Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats.M.Wang, M.Tanida, T.Shibamoto, Y.KurataAmerican journal of physiology. Regulatory, integrative and comparative physiology.305:R900-:R9072013年08月
  • Portal venular constriction during anaphylactic shock in anesthetized rats.M.Kitadate, T.Shibamoto, M.Tsutsumi, H.TonamiBiomedical research (Tokyo, Japan)34:61-682013年04月
  • Effect of hyperpolarization-activated current I(f) on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na(+) concentration.Y.Kurata, I.Hisatome, M.Tanida, T.ShibamotoAmerican journal of physiology. Heart and circulatory physiology.304:H1337-H13512013年03月
  • Involvement of hypothalamic AMP-activated protein kinase in leptin-induced sympathetic nerve activation.M.Tanida, N.Yamamoto, T.Shibamoto, K.RahmouniPloS one8:e56660;1-112013年02月
  • Nitric oxide and β2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice.S.Shinomiya, T.Shibamoto, Y.Kurata, Y.Kuda, W..Zhang, M.Tanida, H.TogaExperimental lung research.39:119-1292013年01月
  • Rat hepatic and splanchnic vascular responses to anaphylactic shock, compared with hemorrhagic or vasodilator-induced shock.W.Zhang, T.Shibamoto, M.Tanida, M.Wang, L.Sun, Y.KurataIn vivo (Athens, Greece)27:485-4942013年
  • Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner.M.Tanida, A.Hayata, N.Shintani, N.Yamamoto, Y.Kurata, T.Shibamoto, D.A.Morgan, Rahmouni K, H.HashimotoNeuroscience.238:297-304.2013年
  • Mast cells are not involved in the ischemia-reperfusion injury in perfused rat liverT.Shibamoto, M.Tsutsumi, Y.Kuda, C.Ohmukai, W.Zhang, Y.KurataThe Journal of surgical research174:114-1192012年05月
  • Vascular perfusion limits mesenteric lymph flow during anaphylactic hypotension in ratsW.Zhang, T.Shibamoto, Y.Kuda, Y.Kurata, S.Shinomiya, H.Kida, H.TsuchidaAmerican journal of physiology. Regulatory, integrative and comparative physiology.302:R1191-R11962012年
  • The responses of the hepatic and splanchnic vascular beds to vasopressin in ratsW.Zhang, T.Shibamoto, Y.Kuda, S.Shinomiya, Y.KurataBiomedical research (Tokyo, Japan)33:83-882012年
  • Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical modelsY.Kurata, I.Hisatome, T.ShibamotoAmerican journal of physiology. Heart and circulatory physiology.302:H2285-H23002012年
  • Pulmonary vasoconstrictive and bronchoconstrictive responses to anaphylaxis are weakened via β2-adrenoceptor activation by endogenous epinephrine in anesthetized ratsW.Zhang, T.Shibamoto, Y.Kuda, C.Omukai, Y.KurataAnesthesiology.114:614-6232011年
  • Portacaval shunting attenuates portal hypertension and systemic hypotension in rat anaphylactic shockC.Kamikado, T.Shibamoto, W.Zhang, Y.Kuda, C.Omukai, Y.KurataThe journal of physiological sciences : JPS61:161-1662011年
  • Ethanol predominantly constricts pre-sinusoids of isolated perfused livers of rat, guinea pig and mouseT.Shibamoto, M.Tsutsumi, C.Omukai, Y.Kuda, W.Zhang, Y.KurataAlcohol and alcoholism : international journal of the Medical Council on Alcoholism.46:117-1222011年
  • Effects of β-adrenoceptor antagonists on anaphylactic hypotension in consciousW.Zhang, T.Shibamoto, Y.Kurata, H.KohnoEuropean journal of pharmacology.650:303-3082011年
  • Roles of hyperpolarization-activated current If in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models.Y.Kurata, H.Matsuda, I.Hisatome, T.ShibamotoAmerican journal of physiology. Heart and circulatory physiology.298:H1748-H17602010年
  • Liver volume, as assessed by four ultrasonic crystals arranged to form a tetrahedron, decreases during anaphylactic shock in anesthetized rats.H.Takano, T.Shibamoto, W.Zhang, Y.KurataShock (Augusta, Ga.)34:586-5912010年
