OSANAI Kazuhiro

FacultyDepartment of Life Sciences
PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Role of alveolar type II epithelial cells in pathogenesis of interstitial lung disease and chronic obstructive lung disease, especially in lung surfactant synthesis, transport, and secretion

Special Field

  • Internal Medicine Respiratory System
  • Lung Molecular Biology

Degree

  • Ph.D in Medicine

Academic & Professional Experience

  • May 1991Mar. 1994Colorado University HSC/National Jewish Center Research Associate
  • Jul. 1995Mar. 2005Respiratory Medicine, Kanazawa Medical University Associate Professor
  • Apr. 2005Respiratory Medicine, Kanazawa Medical University Senior Associate Professor
  • Apr. 1994Jun. 1995Yamagata Prefectural Nihonkai Hosipital Senior Physician
  • Nov. 1989Mar. 1994First Department of Internal Medicine, Yamagata University School of Medicine Assistant Professor
  • May 1982Jan. 1989First Department of Internal Medicine, Yamagata University School of Medicine Physician

Research Activities

Published Papers

  • Lentiviral vector-mediated delivery of lysophatidylcholine acyltransferase 1 attenuates airway inflammation in ovalbumin-induced allergic asthmatic mice, (S.Cheng), H.Chen, A.Wang, M.Xie, J.Xie, K.Osanai, J.Zhao, Y.Xu, W.Xiong, M.Zhou, Asian Pacific Journal of Allergy and Immunology33:320-329Dec. 2015
  • ABPA-like Clinical Condition Associated with Bronchial Stenosis After Lung Lobectomy, T.Oikawa, R.Kato, S.Kitadate, S.Shinomiya, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga, The Journal of the Japan Society for Rsepiratory Endoscopy37:203-208Mar. 2015
  • A Case of Pulmonary Langerhans Cell Histiocytosis Diagnosed by a Cell Block from Bronchoalveolar Lavage Fluid, Y.Takahara, K.Nakase, M.Nojiri, R.Kato, S.Shinomiya, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, The Journal of the Japan Society for Respiratory Endoscopy37:240-244Mar. 2015
  • Adenovector-mediated gene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats, M.Zhou, K.Osanai, M.Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno, Y.Muraki, H.Toga, Critical care medicine.42:e716-e724Nov. 2014
  • A three-microphone acoustic reflection technique using transmitted acoustic waves in the airway, Y.Fujimoto, J.Huang, T.Fukunaga, R.Kato, M.Higashino, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, M.Saito, M.Kobayashi, K.Kojima, T.Oikawa, K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, S.Mizuno, K.Osanai, H.Toga, Journal of applied physiology (Bethesda, Md. : 1985)115:1119-1125Sep. 2013
  • A case of empyema thoracis by Nocardia farcinica successfully treated with sitafloxacin, T.Oikawa, R.Kato, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga2:424-428Jul. 2013
  • A case of lung abscess caused by community-acquired methicillin-resistant Staphylococcus aureus, M.Saito, T.Oikawa, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga2:295-299May 2013
  • Cytokines and proteases involved in pathogenesis of COPD, A.Yamaya, K.Osanai69:1748-1753Oct. 2011
  • A Case of rapidly progressing pulmonary mycosis caused by Aspergillus niger developing fungus ball-like shadows, M.Saito, S.Shinomiya, S.Kitadate, Y.Takahara, A. Yamaya, K.Kouji, Y.Fujimoto, T.Oikawa, K.Nakagawa, K.Tsishihara, M.Iguchi, K.Osanai, H.Toga33:33-37Jan. 2011
  • Two cases of Birt-Hogg-Dube' syndrome in a family, K.Nakagawa, S.Kitadate, M.Saito, Y.Fujimoto, K.Kojima, T.Oikawa, K.Oikawa, M.Iguchi, J.Huang, K.Osanai, H.Toga, K.Araida56:133-137Jan. 2011
