MASUOKA Takayoshi

FacultyDepartment of Pharmacology
PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    My current research focuses on the abnormal sensation regulated through primary sensory afferents in the skin and the cornea as well as its synaptic regulation in CNS. I am also interested in cholinergic and histaminergic receptors regulating synaptic transmission in the hippocampus related to learning and memory.

Education

  • Okayama University Graduate School
  • University of Shizuoka Faculty of Pharmaceutical Science

Degree

  • Ph.D.

Association Memberships

  • Jan. 2003Society for Neuroscience
  • Jan. 2005The Pharmaceutical Society of Japan
  • Apr. 2007The Japan Neuroscience Society
  • Jan. 2015Dec. 2015The Association for Research in Vision and Opthalmology
  • Apr. 2015Japanese Pharmacological Society

Academic & Professional Experience

  • Apr. 2008Mar. 2011Tokushima Bunri University Assistant Professor
  • Apr. 2011Mar. 2017Kanazawa Medical University Senior Assistant Professor
  • Apr. 2017Mar. 2021Kanazawa Medical University Associate Professor
  • Apr. 2021- TodayKanazawa Medical University Professor

Research Activities

Published Papers

  • Voluntary wheel-running activities ameliorate depressive-like behaviors in mouse dry eye model, Katsuya Nakano, Hitomi Nakazawa, Qiang He, Junsuke Uwada, Takeshi Kiyoi, Takaharu Ishibashi, Takayoshi Masuoka16:01-12Sep. 2022
  • Pain Regulation by Peripheral Glutamate and its Abnormalities, Takayoshi Masuoka47:1-6Jun. 2022
  • Editorial: Sensory Abnormalities and Primary Sensory Neurons, Takayoshi Masuoka, M. Carmen Acosta, David J. Adams16:852614Feb. 2022
  • Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum, Ikunobu Muramatsu, Junsuke Uwada, Kazuyasu Chihara, Kiyonao Sada, Mao-Hsien Wang, Takashi Yazawa, Takanobu Taniguchi, Takaharu Ishibashi, Takayoshi Masuoka160:342-355Feb. 2022
  • Alteration of the soluble guanylate cyclase system in coronary arterise of high cholesterol diet-fed rabbits, Masashi Tawa, katsuya Nakano, Yuka Yamashita, Qiang He, Takayoshi Masuoka, Tomio Okamura, Takaharu Ishibashi, Pharmacol Res Perspect9:e00838Jul. 2021
  • Chronic tear deficiency sensitizes transient receptor potential vanilloid 1-mediated responses in corneal sensory nerves, Masuoka Takayoshi, Yamashita Yuka, Nakano Katsuya, Takechi Kenshi, Niimura Takahiro, Tawa Masashi, He Qiang, Ishizawa Keisuke, Ishibashi Takaharu, Frontiers in Cellular Neuroscience14:598678Dec. 2020
  • Sensitization of glutamate receptor-mediated pain behaviour via nerve growth factor-dependent phosphorylation of transient receptor potential V1 under inflammatory conditions, Masuoka Takayoshi, Yamashita Yuka, Yoshida Junko, Nakano Katsuya, Tawa Masashi, Nishio Matomo, Ishibashi Takaharu, British journal of pharmacology177:4223-4241Sep. 2020
  • Effect of Betanin, a Beetroot Component, on Vascular Tone in Isolated Porcine Arteries, Tawa Masashi, Masuoka Takayoshi, Yamashita Yuka, Nakano Katsuya, Ishibashi Takaharu, American Journal of Hypertension33:305-309Apr. 2020
  • Impact of cigarette smoking on nitric oxide-sensitive and nitric oxide-insensitive soluble guanylate cyclase-mediated vascular tone regulation, Tawa Masashi, Kinoshita Takeshi, Masuoka Takayoshi, Yamashita Yuka, Nakano Katsuya, Nishio Matomo, Okamura Tomio, Ishibashi Takaharu, Hypertension Research43:178-185Mar. 2020
  • Chronological change of vascular reactivity to cGMP generators in the balloon-injured rat carotid artery, Masashi Tawa, Takashi Shimosato, Hiroshi Sakonjo, Takayoshi Masuoka, Matomo Nishio, Takaharu Ishibashi, Tomio Okamura, Journal of Vascular Research56:109-116Aug. 2019
  • Persistent activation of histamine H1 receptors in the hippocampal CA1 region enhances NMDA receptor-mediated synaptic excitation and long-term potentiation in astrocyte- and D-serine-dependent manner, Takayoshi Masuoka, Ryo Ikeda, Shiro Konishi, Neuropharmacology151:64-73Jun. 2019