  • Exercise training attenuates anaphylactic venoconstriction in rat perfused liver, but does not affect anaphylactic hypotension in conscious rats.S.Cui, T.Shibamoto, W.Zhang, Y.Kurata, O.Kashimura, S.MiyamaeClinical and experimental pharmacology & physiology.37:889-8932010年
  • Mouse hepatic portal venoconstrictive response to vasoconstrictors is much weaker than that in ratZS.Zhao, T.Shibamoto, M.Tsutsumi, S.Cui, WM.Zhang, H.Takano, Y.KurataJournal of cardiovascular pharmacology.54:421-4262009年
  • Hepatic microvascular pressure during anaphylactic shock in anesthetized ratsH.Takano, T.Shibamoto, W.Zhang, Y.Kurata, H.TogaMicrovascular research78:169-1732009年
  • 7-nitroindazole, but not L-name or aminoguanidine, attenuates anaphylactic hypotension in conscious ratsW.Zhang, T.Shibamoto, S.Cui, H.Takano, Y.KurataShock (Augusta, Ga.)31:201-2062009年
  • Venous resistance increases during rat anaphylactic shock.S.Cui, T.Shibamoto, W.Zhang, H.Takano, Y.KurataShock (Augusta, Ga.)29:733-7392008年
  • Regional difference in dynamical property of sinoatrial node pacemaking: role of Na+ channel current.Y.Kurata, H.Matsuda, I.Hisatome, T.ShibamotoBiophysical journal95:951-9772008年
  • PAF, rather than histamine, participates in mouse anaphylactic hypotension.T.Shibamoto, W.Liu, S.Cui, W.Zhang, H.Takano, Y.KurataPharmacology.82:114-1202008年
  • Increased sinusoidal resistance is responsible for the basal state and endothelin-induced venoconstriction in perfused cirrhotic rat liverT.Shibamoto, C.Kamikado, S.KoyamaPflugers Archiv : European journal of physiology.456:467-4772008年
  • アナフィラキシーショックによる突然死芝本利重昭和医学会雑誌67:322-3282007年08月
  • Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineeringY.Kurata, H.Matsuda, I.Hisatome, T.ShibamotoAmerican journal of physiology. Heart and circulatory physiology.292:H701-7182007年01月
  • Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineeringYasutaka Kurata, Hiroyuki Matsuda, Ichiro Hisatome, Toshishige ShibamotoAm J Physiol Heart Circ Physiol292:H701-H7182007年01月
  • アナフィラキシーショックの病態芝本利重, 崔 森, 髙野博充, 倉田康孝Shock (Augusta, Ga.)22:64-692007年
  • l-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouseS.Cui, T.Shibamoto, Z.Zhao, H.Takano, Y.KurataProstaglandins, leukotrienes, and essential fatty acids.76:277-2832007年
  • The sinusoidal pressure during ischemia-reperfusion injury in perfused mouse liver pretreated with or without L-NAMET.Shibamoto, Z.Ruan, S.Cui, W.Liu, Z-S.Zhao, H.Takano, Y.Kurata, T.Koizumi, K.KuboThe Journal of surgical research139:30-352007年
  • The roles of mast cells and Kupffer cells in rat systemic anaphylaxisT.Shibamoto, T.Shimo, S.Cui, W.Zhang, H.Takano, Y.Kurata, H.TsuchidaAmerican journal of physiology. Regulatory, integrative and comparative physiology.293:R2202-R22092007年
  • Reduced pulmonary vascular reactivity after cold exposure to acute hypoxia: A role of nitric oxide (NO)(K.Watanabe), T.Koizumi, Z.Ruan, K.Kubo, A.Sakai, T.ShibamotoHigh altitude medicine & biology8:43-492007年
  • NG-nitro-L-arginine methyl ester, but not methylene blue, attenuates anaphylactic hypotension in anesthetized miceH.Takano, W.Lui, Z.Zhao, S.Cui, W.Zhang, T.ShibamotoJournal of pharmacological sciences.104::212-2172007年
  • Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat liversS.Cui, T.Shibamoto, H.Takano, W.Zhang, Y.KurataEuropean journal of pharmacology.576:99-1062007年
  • Involvement of splanchnic vascular bed in anaphylactic hypotension in anesthetized BALB/c miceW.Liu, H.Takano, T.Shibamoto, S.Cui, Z-S.Zhao, W.Zhang, Y.KurataAmerican journal of physiology. Regulatory, integrative and comparative physiology.293:R1947-19532007年
