Japanese

IGUCHI Masaharu

■Faculty	Himi Municipal Hospital
■Position	Professor

Researcher Profile & Settings

Research

Overview of research:

clinical respiratory medicine

Education

Kanazawa Medical University Graduate School Division of Medicine
Kochi Medical School Faculty of Medicine

Degree

Ph.D in Medicine

Research Activities

Published Papers

Effects of Tofogliflozin on Cardiac Function in Elderly Patients With Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Susumu Takagi, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Journal of Clinical Medicine Research, 12:165-171, Mar. 2020
Gender Differences in Cardiac Function Following Three-Month Administration of Tofogliflozin in Patients With Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Shinya Yamada, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Journal of Clinical Medicine Research, 12:530-538, Aug. 2020
The effects of 12-month administration of tofogliflozin on electrolytes and dehydration in mainly elderly Japanese patients with type 2 diabetes mellitus., Higashikawa Toshihiro;Ito Tomohiko;Mizuno Takurou;Ishigami Keiichirou;Kohori Masaru;Mae Kunihiro;Sangen Ryusho;Usuda Daisuke;Saito Atsushi;Iguchi Masaharu;Kasamaki Yuji;Fukuda Akihiro;Saito Hitoshi;Kanda Tsugiyasu;Okuro Masashi, JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 46:5117-5126, Dec. 2018
DOI:10.1177/0300060518790870
ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema, Nojiri Masafumi;Mizuno Shiro;Nishiki Kazuaki;Kato Ryo;Nakagawa Ken;Oikawa Taku;Iguchi Masaharu;Osanai Kazuhiro;Ishizaki Takeshi;Toga Hirohisa, Pulmonary pharmacology & Therapeutics, 48:80-87, Feb. 2018
DOI:10.1016/j.pupt.2017.09.004
ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema, Masafumi.Nojiri, Shiro.Mizuno, Kazuaki.Nishiki, Ryo.Kato, Ken.Nakagawa, Taku.Oikawa, Masaharu.Iguchi, Kazuhiro.Osanai, Takeshi.Ishizaki, Hirohisa.Toga, Pulmonary Pharmacology & Therapeutics, 48(2018):80-87, Sep. 2017
p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD, Shiro.Mizuno, Takeshi.Ishizaki, Maiko.Kadowaki, Masaya.Akai, Kohei.Shiozaki, Masaharu.Iguchi, Taku.Oikawa, Ken.Nakagawa, Kazuhiro.Osanai, Hirohisa.Toga, Jose.Gomez-Arroyo, Donatas.Kraskauskas, Carlyne.D.Cool, Herman.J.Bogaard, Norbert.F.Voelkel, CHEST, 152:58-69, Jul. 2017
Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda, Journal Clinical Case Reports, 7:10001021　, 2017
DOI:10.4172/2165-7920.10001021
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease., R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki, N.F.Voelkel, H.Toga, Respiratory research, 17:139-151, 2016
Endocardial invasion of lung cancer undiagnosable before autopsy, T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito, N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda, N.Takekoshi, T.Kanda, Case reports in oncology [electronic resource], 7:144-148, Mar. 2014
A three-microphone acoustic reflection technique using transmitted acoustic waves in the airway, Y.Fujimoto, J.Huang, T.Fukunaga, R.Kato, M.Higashino, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, M.Saito, M.Kobayashi, K.Kojima, T.Oikawa, K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, S.Mizuno, K.Osanai, H.Toga, Journal of applied physiology (Bethesda, Md. : 1985), 115:1119-1125, Sep. 2013
Spontaneous remission of epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly., T.Kanda, T.Mizuno, M.Ishigaki, K.Nakajima, T.Matsue, M.Fukushima, H.Minato, N.Nojima, S.Atsushi, K.Ishigami, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, A.Fukuda, Y.Izumi, N.Takekoshi, Case reports in oncology [electronic resource], 6:269-274, Jun. 2013
A Case of rapidly progressing pulmonary mycosis caused by Aspergillus niger developing fungus ball-like shadows, M.Saito, S.Shinomiya, S.Kitadate, Y.Takahara, A. Yamaya, K.Kouji, Y.Fujimoto, T.Oikawa, K.Nakagawa, K.Tsishihara, M.Iguchi, K.Osanai, H.Toga, 33:33-37, Jan. 2011
Two cases of Birt-Hogg-Dube' syndrome in a family, K.Nakagawa, S.Kitadate, M.Saito, Y.Fujimoto, K.Kojima, T.Oikawa, K.Oikawa, M.Iguchi, J.Huang, K.Osanai, H.Toga, K.Araida, 56:133-137, Jan. 2011
Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-pudlak syndrome, K.Osanai, J.Higuchi, R.Oikawa, M.Kobayashi, K.Tsuchihara, M.Iguchi, J.Huang, D.R.Voelker, H.Toga, American journal of physiology. Lung cellular and molecular physiology., 298:L243-L251, Feb. 2010