  • A case of broncholithiasis lithoptysis occurring spontaneously after repeated pneumonia, R. Oikawa, Y. Takahara, A. Yamaya, M. Saito, K. Kojima, Y. Tachi, T. Oikawa, K. Nakagawa, K. Tsuchihara, M. Iguchi, T. Tobe, M. Takahashi, J. Huang, K. Osanai, H. Toga46:126-130Feb. 2008
  • Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine, T.Sakuma, K.Osanai34:676-6812006
  • Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine, T.Sakuma, X.Gu, Z.Wang, S.Maeda, M.Sugita, M.Sagawa, K.Osanai, H.Toga, L.B.Ware, G.Folkesson, M.A.Matthay, Critical care medicine.34:676-6812006
  • Pulmonary surfactant transport in alveolar type II cells, K.Osanai, Respirology (Carlton, Vic.)11:S70-S732006
  • Expression and characterization of Rab38, a new member of the Rab samll G protein family, K.Osanai, K.Takahashi, K.Nakamura, M.Takahashi, M.Ishigaki, T.Sakuma, H.Toga, T.Suzuki, D.R.Voelker, Biological chemistry.386:143-153Feb. 2005
  • Maximal inspiratory flow with nasal continuous positive airway pressure in patients with sleep-disordered breathing:relevance to the upper airway reflex, J.Huang, Y.Tachi, *T.Fukunaga, K.Tsuchihara, M.Iguchi, T.Tobe, M.Takahashi, M.Ishigaki, K.Osanai, H.Toga, et al., Japanese Journal of Applied Physiology34:169-1762004
  • Detection of inspiratory flow limitation with cardiogenic flow oscillation in patients with obstructive sleep apnea, J.Huang, Y.Tachi, *T.Fukunaga, K.Tsuchihara, M.Iguchi, T.Tobe, M.Takahashi, M.Ishigaki, K.Osanai, H.Toga, et al., Japanese Journal of Applied Physiology34:161-1672004
  • Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs, *T. Sakuma, *M. Sagawa, M. Hida, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, et al., The Journal of thoracic and cardiovascular surgery.124: 668-6742002
  • Pulmonary surfactant phosphatidylcholine transport bypasses Brefeldin A sensitive compartment of alveolar type (]G0002[) cells, OSANAI Kazuhiro, Biochim Biophys Acta-Moll Cell Biol Lipid1531:222-9Jul. 2001
  • Pulmonary surfactant phosphatidylcholine transport bypasses the brefeldin A sensitive compartment of alveolar typeⅡ cells, K. Osanai, et al., Biochimica et biophysica acta-molecular and cell biology of lipids1531: 222-2292001
  • Inducible nitric oxide synthase expression and nuclear factor-κ B activation in alveolar typeⅡ cells in lung injury, H. Toga, *Y. Ueda, K. Osanai, M. Ishigaki, *S. Katsuda, K. Takahashi, N. Ohya, et al., Experimental lung research.27: 485-5042001
  • Expression and localization of a novel Rab small G protein(Rab38)in the rat lung, OSANAI Kazuhiro, Am. J. Pathol.158:1665-752001
  • Expression and Localization of a novel Rab small G protein (Rab 38) in the rat lung, K. Osanai, M. Ishigaki, K. Takahashi, Y. Nambu, *T. Sakuma, H. Toga, N. Ohya, et al., The American journal of pathology.158: 1665-16752001
  • Effect of hypoxia on alveolar fluid transport capacity in rat lungs, *T. Sakuma, M. Hida, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, et al., Journal of applied physiology (Bethesda, Md. : 1985)91: 1766-17742001
  • Denopamine, a β1-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs, *T. Sakuma, C. Tsuchihara, M. Ishigaki, K. Osanai, Y. Nambu, H. Toga, K. Takahashi, N. Ohya, et al., Journal of applied physiology (Bethesda, Md. : 1985)90: 10-162001
  • Denopamine, a β1-adrenergic agonist increases alveolar fluid clearance in ex vivo rat and guinea pig lungs, OSANAI Kazuhiro, J. Appl. Physiol.2001
  • Beta1-Adrenoceptor simulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung, *T. Sakuma, C. Tsuchihara, M. Ishigaki, K. Osanai, Y. Nambu, H. Toga, K. Takahashi, N. Ohya, et al., Experimental lung research.27: 453-4682001
