MASUOKA Takayoshi

FacultyDepartment of Pharmacology
PositionAssociate Professor

Researcher Profile & Settings


    Overview of research:
    My current research focuses on the abnormal sensation regulated through primary sensory afferents in the skin and the cornea as well as its synaptic regulation in CNS. I am also interested in cholinergic and histaminergic receptors regulating synaptic transmission in the hippocampus related to learning and memory.


  • Okayama University Graduate School
  • University of Shizuoka Faculty of Pharmaceutical Science


  • Ph.D.

Association Memberships

  • Apr. 2007The Japan Neuroscience Society
  • Apr. 2015Japanese Pharmacological Society
  • Jan. 2003Society for Neuroscience
  • Jan. 2005The Pharmaceutical Society of Japan
  • Jan. 2015Dec. 2015The Association for Research in Vision and Opthalmology

Academic & Professional Experience

  • Apr. 2008Mar. 2011Tokushima Bunri University Assistant Professor
  • Apr. 2011Mar. 2017Kanazawa Medical University Senior Assistant Professor
  • Apr. 2017Kanazawa Medical University Associate Professor

Research Activities

Published Papers

  • Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission, Muramatsu, Ikunobu;Uwada, Junsuke;Masuoka, Takayoshi;Yoshiki, Hatsumi;Sada, Kiyonao;Lee, Kung-Shing;Nishio, Matomo;Ishibashi, Takaharu;Taniguchi, Takanobu, JOURNAL OF NEUROCHEMISTRY143:76-86Oct. 2017
  • TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root Ganglion Neurons, Masuoka, Takayoshi;Kudo, Makiko;Yamashita, Yuka;Yoshida, Junko;Imaizumi, Noriko;Muramatsu, Ikunobu;Nishio, Matomo;Ishibashi, Takaharu, FRONTIERS IN PHYSIOLOGY8:1-9May 2017
  • Long-term activation of group I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root ganglia, T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio, Frontiers in Cellular Neuroscience10:79-79Mar. 2016
  • Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions., I.Muramatsu, H.Yoshiki, J.Uwada, T.Masuoka, K.Sada, T.Taniguchi, M.Nishio, Journal of Neurochemistry139:566-5752016
  • Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity., T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio, British Journal of Pharmacology172:1020-1033Feb. 2015
  • Ca2+ Signalimg molecules STIM1/Orail and Cancer, J.Yoshida, T.Ishibashi, T.Masuoka, N.Imaizumi, M.Nishio, Journal of Kanazawa Medical University40:69-77Dec. 2015
  • Pharmacologically distinct phenotypes of α1B-adrenoceptors: variation in binding and functional affinities for antagonists., (H.Yoshiki), J.Uwada, AS.Anisuzzaman, H.Umada, R.Hayashi, R.Kainoh, Masuoka T, Nishi M, I.Muramatsu, British journal of pharmacology.171:4890-4901Sep. 2014
  • Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan based motif., (J.Uwada), H.Yoshiki, T.Masuoka, M.Nishio, I.Muramatsu, Journal of cell science127:3131-3140Jul. 2014
  • Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus., (AS.Anisuzzaman), J.Uwada, T.Masuoka, Y.Hatsumi, M.Nishio, Y.Ikegaya, N.Takahashi, N.Matsuki, Y.Fujibayashi, Y.Yonekura, T.Momiyama, I.Muramatsu, Journal of neurochemistry126:360-371Jun. 2013
  • Effects of cyanamide, an aldehyde dehydrogenase type2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced vasodilation in rabbit excised aorta and in anesthetized whole animal., T.Ishibashi, M.Nomura-Nakamoto, F.Abe, T.Masuoka, N.Imaizumi, J.Yoshida, Tomie Kawada, M.Nishio, Biological & pharmaceutical bulletin36:556-563Apr. 2013
  • Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells, J.Yoshida, K.Iwabuchi, T.Matsui, T.Ishibashi, T.Masuoka, M.Nishio, Biochemical pharmacology.84:1592-1603Sep. 2012
  • The inhibition of uric acid formation catalyzed by xanthine oxidase Properties of the alkyl caffeates and cardol, (Masuoka N), Nihei K, Masuoka T, Kuroda K, Sasaki K, Kubo I, J Food Res1(3):257-2622012
  • NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms, Jiu-Gang Xue, Takayoshi Masuoka, Xian-Di Gong, Ken-Shiung Chen, Yuchio Yanagawa, S. K. Alex Law, Shiro Konishi, Journal of neurophysiology.105:2897-2906Jun. 2011
  • Ameliorative effect of a hippocampal metabotropic glutamate 1 receptor agonist on histamine H1 receptor antagonist-induced memory deficit in rats, Takayoshi Masuoka, Azusa Mikami, Chiaki Kamei, Journal of pharmacological sciences.113:41-47Apr. 2010
