Japanese

AKAO Hironobu

■Faculty	Department of Cardiology
■Position	Associate Professor

Researcher Profile & Settings

Research

Overview of research:

Ischemic heart disease, Coronary intervention

Education

Kanazawa Medical University Graduate School

Degree

Ph.D in Medicine

Research Activities

Published Papers

Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design, Tada Hayato, Okada Hirofumi, Yoshida Shohei, Shimojima Masaya, Nomura Akihiro, Tsuda Toyonobu, Mori Mika, Takashima Shin-ichiro, Kato Takeshi, Usui Soichiro, Sakata Kenji, Hayashi Kenshi, Fujino Noboru, Inazu Akihiro, Takahara Shizuko, Imai Yasuhito, Matsubara Takao, Nohara Atsushi, Miwa Kenji, Namura Masanobu, Terai Hidenobu, Yoshida Taiji, Araki Tsutomu, Minamoto Masahiro, Aburao Toru, Ito Yuji, Nakanishi Chiaki, Kawasaki Suguru, Todo Yasuhiro, Koizumi Junji, Kita Yoshihito, Matsumoto Hiroshi, Shintaku Hiroaki, Hodatsu Akihiko, Ino Hidekazu, Higashikata Toshinori, Takata Mutsuko, Misawa Katsushi, Yamaguchi Masato, Noji Yoshihiro, Osato Kazuo, Mabuchi Tomohito, Ichise Taro, Kaku Bunji, Katsuda Shoji, Fujimoto Manabu, Uchiyama Katsuharu, Fujioka Kensuke, Nakahashi Takuya, Nozue Tsuyoshi, Michishita Ichiro, Usuda Kazuo, Otowa Kanichi, Okeie Kazuyasu, Hirota Satoshi, Aburadani Isao, Kurokawa Keisuke, Takatori Osamu, Hondo Shunichiro, Oda Hiroyuki, Takata Shigeo, Murai Hisayoshi, Kinoshita Masaki, Nagai Hideo, Sekiguchi Yoshiteru, Sakagami Satoru, Omi Wataru, Fujita Chikara, Katsuki Tatsuo, Ootsuji Hiroshi, Igarashi Atsushi, Nakano Manabu, Okura Seiichiro, Maeno Koji, Mitamura Yasuhito, Sugimoto Naoki, Yamamoto Masakazu, Akao Hironobu, Kajinami Kouji, Takamura Masayuki, Kawashiri Masa-aki, BMJ open, 10:e038623, Sep. 2020
DOI:10.1136/bmjopen-2020-038623
Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients, (Nora Lee), Kazuya Maeda, Shinya Fukizawa, Ichiro Ieiri, Atsuko Tomaru, Hironobu Akao, Kenji Takeda, Mizuho Iwadare, Osamu Niwa, Tougen Masauji, Naoe Yamane, Kouji Kajinami, Hiroyuki Kusuhara, Yuichi Sugiyama, Drug Metabolism and Pharmacokinetics, 34:387-395, Dec. 2019
DOI:10.1016/j.dmpk.2019.08.004
Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with peripheral artery disease (PAD), Takamura, Taka-aki;Tsuchiya, Taketsugu;Oda, Minako;Watanabe, Makoto;Saito, Ryuhei;Sato-Ishida, Ryoko;Akao, Hironobu;Kawai, Yasuyuki;Kitayama, Michihiko;Kajinami, Kouji, ATHEROSCLEROSIS, 263:192-197, Aug. 2017
DOI:10.1016/j.atherosclerosis.2017.06.029
Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived advanced glycation end products., M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa , R.Saito, H.Aoki, K.Fujibayashi, T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami, Journal of Cardiology, 69:625-631, Apr. 2017
DOI:10.1016/j.jjcc.2016.07.001
Chronic total occlusions of the right coronary and left anterior descending coronary arteries in a young adult patient with antiphospholipid syndrome, Y.Kawai, M.Kitayama, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Takamura, H.Akao, T.Tsuchiya, K.Kajinami, Journal of Cardiology Cases, 14:46-48, Aug. 2016
A possible role for HLA-DRB1*04:06 in statin-related myopathy in Japanese patients, (K.Sai), K.Kajinami, H.Akao, M.Iwadare, R.Sato-Ishida, Y.Kawai, K.Takeda, T.Tanimoto, T.Yamano, T.Akasaka, T.Ishida, K.Hirata, K.Saku, S.Yagi, T.Soeki, M.Sata, M.Ueno, S.Miyazaki, A.Shiraki, J.Oyama, K.Node, K.Sugamura, H.Ogawa, K.Kurose, K.Maekawa, Y.Matsuzawa, T.Imatoh, R.Hasegawa, Y.Saito, Drug metabolism and pharmacokinetics, 31:467-470, 2016
DOI:10.1016/j.dmpk.2016.09.002
Nutri-pharmacogenomics of warfarin anticoagulation therapy : VKORC1 genotype-dependent influence of dietary vitamin K intake, R.Saito, K.Takeda, K.Yamamoto, A.Nakagawa, H.Aoki, K.Fujibayashi, M.Wakasa, A.Motoyama, M.Iwadare, R.Ishida, N.Fujioka, T.Tsuchiya, H.Akao, Y.Kawai, M.Kitayama, K.Kajinami, Journal of thrombosis and thrombolysis., 38:105-114, Jul. 2014
ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment, H.Akao, E.Polisecki, EJ.Schaefer, S.Trompet, M.Robertson, I.Ford, JW.Jukema, AJ.de Craen, C.Packard, BM.Buckley, K.Kajinami, Atherosclerosis., 235:176-181, May 2014
Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm, K.Tanabe, Y.Kawai, M.Kitayama, H.Akao, R.Ishida, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Tsuchiya, H.Kimura, K.Yoshida, K.Kajinami, Journal of cardiology, 64:86-90, Jan. 2014
Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly, H.Akao, E.Polisecki, K.Kajinami, S.Trompet, M.Robertson, I.Ford, J.W.Jukema, A.J.M.de Craen, R.G.J.Westendorp, J.Shepherd, C.Packard, B.M.Buckley, E.J.Schaefer, Atherosclerosis., 220:413-417, Feb. 2012
LDL apheresis int the prevention of coronary atherosclerosis, A.Motoyama, H.Akao, K.Kajinami, 27:42-46, Jan. 2008
Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischemia:results in vasospastic angina pectoris induced by provocation test, (N.Morikawa), Y.Kawai, K.Arakawa, T.Kumamoto, I.Miyamori, H.Akao, M.Kitayama, K.Kajinami, Jong-Dag Lee, H.Takeshita, Y.Kominato, T.Yasuda, European heart journal, 28:2992-2997, Dec. 2007
Pharmacogenomics of statin responsiveness, K.Kajinami, H.Akao, Eliana Polisecki, Ernst J Schaefer, Am J Cardiol, 96:65K-70K, Nov. 2005

Note: Performance information for the past 1-2 years may be revised at a later date due to inspections conducted by the committee from July to September every year.