  • Hepatic pre-sinusoidal vessels contract in anaphylactic hypotension in rabbitsN.Karasawa, T.Shibamoto, S.Cui, H.Takano, Y.Kurata, H.TsuchidaActa physiologica Scandinavica.189:15-222007年
  • Head-down tilt posture attenuates anaphylactic hypotension in mice and ratsZ.Zhao, T.Shibamoto, S.Cui, H.Takano, W.Zhang, Y.KurataThe journal of physiological sciences : JPS57:269-2742007年
  • Effects of L-NAME on thromboxane A2-induced venoconstriction in isolated perfused livers from rat, guinea pig and mouseS.Cui, T.Shibamoto, Z.Zhao, W.Zhang, H.Takano, Y.KurataVascular pharmacology.47:215-2212007年
  • 小動脈の拡張反応におけるスプレッド現象(spreading dilatation)髙野博充, 倉田康孝, 芝本利重金沢医科大学雑誌31:127-1312006年08月
  • Oxygen consumption, assessed with the oxygen absorption spectrophotometer, decreases independently of venoconstriction during hepatic anaphylaxis in perfused rat liverS.Cui., T.Shibamoto, Z.Ruan, H.Takano, W.Liu, Y.KurataShock (Augusta, Ga.)26:62-682006年
  • NG-nitro-L-arginine methyl ester potentiates anaphylactic venoconstriction in rat perfused liversT.Shibamoto, T.Ishibashi, T.Shimo, S.Cui, H.Takano, H.Tsuchida, M.Nishio, Y.KurataClinical and experimental pharmacology & physiology.33:1073-10772006年
  • Effects of platelet-activating factor, thromboxane A2 and leukotriene D4 on isolated perfused rat liverS.Cui., T.Shibamoto, W.Liu, H.Takano, Y.KurataProstaglandins & other lipid mediators.80:35-452006年
  • Effects of Hct on L-NAME-induced potentiation of anaphylactic presinusoidal constriction in perfused rat liversS.Cui., T.Shibamoto, W.Liu, H.Takano, Z.S.Zhao, Y.KurataJournal of cardiovascular pharmacology.48:827-8332006年
  • 心筋自動能の発生機序:非線形力学系モデルの分岐構造解析による理論的検討倉田康孝, 芝本利重金沢医科大学雑誌30:326-3332005年12月
  • Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig liversT.Shibamoto, Z.Ruan, S.Cui, W.Liu, Y.KurataProstaglandins & other lipid mediators.78:218-2302005年12月
  • Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats(M.Hongo), E.Mawatari, A.Sakai, Z.Ruan, T.Koizumi, F.Terasawa, Y.Yazaki, O.Kinoshita, U.Ikeda, T.ShibamotoJournal of cardiovascular pharmacology.46:452-4582005年10月
  • Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical modelY.Kurata, I.Hisatome, H.Matsuda, T.ShibamotoBiophysical journal89:2865-28872005年10月
  • ノルエピネフリンは種差なく前類洞優位の血管収縮により肝内血液量を減少させる芝本利重, 崔 森, ? 威, 髙野博充, 倉田康孝自律神経42:271-2742005年08月
  • Hepatic venoconstriction is involved in anaphylactic hypotension in ratsT.Shibamoto, S.Cui, Z.Ruan, W.Liu, H.Takano, Y.KurataAmerican journal of physiology. Heart and circulatory physiology.289:H1436-H14442005年05月
  • Comparison of cardiopulmonary response to endogenous nitric oxide inhibition in pigs inhabited at three levels of altitude(Z.Ruan), T.Koizumi, A.Sakai, T.Ishizaki, K.Kubo, T.Shibamoto, Z.WangEuropean journal of applied physiology.94:93-962005年05月
  • Effects of norepinephrine and histamine on vascular resistance in isolated perfused mouse liverT.Shibamoto, S.Cui, Z.Ruan, Y.KurataJapanese journal of physiology.55:143-1482005年04月
  • Anaphylactic hepatic venoconstriction is attenuated by nitric oxide released via shear stress-dependent and -independent mechanisms in guinea pigT.Shibamoto, Z.Ruan, S.Cui, Y.Kurata, T.Koizumi, K.KuboClinical and experimental pharmacology & physiology.32:288-2932005年04月
  • Hepatic venoconstriction is involved in anaphylactic hypotension in rats.芝本 利重Am J Physiol Heart Circ Physiol2005年
  • Effects of norepinephrine and histamine on vascular resistance in isolated perfused mouse liver.芝本 利重Jpn J Physiol.2005年
  • Effects of nicorandil on monocrotaline-induced pulmonary arterial hypertension in rats.芝本 利重J Cardiovasc Pharmacol2005年
