TOMOSUGI Naohisa

■FacultyDivision of Systems Bioscience for Drug Discovery Based on Intrinsically Disordered Proteins, Medical Research Institute
■PositionProfessor

Researcher Profile & Settings

Research

    Overview of research:
    Clinical Proteomics

Education

  • Kanazawa University Faculty of Medicine

Degree

  • Ph.D in Medicine

Research Activities

Published Papers

  • The target hemoglobin content values of reticulocytes for efficient anemia improvement are achieved by low ferritin levels and moderate transferrin saturation: a retrospective observational study, Chie Ogawa, Ken Tsuchiya, Naohisa Tomosugi, Katsunori Shimada, Fumiyoshi Kanda, Kunimi Maeda, Hematology (Amsterdam, Netherlands), 25:71-78, Dec. 2020
  • Optimizing hepcidin measurement with a proficiency test framework and standardization improvement, Ellis T Aune, Laura E Diepeveen, Coby M Laarakkers, Siem Klaver, Andrew E Armitage, Sukhvinder Bansal, Michael Chen, Marianne Fillet, Huiling Han, Matthias Herkert, Outi Itkonen, Daan van de Kerkhof, Aleksandra Krygier, Thibaud Lefebvre, Peter Neyer, Markus Rieke, Naohisa Tomosugi, Cas W Weykamp, Dorine W Swinkels, Clinical chemistry and laboratory medicine, 59:315-323, Oct. 2020
  • A Hypoxia-Inducible Factor Stabilizer Improves Hematopoiesis and Iron Metabolism Early after Administration to Treat Anemia in Hemodialysis Patients, Chie Ogawa, Ken Tsuchiya, Naohisa Tomosugi, Kunimi Maeda, International journal of molecular sciences, 21:7153, Sep. 2020
  • Effect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial, Yoshitsugu Obi, Satoshi Yamaguchi, Takayuki Hamano, Yusuke Sakaguchi, Akihiro Shimomura, Tomoko Namba-Hamano, Satoshi Mikami, Osamu Nishi, Motoko Tanaka, Akihito Kamoto, Yasue Obi, Naohisa Tomosugi, Yoshiharu Tsubakihara, Yoshitaka Isaka, Scientific reports, 10:15500, Sep. 2020
  • Tips for erythropoiesis-stimulating agent treatment of renal anemia, Naohisa Tomosugi, Yoshitaka Koshino, Clinical and experimental nephrology, 24:105-106, Jan. 2020
  • Immuno-detection of mRNA-binding protein complex in human cells under transmission electron microscopy, Qingfeng Ma, Takanori Tatsuno, Yuka Nakamura, Shin-Ichi Izumi, Naohisa Tomosugi, Yasuhito Ishigaki, MICROSCOPY RESEARCH AND TECHNIQUE, 82:680-688, Jun. 2019
  • GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells, (Zentaro Kiuchi), YukinoNishibori, Satoru Kutsuna, Masashi Kotani, Ichiro Hada, Toru Kimura, Toshiyuki Fukutomi, Daisuke Fukuhara, Noriko Ito-Nitta, Akihiko Kudo, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Hirotoshi Tanaka, Satsuki Matsushima, Shinya Ogasawara, Yoshiaki Hirayama, Hiromu Takematsu, Kunimasa Yan, FASEB JOURNAL, 33:7387-7402, Jun. 2019
  • Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans., N.Tomosugi, S.Yamamoto, M.Takeuchi, H.Yonekura, Y.Ishigaki, N.Numata, S.Katsuda, Y.Sakai, Journal of atherosclerosis and thrombosis, 24:530-538, May 2017
  • Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai, Journal of Atherosclerosis and Thrombosis, 24:530-538, May 2017
  • High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet engraftment after allogeneic hematopoietic stem cell transplantation., S.Sakamoto, H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi, A.Takaori-Kondo, Cancer medicine, 6:120-128, Jan. 2017
  • A Novel Phenotype of a Hereditary Hemochromatosis Type 4 with Ferroportin-1 Mutation, Presenting with Juvenile Cataracts, N.Yamakawa, K.Oe, N.Yukawa, K.Murakami, R.Nakashima, Y.Imura, H.Yoshifuji, K.Ohmura, Y.Miura, N.Tomosugi, H.Kawabata, A.Takaori-Kondo, T.Mimori, Internal medicine, 55:2697-2701, Sep. 2016
  • Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material, van der Vorm LN, Hendriks JC, Laarakkers CM, Klaver S, Armitage AE, Bamberg A, Geurts-Moespot AJ, Girelli D, Herkert M, Itkonen O, Konrad RJ, Tomosugi N, Westerman M, Bansal SS, Campostrini N, Drakesmith H, Fillet M, Olbina G, Pasricha SR, Pitts KR, Sloan JH, Tagliaro F, Weykamp CW, Swinkels DW, Clinical chemistry, 62:993-1001, Mar. 2016
  • Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis, H.Honda , Y.Kobayashi, S.Onuma, K.Shibagaki, T.Yuza, K.Hirao, T. Yamamoto, N.Tomosugi, T.Shibata, PLoS One, 11:e0151601, Mar. 2016
  • Identification and functional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto, Suizo, 31:76-84, 2016
  • Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation, T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake, H.Yonekura, Molecular and Cellular Biochemistry, 413:155-164, 2016
  • Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm., T.Tatsuno, Y.Nakamura, Ma Shaofu, N.Tomosugi, Y.Ishigaki, Molecular medicine reports, 14:655-660, 2016
  • Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh, Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi, Experimental Biology and Medicine, 240:438-445, 2015
  • Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts, T. Takata, Y. Motoo, N. Tomosugi, Journal of integrative medicine., 12:495-503, Nov. 2014
  • Long-term administration and efficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and the GSTP1 polymorphism., (H.Kitade), T.Shimasaki, S.Igarashi, H.Sakuma, M.Mori, N.Tomosugi, M.Nakai, Oncology letters, 7:1499-1502, May 2014
  • Regulation of hepcidin-25 by short- and long-acting rhEPO may be dependent on ferritin and predict the response to rhEPO in hemodialysis patients., (K.Takasawa), N.Tomosugi, C.Takaeda, T.Maeda, N.Ueda, Nephron extra [electronic resource], 4:55-63, Apr. 2014
  • A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease., (T.Fujiwara), T.Ikeda, Y.Nagasaka, Y.Okitsu, Y.Katsuoka, N.Fukuhara, Y.Onishi, K.Ishizawa, R.Ichinohasama, N.Tomosugi, H.Harigae, PloS one, 8:e75568;1-13, Sep. 2013
  • Serum ferritin levels adversely affect cardiac function in patients with ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention., (T.Suzuki), K.Toba, K.Kato, T.Ozawa, M.Higasimura, T.Kitajima, H.Oda, K.Tsuchida, N.Tomosugi, H.Saitoh, Y.Aizawa, International journal of cardiology, 167:286-288, Jul. 2013
  • Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma., (S.Maru), Y.Ishigaki, N.Shinohara, T.Takata, N.Tomosugi, K.Nonomura, The Journal of urology., 189:1921-1929., May 2013
  • Greater potency of darbepoetin-α than erythropoietin in suppression of serum hepcidin-25 and utilization of iron for erythropoiesis in hemodialysis patients., (S.Shoji), M.Inaba, N.Tomosugi, S.Okuno, M.Ichii, T.Yamakawa, S.Kurihara, European journal of haematology., 90:237-244, Mar. 2013
  • Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi, Experimental biology and medicine (Maywood, N.J.), 238:889-897, 2013
  • Effects of erythropoietin administration on iron status in patients with ST-elevation myocardial infarction who underwent successful percutaneous coronary intervention., (T.Suzuki), K.Toba, K.Kato, T.Ozawa, H.Suzuki, N.Tomosugi, H.Saitoh, Y.Aizawa, International journal of cardiology, 167:1644-1645, Nov. 2012
  • Expression pattern of Galectin 4 in rat placentation, T.Arikawa, E.Shimamura, H.Shimada, N.Nishi, T.Tatsuno, Y.Ishigaki, N.Tomosugi, C.Yamashiro, T.Hata, T.Takegami, H.Mogami, K.Yamaguchi, T.Nakamura, H.Otani, T.Hatta, H.Shoji, Placenta, 33:885-887, Aug. 2012
