SAKAI Akiko

FacultyDepartment of Advanced Medicine
PositionAssociate Professor

Researcher Profile & Settings

Degree

  • Doctor of Biological of Science

Academic & Professional Experience

  • Aug. 2006May 2009Department of Biochemistry, University of Wisconsin-Madison

Research Activities

Published Papers

  • Intracellular toxic advanced glycation end-products promote the production of reactive oxygen species in HepG2 cells, Sakasai-Sakai A, Takata T, Takeuchi M, International Journal of Molecular Sciences21:4861Jul. 2020
  • Nutritional conditions and oxygen concentration affect spontaneous occurrence of homologous recombination events but not spontaneous mutagenesis in Escherichia coli, (Lan Anh Thi Le), Phooi Yee Chang, Sayaka Ando, Thomas M. Conrad, Shohei Nunose, Akiko Sakai, Haruka Uefune, Asako Furukohri, Masahiro Tatsumi Akiyama, Hisaji Maki, Genes & Genetic Systems95:85-93May 2020
  • Exploration of the mystery of the third glycogen metabolite 1,5-anhydro-D-fructose (1,5-AF), Akiko Sakasai-Sakai, Takanobu Takata, Hirokazu Suzuki, Ikuro Maruyama, Kenji Tanaka, Yoshihiro Motomiya, Masayoshi Takeuchi, The Journal of Japan Mibyou Association26:67-72Jan. 2020
  • Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite, Sakasai-Sakai Akiko, Takata Takanobu, Suzuki Hirokazu, Maruyama Ikuro, Motomiya Yoshihiro, Takeuchi Masayoshi, Scientific Reports9:10194Jul. 2019
  • Evidence for toxic advanced glycation end-products generated in the normal rat liver, Takata Takanobu, Sakasai-Sakai Akiko, Takino Jun-ichi, Takeuchi Masayoshi, Nutrients11:1612Jul. 2019
  • The relevance of toxic AGEs (TAGE) cytotoxicity to NASH pathogenesis: A mini-review, Sakasai-Sakai Akiko, Takata Takanobu, Takino Jun-Ichi, Takeuchi Masayoshi, Nutrients11:462Feb. 2019
  • Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease, Takata Takanobu, Sakasai-Sakai Akiko, Ueda Tadashi, Takeuchi Masayoshi, Scientific Reports9:2121Feb. 2019
  • Novel biomarker toxic AGEs (TAGE) in the onset / progression of lifestyle-related (LSRD), Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi, The journal of Japan Mibyo System Association24:27-33Aug. 2018
  • Toxic AGEs (TAGE) theory for pathophysiology of the onset / progression of NAFLD and ALD, Akiko Sakasai-Sakai, Jun-ichi Takano, Atsushi Fukumura, Takanobu Takata, Mikihiro Tsutsumi, Masayoshi Takeuchi, The journal of Japan Mibyo System Association24:19-25Mar. 2018
  • Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Masayoshi Takeuchi7:1Oct. 2017
  • Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion, Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi, World Journal of Gastroenterology23:4910-4919Jul. 2017
  • Toxic AGE (TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi, Nutrients9:634Jun. 2017
  • Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function, (Jun-ichi Takino), Kentaro Nagamine, Mikoto Suzuki, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hori, American Journal of Molecular Biology7:87-98Apr. 2017
  • Involvement of toxic AGEs(TAGE) in the onset / progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy, Masayoshi Takeuchi,Akiko Sakasai-Sakai,Takanobu Takata23:20-302017
  • Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma, (J.Takino), K.Nagamine, T.Hori, A.Sakasai-Sakai, M.Takeuchi, World Journal of Hepatology7:2459-2469Aug. 2015
  • Toxic AGEs (TAGE) theory in the pathogenesis of NAFLD and ALD, M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi, International Journal of Diabetes and Clinical Researsh2:1-5Jul. 2015
  • Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH., M.Takeuchi, A.Sakasai-Sakai, T.Takata, T.Ueda, J.Takino, M.Tsutsumi, H.Hyogo, S.Yamagishi, Medical Hypotheses84:490-4932015
  • Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi, World journal of hepatology [electronic resource]6:880-893Dec. 2014
  • Impact of Reactive Oxygen Species on Spontaneous Mutagenesis in Escherichia coli., Sakai A, Nakanishi M, Yoshiyama K, Maki H11:767-787Jul. 2006
  • Impact of intracellular toxic advanced glycation end-products (TAGE) on murine myoblast cell death, Takata Takanobu, Sakasai-Sakai Akiko, Takeuchi Masayoshi, Diabetology & Metabolic Syndrome12:54Jun. 2020
  • Accumulation of toxic advanced glycation end-products induces cytotoxicity and inflammation in hepatocyte-like cells differentiated from human induced pluripotent stem cells., (Kikuchi C), Sakasai-Sakai A, Okimura R, Tanaka H, Takata T, Takeuchi M, Matsunaga T, Biol. Pharm. Bull.44:1399-1402Oct. 2021
  • Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis., (Tanaka K), Sakasai-Sakai A, Motomiya Y, Yoneda T, Takeuchi M13:85Aug. 2021
  • Intracellular toxic AGEs (TAGE) triggers numerous types of cell damage., Takeuchi M, Sakasai-Sakai A, Takata T, Takino J, Koriyama Y, Furukawa A, Kikuchi C, Nagamine K, Hori T, Matsunaga T, Biomolecules11:387Mar. 2021
  • Suppression of hepatic stellate cell death by toxic advanced glycation end-products., (Takino J), Sato T, Nagamine K, Sakasai-Sakai A, Takeuchi M, Hori T, Biol. Pharm. Bull.44:112-117Jan. 2021
  • Intracellular Toxic Advanced Glycation End-Products in 1.4E7 Cell Line Induce Death with Reduction of Mirotubule-Associated Protein 1 Light Chain 3 and p62, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi14:332Jan. 2022
  • Intracellular Toxic Advanced Glycation End-Products May Induce Cell Death and Suppress Cardiac Fibroblasts, Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi12:615Jul. 2022
  • Effects of Toxic AGEs (TAGE) on Human Health, Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata11:2178Jul. 2022
  • The association between accumulation of toxic advanced glycation end-products and cytotoxic effect in MC3T3-E1 cells.14:990Feb. 2022