MIZUNO Shiro

FacultyDepartment of Respiratory Medicine
PositionProfessor

Researcher Profile & Settings

Degree

  • Ph.D in Medicine

Research Activities

Published Papers

  • Trafficking of newly synthesized surfactant protein B to the lamellar body in alveolar type II cells, Osanai Kazuhiro, Mizuno Shiro, Toga Hirohisa, Takahashi Keiji, Cell and Tissue Research381:427-438Sep. 2020
  • Cognitive deterioration upon admission is an important risk indicator of falls in the respiratory ward, Masafumi Nojiri, Tatsuya Watanabe, Koichi Yamamura, Saki Matsuura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Ryo Kato, Shohei Shinomiya, Yutaka Takahara, Yuki Fujimoto, Taku Oikawa, Shiro Mizuno, Physical Medicine and Rehabilitation Resarch5:1-5Aug. 2020
  • Second SVC stent treatment for tumour ingrowth, Takahara Yutaka, Ishige Yoko, Shionoya Ikuyo, Fujimoto Yuki, Oikawa Taku, Mizuno Shiro, Respirology Case Reports8:e00619Aug. 2020
  • A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis, Takahara Yutaka, Yamamura Kouichi, Matsuura Saki, Sakuma Takashi, Nishiki Kazuaki, Nakase Keisuke, Nojiri Masafumi, Kato Ryo, Shinomiya Shohei, Oikawa Rieko, Fujimoto Yuki, Oikawa Taku, Osanai Kazuhiro, Ueda Yoshimichi, Mizuno Shiro, Respiratory Medicine Case Reports30:101124Jun. 2020
  • Effectiveness of Long Pepper Extract in Reducing Leg Swelling in Healthy Women during Prolonged SittingーA Randomized,Double-blind,Placebo-controlled Crossover Trialー, Yuki Fujimoto, Keiji Fujimoto, Rieko Oikawa, Mio Sawada, Mutsumi Tsuchishima, Junji Moriya, Hiroaki Uenishi, Hisakazu Furuta, Junji Kobayashi, Shiro Mizuno, Hirohisa Toga, Noboru Takekoshi, Susumu Yoshino, Yasuo Miyake, Nobuaki Ohto, Sumiyo Akazawa, Japanese Pharmacology & Therapeutics48:401-407Mar. 2020
  • A Case of Limited-disease Small Cell Lung Cancer Behind a Cardiac Pacemaker, Nishiki Kazuaki, Sakuma Takashi, Nojiri Masafumi, Kawasaki Yasutaka, Shinomiya Shohei, Mizuno Shiro, Japanese Journal of Lung Cancer60:27-32Feb. 2020
  • A Case of Lung Adenocarcinoma Associated with Eosinophilic Sinusitis Induced by Pembrolizumab Administration, Shohei Shinomiya, Yoko Ishige, Ryo Kato, Yutaka Takahara, Yuki Fujimoto, Taku Oikawa, Shiro Mizuno, Clinical Oncology: Case Reports3:1000122Jan. 2020
  • Examination of Factors Influencing the Success Rates of an In Vitro Chemosensitivity Test for Lung Cancer Using Collagen Gel Droplet-Embedded Cultures, Takahara Y, Kawasaki Y, Kato R, Shinomiya S, Oikawa T, Mizuno S, Journal of Cancer Biology and Therapeutics5:295-300Dec. 2019
  • A Lung Abscess Caused by Porphyromonas gingivalis Infection Associated with Marked Thrombocytosis and Thromboembolism, Ryo Kato, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Shohei Shinomiya, Yutaka Takahara, Taku Oikawa, Kazuhiro Osanai, Shiro Mizuno, The Journal of the Japan Society for Respiratory Endoscopy41:375-380Jul. 2019
  • A case of Propionibacterium acnes empyema treated with thoracoscopic decortication, Yutaka Takahara, Saki Matsuura, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Shiro Mizuno, Annals of the Japanese Respiratory Society8:250-254Jul. 2019
  • Primary pulmonary T-cell lymphoma with lung adenocarcinoma: a case report, Takahara Yutaka, Sakuma Takashi, Nishiki Kazuaki, Nakase Keisuke, Nojiri Masafumi, Ueda Yoshimichi, Mizuno Shiro, Journal of medical case reports13:199Jun. 2019
  • Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography, (Kojonazarov.B), Belenkov.A, Shinomiya.S, Wilchelm.J, Kampschulte.M, Mizuno.S, Ghofrani.H.A, Grimminger. F, Weissmann.N, Seeger.W, Schermuly.R.T, Circulation-Cardiovascular Imaging11:1-10Dec. 2018
  • ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema, Nojiri Masafumi;Mizuno Shiro;Nishiki Kazuaki;Kato Ryo;Nakagawa Ken;Oikawa Taku;Iguchi Masaharu;Osanai Kazuhiro;Ishizaki Takeshi;Toga Hirohisa, Pulmonary pharmacology & Therapeutics48:80-87Feb. 2018
  • p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD, Shiro.Mizuno, Takeshi.Ishizaki, Maiko.Kadowaki, Masaya.Akai, Kohei.Shiozaki, Masaharu.Iguchi, Taku.Oikawa, Ken.Nakagawa, Kazuhiro.Osanai, Hirohisa.Toga, Jose.Gomez-Arroyo, Donatas.Kraskauskas, Carlyne.D.Cool, Herman.J.Bogaard, Norbert.F.Voelkel, CHEST152:58-69Jul. 2017
  • A case of pulmonary arteriovenous malformation having difficulty in differential diagnosis of the hemoptysis during each menstrual period, Yutaka.Takahara, Ryo.Kato, Ken.Nakagawa, Shiro.Mizuno, Kazuhiro.Osanai, Hirohisa.Toga, Annals of the Japanese Respiratory Society6:215-219May 2017
  • Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats, Kazuhiro.Osanai, Keisuke.Nakase, Takashi.Sakuma, Kazuaki.Nishiki, Masafumi.Nojiri, Ryo.Kato, Masatoshi.Saito, Yuki.Fujimoto, Shiro.Mizuno, Hirohisa.Toga, Respiratory Research18:70Apr. 2017
  • Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease., R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki, N.F.Voelkel, H.Toga, Respiratory research17:139-1512016
  • Role of p53 in lung tissue remodeling, S.Mizuno, HJ.Bogaard, T.Ishizaki, H.Toga, World Journal of Respirology5:40-46May 2015
  • ABPA-like Clinical Condition Associated with Bronchial Stenosis After Lung Lobectomy, T.Oikawa, R.Kato, S.Kitadate, S.Shinomiya, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga, The Journal of the Japan Society for Rsepiratory Endoscopy37:203-208Mar. 2015
  • A Case of Pulmonary Langerhans Cell Histiocytosis Diagnosed by a Cell Block from Bronchoalveolar Lavage Fluid, Y.Takahara, K.Nakase, M.Nojiri, R.Kato, S.Shinomiya, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, The Journal of the Japan Society for Respiratory Endoscopy37:240-244Mar. 2015
  • Iloprost reverses established fibrosis in experimental right ventricular failure, (J.Gomez-Arroyo), M.Sakagami, AA.Syed, L.Farkas, BV.Tassell, D.Kraskauskas, S.Mizuno, A.Abbate, HJ.Bogaard, PR.Byron, NF.Voelkel, European Respiratory Journal45:449-4622015
  • Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks, S.Mizuno, T.Ishizaki, H.Toga, A.Sakai, J.Isakova, E.Taalaibekova, Z.Baiserkeev, B.Kojonazarov, A.Aldashev, Biomed Research International2015:1-62015
  • Blunted Activation of Rho-Kinase in Yak Pulmonary Circulation, T.Ishizaki, S.Mizuno, A.Sakai, S.Matsukawa, B.Kojonazarov, B.Zamirbek, Y.Umeda, M.Morikawa, M.Anzai, T.Ishizuka, A.Aldashev, Biomed Research International2015:1-52015
  • Does drug-induced emphysema exist?, (N.F.Voelkel), S.Mizuno, Y.Masanori, The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology42:1464-1468Dec. 2013
  • A three-microphone acoustic reflection technique using transmitted acoustic waves in the airway, Y.Fujimoto, J.Huang, T.Fukunaga, R.Kato, M.Higashino, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, M.Saito, M.Kobayashi, K.Kojima, T.Oikawa, K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, S.Mizuno, K.Osanai, H.Toga, Journal of applied physiology (Bethesda, Md. : 1985)115:1119-1125Sep. 2013
  • A case of empyema thoracis by Nocardia farcinica successfully treated with sitafloxacin, T.Oikawa, R.Kato, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga2:424-428Jul. 2013
