FacultyDepartment of Ophthalmology

Researcher Profile & Settings


  • Fukui University Graduate School Division of Medicine


  • Ph.D in Medicine

Research Activities

Published Papers

  • Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2), Naoki Yamamoto, Shun Takeda, Natsuko Hatsusaka, Noriko Hiramatsu, Noriaki Nagai, Saori Deguchi, Yosuke Nakazawa, Takumi Takata, Sachiko Kodera, Akimasa Hirata, Eri Kubo, Hiroshi Sasaki, Cells9:2670Dec. 2020
  • Aging of the crystalline lens from the viewpoint of anti-glycation and anti-oxidation., Eri Kubo, Glycative Stress Research7:283-286Dec. 2020
  • Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat, Hidetoshi Ishida, Teppei Shibata, Yuka Nakamura, Yasuhito Ishigaki, Dhirendra P.Singh, Hiroshi Sasaki, Eri Kubo, BioMed Research International2020:7319590Nov. 2020
  • Model-based approach for analyzing prevalence of nuclear cataracts in elderly residents, (Sachiko Kodera), Akimasa Hirata, Fumiaki Miura, Essam A.Rashed, Natsuko Hatsusaka, Naoki Yamamoto, Eri Kubo, Hiroshi Sasaki, Computers in Biology and Medicine126:104009Sep. 2020
  • Relative gene expression analysis of human pterygium tissues and UV radiation-evoked gene expression patterns in corneal and conjunctival cells, Naoko Shibata, Hidetoshi Ishida, Etsuko Kiyokawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo, Experimental Eye Research199:108194Aug. 2020
  • Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6, (Bhavana Chhunchha), Eri Kubo, Dhirendra P. Singh9:1861Aug. 2020
  • Lutein plus Water Chestnut (Trapa bispinosa Roxb.) Extract Inhibits the Development of Cataracts and Induces Antioxidant Gene Expression in Lens Epithelial Cells, Hidetoshi Ishida, Teppei Shibata, Shinsuke Shibata, Yuki Tanaka, Hiroshi Sasaki, Eri Kubo, Biomed Research International2020:9204620May 2020
  • Enhancement of Amyloid β1-43 Production in the Lens Epithelium of Japanese Type 2 Diabetic Patients, (Yu Mano), Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Noriaki Nagai, Biomedicines8:87Apr. 2020
  • Visual Function and Functional Decline in Patients With Waterclefts, Tanimura N, Hatsusaka N, Miyashita H, Shibata T, Ishida H, Kunisho A, Kubo E, Sasaki H, Investigative ophthalmology & visual science60:3652-3658Aug. 2019
  • Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells, (Bhavana Chhunchha), Eri Kubo, Dhirendra P. Singh, Cells8:1159Aug. 2019
  • Changes in mitochondrial cytochrome c oxidase mRNA levels with cataract severity in lens epithelia of Japanese Patients, (Nagai N), Mano Y, Otake H, Shibata T, Kubo E, Sasaki H, Molecular medicine reports19:5464-5472Jun. 2019
  • Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study, Miyashita H, Hatsusaka N, Shibuya E, Mita N, Ymazaki M, Shibata T, Ishida H, Ukai Y, Kubo E, Sasaki H, PLoS One14:e0215338Apr. 2019
  • Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition, Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H, Biology Open8:bio035691Feb. 2019
  • Roles of TGF β and FGF Signals in the Lens : Tropomyosin Regulation for Posterior Capsule Opacity, Eri Kubo, Teppei Shibata, Dhirendra P. Singh and Hiroshi Sasaki, International Journal of Molecular Sciences19:3093Oct. 2018
  • Tropomyosin 2 heterozygous knockout in mice using CRISPR-Cas9 system displays the inhibition of injury-induced epithelial-mesenchymal transition, and lens opacity, Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Mechanisms of Ageing and Development171:24-30Apr. 2018
  • Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress, (Bhavana Chhunchha), Eri Kubo, Prerna Singh, Dhirendra P.Singh, AGING10:2284-23152018
  • Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities, (Bhavana Chhunchha), Prerna Singh, Dhirendra P. Singh, Eri Kubo, International Journal of Molecular Sciences19:1-262018
  • Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment, Masamichi Fukuda, Shinsuke Shibata, Naoko Shibata, Nobuyuki Fujita, Hisanori Miyashita, Naoki Tanimura, Hidetoshi Ishida, Eri Kubo , Hiroshi Sasaki, PLOS ONE13:e02081982018
  • Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells, Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa, Molecular Vision23:1081-1092Dec. 2017
  • Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh, Scientific reports7:14130Oct. 2017
  • Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients, (Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Investigative Ophthalmology & Visual Science58:3294-33022017
  • A positive feedback loop between nitric oxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, (Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki, Toxicology381:19-302017
  • Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation, (Bhavana Chhunchha), Eri Kubo, Nigar Fatma, Dhirendra P Singh, Cell Death and Disease8:12017
  • FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity., E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh, Journal of Cellular and Molecular Medicine21:916-9282017
  • The role of Prdx6 in the protection of cell of the crystalline lens from oxidative stress induced by UV exposure, S.Shibata, N.Shibata, T.Shibata, H.Sasaki, DP.Singh, E.Kubo, Japanese Journal of Ophthalmology60:408-4182016
  • Propolis, a constituent of honey, inhibits the development of sugar cataracts and high-glucose-induced reactive oxygen species in rat lenses, T.Shibata, S.Shinnsuke, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo, Journal of Ophthalmologydoi: 10.1155/2016/1917093.:0-02016
  • Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells, (SP.Singh), B.Chhunchha, N.Fatma, E.Kubo, SP.Singh, DP.Singh, American Journal of Physiology-Cell Physiology310:C-1-C-162016
  • Optical simulation for subsurface nanoglistening, Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki, Journal of Cataract and Refractive Surgery41:193-198Oct. 2015
  • Emerging issues in radiogenic cataracts and cardiovascular disease, (N.Hamada), Y.Fujimichi, T.Iwasaki, N.Fujii, M.Furuhashi, E.Kubo, T.Minamino, T.Nomura, H.Sato, Journal of radiation research55:831-846Jun. 2014
  • Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription, (B.Chhunchha), N.Fatma, E.Kubo, DP.Singh, The FEBS journal281:3357-3381May 2014
  • Cases in which prescribed glaucoma medications were unnecessary., (N.Ibaraki), E.Kubo, H.Sasaki30:1472-1474Oct. 2013
  • Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-kB regulation., (B.Chhunchha), N.Fatma, E.Kubo, P.Rai, SP.Singh, DP.Singh, American journal of physiology. Cell physiology.304:C636-C655Jul. 2013
  • Corrected near and intermediate vfisual acuity in eyes with aspheric mono focal intraocular lens., M.Sasaki, M.Takahashi, E.Shibuya, A.Okamoto, N.Mita, Y.Takahashi, E.Kubo, H.Sasaki25:61-64Jun. 2013
  • Pharmacological prevention of cataract55:261-265Mar. 2013
  • Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island., (B.Bhanrgavan), B.Chhunchha, N.Fata, E.Kubo, DP.Shigh, Epigenetics8:268-280Mar. 2013
  • Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells., E.Kubo, N.Hasanova, N.Fatma, H.Sasaki, DP.Singh, Journal of cellular and molecular medicine.17:212-221Jan. 2013
  • Safety comparison of additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations., M.Fukuda, S.Shibata, N.Shibata, K.Hagihara, H.Osada, N.Takahashi, E.Kubo, H.Sasaki, Clinical ophthalmology.7:515-5202013
  • Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis, (N.Fatma), P.Singh, B.Chhunchha, E.Kubo, T.Shinohara, B.Bhargavan, DP.Singh, American journal of physiology. Cell physiology.301:C954-C967Jun. 2011