  • Within-day variation in spatial memory deficit induced by scopolamine., (Hiroki Fujitaka), Akiko Okada, Takayoshi Masuoka, Chiaki Kamei, Pharmacology.84:340-345Oct. 2009
  • The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits., Takayoshi Masuoka, Chiaki Kamei, Psychopharmacology206:259-265Oct. 2009
  • The ameliorating effects of NMDA receptor agonists on histamine H1 antagonist-induced memory and hippocampal theta disruptions are prevented by the H3 receptor agonist in rats., Takayoshi Masuoka, Chiaki Kamei, Brain Res. Bull.79:422-425Aug. 2009
  • Participation of hippocampal ionotropic glutamate receptors in histamine H1 antagonist-induced memory deficit in rats, Masuoka T, Saito S, Kamei C, Psychopharmacology197:107-1142008
  • Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task., Sun XL, Ito H, Masuoka T, Kamei C, Hatano T., Biol Pharm Bull.30:1727-1731Sep. 2007
  • Effects of histamine H(1) receptor antagonists on hippocampal theta rhythm during spatial memory performance in rats., Masuoka T, Mikami A, Yasuda M, Shinomiya K, Kamei C., Eur J Pharmacol576:77-82Aug. 2007
  • Role of hippocampal H1 receptors in radial maze performance and hippocampal theta activity in rats., Masuoka T, Kamei C., Brain Res Bull.73:231-237Jul. 2007
  • Participation of cholinergic system in memory deficits induced by blockade of hippocampal mGlu(1) receptors., Mikami A, Masuoka T, Yasuda M, Yamamoto Y, Kamei C., Eur J Pharmacol.73:231-237Jul. 2007
  • Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase., Abe I, Abe T, Lou W, Masuoka T, Noguchi H., Biochem Biophys Res Commun.352:259-263Jan. 2007
  • Participation of endogenous brain histamine on learning and memory, Masuoka T, Nishiga M, Chen Z, Kamei C., Jpn J Neuropsychopharmacol26:141-148Aug. 2006
  • Potentiation of ethanol in spatial memory deficits induced by some benzodiazepines., Takiguchi A, Masuoka T, Yamamoto Y, Mikami A, Kamei C., J Pharmacol Sci.101:325-328Aug. 2006
  • Participation of the hippocampal theta rhythm in memory formation for an eight-arm radial maze task in rats., Masuoka T, Fujii Y, Kamei C., Brain Res.1103:159-163Aug. 2006
  • Characterization of acatalasemic erythrocytes treated with low and high dose hydrogen peroxide. Hemolysis and aggregation., Masuoka N, Sugiyama H, Ishibashi N, Wang DH, Masuoka T, Kodama H, Nakano T., J Biol Chem.281:21728-21734Aug. 2006
  • Effect of scopolamine on the hippocampal theta rhythm during an eight-arm radial maze task in rats., Masuoka T, Fujii Y, Kamei C., Eur J Pharmacol.539:76-80Jul. 2006
  • Effects of kava-kava extract on the sleep-wake cycle in sleep-disturbed rats., Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C., Psychopharmacology (Berl).180:564-569Jul. 2005
  • Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats., Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C., Biol Pharm Bull.28:808-810May 2005
  • Inhibitory effect of amitriptyline on the impulse activity of cold thermoreceptor terminals of intact and tear-deficit guinea pig corneas, Takayoshi Masuoka, Juana Gallar, Carlos Belmonte., Journal of Ocular Pharmacology and Therapeutics34:195-203Nov. 2018
  • Augmentation of endogenous acetylcholine uptake and cholinergic facilitation of hippocampal long-term potentiation by acetylcholinesterase inhibition, Takayoshi Masuoka, Junsuke Uwada, Makiko Kudo, Hatsumi Yoshiki, Yuka Yamashita, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Ikunobu Muramatsu, Neuroscience404:39-47Apr. 2019

Books etc

  • A New Aspect of Cholinergic Transmission in the Central Nervous System
    Nicotinic Acetylcholine Receptor Signaling in Neuroprotection, , Springer
    Ikunobu Muramatsu, Takayoshi Masuoka, Junsuke Uwada, Hatsumi Yoshiki, Takashi Yazama, Kung-Shing Lee, Kiyonao Sada, Matomo Nishio, Takaharu Ishibashi, Takanobu Taniguchi.
      Apr. 2018
  • Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor's Natural Environment
    Muscarinic Receptor: From Structure to Animal Models, Volume 107 of the series Neuromethods
    I.Muramatsu, H.Yoshiki, K.Sada, J.Uwada, T.Taniguchi, T.Masuoka, M.Nishio
    Springer  Jan. 2016

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