  • A case of lung abscess caused by community-acquired methicillin-resistant Staphylococcus aureus, M.Saito, T.Oikawa, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga2:295-299May 2013
  • Thyroid hormone is highly permissive in angioproliferative pulmonary hypertention in rats, (A.A.Husseini), G.Bagnato, L.Farkas, J.G.Arroyo, D.Farkas, S.Mizuno, D.Kraskauskas, A.Abbate, B.V.Tassel, N.F.Voelkel, H.J.Bogaard, The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology41:104-114Jan. 2013
  • Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy because of pulmonary arterial hypertension, (J.G.Arroyo), S.Mizuno, K.Szczepanek, B.V.Tassell, R.Natarajan, C.G.dos Renoeios, J.I.Drake, L.Farkas, D.Kraskauskas, D.S.Wijesinghe, C.E.Chalfant, J.Bigbee, A.Abbate, E.J.Lesnefsky, H.J.Bogaard, N.F.Voelkel, Circulation. Heart failure.6:136-1444Jan. 2013
  • Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate., (M.Yasuo), S.Mizuno, J.Allegood, D.Kraskauskas, H.J.Bogaard, S.Spiegel, N.F.Voelkel, PloS one8:e53927;1-10Jan. 2013
  • A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects, (J.G.Arroyo), S.J.Saleem, S.Mizuno, A.A.Syed, H.J.Boggard, A.Abbate, L.T.Stewart, Y.Sung, D.Kraskauskas, D.Farkas, D.H.Conrad, M.R.Nicolls, N.F.Voelkel, American journal of physiology. Lung cellular and molecular physiology.302:L977-L991Feb. 2012
  • Molecular signature of a right heart failure program in chronic severe pulmonary hypertension., (Drake JI), Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, Dumur CI, Fawcett P, Voelkel NF, Natarajan R, American journal of respiratory cell and molecular biology45(6):1239-47Dec. 2011
  • COPD/emphysema: The vascular story, (N.F.Voelker), J.G.Arroyo, S.Mizuno, Pulmonary circulation.1:320-326Jul. 2011
  • Multi-arterial infusion chemotherapy for non-small cell lung carcinoma--significance of detecting feeding arteries and tumor staining., (Nakanishi M), Demura Y, Umeda Y, Mizuno S, Ameshima S, Chiba Y, Ishizaki T, Lung cancer (Amsterdam, Netherlands)61(2):227-34.Aug. 2008
  • Hypoxia-induced proliferation of human pulmonary arterial smooth musclecells (PASMC) is involved in the suppression of cyclin-dependent kinase inhibitors, p21, p27 and p53., (Ishizaki T), Mizuno S, Kadowaki M, Uesaka D, Umeda Y, Morikawa M, Nkanishi M, Demura Y, Ameshima S, Matsukawa S, Problems of High Altitude Medicine Biology.10:87-99Oct. 2007
  • 18F-FDG accumulation with PET for differentiation between benign and malignant lesions in the thorax., (Demura Y), Tsuchida T, Ishizaki T, Mizuno S, Totani Y, Ameshima S, Miyamori I, Sasaki M, Yonekura Y, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.44(4):540-8.Apr. 2003
  • Serum Creatinine/Cystatin C Ratio Associated with Cross-Sectional Area of Erector Spinae Muscles and Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Takeshi Ishizaki, Hirohisa Toga, Shiro Mizuno, International Journal of Chronic Obstructive Pulmonary Disease2021:3513-3524Dec. 2021
  • Risk factors for acute exacerbation in lung cancer complicated by interstitial lung disease with slight reticular shadows., Takahara Yutaka, Tanaka Takuya, Ishige Yoko, Shionoya Ikuyo, Yamamura Kouichi, Sakuma Takashi, Nishiki Kazuaki, Nakase Keisuke, Nojiri Masafumi, Kato Ryo, Shinomiya Shohei, Fujimoto Yuki, Oikawa Taku, Mizuno Shiro, Thoracic cancer12:2758-2766Oct. 2021
  • First case of lung cancer with pneumoconiosis and endobronchial leiomyoma complicating the diagnosis., Takahara Yutaka, Yamamura Kouichi, Motono Nozomu, Oikawa Taku, Uramoto Hidetaka, Mizuno Shiro, BMC pulmonary medicine21:286-292Sep. 2021
