YABE-WADA Toshiki

Researcher Profile & Settings

Research

Overview of research:
My research is focused on regulation mechanisms of cytokine production via Toll-like receptors in the innate immune system by using mouse models. Current project is to study the regulation of cytokine production via the posttranscriptional control of the novel cytokine trafficking mediator in plasmacytoid dendritic cells.

Education

• Osaka University Graduate School Graduate School of Science
• Kyoto Institute of Technology Faculty of Textile Science and Technology Department of Applied Biology

Degree

• Ph.D.

Academic & Professional Experience

• Apr. 2010- Nov. 2011NIDDK, NIH Liver Diseases Branch Project Postdoctoral Fellow
• Apr. 2007- Mar. 2010Institute of Multidisciplinary Research for Advanced Materials Tohoku University Assistant Professor
• Apr. 2006- Mar. 2007Institute for Protein Research, Osaka University Project Postdoctoral Fellow

Research Activities

Published Papers

• PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR, Toshiki Yabe-Wada , Caroline C Philpott, Nobuyuki Onai, FEBS open bio, 10:407-413, Mar. 2020
• Crystal structure of the ligand-free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH, T. Yabe-Wada, S. Matsuba, M. Unno, N. Onai, FEBS Letters, 592:2647-2657, Aug. 2018
  DOI:10.1002/1873-3468.13181
• Identification of Secretory Leukoprotease Inhibitor As an Endogenous Negative Regulator in Allergic Effector Cells, S.Matsuba, T.Yabe-Wada, K.Takeda, T.Sato, M.Suyama, T.Takai, T. Kikuchi, T. Nukiwa, A.Nakamura, FRONTIERS IN IMMUNOLOGY, 8:1538, Nov. 2017
  DOI:10.3389/fimmu.2017.01538
• Monomeric Form of Peptidylarginine Deiminase Type I Revealed by X-ray Crystallography and Small-Angle X-ray Scattering., (S.Saijo), A.Nagai, S.Kinjo, R.Mashimo, M. Akimoto, K.Kizawa, T.Yabe-Wada, N.Shimizu, H.Takahara, M. Unno, Journal of Molecular Biology, 428:3058-3073, 2016
  DOI:10.1016/j.jmb.2016.06.018
• TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin., T.Yabe-Wada, S.Matsuba, K.Takeda, T.Sato, M.Suyama, Y.Ohkawa, T.Takai, H.Shi, C.C. Philpott, A.Nakamura, Scientific Reports, 6:26566-26566, 2016
  DOI:10.1038/srep26566
• A critical role of Dectin-1 in hypersensitivity pneumonitis., M.Higashino, T.Yabe-Wada, S.Matsuda, K.Takeda, K.Anzawa, T.Mochizuki, K.Makimura, S.Saijyo, Y.Iwakura, H.Toga, A.Nakamura, Inflammation Research, 65:235-244, 2016
  DOI:10.1007/s00011-015-0910-1
• Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase, (Avery G. Frey), Anjali Nandal, Jong Hwan Park, Pamela M. Smith, Toshiki Yabe, Moon-Suhn Ryu, Manik C. Ghosh, Jaekwon Lee, Tracey A. Rouault, Myung Hee Park, Caroline C. Philpotta, Proceedings of the National Academy of Sciences of the United States of America, 111:8031-8036, Jun. 2014
• Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin, (Sebastien Leidgens), Kimberly Z. Bullough, Haifeng Shi, Fengmin Li, Minoo Shakoury-Elizeh, Toshiki Yabe, Poorna Subramanian, Emory Hsu, Navin Natarajan, Anjali Nandal, Timothy L. Stemmler, Caroline C. Philpott, The Journal of Biological Chemistry, 288:17791-17802, Jun. 2013
• Regulation of plasmacytoid dendritic cell responses by PIR-B, (Y.Mitsuhashi), A.Nakamura, S.Endo, K.Takeda, T.Yabe-Wada, T.Nukiwa, T.Takai, Blood., 120:3256-3259, Oct. 2012
• Arabidopsis cytosolic Nbp35 homodimer can assemble both [2Fe？2S] and [4Fe？4S] clusters in two distinct domains, (Hirokazu Kobushi), Yumi Nakai, Shingo Kikuchi, Toshiki Yabe, Hiroshi Hori, Masato Nakai, Biochemical and biophysical research communications, 378:810-815, 2009
• Structural Analysis of Arabidopsis CnfU Protein: An Iron-Sulfur Cluster Biosynthetic Scaffold in Chloroplasts, Toshiki Yabe, Eiki Yamashita, Akihiro Kikuchi, Kozo Morimoto, Atsushi Nakagawa, Tomitake Tsukihara, Masato Nakai, Journal of molecular biology, 381:160-173, 2008
• Arabidopsis AtIscA-I is affected by deficiency of Fe-S cluster biosynthetic scaffold AtCnfU-V, Toshiki Yabe, Masato Nakai, Biochemical and biophysical research communications, 340:1047-1052, 2006
• The Arabidopsis Chloroplastic NifU-Like Protein CnfU, Which Can Act as an Iron-Sulfur Cluster Scaffold Protein, Is Required for Biogenesis of Ferredoxin and Photosystem I, Toshiki Yabe, Kozo Morimoto, Shingo Kikuchi, Kazuaki Nishio, Ichiro Terashima, Masato Nakai, Plant Cell, 16:993-1007, 2004
• Detailed structure of mouse interferon α2 and its interaction with Sortilin, (Honoka Watanabe), Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno, The Journal of Biochemistry, 170:265-273, Aug. 2021