TOSHIKUNI Nobuyuki

FacultyDepartment of Hepatology
PositionAssociate Professor

Researcher Profile & Settings

Degree

  • doctor of medical science

Research Activities

Published Papers

  • Recombinant thrombomodulin prevented hepatic ischemia-reperfusion injury by inhibiting high-mobility group box 1 in rats, Yuki Hirakawa, Mutsumi Tsuchishima, Atsushi Fukumura, Kaori Kinoshita, Nobuhiko Hayashi, Takashi Saito, Joseph George, Toshikuni Nobuyuki, Ueda Yoshimichi, Tsutsumi Mikihiro, European Journal of Pharmacology863:172681Dec. 2019
  • The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people, Kaori Kinoshita, Nobuyuki Toshikuni, Takashi Saito, Nobuhiko Hayashi, Takahiro Minato, Yasuhiro Matsue, Yoshimichi Ueda, Mutsumi Tsuchishima, Mikihiro Tsutsumi, Turkish Journal of Medical Scences49:1350-1357Oct. 2019
  • An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma, Toshikuni, Nobuyuki;Matsue, Yasuhiro;Ozaki, Kazuaki;Yamada, Kaho;Hayashi, Nobuhiko;Tsuchishima, Mutsumi;Tsutsumi, Mikihiro, RADIOLOGY AND ONCOLOGY51:263-269Sep. 2017
  • Therapy with Direct-Acting Antiviral Agents for Hepatitis C-Related Liver Cirrhosis, Toshikuni, Nobuyuki, GUT AND LIVER11:335-348May 2017
  • Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and Nonalcoholic Steatohepatitis, Toshikuni, Nobuyuki;Tsuchishima, Mutsumi;Fukumura, Atsushi;Arisawa, Tomiyasu;Tsutsumi, Mikihiro, GASTROENTEROLOGY RESEARCH AND PRACTICE2017:91278472017
  • Management of gastroesophageal varices in cirrhotic patients: current status and future directions., N.Toshikuni, Y.Takuma, M.Tsutsumi, Annals of hepatology15:314-325May 2016
  • GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats., K.Tamura, N.Hayashi, J.George, M.Toshikuni, T.Arisawa, J.Hiratake, M.Tsuchishima, M.Tsutsumi, American journal of physiology. Gastrointestinal and liver physiology311:G305-G3122016
  • Elevated serum gamma-glutamyl transpeptidase levels and fatty liver strongly predict the presence of carotid plaque, N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi, Journal of Atherosclerosis and Thrombosis22:1051-1060Feb. 2015
  • Serum osteopontin predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George, PLoS One10:e0118744-e01187442015
  • Serum endocan as a survival predictor for patients with liver cirrhosis, N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi, Canadian Journal of Gastroenterology and Hepatology29:427-4302015
  • Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease, N.Toshikuni, M.Tsutsumi, T.Arisawa, World journal of gastroenterology : WJG.20:8393-8406Jul. 2014
  • Nutrition and exercise in the management of liver cirrhosis, N.Toshikuni, T.Arisawa, M.Tsutsumi, World journal of gastroenterology : WJG.20:7286-7297Jun. 2014
  • Hepatitis C-related liver cirrhosis - strategies for the prevention of hepatic decompensation,hepatocarcinogenesis,and mortality, N.Toshikuni, T.Arisawa, M.Tsutsumi, World journal of gastroenterology : WJG.20:2876-2887Mar. 2014
  • The *1244A>G polymorphism of MyD88(rs7744)is closely associated with susceptibility to ulcerative colitis, K.Matsunaga, T.Tahara, H.Shiroeda, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata, T.Arisawa, Molecular medicine reports.9:28-32Jan. 2014
  • Serum endocan as a novel prognostic biomarker in patients with hepatocellular carcinoma, K.Ozaki, N.Toshikuni, J.George, T.Minato, Y.Matsue, T.Arisawa, M.Tsutsumi, Journal of Cancer [electronic resource]5:221-2302014
  • Real-time image fusion for successful percutaneous radiofrequency ablation of hepatocellular carcinoma., N.Toshikuni, M.Tsutsumi, Y.takuma, T.Arisawa, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.33:2005-20102014
  • Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple steatosis, T.Minato, M.Tsutsumi, M.Tsuchishima, N.Hayashi, T.Saito, Y.Matsue, N.Toshikuni, T.Arisawa, J.George, Molecular medicine (Cambridge, Mass.)20:490-5022014
  • Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease., N.Hayashi, J.George, M.Takeuchi, A.Fukumura, N.Toshikuni, T.Arisawa, M.Tsutsumi, PloS one8:e70034;1-14Jul. 2013
  • Irsogladine maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon and ribavirin: a pilot study., N.Hayashi, J.George, H.Shiroeda, T.Saito, N.Toshikuni, M.Tsuchishima, T.Arisawa, M.Tsutsumi, Journal of gastroenterology and hepatology.28:1015-1018Jun. 2013
  • Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension,diabetes mellitus,and dyslipidemia., N.Toshikuni, A.Fukumura, N.Hayashi, T.Nomura, M.Tsuchishima, T.Arisawa, M.Tsutsumi, Journal of clinical biochemistry and nutrition52:82-88Jan. 2013
  • Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium., T.Nomura, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura, N.Toshikuni, T.Shibata, T.Arisawa, BMC gastroenterology13:1471-14792013
  • Functional promoter polymorphisms of NFKB1 influence susceptibility to the diffuse type of gastric cancer., T.Arisawa, T.Tahara, H.Shiroeda, K.Yamada, T.Nomura, H.Yamada, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata, Oncology reports.30:3013-30192013
  • Advanced ultrasonography technologies to assess the effects of radiofrequency ablation on hepatocellular carcinoma., N.Toshikuni, H.Shiroeda, K.Ozaki, Y.Matsue, T.Minato, T.Nomura, N.Hayashi, T.Arisawa, M.Tsutsumi, Radiology and oncology.47:224-2292013