  • Dynamical Mechanisms of Pacemaker Generation in IK1-Downregulated Human Ventricular Myocytes: Insights from bifurcation analyses of a mathematical model.芝本 利重Biophysic J2005年
  • Comparison of cardiopulmonary response to endogenous nitric oxide inhibition in pigs inhabited at three levels of altitude.芝本 利重Eur J Appl Physiol.2005年
  • Anaphylactic hepatic venoconstriction is attenuated by nitric oxide released via shear stress-dependent and -independent mechanisms in Guinea pig.芝本 利重Clin Exp Pharmacol Physiol.2005年
  • 血管閉塞法による肝微小血管圧の測定とその応用芝本利重, 倉田康孝, 他循環制御25:146-1572004年
  • NO, but not CO, attenuates anaphylaxis-induced postsinusoidal contraction and congestion in guinea pig liver.芝本 利重Am J Physiol Regul Integr Comp Physiol2004年
  • NO, but not CO, attenuates anaphylaxis-induced postsinusoidal contraction and congestion in guinea pig liver Z. Ruan., T. Shibamoto, *T. Shimo, *H. Tsuchida, *M. Nishio, et al.American journal of physiology. Regulatory, integrative and comparative physiology.286:R94-R1002004年
  • Effects of platelet-activating factor and thromboxane A2 on isolated perfused-guinea pig liver.芝本 利重Prostaglandins Other Lipid Mediators2004年
  • Effects of platelet-activating factor and thromboxane A2 on isolated perfused-guinea pig liver Z. Ruan, T. Shibamoto, *T. Shimo, *H. Tsuchida, Y. Kurata, T. Ogura, et al.Prostaglandins & other lipid mediators.73:73-852004年
  • Effects of hematocrit and norepinephrine on segmental vascular resistance distribution in isolated perfused rat livers.芝本 利重Am J Physiol Heart Circ Physiol.2004年
  • Effects of Hct and norepinephrine on segmental vascular resistance distribution in isolated perfused rat livers(C. Kamikado), T. Shibamoto, et al.American journal of physiology. Heart and circulatory physiology.286:H121-H1302004年
  • Effects of Angiotensin II on sustained outward currents in rat ventricular myocytes.芝本 利重Pflugers Arch2004年
  • Effects of Angiotensin II on sustained outward currents in rat ventricular myocytes H. Matsuda, Y. Kurata, T. Shibamoto, et al.Pflugers Archiv : European journal of physiology.448:54-622004年
  • Different hepatic vascular response to noradrenaline and histamine between guinea pig and rat.芝本 利重Acta Physiol Scand2004年
  • Different hepatic vascular response to noradrenaline and histamine between guinea pig and rat T. Shibamoto, *T. Shimo, *H. Tsuchida, Y. Kurata, T. Ogura, et al.Acta physiologica Scandinavica.180:255-2632004年
  • Roles of L-type Ca2+ and delayed-rectifier K+ currents in sinoatrial node pacemaking:insights from stability and bifurcation analyses of a mathematical modelY. Kurata, S. Imanishi, T. Shibamoto, et al.American journal of physiology. Heart and circulatory physiology.285: H2804-H28192003年
  • Roles of L-type Ca2+ and delayed-rectifier K+ currents in sinoatrial node pacemaking: insights from stability and bifurcation analyses of a mathematical model.芝本 利重Am J Physiol Heart Circ Physiol.2003年
  • Part IV 心血管系芝本 利重バーンレヴィ カラー基本生理学2003年
  • Osmoseusitive properties of rapid and slow delayed rectifier K+ currents in guinea-pig heart cells芝本 利重Clin. Exp. Pharmacol. Physiol.2003年
  • Osmosensitive properties of rapid and slow delayed rectifier K+ currents in guinea-pig heart cellsT. Ogura, H. Matsuda, T. Shibamoto, et al.Clinical and experimental pharmacology & physiology.30: 616-6222003年
  • Osmomseusitive properties of rapid and slow delayed rectifier K+ currents in guinea-pig heart cells SHIBAMOTO ToshishigeClin. Exp. Pharmacol. Physiol.2003年
  • 血管閉塞法による肝類洞圧の測定とその応用芝本利重金沢医科大学雑誌27: 91-1012002年