  • Protein Expression Prodiling of Lens Epithelial Cells from Prdx6-depleted Mice and Their Vulnerability to UV Radiation Exposure, E.Kubo, N.Hasanova, Y.Tanaka, N.Fayma, Y.Takamura, DP.Singh, Y.Akagi, Am J Physiol Cell Physiol298(2):C342-354Feb. 2010
  • Degradation of connexin 50 protein causes waterclefts in human lens, (Yosuke Nakazawa), Teppei Shibata, Noriaki Nagai, Eri Kubo, Hiroomi Tamura, Hiroshi Sasaki, Open Medicine15:1163-1171Oct. 2020
  • Engineered Sumoylation-Deficient Prdx6 Mutant Protein-Loaded Nanoparticles Provide Increased Cellular Defense and Prevent Lens Opacity., (Bhavana Chhunchha), Eri Kubo, Uday B. Kompella, Dhirendra P. Singh, Antioxidants10:1245Aug. 2021
  • Novel Technique for Retinal Nerve Cell Regeneration with Electrophysiological Functions Using Human Iris-Derived iPS Cells., Naoki Yamamoto, Noriko Hiramatsu, Mahito Ohkuma, Natsuko Hatsusaka, Shun Takeda, Noriaki Nagai, Ei-ichi Miyachi, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi, Eri Kubo, Hiroshi Sasaki, Cells10:743Mar. 2021
  • Association among pterygium, cataracts, and cumulative ocular ultraviolet exposure: A cross-sectional study in Han people in China and Taiwan., Natsuko Hatsusaka, Naoki Yamamoto, Hisanori Miyashita, Eri Shibuya, Norihiro Mita, Mai Yamazaki, Teppei Shibata, Hidetoshi Ishida, Yuki Ukai, Eri Kubo, Hong-Ming Cheng, Hiroshi Sasaki, PLoS ONE16:e0253093Jun. 2021
  • UV Index Does Not Predict Ocular Ultraviolet Exposure., Natsuko Hatsusaka, Yusuke Seki, Norihiro Mita, Yuki Ukai, Hisanori Miyashita, Eri Kubo, David Sliney, Hiroshi Sasaki, Translational Vision Science & Technology10:1Jun. 2021
  • Role of Decorin in Posterior Capsule Opacification and Eye Lens Development., Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Cells10:863Apr. 2021
  • Lens–specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity., Teppei Shibata, Masahito Ikawa, Ryo Sakasai, Yasuhito Ishigaki, Etsuko Kiyokawa, Kuniyoshi Iwabuchi, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo, Mechanisms of Ageing and Development196:111492Apr. 2021
  • Quantitative assessment of photic phenomena in the presbyopia-correcting intraocular lens., Yuki Ukai, Hajime Okemoto, Yusuke Seki, Yui Nakatsugawa, Akane Kawasaki, Teppei Shibata, Tsuyoshi Mito, Eri Kubo, Hiroshi Sasaki, PLoS One16:e0260406Dec. 2021
  • Analyzing Effect of Waterclefts on Visual Functions Via Optical Simulations, Yusuke Seki, Takushi Kawamorita, Naoki Yamamoto, Takashi Tanigawa, Norihiro Mita, Natsuko Hatsusaka, Eri Kubo, Hiroshi Sasaki63:22Feb. 2022
  • Vision With Retrodots and Factors for Declining Visual Function, Natsuko Hatsusaka, Naoki Tanimura, Mai Yamazaki, Norihiro Mita, Yuki Ukai, Yusuke Seki, Hisanori Miyashita, Tsuyoshi Mito, Eri Kubo, Hiroshi Sasaki63:17Nov. 2022
  • Benzalkonium Chloride-Induced Corneal Epithelial Injury in Rabbit Reduced by Rebamipide, Masamichi Fukuda, Nobuo Takeda, Hidetoshi Ishida, Yusuke Seki, Naoko Shibata, Nobuo Takahashi, Kazuhisa Sugiyama, Eri Kubo, Hiroshi Sasaki38:85-91Jan. 2022
  • Switching of Redox signaling by Prdx6 expression decides cellular fate by hormetic phenomena involving Nrf2 and reactive oxygen species, (Bhavana Chhunchha), Eri Kubo, Dhirendra P. Singh11:1266Apr. 2022
  • Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity, (Bhavana Chhunchha), Eri Kubo, Dhirendra P. Singh11:3021Sep. 2022
  • Positive dysphotopsia after intrascleral intraocular lens fixation: a case report, Tsuyoshi Mito, Honoka Kawakami, Toru Ikoma, Yuki Ukai, Mizuho Tsuchiya, Eri Kubo, Hiroshi Sasaki22:263Jun. 2022
  • Acute cataract by a high-intensity focused ultrasound procedure: a case report, Toru Ikoma, Teppei Shibata, Naoko Shibata, Tsuyoshi Mito, Eri Kubo, Hiroshi Sasaki22:164Apr. 2022
  • Role of Decorin in the Lens and Ocular Diseases, Eri Kubo, Shinsuke Shibata, Teppei Shibata, Hiroshi Sasaki, Dhirendra P Singh.12:74Dec. 2022

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