FacultyDepartment of Hepatology

Researcher Profile & Settings


    Overview of research:
    anti hepatic virus therapy to viral hepatitis mechanism of Alcoholic liver disease

Special Field

  • Gastroenterology


  • Kanazawa Medical University Faculty of Medicine


  • Ph.D in Medicine

Research Activities

Published Papers

  • Inhibition of γ-glutamyltransferase ameliorates ischemia-reoxygenation tissue damage in rats with hepatic steatosis, Ryuichi Kubota, Nobuhiko Hayashi, Kaori Kinoshita, Takashi Saito, Kazuaki Ozaki, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Joseph George, British Journal of Pharmacology177:5195-5207Nov. 2020
  • Metabolism of N-nitrosodimethylamine, methylation of macromolecules, and development of hepatic fibrosis in rodent models, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Journal of Molecular Medicine98:1203-1213Sep. 2020
  • Effectiveness of Long Pepper Extract in Reducing Leg Swelling in Healthy Women during Prolonged SittingーA Randomized,Double-blind,Placebo-controlled Crossover Trialー, Yuki Fujimoto, Keiji Fujimoto, Rieko Oikawa, Mio Sawada, Mutsumi Tsuchishima, Junji Moriya, Hiroaki Uenishi, Hisakazu Furuta, Junji Kobayashi, Shiro Mizuno, Hirohisa Toga, Noboru Takekoshi, Susumu Yoshino, Yasuo Miyake, Nobuaki Ohto, Sumiyo Akazawa, Japanese Pharmacology & Therapeutics48:401-407Mar. 2020
  • Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats, Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro, European Journal of Pharmacology863:172681Dec. 2019
  • The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Turkish Journal of Medical Scences49:1350-1357Oct. 2019
  • Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis, Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Scientific Reports9:708Jan. 2019
  • Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis, Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Cell Death & Disease10:18Jan. 2019
  • MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, George, Joseph;Tsutsumi, Mikihiro;Tsuchishima, Mutsumi, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE21:3821-3835Dec. 2017
  • An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma, Toshikuni, Nobuyuki;Matsue, Yasuhiro;Ozaki, Kazuaki;Yamada, Kaho;Hayashi, Nobuhiko;Tsuchishima, Mutsumi;Tsutsumi, Mikihiro, RADIOLOGY AND ONCOLOGY51:263-269Sep. 2017
  • Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis, Toshikuni, Nobuyuki;Tsuchishima, Mutsumi;Fukumura, Atsushi;Arisawa, Tomiyasu;Tsutsumi, Mikihiro, GASTROENTEROLOGY RESEARCH AND PRACTICE2017:91278472017
  • GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats., K.Tamura, N.Hayashi, J.George, M.Toshikuni, T.Arisawa, J.Hiratake, M.Tsuchishima, M.Tsutsumi, American journal of physiology. Gastrointestinal and liver physiology311:G305-G3122016
  • Mural nodule of 10 mm or larger as predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiological evaluations., (N.Kawada), H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita, Pancreatology16:441-4482016
  • Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George, PLoS One10:e0118744-e01187442015
  • Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma, N.Kawada, H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita, Pancreatology15:654-6602015
  • Pathogenesis of alcoholic chronic hepatitis, N.Hayashi, T.Saito, M.Kakuda, Y.Matsue, T.Minato, A.Fukumura, K.Ozaki, M.Tsuchisima, M.Tsutsumi49:219-226Oct. 2014
  • Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis, T.Minato, M.Tsutsumi, M.Tsuchishima, N.Hayashi, T.Saito, Y.Matsue, N.Toshikuni, T.Arisawa, J.George, Molecular medicine (Cambridge, Mass.)20:490-5022014
  • Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult., M.Tsuchishima, J.George, H.Shiroeda, T.Arisawa, T.Takegami, M.Tsutsumi, Digestive diseases and sciences.58:1923-1933Jul. 2013
  • Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study., N.Hayashi, J.George, H.Shiroeda, T.Saito, N.Toshikuni, M.Tsuchishima, T.Arisawa, M.Tsutsumi, Journal of gastroenterology and hepatology.28:1015-1018Jun. 2013
  • Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension,diabetes mellitus,and dyslipidemia., N.Toshikuni, A.Fukumura, N.Hayashi, T.Nomura, M.Tsuchishima, T.Arisawa, M.Tsutsumi, Journal of clinical biochemistry and nutrition52:82-88Jan. 2013
  • Association between functional promoter polymorphisms of macrophage migration inhibitory factor(MIF)gene and ulcerative colitis in Japan, H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, T.Nomura, H.Yamada, R.Hayashi, T.Saito, M.Yamada, T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa, Cytokine.51:173-177May 2010
  • Functional promoter polymorphisms of macrophage migration inhibitory factor in peptic ulcer diseases, H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, H.Yamada, T.Nomura, R.Hayashi, T.saito, T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa, International journal of molecular medicine26:707-7112010
  • A case of IL-6 producing malignant mesothelioma of abdomen with thrombocytosis, T.Fukuyama, H.Kawahara, M.Yamada, N.Hayashi, H.Yano, M.Fukura, K.Ozaki, M.Tsuchishima, S.Takase, T.Arisawa, K.Omote, T.Nojima109:546-553Apr. 2009
  • Successful rituximab monotherapy for API2-MALT1 fusion posotive primary mucosa-associated lymphoid tissue lymphoma of the transverse colon in a patient with liver cirrhosis, M.Yamada, H.Kawahara, H.Shiroeda, M.Tsuchishima, Y.Masaki, K.Sato, S.Takase, Scandinavian journal of gastroenterology43:761-764Jun. 2008
  • Mutation of mitochondrial DNA in livers from patients with alcoholic hepatitis and nonalcoholic steatohepatitis, H.Kawahara, M.Fukura, M.Tsuchishima, S.Takase, Alcoholism, clinical and experimental research.31(Suppl.1)54S-60SJan. 2007
  • Effect of the inducer of interleukin-6(ME3738) on rat liver treated with ethanol, A.Fukumura, M.Tsutsumi, M.Tsuchishima, N.Hayashi, M.Fukura, H.Yano, K.Ozaki, S.Takase, Alcoholism, clinical and experimental research.31(Suppl.1):49S-53SJan. 2007
  • Effect of chronic dietary ethanol consumption on colonic cancer in rats induced by l,l-dimethylhydrazine, N.Hayashi, M.Tsutsumi, M.Fukura, H.Yano, M.Tsuchishima, S.Takase, Alcoholism, clinical and experimental research.31(Suppl.1):72S-76SJan. 2007
  • Usefulness of a combined evaluation of the serum adiponectin level, HOMA-IR, and serum Type IV collagen 7S level to predict the early stage of nonalcoholic steatohepatitis, M.Shimada, H.Kawahara, K.Ozaki, M.Fukura, H.Yano, M.Tsuchishima, M.Tsutsumi, S.Takase, The American journal of gastroenterology102:1931-19382007
  • Effects of New Orally Active Dopamine Prodrug, Docarpamine, on Pefractory Ascites : A Pilot Study., M.Tsuchishima, T.Funasaki, M.Tsutsumi, S.Takase, Y.Ueshima, S.Urashima, K.Shimanaka, T.Itoh, H.Kawahara, Am J Gastroenterol;94:2475-24811999
  • Clinical significance of hepatitis GB virus C infection in alcoholic liver disease.;18:136-1391998
  • Characteristic of serum hyaluronate concentrations in patients with alcoholic liver disease., M.Tsutsumi, S.Urashima, S.Takase, Y.Ueshima, M.Tsuchishima, K.Shimanaka, H.Kawahara, Alcohol Clini Exp Res;21:1716-17211997
  • Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report., Miura S, Niida Y, Hashizume C, Fujii A, Takagaki Y, Kusama K, Akazawa S, Minami T, Mukai T, Furuichi K, Tsuchishima M, Ueda N, Takamura H, Koya D, Ito T.9:25Mar. 2022
  • Surgical implanation of human adipose derived stem cells attenuates experimentally induced hepatic fibrosis in rats28: 143:s10020-022-00566-6Nov. 2022

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