  • Sarcolemmal hydraulic conductivity of guinea-pig and rat ventricular myocytesT. Ogura, H. Matsuda, S. Imanishi, T. ShibamotoCardiovascular research.54: 590-6002002年
  • Sarcolemmal Hydraulic conductivity of guinea-pig and not ventricular myocytesSHIBAMOTO ToshishigeCardiovascular Research2002年
  • Sarcolemmal Hydraulic conductivity of guinea-pig and not ventricular myocytes芝本 利重Cardiovascular Research2002年
  • Osmometric and water-transporting properties of guinea pig cardiac myocytes SHIBAMOTO ToshishigeJpn. J. Physiol.2002年
  • Osmometric and water-transporting properties of guinea pig cardiac myocytesT. Ogura, S. Imanishi, T. ShibamotoJapanese journal of physiology.52: 333-3422002年
  • Osmometric and water-transporting properties of guinea pig cardiac myocytes芝本 利重Jpn. J. Physiol.2002年
  • Effects of resuscitation with hydroxyethyl starch (HES) on pulmonary hemodyonamics and lung lymph balance in hemorrhagic sheep : comparative study of low and high molecular HESSHIBAMOTO ToshishigeResuscitation2002年
  • Effects of resuscitation with hydroxyethyl starch (HES) on pulmonary hemodyonamics and lung lymph balance in hemorrhagic sheep : comparative study of low and high molecular HES芝本 利重Resuscitation2002年
  • Effects of resuscitation with hydroxyethyl starch (HES) on pulmonary hemodynamics and lung lymph balance in hemorrhagic sheep; comparative study of low and high molecular HES(T. Kaneki), T. Shibamoto, et al.Resuscitation52: 101-1082002年
  • Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell.芝本 利重Am J Physiol Heart Circ Physiol2002年
  • Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cellY. Kurata, S. Imanishi, T. Shibamoto, et al.American journal of physiology. Heart and circulatory physiology.283: H2074-H21012002年
  • Dynamic description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell SHIBAMOTO ToshishigeAm. J. Physiol. Heart Circ. Physiol.2002年
  • Dynamic description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell芝本 利重Am. J. Physical. Heart Circ. Physiol.2002年
  • 肝微小血管圧芝本 利重信州医学雑誌2001年
  • ノルエピネフリンの肝血管収縮反応芝本 利重環境科学年報 信州大学2001年
  • Effects of growth hormone follwoing chronic angioteusin-converting enzyme inhibition in chronic heart failure : their relation to infarct sizeSHIBAMOTO ToshishigeCardiovasc. Drug Ther.2001年
  • Effects of growth hormone follwoing chronic angioteusin-converting enzyme inhibition in chronic heart failure : their relation to infarct size芝本 利重Cardiovasc. Drug Ther.2001年
  • Effects of growth hormone following chronic angiotensin-converting enzyme inhibition in chronic heart failure: their relation to infarct size(M. Hongo), T. Shibamoto, et al.Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy.15: 241-2492001年
  • Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea-pig ventricular myocytesT. Ogura, S. Imanishi, T. ShibamotoJapanese journal of pharmacology.87: 235-2392001年
  • Activation of background membrance conductance by the throsine kinase inhibitor Tyrophostin A23 and its inactive analog Tyrphostin A1 in guinea-pig ventricular myocytesSHIBAMOTO ToshishigeJpn. J. Pharmacol.2001年
  • Activation of background membrance conductance by the throsine kinase inhibitor Tyrophostin A23 and its inactive analog Tyrphostin A1 in guinea-pig ventricular myocytes芝本 利重Jpn. J. Pharmacol.2001年
  • Lung lymph response to overinfusion with hydroxyethyl starch in sheep : comparative studies of high and low molecular weight compoundsSHIBAMOTO ToshishigeActa Anaesthesiol. Scand.2000年
  • Increased sinusoidal pressure is associated with early liver weight gain in ischemia-reperfusion injury in isolated perfused nat liverSHIBAMOTO ToshishigeJournal of Surgical Research2000年
