YOSHITOMI Yasuo

FacultyDepartment of Biochemistry Ⅱ
PositionSenior Assistant Professor

Researcher Profile & Settings

Academic & Professional Experience

  • Jan. 2011Kanazawa Medical University
  • Jan. 2007Dec. 2010National Institutes of Dental and Craniofacial Research / National Institutes of Health Researcher
  • Apr. 2009Dec. 2010JSPS JSPS fellowship (NIH)

Research Activities

Published Papers

  • Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA, Takayuki Ikeda, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Hideto Yonekura, International Journal of Molecular Sciences21:6460Sep. 2020
  • Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open8:bio035691Feb. 2019
  • Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis, Yang Fan, Takagaki Yuta, Yoshitomi Yasuo, Ikeda Takayuki, Li Jinpeng, Kitada Munehiro, Kumagai Asako, Kawakita Emi, Shi Sen, Kanasaki Keizo, Koya Daisuke, Cancer research79:735-746Feb. 2019
  • JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin, Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura, Jonal of Cell Science130:916-926Jan. 2017
  • Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry413:155-1642016
  • Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto, Medical Molecular Morphology48:69-75Jun. 2015
  • Epiprofin orchestrates epidermal keratinocyte proliferation and differentiation, (T. Nakamura), Y. Yoshitomi, K. Sakai, V. Patel, S. Fukumoto, Y. Yamada, Journal of cell science127(24):5261-72Dec. 2014
  • Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura, The Biochemical journal.436:399-407Jun. 2011
  • Role of Epiprofin, a zinc-finger transcription factor, in limb development., (A.Talamillo), I.Delgado, T.Nakamura, S.De-Vega, Y.Yoshitomi, F.Unda, W.Birchmeier, Y.Yamada, MA.Ros, Dev Biol.337:363-3742010
  • Matrix Metalloproteinase-9 accociated with Heparan sulfate chains of GPI-anchored cell surface proteoglycans mediates motility of murine colon adenocarcinoma cells., (Y.Koyama), H.Naruo, Y.Yoshitomi, S.Munesue, S.Kiyono, Y.Kusano, K.Hashimoto, T.Yokoi, H.Nakanishi, S.Shimizu, M.Okayama, K.Oguri, J Biochem.143: 581-922008
  • A novel function of syndecan-2, suppression of matrix metalloproteinase-2 activation, which causes suppression of metastasis., (S.Munesue), Y.Yoshitomi, Y.Kusano, Y.Koyama, A.Nishiyama, H.Nakanishi, K.Miyazaki, T.Ishimaru, S.Miyaura, M.Okayama, K.Oguri, J Biol Chem282:28164-281742007
  • Inhibition of experimental lung metastases of Lewis lung carcinoma cells by chemically modified heparin with reduced anticoagulant activity., Y.Yoshitomi, H.Nakanishi, Y.Kusano, S.Munesue, K.Oguri, M.Tatematsu, I.Yamashina, M.Okayama, Cancer Letters207:165-1742004
  • Cooperation of syndecan-2 and syndecan-4 among cell surface heparan sulfate proteoglycans in the actin cytoskeletal organization of Lewis lung carcinoma cells., (Y.Kusano), Y.Yoshitomi, S.Munesue, M.Okayama, K.Oguri, J Biochem.135:129-1372004
  • The role of syndecan-2 in regulation of actin- cytoskeletal organization of Lewis lung carcinoma-derived metastatic clones., (S.Munesue), Y.Kusano, K.Oguri, N.Itano, Y.Yoshitomi, H.Nakanishi, I.Yamashina, M.Okayama, Biochem J363: 201-2092002
  • Involvement of syndecans in actin cytoskeletal organization and tumor metastasis., (K.Oguri), S.Munesue, Y.Kusano, Y.Yoshitomi, M.Okayama, Connective Tissue34:283-2902002
  • Metformin mitigates DPP-4 inhibitor-induced breast cancer metastasis via suppression of mTOR signaling, Emi Kawakita, Fan Yang, Asako Kumagai, Yuta Takagaki, Munehiro Kitada, Yasuo Yoshitomi, Takayuki Ikeda, Yuka Nakamura, Yasuhito Ishigaki, Keizo Kanasaki, Daisuke Koya, Molecular Cancer Research19:61-73Jan. 2021
  • Sp6/Epiprofin is a master regulator in the developing tooth, Craig S. Rhodes, Yasuo Yoshitomi, Peter D. Burbelo, Nowlan H. Freese, Takashi Nakamura, Yuta Chiba, Yoshihiko Yamada, Biochemical and Biophysical Research Communications581:89-95Dec. 2021
  • EAPC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells, Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura, Scientific reports11:19453Sep. 2021
  • Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients13:2226Jun. 2021
  • Emerging Role of AP-1 Transcription Factor JunB in Angiogenesis and Vascular Development, Yasuo Yoshitomi, Takayuki Ikeda, Hidehito Saito-Takatsuji, Hideto Yonekura, International Journal of Molecular Sciences22:2804Mar. 2021
  • Role of Decorin in Posterior Capsule Opacification and Eye Lens Development., Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Cells10:863Apr. 2021