YOSHIZAKI Hisayoshi

Researcher Profile & Settings

Research

Overview of research:
(1) Identification of the risk factors of Hirschsprung's disease using RNA-Seq and microarray analysis of Hirschsprung's disease model mice. (2)Proteome-wide analysis of human cancer-specific nsSNV on the phosphorylation motifs.

Degree

• Ph.D in Medicine

Academic & Professional Experience

• Apr. 2008- Mar. 2012Ritsumeikan University Department of Biomedical Sciences, College of Life Sciences Assistant Professor
• Apr. 2007- Mar. 2008Kyoto University Graduate School of Biostudies Research Fellow

Research Activities

Published Papers

• Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins., S.Nishida, H.Yoshizaki, Y.Yasui, T.Kuwahara, E.Kiyokawa, M.Kohno, Biochemical and Biophysical Research Communications, 495:1461-1467, Jan. 2018
  DOI:10.1016/j.bbrc.2017.11.184
• Upregulation of multiple signaling pathways by Dock5 deletion in epithelial cells, Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa, Molecular Vision, 23:1081-1092, Dec. 2017
• Comparative lipid analysis in the normal and cancerous organoids of MDCK cells., H.Yoshizaki, H.Ogiso, T.Okazaki, E.Kiyokawa, Journal of Biochemistry, 159:573-584, Jun. 2016
  DOI:10.1093/jb/mvw001
• Regulation of Ripply1 expression in MDCK organoids, H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa, Biochemical and Biophysical Research Communications, 468:337-342, Dec. 2015
  DOI:10.1016/j.bbrc.2015.10.099
• Large-scale analysis of evolutionary histories of phosphorylation motifs in the human genome, H.Yoshizaki, S.Okuda, GigaScience, 4:1-6, May 2015
  DOI:10.1186/s13742-015-0057-6
• Elucidation of the evolutionary expansion of phosphorylation signaling networks using comparative phosphomotif analysis., H.Yoshizaki, S.Okuda, BMC genomics, 15:547-1-17, Jul. 2014
  DOI:10.1186/1471-2164-15-546
• Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells., (T.Nishioka), K.Aoki, K.Hikake, H.Yoshizaki, E.Kiyokawa, M.Matsuda, Molecular biology of the cell., 19:4213-4223, Oct. 2008
  DOI:10.1091/mbc.E08-03-0315
• Akt-PDK1 Complex Mediates EGF-induced Membrane Protrusion through Ral Activation., H.Yoshizaki, N.Mochizuki, Y.Gotoh, M.Matsuda, Molecular biology of the cell., 18:119-128, Jan. 2007
  DOI:10.1091/mbc.E06-05-0467
• Regulation of RalA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes., H.Yoshizaki, K.Aoki, T.Nakamura, M.Matsuda, Biochemical Society transactions, 34:851-854, Oct. 2006
  DOI:10.1042/BST0340851
• Activity of Rho-family G proteins as visualized with FRET-based probes., H Yoshizak, N Mochizuki, M Matsuda, Tanpakushitsu Kakusan Koso, 51:699-704, May 2006
• Dynamics of Rho-family G proteins as visualized with FRET-based probes, H.Yoshizaki, K.Aoki, N.Mochizuki, M.Matsuda, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 126:135-141, Aug. 2005
• Cell type-specific regulation of RhoA activity during cytokinesis., H.Yoshizaki, Y.Ohba, MC. Parrini, N.G.Dulyaninova, A.R. Bresnick, N.Mochizuki, M.Matsuda, The Journal of biological chemistry., 279:44756-62, Oct. 2004
  DOI:10.1074/jbc.M402292200
• STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension., (C.Miyagi), S.Yamashita, Y.Ohba, H.Yoshizaki, M.Matsuda, T.Hirano, The Journal of cell biology., 166:975-981, Sep. 2004
  DOI:10.1083/jcb.200403110
• Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor., (K.Kurokawa), R.E.Itoh, H.Yoshizaki, T.Nakamura, Y.Ohba, M.Matsuda, Molecular biology of the cell., 15:1003-1010, Mar. 2004
  DOI:10.1091/mbc.E03-08-0609
• Activity of Rho-family GTPases during cell division as visualized with FRET-based probes., H.Yoshizaki, Y. Ohba, K. Kurokawa, R. E Itoh, T. Nakamura, N. Mochizuki, M. Matsuda, The Journal of cell biology., 162:223-232, Jul. 2003
  DOI:10.1083/jcb.200212049
• Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells., (R.E.Itoh), K.Kurokawa, Y.Ohba, H.Yoshizaki, N.Mochizuki, M.Matsuda, Molecular and cellular biology, 22:6582-6591, Sep. 2002
• Recipient colon preoperative treatment with type I collagenase and fibronectin promotes the growth of transplanted enteric neural crest cells into Auerbach’s plexus, Tsuyoshi Kuwahara, Yoshitomo Yasui, Hisayoshi Yoshizaki, Mari Morikawa, Miyuki Kohno & Hideaki Okajima, Pediatric Surgery International, 38:1793-1798, Sep. 2022
• Transplanted neural crest cells migrate toward Auerbach’s plexus layer instead of the colon surface in recipient colon pretreated with collagenase and fibronectin, Yoshitomo Yasui, Hisayoshi Yoshizaki, Tsuyoshi Kuwahara, Shoichi Nishida, Miyuki Kohno, Hideaki Okajima, Biochemical and Biophysical Research Communications, 601:116-122, Feb. 2022

Books etc

• Spatio-temporal regulation of Rho-family GTPases during cell division
  Signal transduction of Cell Division. edited by Miki T
  H.Yoshizaki, N. Mochizuki, M. Matsuda
  Research Signpost  Apr. 2005