  • Presinusoidal vessels predominantly contract in response to novepinephrine, histamine, and KCL in rabbit liverSHIBAMOTO ToshishigeJournal of Applied Physiology1999年
  • Endothelin receptor blockade attenuates air embolization-induced pulmonary hypertension in sheep.SHIBAMOTO ToshishigeEuropean Journal of Pharmacology1999年
  • Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lungSHIBAMOTO ToshishigeExperimental Lung Research1999年
  • The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogsSHIBAMOTO ToshishigeShock1998年
  • Lecithinized superoxide dismutase attenuates phorbol myristate acetate-induced injury in isolated dog lung.SHIBAMOTO ToshishigeEur. J. Pharmacol.1998年
  • Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs.SHIBAMOTO ToshishigeJ. Appl. Physiol.1997年
  • Endothelin-1 selectively contracts portol vein through both ETA and ETB receptors in isolated rabbit liverSHIBAMOTO ToshishigeAm. J. Physiol.1997年
  • Effect of platelet-activating factor on hepatic capillary pressure in isoloted dog liverSHIBAMOTO ToshishigeProstaglandind Leukot. Essent. Fotty Acids1997年
  • 第41章 腎機能芝本 利重バーン・レヴィ 生理学 第3版,西村書店1996年
  • 第31章 特殊臓器の循環芝本 利重バーン・レヴィ 生理学 第3版,西村書店1996年
  • Thromboxane A2 analogue contracts predominantly the hepatic veins in isolated canine liverSHIBAMOTO ToshishigeProstaglandins1996年
  • The effects of sevoflurane, enflurane, and isoflurane on baroreceptor-sympathetic reflex in rabbits.SHIBAMOTO ToshishigeAnesth. Analg.1996年
  • Participation of nitric oxide in the sympathetic response to anaphylactic hypotension in anesthetized dogsSHIBAMOTO ToshishigeNeuroscience Letter1996年
  • Hepatic capillary pressure is estimated using triple vascular occlusion wethod in isolated canine liverSHIBAMOTO ToshishigeAmerican Journal of Physiology1996年
  • Differential regional sympathetic responses to somatic stimulation in anesthetized dogsSHIBAMOTO ToshishigeJournal of Autouomic Nervous Sgstem1996年
  • Changes in tissue blood flow and sympathetic activities to various organs during prolonged hemorrhagic hypotension in monkeysSHIBAMOTO ToshishigeJournal of Autouomic Nervous System1996年
  • rBPI23 attenuates endotoxin-induced cardiovascular depression in awake rabbits.SHIBAMOTO ToshishigeShock.1995年
  • Suppression of sympathetic nervous system is involved in hypotension and bradycardia during hemofiltration in anesthetized dogs.SHIBAMOTO ToshishigeCan. J. Physiol. Pharmacol.1995年
  • No effects of large doses of catecholamines on vascular permeability in isolated blood-perfused dog lungs.SHIBAMOTO ToshishigeActa. Physiol. Scand.1995年
  • Effects of thromboxane A2 analogue on vascular resistance distribution and permeability in isolated blood-perfused dog lungs.SHIBAMOTO ToshishigeLung1995年
  • Baroreflex attenuation after hypotension induced by vena caval occlusion in anesthetized dogs.SHIBAMOTO ToshishigeAm. J. Physiol.1995年
  • Role of hypogastric nerve activity in opposum internal aual sphincter function : Influence of Surgical and chemical deuervationSHIBAMOTO ToshishigeJ. Pharmacol. Exp. Ther.1994年
  • Hepatic vascular response to anaphylaxis in isolated canine liverSHIBAMOTO ToshishigeAm. J. Physiol.1994年
  • 低血圧時の神経性循環制御における迷走神経の役割芝本 利重循環制御1993年
  • 交感神経-圧受容器反射に及ぼす静脈内高張食塩水の影響芝本 利重自律神経1993年
  • Pulmonary anaphylaxis in isolated canine lungsSHIBAMOTO ToshishigePulmonary Circulation Research 19921993年
  • PAF increases capillary pressure but not vascular permeability in isolated blood perfused-canine lungs.SHIBAMOTO ToshishigeAmerican Journal of Physiology1993年