A mulation in rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice, K.Osanai, R.Oikawa, J.Higuchi, M.Kobayashi, K.Tsuchihara, M.Iguchi, J.Huang, H.Toga, D.R.Voelker, The American journal of pathology., 173:1265-1274, Nov. 2008
A case of broncholithiasis lithoptysis occurring spontaneously after repeated pneumonia, R. Oikawa, Y. Takahara, A. Yamaya, M. Saito, K. Kojima, Y. Tachi, T. Oikawa, K. Nakagawa, K. Tsuchihara, M. Iguchi, T. Tobe, M. Takahashi, J. Huang, K. Osanai, H. Toga, 46:126-130, Feb. 2008
A case undergoing repeated anaphylactic shok after systemic administration of vinorelbine, Y.Takahashi, T.Kiba, K.Yamaguchi, Y.Saitou, K.Nishio, M.Iguchi, Y.Motoo, 34:2321-2323, Dec. 2007
Pulmonary surfactant transport in alveolar type Ⅱ cells, K.Osanai, C.Tsuchihara, R.Hatta, T.Oikawa, K.Tsuichihara, M.Iguchi, T.Seki, M.Takahashi, J.Huang, H.Toga, Respirology (Carlton, Vic.), 11:S70-S73, Jan. 2006
A case of diffuse aspiration bronchiolitis complicated with idiopathic pulmonary fibrosis, 20:600-604, Nov. 1998
Effects of Tofogliflozin on Cardiac Function in Elderly Patients With Diabetes Mellitus., Higashikawa Toshihiro;Ito Tomohiko;Mizuno Takurou;Ishigami Keiichirou;Kohori Masaru;Mae Kunihiro;Usuda Daisuke;Takagi Susumu;Sangen Ryusho;Saito Atsushi;Iguchi Masaharu;Kasamaki Yuji;Fukuda Akihiro;Kanda Tsugiyasu;Okuro Masashi, Journal of clinical medicine research, 12, 2020
DOI:10.14740/jocmr4098
[Resection of Metastatic Lung Tumor with a Right Displaced Segmental Bronchus (B1+3);Report of a Case]., Machida Yuichiro;Kobata Takashi;Yamada Shinya;Nakagawa Ken;Iguchi Masaharu;Toga Hirohisa;Shimizu Junzo, Kyobu geka. The Japanese journal of thoracic surgery, 73, 2020
Gender Differences in Cardiac Function Following Three-Month Administration of Tofogliflozin in Patients With Diabetes Mellitus., Higashikawa Toshihiro;Ito Tomohiko;Mizuno Takurou;Ishigami Keiichiro;Kohori Masaru;Mae Kunihiro;Usuda Daisuke;Takeshima Kento;Takagi Susumu;Izumida Toshihide;Yamada Shinya;Kuroki Kengo;Sangen Ryusho;Saito Atsushi;Iguchi Masaharu;Kamasaki Yuji;Nakahashi Takeshi;Fukuda Akihiro;Kanda Tsugiyasu;Okuro Masashi, Journal of clinical medicine research, 12, 2020
DOI:10.14740/jocmr4278
Intracranial malignant solitary fibrous tumor metastasized to the chest wall: A case report and review of literature., Usuda Daisuke;Yamada Shinya;Izumida Toshihide;Sangen Ryusho;Higashikawa Toshihiro;Nakagawa Ken;Iguchi Masaharu;Kasamaki Yuji, World journal of clinical cases, 8, 2020
DOI:10.12998/wjcc.v8.i20.4844
The 12-Month Administration of Tofogliflozin for Glycemic Control with Monitoring Electrolytes, Renal and Cardiac Function in Japanese Elderly Patients with Type 2 Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Masaru Kohori, Kunihiro Mae, Daisuke Usuda, Kazu Hamada, Takuro Morita, Kento Takeshima, Susumu Takagi, Toshihide Izumida, Kengo Kuroki, Ryusho Sangen, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, International Journal of Geriatrics and Gerontology, 5:1-8, Feb. 2021
Effects of tofogliflozin on adrenocorticotropic hormone, renin and aldosterone, and cortisol levels in elderly patients with diabetes mellitus: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Takuro Morita, Kazu Hamada, Susumu Takagi, Kento Takeshima, Shinya Yamada, Ryusho Sangen, Toshihide Izumida, Hideyuki Mori, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Okuro, Medicine, 100:e27638, Nov. 2021
The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus, Toshihiro Higashikawa, Tomohiko Ito, Takurou Mizuno, Keiichiro Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Toshihide Izumida, Shinya Yamada, Ryusho Sangen, Kazu Hamada, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Yuji Kasamaki, Takeshi Nakahashi, Akihiro Fukuda, Hitoshi Saito, Tsugiyasu Kanda, Masashi Okuro, Acta Medica Okayama, 76:705-713, Dec. 2022
A new predictive tool consolidating CURB-65 with procalcitonin and albumin to assess short-term mortality in hospitalized elderly patients with infectious disease: A retrospective study of a patient cohort, Toshihiro Higashikawa, Tomohiko Ito, Takuro Mizuno, Keiichirou Ishigami, Kengo Kuroki, Naoto Maekawa, Daisuke Usuda, Shinichiro Nakao, Kazu Hamada, Susumu Takagi, Nao Terada, Kento Takeshima, Shinya Yamada, Ryusho Sangen, Toshihide Izumida, Jun Kiyosawa, Atsushi Saito, Masaharu Iguchi, Hiroyuki Wato, Takeshi Nakahashi, Yuji Kasamaki, Akihiro Fukuda, Tsugiyasu Kanda, Masashi Oku, Medicine, 101:e31614., Nov. 2022

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.