  • Beta1-Adrenergic Agonist is a Potent Stimulator of Alveolar Fluid Clearance in Hyperoxic Rat Lungs, OSANAI Kazuhiro, Jpn. J. Pharmacology2001
  • Beta1-Adrenergic Agonist a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs, T. Sakuma, M. Hida, Y. Nambu, K. Osanai, H. Toga, K. Takahashi, N. Ohya, Japanese journal of pharmacology.85: 161-1662001
  • Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs, T.Sakuma, K.Osanai, Transplantation69:1785-17932000
  • Lung deflation impairs alveolar epithelial fluid transport in ischemic rabbit and rat lungs, T.Sakuma, C.Tsukano, M.Ishigaki, Y.Nambu, K.Osanai, H.Toga, K.Takahashi, N.Ohya, et al., Transplantation.69:1785-17932000
  • Expression and localization of a novel rat small G protein in the rat lung, OSANAI Kazuhiro, The FASEB Journal2000
  • Trafficking of newly synthesized surfactant protein A in isolated rat alveolar type (]G0002[) cells, OSANAI Kazuhiro, Am. J. Respir. Cell Mol Biol.19:929-351998
  • Effects of interleukin-1β ow DNA synthesis in rat alveolar type (]G0002[) cells in primary culture, Yang GH, OSANAI Kazuhiro, Respirology (Carlton, Vic.)4:139-451998
  • How to use therapeutic drugs for bronchial asthma-theophylline derivatives, OSANAI Kazuhiro1996
  • Cloning of a novel small G protein expressed in type (]G0002[) alveolar epithelial cells, OSANAI Kazuhiro1996
  • Respiratory Disease - states of arts - function and metabolism of various cells macrophages, OSANAI Kazuhiro, Igaku no Ayumi(supplement)1991
  • Changes of lung surfactant and pressure-volume curve in bleomycin・induced pulmonary fibrosis, OSANAI Kazuhiro, J. Appl. Physiol.70:1300-81991
  • Smoking and lung function, OSANAI Kazuhiro, Kokyu to Junkan1990
  • The effect of cigarette smoke on bleomycin-induced pulmonary fibrosis in hamsters, OSANAI Kazuhiro, Am. Rev. Respir. Dis.(Am J Respir Crit Care Med)138:1276-12811988
  • Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease., R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki, N.F.Voelkel, H.Toga, Respiratory research17:139-1512016
  • p53 Signaling Pathway Polymorphisms Associated With Emphysematous Changes in Patients With COPD, Shiro.Mizuno, Takeshi.Ishizaki, Maiko.Kadowaki, Masaya.Akai, Kohei.Shiozaki, Masaharu.Iguchi, Taku.Oikawa, Ken.Nakagawa, Kazuhiro.Osanai, Hirohisa.Toga, Jose.Gomez-Arroyo, Donatas.Kraskauskas, Carlyne.D.Cool, Herman.J.Bogaard, Norbert.F.Voelkel, CHEST152:58-69Jul. 2017
  • A case of pulmonary arteriovenous malformation having difficulty in differential diagnosis of the hemoptysis during each menstrual period, Yutaka.Takahara, Ryo.Kato, Ken.Nakagawa, Shiro.Mizuno, Kazuhiro.Osanai, Hirohisa.Toga, Annals of the Japanese Respiratory Society6:215-219May 2017
  • Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant lung surfactant homeostasis in Ruby rats, Kazuhiro.Osanai, Keisuke.Nakase, Takashi.Sakuma, Kazuaki.Nishiki, Masafumi.Nojiri, Ryo.Kato, Masatoshi.Saito, Yuki.Fujimoto, Shiro.Mizuno, Hirohisa.Toga, Respiratory Research18:70Apr. 2017
  • ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema, Nojiri Masafumi;Mizuno Shiro;Nishiki Kazuaki;Kato Ryo;Nakagawa Ken;Oikawa Taku;Iguchi Masaharu;Osanai Kazuhiro;Ishizaki Takeshi;Toga Hirohisa, Pulmonary pharmacology & Therapeutics48:80-87Feb. 2018
  • Rab38 Mutation and the Lung Phenotype., Osanai Kazuhiro, International journal of molecular sciences19:E2203Jul. 2018


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