  • Differential control of sympathetic outflow to kidney, heart, adrenal gland, and liver during systemic hypotension induced by cardiac tamponade in anesthetized dogs.SHIBAMOTO ToshishigeCirculatory Shock1993年
  • Pulmonary vascular response to anaphylaxis in isolated canine lungsSHIBAMOTO ToshishigeAmerican Journal of Physiology1992年
  • Acute effect of hypobaria and hypoxia on renal nerve activity in anesthetized rabbitsSHIBAMOTO ToshishigeActa Physiologica Scandinavica1992年
  • PO2 modulation of paraquat induced microvascular injury in isolated dog lungsSHIBAMOTO ToshishigeJournal of Applied Physiology1990年
  • Fructose 1, 6 - diphosphate augments paraquat injury in isolated dog lungsSHIBAMOTO ToshishigeJournal of Applied Physiology1990年
  • Derecruitment of filtration surface area in paraquat-injured isolated dog lungsSHIBAMOTO ToshishigeJournal of Applied Physiology1990年
  • Platelike and globelike inclusion bodies associated with rough endoplasmic reticulum in alveolar type 2 cells of the sheepSHIBAMOTO ToshishigeAnatomical Record1989年
  • Electron microscopic studies on the alterations in the alveoli of paraquat-administered sheep, with special reference to the relationship between lung lymph dynamics and ultrastructure.SHIBAMOTO ToshishigeJournal of Clinical Electron Microscopy1987年
  • 急性肺傷害における6-keto PGF1の濃度の変動に関する実験的研究芝本 利重日本臨床生理学会雑誌1986年
  • Acute effect of paraquat on lung fluid balance and prostanoid production in awake sheepSHIBAMOTO ToshishigeAmerican Review of Respiratory Disease1986年
  • Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by Sustained Renal Sympathoexcitation.Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T.frontiers in Physiology8:6692017年
  • Biphasic Renal Sympathetic Response to Hemorrhagic Hypotension in Mice.Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T.Shock48:576-5822017年
  • Blockade of β2-adrenoceptor, rather than β1-adrenoceptor, deteriorates cardiac anaphylaxis in isolated blood-perfused rat hearts.Kuda Y, Shibamoto T, Yang W, Zhang T, Tanida M, Kurata Y.Cardiol J24:403-4082017年
  • Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models.Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T.Am J Physiol Heart Circ Physiol312:H106-H1272017年
  • Gastric vascular and motor responses to anaphylactic hypotension in anesthetized rats, in comparison to those with hemorrhagic or vasodilator-induced hypotension.Kuda Y, Shibamoto T, Zhang T, Yang W, Tanida M, Kurata Y.J Physiol Sci68:253-2602017年
  • Renal response to anaphylaxis in anesthetized rats and isolated perfused rat kidneys: roles of nitric oxide.Mukai K, Kuda Y, Shibamoto T, Tanida M, Kurata Y, Yokoyama H.J Physiol Sci(in press):(in press)2017年
  • Renal response to anaphylaxis in anesthetized rats and isolated perfused rat kidneys: roles of nitric oxide.Mukai K, Kuda Y, Shibamoto T, Tanida M, Kurata Y, Yokoyama H.The Journal of Physiological Sciences(in press):(in press)2018年

書籍等出版物

  • アナフィラキシーショックの病態:生理学
    アナフィラキシーショック(光畑 裕正)
    芝本利重
    克誠堂 2008年11月

受賞

  • 1994年 信州大学医学部松医会賞
    芝本 利重,

競争的資金

  • アナフィラキシーショックにおけるAngiopoietin 2の役割
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2016年 - 2018年  
    代表者:芝本利重
  • アナフィラキシーショックにおける脳循環の統合的研究
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2013年 - 2015年  
    代表者:芝本利重分担・連携研究者:倉田康孝,利波久雄
  • アナフィラキシーショックにおける心機能の統合的研究
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2008年 - 2010年  
    代表者:芝本利重分担・連携研究者:倉田康孝
  • 循環ショックにおける肝臓の微小血管圧の測定法の確立
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2006年 - 2007年  
    代表者:芝本利重
  • 肝アナフィラキシィー反応の統合的研究
    文部科学省:科学研究費 基盤研究(C)
    研究期間:2003年 - 2004年  
    代表者:芝本利重


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