  • Hepcidin expression in iron overload diseases is variably modulated by circulating factors., (R.Giulia), S.Pelucchi, R.Mariani, N.Tomosugi, G.L.Modignani, M.Pozzi, E.Nemeth, T.Ganz, H.Hayashi, D.Barisani, A.Piperno, PloS one, 7:e36425, May 2012
  • Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured human cells by scanning electron microscopy., Y.Ishigaki, Y.Nakamura, T.Takehara, T.Kurihara, H.Koga, T.Takegami, H.Nakagawa, N.Nemoto, N.Tomosugi, S.Kuwabata, S.Miyazawa, Microscopy research and technique, 74:1104-1108, Dec. 2011
  • Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura, Molecular vision, 17:159-169, Jan. 2011
  • Scanning electron microscopy with an ionic liquid reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami, H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa, Microscopy research and technique, 74:1024-1031, 2011
  • Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa, 24:8-13, Nov. 2010
  • Ionic liquid enables simple and rapid sample preparation of human culturing cells for scanning electron microscope analysis, Y.Ishigaki, Y.Nakamura, T.Takehara, N.Nemoto, T.Kurihara, H.Koga, H.Nakagawa, T.Takegami, N.Tomosugi, S.Miyazawa, S.Kuwabata, Microscopy research and technique, 74:415-420, Sep. 2010
  • Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease, (S.Nakazawa J.Song), N.Tomosugi, H.Kawabata, T.Ishikawa, T.Nishikawa, K.Yoshizaki, Blood., 116:3627-3634, Jul. 2010
  • Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin, (S.Kono), K.Yoshida, N.Tomosugi, T.Terada, Y.Hamaya, S.Kanaoka, H.Mitajima, Biochimica et biophysica acta-molecular and cell biology of lipids, 1802:968-975, Jul. 2010
  • Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders, (Y.Kaneko), H.Miyajima, A.Piperno, N.Tomosugi, H.Hayashi, N.Morotomi, K.Tsuchida, T.Ikeda, A.Ishikawa, Y.Ota, S.Wakusawa, K.Yoshioka, S.Kono, S.Pelucchi, A.Hattori, Y.Tatsumi, T.Okada, M.Yamagishi, Journal of gastroenterology., 45:1163-1171, Jun. 2010
  • Iron regulatory hormone hepcidin decreases in chronic heart failure patients with anemia, (M.Matsumoto), T.Tsujino, Masaaki Lee-Kawabata, Y.Naito, H.Akahori, T.Sakoda, M.Ohyanagi, N.Tomosugi, T.Masuyama, Circulation journal : official journal of the Japanese Circulation Society, 74:301-306, Feb. 2010
  • Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation, H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara, N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo, International journal of oncology, 37:583-593, 2010
  • Isolation of N-acetylneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens., T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugi, F.Takano, T.Ohta, Journal of health science (Tokyo, Japan), 55：373-379, Mar. 2009
  • The relationship between initial diagnosis and long-term prognosis in lupus nephritis, H.Okuyama, S.Kimura, H.Atsumi, J.Imura, K.Fujimoto, Y.Chikazawa, M.Nakagawa, H.Imamura, H.Yamaya, M.Asaka, N.Tomosugi, H.Yokoyama, 51：44-50, Jan. 2009
  • Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization, (JJ.Kroot), EH.J.M.Kemna, SS.Bansal, M.Busbridge, N.Campostrini, D.Girelli, RC.Hider, V.Koliaraki, A.Mamalaki, G.Olbina, N.Tomosugi, C.Tselepis, DG.Ward, T.Ganz, JC.M.Hendriks, DW.Swinkels, Haematologica, 94:1748-1752, 2009
  • Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines, (J.Kanda), T.Uchiyama, N.Tomosugi, M.Higuchi, T.Uchiyama, H.Kawabata, International journal of hematology., 90:545-552, 2009
  • Increased serum hepcidin-25 level and increased tumor expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma, (T.Kamai), N.Tomosugi, H.Abe, K.Arai, K.Yoshida, BMC cancer [electronic resource]., 0.5625, 2009