  • Relationship between clinical features and gene mutations in non-small cell lung cancer with osteoblastic bone metastasis., Takahara Yutaka, Nakase Keisuke, Nojiri Masafumi, Kato Ryo, Shinomiya Shohei, Oikawa Taku, Mizuno Shiro, Cancer treatment and research communications28:100440Jul. 2021
  • Ruptured pseudoaneurysm of the thoracic aorta mimicking lung cancer: A case report., Takahara Yutaka, Nishiki Kazuaki, Nakase Keisuke, Mizuno Shiro, Thoracic cancer12:685-689Mar. 2021
  • Tocilizumab and PMX-DHP have efficacy for severe COVID-19 pneumonia., Shinomiya Shohei, Nakase Keisuke, Fujii Ai, Takahara Yutaka, Adachi Hiroki, Okuro Masashi, Iinuma Yoshitsugu, Yokoyama Hitoshi, Ito Toru, Mizuno Shiro, SAGE open medical case reports9:1-5Feb. 2021
  • Clinical outcomes and survival following placement of self-expandable metallic stents for central airway stenosis and fistula, Usuda Katsuo, Iwai Shun, Yamagata Aika, Iijima Yoshihito, Motono Nozomu, Takahara Yutaka, Shinomiya Shohei, Oikawa Taku, Mizuno Shiro, Uramoto Hidetaka, Thoracic Cancer12:48-56Jan. 2021
  • Foreign body removed using curette and retrieval net after tracheostomy., Nishiki Kazuaki, Ishige Yoko, Kawasaki Yasutaka, Mizuno Shiro, Lung India : official organ of Indian Chest Society38:199-200Mar. 2021
  • Early recurrence factors in patients with stage Ⅲ non-small cell lung cancer treated with concurrent chemoradiotherapy, Yutaka Takahara, Takuya Tanaka, Yoko Ishige, Ikuyo Shionoya, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Shiro Mizuno, Thorac Cancer13:3451-3458Dec. 2022
  • Differential response in patients with large cell neuroendocrine carcinoma of the lung to initial therapy: A case series, Yutaka Takahara, Takuya Tanaka, Yoko Ishige, Ikuyo Shionoya, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Shiro Mizuno, Cancer Reports(Hoboken,NJ)e1754:1-8Nov. 2022
  • Lung cancer with post-fracture healing changes causing difficulty in staging, Yutaka Takahara, Ikuyo Shionoya, Akihiro Shioya, Shohei Shinomiya, Taku Oikawa, Sohsuke Yamada, Shiro Mizuno, Respiratory Medicine Case Reports38:101694-101694Jun. 2022
  • Laryngeal papilloma-induced chronic airway obstruction: A case report, Yutaka Takahara, Takuya Tanaka, Masafumi Nojiri, Shohei Shinomiya, Sohsuke Yamada, Shiro Mizuno, Respiratory Medicine Case Reports36:101607-101607Feb. 2022
  • Efficacy and predictors of rechallenge with immune checkpoint inhibitors in non-small cell lung cancer, Yutaka Takahara, Takuya Tanaka, Yoko Ishige, Ikuyo Shionoya, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Yuki Fujimoto, Taku Oikawa, Shiro Mizuno, Thorac Cancer13:624-630Feb. 2022
  • Acquired pulmonary arteriovenous malformation associated with bronchiectasis: a case report, Yasutaka Kawasaki, Masafumi Nojiri, Taku Oikawa, Kazuaki Nishiki, Keisuke Nakase, Yutaka Takahara, Shiro Mizuno, Journal of Medical Case Reports16:24-24Jan. 2022
  • Serum Derivatives of Reactive Oxygen Metabolites are Associated with Severity of Chronic Obstructive Pulmonary Disease and Affected by a P53 Gene Polymorphism, Koichi Yamamura, Masafumi Nojiri, Kazuaki Nishiki, Ryo Kato, Shohei Shinomiya, Yutaka Takahara, Taku Oikawa, Takeshi Iahizaki, Hirohisa Toga, Shiro Mizuno, International Journal of Chronic Obstructive Pulmonary Disease17:1589-1600Jul. 2022
  • Awake Hypercapnic Ventilatory Response in Obstructive Sleep Apnea Syndrome, Takashi Sakuma, Shohei Shinomiya, Yutaka Takahara, Shiro Mizuno,, Sleep Medicine Research13:15-21Jun. 2022