  • Novel regulatory systems for acetylcholine release in rat striatum and anti-Alzheimer’s disease drugs, Ikunobu Muramatsu, Junsuke Uwada, Hatsumi Yoshiki, Kiyonao Sada, Kung-Shing Lee, Takashi Yazawa, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Takayoshi Masuoka, Journal of Neurochemistry149:605-623Jun. 2019
  • Responsiveness of rat aorta and pulmonary artery to cGMP generators in the presence of thiol or heme oxidant, Masashi Tawa, Yuka Yamashita, Takayoshi Masuoka, Katsuya Nakano, Junko Yoshida, Matomo Nishio, Takaharu Ishibashi, Journal of Pharmacological Sciences140:43-47May 2019
  • Augmentation of endogenous acetylcholine uptake and cholinergic facilitation of hippocampal long-term potentiation by acetylcholinesterase inhibition, Takayoshi Masuoka, Junsuke Uwada, Makiko Kudo, Hatsumi Yoshiki, Yuka Yamashita, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Ikunobu Muramatsu, Neuroscience404:39-47Apr. 2019
  • Inhibitory effect of amitriptyline on the impulse activity of cold thermoreceptor terminals of intact and tear-deficit guinea pig corneas, Takayoshi Masuoka, Juana Gallar, Carlos Belmonte., Journal of Ocular Pharmacology and Therapeutics34:195-203Nov. 2018
  • Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission, Muramatsu, Ikunobu;Uwada, Junsuke;Masuoka, Takayoshi;Yoshiki, Hatsumi;Sada, Kiyonao;Lee, Kung-Shing;Nishio, Matomo;Ishibashi, Takaharu;Taniguchi, Takanobu, JOURNAL OF NEUROCHEMISTRY143:76-86Oct. 2017
  • TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root Ganglion Neurons, Masuoka, Takayoshi;Kudo, Makiko;Yamashita, Yuka;Yoshida, Junko;Imaizumi, Noriko;Muramatsu, Ikunobu;Nishio, Matomo;Ishibashi, Takaharu, FRONTIERS IN PHYSIOLOGY8:1-9May 2017
  • Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia, T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio, Frontiers in Cellular Neuroscience10:79-79Mar. 2016
  • Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions., I.Muramatsu, H.Yoshiki, J.Uwada, T.Masuoka, K.Sada, T.Taniguchi, M.Nishio, Journal of Neurochemistry139:566-5752016
  • Ca2+ Signalimg molecules STIM1/Orail and Cancer, J.Yoshida, T.Ishibashi, T.Masuoka, N.Imaizumi, M.Nishio, Journal of Kanazawa Medical University40:69-77Dec. 2015
  • Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity., T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio, British Journal of Pharmacology172:1020-1033Feb. 2015
  • Pharmacologically distinct phenotypes of α1B-adrenoceptors: variation in binding and functional affinities for antagonists., (H.Yoshiki), J.Uwada, AS.Anisuzzaman, H.Umada, R.Hayashi, R.Kainoh, Masuoka T, Nishi M, I.Muramatsu, British journal of pharmacology.171:4890-4901Sep. 2014
  • Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan based motif., (J.Uwada), H.Yoshiki, T.Masuoka, M.Nishio, I.Muramatsu, Journal of cell science127:3131-3140Jul. 2014
  • Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus., (AS.Anisuzzaman), J.Uwada, T.Masuoka, Y.Hatsumi, M.Nishio, Y.Ikegaya, N.Takahashi, N.Matsuki, Y.Fujibayashi, Y.Yonekura, T.Momiyama, I.Muramatsu, Journal of neurochemistry126:360-371Jun. 2013
  • Effects of cyanamide, an aldehyde dehydrogenase type2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced vasodilation in rabbit excised aorta and in anesthetized whole animal., T.Ishibashi, M.Nomura-Nakamoto, F.Abe, T.Masuoka, N.Imaizumi, J.Yoshida, Tomie Kawada, M.Nishio, Biological & pharmaceutical bulletin36:556-563Apr. 2013
  • Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells, J.Yoshida, K.Iwabuchi, T.Matsui, T.Ishibashi, T.Masuoka, M.Nishio, Biochemical pharmacology.84:1592-1603Sep. 2012
  • The inhibition of uric acid formation catalyzed by xanthine oxidase Properties of the alkyl caffeates and cardol, (Masuoka N), Nihei K, Masuoka T, Kuroda K, Sasaki K, Kubo I, J Food Res1:257-2622012
  • NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms, Jiu-Gang Xue, Takayoshi Masuoka, Xian-Di Gong, Ken-Shiung Chen, Yuchio Yanagawa, S. K. Alex Law, Shiro Konishi, Journal of neurophysiology.105:2897-2906Jun. 2011
  • Ameliorative effect of a hippocampal metabotropic glutamate 1 receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats, Takayoshi Masuoka, Azusa Mikami, Chiaki Kamei, Journal of pharmacological sciences.113:41-47Apr. 2010
  • Within-day variation in spatial memory deficit induced by scopolamine., (Hiroki Fujitaka), Akiko Okada, Takayoshi Masuoka, Chiaki Kamei, Pharmacology.84:340-345Oct. 2009
  • The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits., Takayoshi Masuoka, Chiaki Kamei, Psychopharmacology206:259-265Oct. 2009
  • The ameliorating effects of NMDA receptor agonists on histamine H1 antagonist-induced memory and hippocampal theta disruptions are prevented by the H3 receptor agonist in rats., Takayoshi Masuoka, Chiaki Kamei, Brain Res. Bull.79:422-425Aug. 2009
  • Participation of hippocampal ionotropic glutamate receptors in histamine H1 antagonist-induced memory deficit in rats, Masuoka T, Saito S, Kamei C, Psychopharmacology197:107-1142008
  • Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task., Sun XL, Ito H, Masuoka T, Kamei C, Hatano T., Biol Pharm Bull.30:1727-1731Sep. 2007
  • Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats., Masuoka T, Mikami A, Yasuda M, Shinomiya K, Kamei C., Eur J Pharmacol576:77-82Aug. 2007
  • Role of hippocampal H1 receptors in radial maze performance and hippocampal theta activity in rats., Masuoka T, Kamei C., Brain Res Bull.73:231-237Jul. 2007
  • Participation of cholinergic system in memory deficits induced by blockade of hippocampal mGlu(1) receptors., Mikami A, Masuoka T, Yasuda M, Yamamoto Y, Kamei C., Eur J Pharmacol.73:231-237Jul. 2007
  • Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase., Abe I, Abe T, Lou W, Masuoka T, Noguchi H., Biochem Biophys Res Commun.352:259-263Jan. 2007
  • Participation of endogenous brain histamine on learning and memory, Masuoka T, Nishiga M, Chen Z, Kamei C., Jpn J Neuropsychopharmacol26:141-148Aug. 2006
  • Potentiation of ethanol in spatial memory deficits induced by some benzodiazepines., Takiguchi A, Masuoka T, Yamamoto Y, Mikami A, Kamei C., J Pharmacol Sci.101:325-328Aug. 2006
  • Participation of the hippocampal theta rhythm in memory formation for an eight-arm radial maze task in rats., Masuoka T, Fujii Y, Kamei C., Brain Res.1103:159-163Aug. 2006
  • Characterization of acatalasemic erythrocytes treated with low and high dose hydrogen peroxide. Hemolysis and aggregation., Masuoka N, Sugiyama H, Ishibashi N, Wang DH, Masuoka T, Kodama H, Nakano T., J Biol Chem.281:21728-21734Aug. 2006
  • Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats., Masuoka T, Fujii Y, Kamei C., Eur J Pharmacol.539:76-80Jul. 2006
  • Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats., Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C., Psychopharmacology (Berl).180:564-569Jul. 2005
  • Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats., Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C., Biol Pharm Bull.28:808-810May 2005

Books etc

  • A New Aspect of Cholinergic Transmission in the Central Nervous System
    Nicotinic Acetylcholine Receptor Signaling in Neuroprotection, , Springer
    Ikunobu Muramatsu, Takayoshi Masuoka, Junsuke Uwada, Hatsumi Yoshiki, Takashi Yazama, Kung-Shing Lee, Kiyonao Sada, Matomo Nishio, Takaharu Ishibashi, Takanobu Taniguchi.
      Apr. 2018
  • Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor's Natural Environment
    Muscarinic Receptor: From Structure to Animal Models, Volume 107 of the series Neuromethods
    I.Muramatsu, H.Yoshiki, K.Sada, J.Uwada, T.Taniguchi, T.Masuoka, M.Nishio
    Springer  Jan. 2016