  • The liquid culture filtrates of entomogenous fungus Paecilomyces tenuipes and its glycoprotein constituent protects against anemia in mice treated with 5-fluorouracil, (T.Takata), T.Taanaka, N.Yahagi, R.Yahagi, H.Tsuchida, Y.Ishigaki, N.Tomosugi, S.Fushiya, F.Takano, T. Ohta, Biological & pharmaceutical bulletin, 31:1565-1573, Aug. 2008
  • Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma, (H.Kijima), T.Sawada, N.Tomosugi, K.Kubota, BMC cancer [electronic resource]., 0.449305556, Jun. 2008
  • Perioperative management in a maintenance hemodialysis patient with congenital antithrombin Ⅲ deficiency undergoing surgery for renal cell carcinoma, (H.Suzuki), F.Ito, H.Nakazawa, Y.Maeda, K.Yoshida, H.Tomoe, N.Tomosugi, 41:641-645, 2008
  • Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantaion, (J.Kanda), C.Mizumoto, H.Kawabata, H.Tsuchida, N.Tomosugi, K.Matsuo, T.Uchiyama, Haematologica, 93:1550-1554, 2008
  • Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion, (N.Fujita), R.Sugimoto, S.Motonishi, N.Tomosugi, H.Tanaka, M.Takeo, M.Iwasa, Y.Kobayashi, H.Hayashi, M.Kaito, Y.Takei, 49:702-710, 2008
  • Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease, (H.Kawabata), N.Tomosugi, J.Kanda, Y.Tanaka, K.Yoshizaki, T.Uchiyama, Haematologica, 92:857-858, Jun. 2007
  • Proteomic analysis of serum, outflow dialysate and adsorbed protein onto dialysis membranes (polysulfone and PMMA) during hemodialysis treatment using SELDI-TOF-MS, I.Ishikawa, Y.Chikazawa, K.Sato, M.Nakagawa, H.Imamura, S.Hayama, H.Yamaya, M.Asaka, N.Tomosugi, H.Yokoyama, K.Matsumoto, American journal of nephrology, 26:372-380, Jun. 2006
  • Proteomic analysis of rat plasma by SELDI-TOF-MS under the condition of prevention of progressive adriamycin nephropathy using oral adsorbent AST-120, I.Ishikawa, T.Hayama, S.Yoshida, M.Asaka, N.Tomosugi, M.Watanabe, H.Yamato, M.Sugano, Nephron. Physiology, 103:125-130, 2006
  • Fifteen-year follow-up of acquired renal cystic disease-A gender difference., Ishikawa I, Saito Y, Nakamura M, Takada K, Ishii H, Nakazawa T, Fukuda Y, Asaka M, Tomosugi N, Yuri T, Nephron., 75: 315-320, 1997
  • Activation of metalloproteinase-2 by membrane type metalloproteinase expressed on human mesangial cell membrane., Tomosugi N, Yamaya H, Yuri T, Nakamura M, Nakazawa T, Asaka M, Ishikawa I, Contrib Nephrol, 118: 135-140, 1996
  • Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression, Hidehito Saito-Takatsuji, Yasuo Yoshitomi, Yasuhito Ishigaki, Shoko Yamamoto, Noriaki Numata, Yasuo Sakai, Masayoshi Takeuchi, Naohisa Tomosugi, Shogo Katuda, hideto Yonekura, Takayuki Ikeda, Nutrients, 13:2226, Jun. 2021
  • Hypoxia-inducible factor prolyl hydroxylase domain inhibitor may maintain hemoglobin synthesis at lower serum ferritin and transferrin saturation levels than darbepoetin alfa, (Chie Ogawa), Ken Tsuchiya, Naohisa Tomosugi, Kunimi Maeda, PLOS ONE, 16:e0252439, Jun. 2021
  • Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis, (Hirokazu Honda), Kenji Tanaka ,Tetsuo Michihata , Keigo Shibagaki ,Toshitaka Yuza, Keiichi Hirao, Naohisa Tomosugi, Tomas Ganz, Yuichiro Higashimoto, Clinical Kidney Journal, 4:943-949, Mar. 2021
  • Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate, Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T., micromachines, 12:1431, Nov. 2021
  • Comprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease, Takafumi Kawanami, Haruka Kawanami-Iwao, Takanobu Takata, Yasuhito Ishigaki, Naohisa Tomosugi, Tsutomu Takegami, Hiroto Yanagisawa, Shino Fujimoto, Tomoyuki Sakai, Yoshimasa Fujita, Kazunori Yamada, Shuichi Mizuta, Hiroshi Kawabata, Toshihiro Fukushima, Yuko Hirose, Yasufumi Masaki, Clinica Chimica Acta, 523:45-57, 2021